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Publications of the Chmielewski Group

  1. Bishop, P.; Chmielewski, J., "Cyanogen Iodide, A New Reagent for Disulfide Bond Formation in Peptides", Tetrahedron Lett., 1992, 33, 6263-6266.

  2. Lutgring, R.; Sujatha, K.; Chmielewski, J., "The Synthesis of Homologs of Cysteine Suitable for Peptide and Protein Crosslinking", Bioorganic and Medicinal Chemistry Letters, 1993, 3, 739-742.

  3. Franciskovich, J.; Houseman, K.; Mueller, R.; Chmielewski, J., "A Systematic Evaluation of the Inhibition of HIV-1 Protease by its C- and N-Terminal Peptides", Bioorganic and Medicinal Chemistry Letters, 1993, 3, 765-768.

  4. Mihara, H.; Chmielewski, J.; Kaiser, E. T., "Synthesis of the 60 Amino Acid Homeo Domain and Smaller Fragments of the Drosophila Gene Regulatory Protein Antennapedia by a Segment Synthesis-Condensation Approach", Journal of Organic Chemistry, 1993, 58, 2209-2215.

  5. Bishop, P.; Jones, C.; Chmielewski, J., "Dimethyl(methylthio)-sulfonium Tetrafluoroborate: A Reagent for Disulfide Bond Formation in Peptides", Tetrahedron Lett., 1993, 34, 4469-4473.

  6. Lutgring, R.; Chmielewski, J., "A General Stategy for Covalently Stabilizing Helical Bundles: A Disulfide Crosslinked Five Helix Bundle", J. Am. Chem. Soc., 1994, 116, 6451-6452.

  7. Vogel, K.; Chmielewski, J., "A Rapid and Efficient Resynthesis of Proteolyzed Triose Phosphate Isomerase", J. Am. Chem. Soc., 1994, 116, 11163-11164.

  8. Ulysse, Luckner; Chmielewski, J., "The Synthesis of a Light-Switchable Amino Acid for Inclusion into Conformationally Mobile Peptides", Bioorganic and Medicinal Chemistry Letters, 1994, 4, 2145-2146.

  9. Chmielewski, J.; Lipton, M., "The Rational Design of Highly Stable Amphiphilic Helical Peptides", Int. J. Peptide and Protein Res., 1994, 44, 152-157.

  10. Chmielewski, J.; Franciskovich, J.; Wilson, M., "Inhibition of HIV-1 Protease by its C- and N-Terminal Peptides", Peptides: Chemistry, Structure and Biology,1994, 595-597.

  11. Chmielewski, J.; Lutgring, R.; Lewen K., "The Design of Associating Amphiphilic alpha-Helical Peptides", Peptides: Chemistry, Structure and Biology, 1994, 1054-1056.

  12. Bishop, P.; Ghosh, I.; Jones, C.; Chmielewski, J., "Basic-Helix-Loop-Helix Region of Tal: Structure and DNA Binding" J. Am. Chem. Soc., 1995, 117, 8283-8284.

  13. Ulysse, L.; Cubillos, J.; Chmielewski, J., "Photoregulation of Cyclic Peptide Conformation" J. Am. Chem. Soc., 1995, 117, 8466-8467.

  14. Bishop, P.; Jones, C.; Ghosh, I.; Chmielewski, J., "The Basic-Helix-Loop-Helix Region of IEB E47: Evaluation of Structure and DNA Affinity", Int. J. Pept. Prot. Res., 1995, 46, 149-154.

  15. Vogel, K.; Wang, S.; Chmielewski, J.; Low, P., "Peptide Mediated Endosomal Release of Folate-Targeted Liposomes" J. Am. Chem. Soc., 1996, 117, 1581-1586.

  16. Vogel, K.; Cooks, J.;Chmielewski, J., "Subtilisin-Catalyzed Religation of Proteolyzed Hen Egg-White Lysozyme: Investigation of the Role of Disulfides", Chemistry & Biology, 1996, 3, 295-299.

  17. Lutgring, R.; Lipton, M.; Chmielewski, J., "Differential Self-Assembly of Amphiphilic Helical Peptides", Amino Acids, 1996, 10, 295-304.

  18. Zutshi, R.; Bishop, P.; Franciskovich, J.; Chmielewski, J., "Dissociation of Dimeric HIV-1 Protease: A Novel Means of Enzyme Inhibition", Peptides: Chemistry, Structure and Biology, 1996, 14, 249-251.

  19. Vogel, K.; Wang, S.; Chmielewski, J.; Low, P., "The Design of pH-Dependent Amphiphilic alpha-Helices to Trigger Cytoplasmic Release of Liposome Encapsulated Molecules", Peptides: Chemistry, Structure and Biology, 1996, 14, 577- 578.

  20. Ulysse, L.; Chmielewski, J., "Light Induced Conformational Switch in Cyclic Peptides", Peptides: Chemistry, Structure and Biology, 1996, 14, 203-204.

  21. Zutshi, R.; Franciskovich, J.; Shultz, M.; Schweitzer, B.; Bishop, P.; Wilson, M.; Chmielewski, J., "Targeting the Dimerization Interface of HIV-1 Protease: Inhibition with Crosslinked Interfacial Peptides", J. Am. Chem. Soc., 1997, 119, 4841-4845.

  22. Yao, S.; Ghosh, I.; Zutshi, R.; Chmielewski, J., "A pH-Modulated, Self-Replicating Peptide", J. Am. Chem. Soc., 1997, 119, 10559-10560.

  23. Chmielewski, J.; Lewis, J.; Lovell, S.; Zutshi, R.; Savickas, P.; Mitchell, C.; Subramony, A.; Kahr, B., "Single-Crystal Matrix Isolation of Biopolymers", J. Am. Chem. Soc., 1997, 119, 10565-10566.

  24. Shultz, M.; Chmielewski, J., "Hydrophobicity versus Hydrophilicity with Dimerization Inhibitors of HIV-1 Protease",Tetrahedron Asymmetry, 1997, 8, 3881.

  25. Yao, S.; Ghosh, I.; Zutshi, R.; Chmielewski, J., "Selective Amplification via Auto- and Cross-Catalysis in a Replicating Peptide System", Nature, 396, 1998, 447-450.

  26. Yao, S.; Ghosh, I.; Zutshi, R.; Chmielewski, J., "A Self-Replicating Peptide under Ionic Control", Angewandte Chemie Int. Ed., 1998, 37, 478-479.

  27. Brickner, M., Chmielewski, J., "Inhibition of the Dimerization of Eco RI", Chemistry; Biology, 1998, 5, 339-343.

  28. Ghosh, I.; Chmielewski, J., "A beta-Sheet Peptide Inhibitor of IEB E47 Dimerization and DNA Binding", Chemistry; Biology, 5, 1998, 439-445.

  29. Yao, S.; Zutshi, R.; Chmielewski, J., "Endothiopeptide Inhibitors of HIV-1 Protease", Bioorganic and Med. Chem. Lett., 1998, 8, 699-704.

  30. Yao, S.; Brickner, M.; Pares-Matos, E.; Chmielewski, J., "Uncoiling c-Jun Coiled-Coils: Inhibitory Effects of Truncated Fos Peptides on Jun Dimerization and DNA Binding",Biopolymers: Peptide Science, 47, 1998, 277-283.

  31. Ulysse, L.; Chmielewski, J., "Restricting the Flexibility of Crosslinked, Interfacial Peptide Inhibitors of HIV-1 Protease", Bioorg. Med. Chem. Lett., 8, 1998, 3281-3286.

  32. Kurimoto, M.; Subramony, P.; Chmielewski, J.; Kahr, B., "Kinetic Stabilization of Biopolymers in Single Crystal Hosts: Green Fluorescent Protein in a-Lactose Monohydrate", J. Am. Chem. Soc., 29, 1999, 6952-6953.

  33. Shultz, M.; Chmielewski, J., "Probing the Role of Interfacial Residues in Dimerization Inhibitors of HIV-1 Protease", Bioorg. Med. Chem. Lett., 9, 1999, 2431-2436.

  34. Ghosh, I.; Issac, R.; Chmielewski, J. "Structure-Function Relationship in a beta-Sheet Peptide Inhibitor of E47 Dimerization and DNA Binding", Bioorg. Med. Chem., 7, 1999, 61-66.

  35. Yao, S.; Pares-Matos, E.; Brickner, M.; Chmielewski, J., "Inhibiting Dimerization and DNA Binding of c-Jun", Peptides: Chemistry, Structure and Biology, 15, 1999, 751-52.

  36. Yao, S.; Ghosh, I.; Zutshi, R.; Chmielewski, J., "Natural Selection with Self-Replicating Peptides", Peptides: Chemistry, Structure and Biology, 15, 1999, 366-368.

  37. Brickner, M.; Yusuf, C.; Vogel, K.; Chmielewski, J., "Design and Use of Amphiphilic Peptides in Liposomes as pH-Triggered Releasing Agents", Peptides: Chemistry, Structure and Biology, 15, 1999, 461-462.

  38. Yao, S.; Chmielewski, J., "A pH-Tunable Peptide Ligase", Biopolymers: Peptide Science, 8, 1999, 370-375.

  39. Micklatcher, C.; Lutgring, R.; Hart, S.; Issac, R.; Chmielewski, J., "Expanding the Repertoire of Helical Bundles: Stabilization of Five+ Helical Bundles", Peptides: Chemistry, Structure and Biology, 16, 2000, 297-299.

  40. Ragin, A.; Brickner, M.; Chmielewski, J., "Peptide Shuttles for Cytoplasmic and Nuclear Targeting", Peptides: Chemistry, Structure and Biology, 16, 2000, 212-213.

  41. Shultz, M. D.; Bowman, M. J.; Ham, Y.-W.; Zhao, X.; Tora, G.; Chmielewski, J., "Small Molecule Dimerization Inhibitors of HIV-1 Protease", Angewandte Chemie Int. Ed., 2000, 112, 2710-2713.

  42. Zutshi, R.; Chmielewski, J., "Targeting the Dimerization Interface for Irreversible Inhibition of HIV-1 Protease", Bioorg. Med. Chem. Lett., 10, 2000, 1901-1903.

  43. Ghosh, I.; Bishop, P.; Chmielewski, J., "DNA binding Properties of Tal and E47 Basic-Helix-Loop-Helix Fusion Proteins", J. Pept. Res., 2001, 57, 354-360.

  44. Wang, H.; Kurimoto, M.; Kahr, B.; Chmielewski, J., "Lactose Monohydrate Single Crystals as Hosts for Matrix Isolation of Guest Biopolymers", Bioorg. Med. Chem., 2001, 9, 2279-2283.

  45. Turk, M. J.; Reddy, J. A.; Chmielewski, J.; Low, P. S., "Characterization of a Novel pH-Sensitive Peptide Which Enhances Folate-Targeted Liposomal Drug Delivery and Serum Stable Transfection of Cancer Cells", Biochimica et Biophysica Acta, 2002, 1559, 56-68.

  46. Ragin, A.; Brickner, M.; Morgan, R.; Chmielewski, J., "Cellular Import Mediated by Nuclear Localization Signal Sequences", Chemistry & Biology, 2002, 8, 943-948.

  47. Issac, R.; Chmielewski, J., "Approaching Exponential Growth with a Self Replicating Peptide",J. Am. Chem. Soc., 2002, 124, 6808-6809.

  48. Bowman, M.; Chmielewski, J., "Novel strategies for targeting the Dimerization Interface of HIV Protease with Cross-linked Interfacial Peptides", Biopolymers, 2002, 2, 126-133.

  49. Zhao, L.; O'Reilly, M.; Shultz, M.; Chmielewski, J., "Interfacial Peptide Inhibitors of HIV-1 Integrase Activity and Dimerization", Bioorg. Med. Chem. Lett., 13, 2003, 1175-1177.

  50. Li, X.; Chmielewski, J., "Challenges in the Design of Self Replicating Peptides", Org. Biomol. Chem., 2003, 6, 901-904.

  51. Li, X.; Chmielewski, J., "Peptide Self-replication Enhanced by a Proline Kink", J. Am. Chem. Soc., 2003, 125, 11820-11821.

  52. Zhao, L.; Chmielewski, J., "Interfacial Peptide Inhibitors of HIV-1 Integrase Activity and Dimerization", Biopolymers, 2003, 71, 397-397.

  53. Hwang, Y.; Chmielewski, J., "Development of Low Molecular Weight HIV-1 Protease Dimerization Inhibitors", Biopolymers, 2003, 71, 395-395.

  54. Ragin, A.; Chmielewski, J., "Probing Essential Residues for Cellular Uptake with a Cationic Nuclear Localization Signal Sequence", J. Pep. Res., 2003, 63, 155-160.

  55. Bowman, M.; Chmielewski, J., "Crucial Amides for Dimerization Inhibitors of HIV-1 Protease", Bioorg. Med. Chem. Lett., 14, 2004, 1395-1398.

  56. Hwang, Y.; Chmielewski, J., "Unidirectional Crosslinking Strategy for HIV-1 Protease Dimerization Inhibitors", Bioorg. Med. Chem. Lett., 14, 2004, 4297-4300.

  57. Shultz, M.; Ham Y.; Lee, S.; Davis, D.; Brown. C.; Chmielewski, J., "Small-molecule Dimerization Inhibitors of Wild-type and Mutant HIV Protease: A Focused Library Approach", J. Am. Chem. Soc., 2004, 126, 9886-9887.

  58. Nayak, S.; Lee, H.; Chmielewski, J.; Lyon, L., "Folate-mediated Cell Targeting and Cytotoxicity Using Thermoresponsive Microgels", J. Am. Chem. Soc., 2004, 126,10258-10259.

  59. Hwang, Y.; Chmielewski, J., "Development of Low Molecular Weight HIV-1 protease dimerization inhibitors", J. Med. Chem., 2005, 48, 2239-2242.

  60. Lee, H.; Chmielewski, J., "Liposomal Cargo Unloading Induced by pH-sensitive Peptides", J. Pep. Res., 2005, 65, 355-363.

  61. Bowman, M.; Byrne, S.; Chmielewski, J., "Switching Between Allosteric and Dimerization Inhibition of HIV-1 Protease", Chem. Biol.,2005, 12, 439-444.

  62. Fillon, Y.; Chmielewski, J., "Cell Penetrating Agents Based on a Polyproline Helix Scaffold", J. Am. Chem. Soc., 2005, 127, 11798-11803.

  63. Ulysse, L.; Chmielewski, J., "A Light-activated Beta-turn Scaffold Within a Somatostatin Analog: NMR Structure and Biological Activity", Chem. Biol. Drug Des., 2006, 2, 127-136.

  64. Lee, S.; Chmielewski, J., "Rapid synthesis and in situ screening of potent HIV-1 protease dimerization inhibitors", Chem. Biol., 2006, 13, 421-426.

  65. Pires, M. M.; Hrycyna, C.; Chmielewski, J., "Bivalent probes of the multidrug transporter P-glycoprotein", Biochemstry, 2006, 45, 11695-11702.

  66. Geisler, I.; Chmielewski, J., "Probing length effects and mechanism of cell Penetrating Agents Mounted on a Polyproline Helix Scaffold", Bioorg. Med. Chem. Lett., 17, 2007, 2765-2768.

  67. Fillon, Y.; Verma, A.; Ghosh, P.; Ernenwein, D.; Rotello, V.M.; Chmielewski, J., "Peptide Ligation Catalyzed by Functionalized Dold Nanoparticles", J. Am. Chem. Soc., 2007, 129, 6676-6677.

  68. Gaddis, B. D.; Avramova, L. V.; Chmielewski, J., "Inhibitors of anthrax lethal factor", Bioorg. Med. Chem. Lett., 17, 2007, 4575-4578.

  69. Pires, M. M.; Chmielewski, J., "Fluorescence Imaging of Cellular Glutathione Using a Latent Rhodamine", Org. Lett., 10, 2008, 837-840.

  70. Gaddis, B. D.; Rubert Pérez, C. M.; Chmielewski, J., "Inhibitors of Anthrax Lethal Factor Based Upon N-oleoyldopamine", Bioorg. Med. Chem. Lett., 18, 2008, 2467-2470.

  71. Bowman, M. J.; Chmielewski, J., "Sidechain-linked Inhibitors of HIV-1 Protease Dimerization", Bioorg. Med. Chem., In Press

  72. Zhu, H.; Coleman, D.M.; Dehen, C.J.; Geisler, I.M.; Zemlyanov, D.; Chmielewski, J.; Simpson, G.J.; Wei, A., " Assembly of Dithiocarbamate-anchored Monolayers on Gold Surfaces in Aqueous Solutions", Langmuir, 24, 2008, 8660-6.

  73. Przybyla, D.E.; Chmielewski, J., "Metal-Triggered Radial Self-Assembly of Collagen Peptide Fibers", J. Am. Chem. Soc., 2008, 130, 12610-12611.

  74. Lee, S.; Lee, J.Y.; Chmielewski, J., "Investigating pH-sensitive Collagen", Angew. Chem. Int. Ed. Engl., In Press

  75. Pires, M.M.; Dana, E.; Hrycyna, C.A.; Chmielewski, J., "Inhibition of P-Glycoprotein-Mediated Taxol Resistance by Reversibly-Linked Quinine Homodimers", Mol. Pharm., submitted.

  76. Li, L.; Gisler, I.; Chmielewski, J.; Ji-Xing, C., "Cationic Amphiphilic Polyproline Helix P11LRR Targets Intracellular Mitochondria", Biophys. J., submitted.

  77. Pires, M.M.; Chmielewski, J., "Self-Assembly of Collagen Peptides into Microspheres via Metal Coordination", J. Am. Chem. Soc., submitted.

Book Chapters/Review Articles

  1. Chmielewski, J.; Zutshi, R.; Brickner, M.; "Inhibiting the Assembly of Protein-Protein Interfaces", Current Opinion in Chemical Biology, 1998, 2, 62-66.

  2. Chmielewski, J. "Dimerization Inhibitors of HIV-1 Protease", SynLett., 1998, 1040-1044.

  3. Ghosh, I.; Yao, S.; Chmielewski, J., "DNA Binding Peptides", Comprehensive Natural Products Chemistry, Volume 7, 1999, 477-490.

  4. Micklatcher, Cindy; Chmielewski, J., "Helical Peptide and Protein Design", Current Opinion in Chemical Biology, 1999, 3, 724-729.

  5. Issac, R.; Ham, Y.-W.; Chmielewski, J., "The Design of Self-Replicating Helical Peptides", Current Opinion in Structural Biology, 2001, 11, 458-463.

  6. Ghosh, I.; Chmielewski, J., "Peptide self-assembly as a model of proteins in the pre-genomic world", Current Opinion in Chemical Biology, 2004, 3, 724-729.

  7. Zhao, L.; Chmielewski, J., "Inhibiting protein-protein interactions using designed molecules", Current Opinion in Structural Biology,2005, 15, 31-34.

  8. Hershberger, S.J.; Lee, S.G.; Chmielewski, J., "Scaffolds for blocking protein-protein interactions", Current Topics in Medicinal Chemistry,2007, 7, 929-943.