Purdue University’s Biochemistry core area offers leading-edge research programs for studies of biological systems. Our multidisciplinary programs encompass both fundamental and applied research, including:
- Mechanisms of transport of nutrients and therapeutic agents across the cell membrane.
- Integral membrane proteins involved in cancer and cancer treatment.
- Signal transduction pathways that control cell shape and flexibility.
- Development of novel chemical tools for drug discovery.
- Chemical Genetic Dissection of Kinases and G-Proteins for Target Identification and Validation in Cancer and Neurodegenerative diseases.
- Functional role of deubiquitinating enzymes in cellular pathways, particularly those implicated in neurodegenerative disorders including Alzheimer and Parkinson disease.
- Development and application of NMR techniques for studies of proteins and complex forms of molecular motion.
- Design and synthesis of receptor-targeted imaging and therapeutic agents for cancer, infectious and inflammatory diseases.
- Targeting ligands to deliver covalently attached therapeutic and imaging agents to cancerous and other pathologic tissues.
- Novel methods for the rapid detection and identification of pathogens that will prove critical in the detection of both biowarfare agents and naturally transmitted human pathogens.
- Using structural tools and tools of biochemistry, cell and molecular biology, organic synthesis, and bioanalytical chemistry, to define the molecular mechanisms of substrate recognition by enzymes and membrane-associated proteins.
- Development of tools in proteomics for discovery of molecular markers for cancer detection.
- Development of tools in Bioinformatics for studies of chromatin structure and gene regulation.
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Biochemistry Faculty
Shared Facilities |
