Occurence of Residues in the P6-P3' Region
in
Different Inhibitor Families

Inhibitor Family	Residue Frequency
Antistasin
P6	T2, I2, N2, S2, P1
P5	D3, E2, A1, G1, K1, Q1
P4	I5, V3, L1
P3	R4, H2, N2, Q1
P2	C9
P1	R6, M2, K1
P1'	I3, V3, K2, M1
P2'	F3, T2, Y1, K1, R1, H1
P3'	C9
Sum: 9
Arrowhead
P6	H2, M2
P5	K2, Q2
P4	D2, L2
P3	G2, V1, A1
P2	C2, S2
P1	K2, R2
P1'	S2, Y2
P2'	Y2, K2
P3'	V2, F2
Sum: 4
Ascaris
P6	D3, P2, N1, I1, K1, V1, L1
P5	K3, T2, V2, I2, P1
P4	P6, C3, L1
P3	C7, R2, L1
P2	A3, S2, P2, T1, V1, D1
P1	R3, T2, L2, A1, F1, K1
P1'	M3, I2, E1, G1, S1, V1, K1
P2'	C10
P3'	G3, R2, K1, L1, P1, H1
Sum: 10
Bombyx	Q, N, S, C, I, T, V, I, R (The P1 residue is T)
Bowman Birk
P6	S16, L6, Q5, K3, T3, R3, F3, I2, E2, H2, S2, G1, C1, Z1, D1, A1
P5	C41, A6, Q2, S1, R1, T1
P4	A11, I8, M7, V7, L6, T3, P2, F2, S1, N1, D1, C1, G1, E1
P3	C50, P2
P2	T42, A4, N3, R1, D1, S1
P1	K19, R16, L5, F5, Y3, A2, V1, H1
P1'	S48, R1, P1, M1, G1
P2'	I23, N8, M7, D3, Y3, F2, E2, Q2, A1, R1
P3'	P51, S1
Sum: 52
BPTI (Kunitz)
P6	D23, E21, Y15, V13, S7, R6, N6, A5, M1, I1, K1
P5	T31, P13, Q12, R7, S6, V6, D5, A4, K4, I3, Y3, G1, E4
P4	G95, E1, D1, I1, K1
P3	P62, L9, R9, I6, S4, N3, D2, T2, Q1, V1
P2	C99
P1	R34, K33, L7, F5, T4, M3, Y3, S2, G2, N2, Q2, E1, D1
P1'	A60, G24, D4, K4, Q2, R2, E1, F1, T1
P2'	R17, Y14, F13, M13, K7, S6, H6, N5, G4, L3, 12, A2, I2, T2, P2, V1
P3'	I51, F13, M12, V8, E4, T3, L3, A2, P1, K1, D1
Sum: 99
Cereal
P6	C4
P5	G2, H2
P4	V2, Q1, I1
P3	G4
P2	P4
P1	R4
P1'	L4
P2'	A1, P1, F1, L1
P3'	T3, W1
Sum: 4
Chelonianin
P6	I3, T2, K2, V1, G1
P5	L3, Y2, Q1, S1, I1, P1
P4	I3, G3, A2, F1
P3	R4, Q3, F1, I1
P2	C9
P1	L4, M2, P2, A1
P1'	M5, L2, R1, H1
P2'	L4, V2, Y1, G1, S1
P3'	N7, K1, C1
Sum: 9
Ecotin	S P V S T MMAC (The P1 residue is M)
Grasshopper
P6	S7, A3, V2, I2, L2, K1
P5	A8, W4, G2, P1, S1, R1
P4	A4, S4, G2, I2, V1, Q1, M1, L1, P1
P3	C17
P2	T16, S1
P1	L7, R5, E2, T1, V1, K1
P1'	K12, M2, R1, E1, I1
P2'	G7, A5, L3, Y1, E1
P3'	C17
Sum: 17
Kazal
P6	V175, K157, M17, L17, R15, P13, S12, Q11, A10, T10, D8, E7, G6, C3, I3, W2, N1
P5	P175, L172, I27, V25, A10, S9, F8, N7, T6, E6, D5, C4, M4, H3, K3, Q2, R2, Y2, F1
P4	A152, V137, L73, G22, D17, T13, E11, F9, I8, M6, R6, P5, N3, Y2, S1
P3	C471
P2	T252, P71, S59, A28, N25, D8, L7, E3, K3, Q3, M3, V3, R2, I2, F1, G1
P1	K137, M74, E72, L71, R48, A13, Q10, G9, S7, D6, V6, P6, T5, N2, H2, F1, I1, Y1
P1'	E202, D100, I63, A29, N17, S12, T11, P7, V7, Q6, H4, L4, M2, R2, K2, Y2, F1
P2'	Y169, L160, F23, P20, V17, N13, S11, D9, R8, Q7, I7, K4, A4, M3, W2, T1, G1
P3'	R117, S96, M76, N40, D30, H25, K18, Q10, L10, F9, V8, A8, E4, G4, T3, P3, W2
Sum: 471
Marinostatin	H2 N-A T M R Y P (The P1 residue is M)
Potato 1
P6	G24, D5, T1, R1
P5	S19, T7, A3, G1, I1
P4	P19, I4, M3, F2, A1, G1, K1
P3	V28, F2, I1
P2	T26, P3, A1, H1
P1	M10, L8, A4, K4, E3, D1, Q1
P1'	D24, E4, N2, V1
P2'	Y14, F10, L5, I2
P3'	R24, N3, D1, H1, K1, L1
Sum: 31
Potato 2
P6	P16, K1, A1
P5	K15, N3
P4	A16, V2
P3	C18
P2	P14, T4
P1	R10, L5, F1, Q1, K1
P1'	N15, Y1, F1, E1
P2'	C18
P3'	D18
Sum: 18
Rapeseed	RTI....G R C A P R I Y P (The P1 residue is R) MTI2..P F C A P R I F P (The P1 residue is R)
Squash
P5	R29, M2, G2, N2
P4	I12, R9, V7, M5, G5, S1
P3	C41
P2	P41
P1	R29, K8, L4
P1'	I41
P2'	L27, Y8, W6
P3'	M36, N3, K2
Sum: 41
SSI
P6	G9, D8, A1, S1
P5	V11, R4, T4
P4	M9, V4, A3, I1, W1, Y1
P3	C19
P2	T13, P4, N2,
P1	K9, R6, M3, Q1
P1'	E9, Q4, L2, H2, V1, I1
P2'	Y14, W3, F2
P3'	D8, A6, N3, R2
Sum: 19
STI
P6	I17, S4, D2, L2, K1, E1, V1, Y1
P5	S10, G7, A6, W2, E2, V1, G1
P4	S15, T7, F3, A2, G1, L1
P3	P16, Q5, R4, L3, V1
P2	P7, V7, L7, Y4, F3, R1
P1	R23, L3, K2, Q1
P1'	I10, S10, F5, T2, A1
P2'	A7, I4, R4, T3, G3, L3, F2, M1, E1, S1
P3'	F13, P7, I4, Y2, S1, H1, N1
Sum: 29

Return to Laskowski Home Page