Hyperspectral Imaging

We have developed an instrument designed for compressive detection imaging, which allows us to collect data much faster than conventional Raman spectroscopy - milliseconds vs. minutes or hours - without sacrificing resolution and image quality. Thus, we are able to rapidly distinguish different chemical components in biological samples, pharmaceuticals, and engineering materials. Fast imaging of this nature has broad applications, from medical diagnostics to industrial process monitoring to kinetic studies. The figure below shows a Schematic of the Digital Micromirror (DMD)-based near infrared digital compressive detection instrument.

Compressive Detection allows the classification of highly overlapping spectra. The Raman spectra of n-heptane (plus background), n-octane (plus background), and the background are shown in panels (a)–(c), respectively. The shaded regions denote the wavelengths directed toward the detector, as determined by the OB filters. The score plot in panel (d) shows the classification of n-heptane (red) and n-octane (blue) using a linear discriminant. Each point was obtained using three OB filters applied for a total integration time of 5 ms. The darkness of each colored disk represents the number of times each pair of photon rates was obtained in 1000 independent measurements (per cloud) – the lightest disks indicate one result each, the darkest disk for both n-heptane and n-octane indicates 2 results.