Chmielewski Research Group
Publications
  1. Chmielewski, Jean; Breslow, Ronald, "Racemase versus Transaminase Activity of Pyridoxal Analogs", Heterocycles 1987, 25, 533.
  2. Breslow, R.; Chmielewski, J.; Foley, D.; Johnson, B.; Kumabe, N.; Varney, M.;Mehra, R., "Optically Active Amino Acid Synthesis by Artificial Transaminase Enzymes", Tetrahedron 1988, 44, 5515-5524.
  3. Chmielewski, Jean; Schultz, Peter, "Monoclonal Antibodies with Sequence Specific Binding Affinity for a Stem - Loop Structure in DNA", Tetrahedron, 1991, 47, 2563-2572.
  4. Jackson, Dave; King, David; Chmielewski, Jean; Singh, Sunil; Schultz, Peter, "A General Approach to the Synthesis of Short Helical Peptides", J. Am. Chem. Soc, 1991, 113, 9391-9392.
  5. Bishop, Patricia; Chmielewski, Jean, "Cyanogen Iodide, A New Reagent for Disulfide Bond Formation in Peptides", Tetrahedron Lett., 1992, 33, 6263-6266.
  6. Lutgring, Ray; Sujatha, K.; Chmielewski, Jean, "The Synthesis of Homologs of Cysteine Suitable for Peptide and Protein Crosslinking", Bioorganic and Medicinal Chemistry Letters, 1993, 3, 739-742.
  7. Franciskovich, Jeff; Houseman, Kathryn; Mueller, Richard; Chmielewski, Jean, "A Systematic Evaluation of the Inhibition of HIV-1 Protease by its C- and N-Terminal Peptides", Bioorganic and Medicinal Chemistry Letters, 1993, 3, 765-768.
  8. Mihara, Hisakazu; Chmielewski, Jean; Kaiser, Emil T., "Synthesis of the 60 Amino Acid Homeo Domain and Smaller Fragments of the Drosophila Gene Regulatory Protein Antennapedia by a Segment Synthesis-Condensation Approach", Journal of Organic Chemistry, 1993, 58, 2209-2215.
  9. Bishop, Patricia; Jones, Cory; Chmielewski, Jean, "Dimethyl(methylthio)-sulfonium Tetrafluoroborate: A Reagent for Disulfide Bond Formation in Peptides", Tetrahedron Lett., 1993, 34, 4469-4473.
  10. Chmielewski, Jean; Lewen, Ken; Lutgring, Ray, "The Design of Coiled-Coil Peptides", Journal of Cellular Biochemistry, 1993, Suppl. 17C, 214.
  11. Lutgring, Ray; Chmielewski, Jean, "A General Strategy for Covalently Stabilizing Helical Bundles: A Disulfide Crosslinked Five Helix Bundle", J. Am. Chem. Soc., 1994, 116, 6451-6452.
  12. Vogel, Karen; Chmielewski, Jean, "A Rapid and Efficient Resynthesis of Proteolyzed Triose Phosphate Isomerase", J. Am. Chem. Soc., 1994, 116, 11163-11164.
  13. Chmielewski, Jean; Franciskovich, Jeff; Wilson, Matt, "Inhibition of HIV-1 Protease by its C- and N-Terminal Peptides", Peptides: Chemistry, Structure and Biology, 1994, 595-597.
  14. Chmielewski, Jean; Lutgring, Ray; Lewen Ken, "The Design of Associating Amphiphilic Helical Peptides", Peptides: Chemistry, Structure and Biology, 1994, 1054-1056.
  15. Chmielewski, Jean; Lipton, Mark, "The Rational Design of Highly Stable Amphiphilic Helical Peptides", Int. J. Peptide and Protein Res., 1994, 44, 152-157.
  16. Ulysse, Luckner; Chmielewski, Jean, "The Synthesis of a Light-Switchable Amino Acid for Inclusion into Conformationally Mobile Peptides", Bioorganic and Medicinal Chemistry Letters, 1994, 4, 2145-2146.
  17. Bishop, Pat; Ghosh, Indraneel; Jones, Cory; Chmielewski, Jean, "Basic-Helix-Loop-Helix Region of Tal: Structure and DNA Binding" J. Am. Chem. Soc., 1995, 117, 8283-8284.
  18. Ulysse, Luckner; Cubillos, Juanita; Chmielewski, Jean, "Photoregulation of Cyclic Peptide Conformation" J. Am. Chem. Soc., 1995, 117, 8466-8467.
  19. Bishop, Patricia; Jones, Cory; Ghosh, Indraneel; Chmielewski, Jean, "The Basic-Helix-Loop-Helix Region of IEB E47: Evaluation of Structure and DNA Affinity", Int. J. Pept. Prot. Res., 1995, 46, 149-154.
  20. Vogel, Karen; Wang, Susan; Chmielewski, Jean; Low, Philip, "Peptide Mediated Endosomal Release of Folate-Targeted Liposomes" J. Am. Chem. Soc., 1996, 117, 1581-1586.
  21. Vogel, Karen; Cooks, Julia; Chmielewski, Jean, "Subtilisin-Catalyzed Religation of Proteolyzed Hen Egg-White Lysozyme: Investigation of the Role of Disulfides", Chemistry & Biology, 1996, 3, 295-299.
  22. Lutgring, Ray; Lipton, Mark; Chmielewski, Jean, “Differential Self-Assembly of Amphiphilic Helical Peptides”, Amino Acids, 1996, 10, 295-304.
  23. Zutshi, R.; Bishop, P.; Franciskovich, J.; Chmielewski, J., "Dissociation of Dimeric HIV-1 Protease: A Novel Means of Enzyme Inhibition", Peptides: Chemistry, Structure and Biology, 1996, 14, 249-251.
  24. Vogel, Karen; Wang, Susan; Chmielewski, Jean; Low, Philip, "The Design of pH-Dependent Amphiphilic Helices to Trigger Cytoplasmic Release of Liposome Encapsulated Molecules", Peptides: Chemistry, Structure and Biology, 1996, 14, 577-578.
  25. Ulysse, Luckner; Chmielewski, Jean, "Light Induced Conformational Switch in Cyclic Peptides", Peptides: Chemistry, Structure and Biology, 1996, 14, 203-204.
  26. Zutshi, Reena; Franciskovich, Jeff; Shultz, Mike; Schweitzer, Barbara; Bishop, Patricia; Wilson, Matt; Chmielewski, Jean, "Targeting the Dimerization Interface of HIV-1 Protease: Inhibition with Crosslinked Interfacial Peptides", J. Am. Chem. Soc. 1997, 119, 4841-4845.
  27. Yao, S.; Ghosh, I.; Zutshi, R.; Chmielewski, J., “A pH-Modulated, Self-Replicating Peptide”, J. Am. Chem. Soc. 1997, 119, 10559-10560.
  28. Chmielewski, J.; Lewis, J.; Lovell, S.; Zutshi, R.; Savickas, P.; Mitchell, C.; Subramony, A.; Kahr, B. “Single-Crystal Matrix Isolation of Biopolymers”, J. Am. Chem. Soc. 1997, 119, 10565-10566.
  29. Shultz, Michael; Chmielewski, Jean, “Hydrophobicity versus Hydrophilicity with Dimerization Inhibitors of HIV-1 Protease” Tetrahedron Asymmetry, 1997, 8, 3881.
  30. Yao, S.; Ghosh, I.; Zutshi, R.; Chmielewski, J., “Selective Amplification via Auto- and Cross-Catalysis in a Replicating Peptide System”, Nature, 1998, 396, 447-450.
  31. Yao, S.; Ghosh, I.; Zutshi, R.; Chmielewski, J., “A Self-Replicating Peptide under Ionic Control”, Angewandte Chemie Int. Ed., 1998, 37, 478-479.
  32. Brickner, Michelle, Chmielewski, Jean, “Inhibition of the Dimerization of Eco RI” Chemistry & Biology, 1998, 5, 339-343.
  33. Ghosh, I.; Chmielewski, J. “A Beta-Sheet Peptide Inhibitor of IEB E47 Dimerization and DNA Binding”, Chemistry & Biology, 1998, 5, 439-445.
  34. Yao, Shao; Zutshi, Reena; Chmielewski, J., “Endothiopeptide Inhibitors of HIV-1 Protease”, Bioorganic and Med. Chem. Lett., 1998, 8, 699-704.
  35. Yao, S.; Brickner, M.; Pares-Matos, E.; Chmielewski, J. “Uncoiling c-Jun Coiled-Coils: Inhibitory Effects of Truncated Fos Peptides on Jun Dimerization and DNA Binding” Biopolymers: Peptide Science, 1998, 47, 277-283.
  36. Ulysse, L.; Chmielewski, J., “Restricting the Flexibility of Crosslinked, Interfacial Peptide Inhibitors of HIV-1 Protease”, Bioorg. Med. Chem. Lett., 1998, 8, 3281-3286.
  37. Chmielewski, J.; Zutshi, R.; Brickner, M.; “Inhibiting the Assembly of Protein-Protein Interfaces”, Current Opinion in Chemical Biology, 1998, 2, 62-66.
  38. Chmielewski, J. “Dimerization Inhibitors of HIV-1 Protease” SynLett., 1998, 1040-1044.
  39. Kurimoto, M.; Subramony, P.; Chmielewski, J.; Kahr, B., “Kinetic Stabilization of Biopolymers in Single Crystal Hosts: Green Fluorescent Protein in alpha-Lactose Monohydrate”, J. Am. Chem. Soc., 1999, 29, 6952-6953.
  40. Shultz, Michael; Chmielewski, Jean, “Probing the Role of Interfacial Residues in Dimerization Inhibitors of HIV-1 Protease” Bioorg. Med. Chem. Lett., 1999, 9, 2431- 2436.
  41. Ghosh, I.; Issac, R.; Chmielewski, J. “Structure-Function Relationship in a Beta-Sheet Peptide Inhibitor of E47 Dimerization and DNA Binding”, Bioorg. Med. Chem., 1999, 7,61-66.
  42. Ghosh, I.; Yao, S.; Chmielewski, J., “DNA Binding Peptides”, Comprehensive Natural Products Chemistry, Volume 7, 1999, 477-490.
  43. Micklatcher, Cindy; Chmielewski, Jean, “Helical Peptide and Protein Design”, Current Opinion in Chemical Biology, 1999, 3, 724-729.
  44. Yao, S.; Pares-Matos, E.; Brickner, M.; Chmielewski, J., “Inhibiting Dimerization and DNA Binding of c-Jun”, Peptides: Chemistry, Structure and Biology, 1999, 15, 751-52.
  45. Yao, S.; Ghosh, I.; Zutshi, R.; Chmielewski, J., “Natural Selection with Self-Replicating Peptides”, Peptides: Chemistry, Structure and Biology, 1999, 15, 366-368.
  46. Brickner, M.; Yusuf, C.; Vogel, K.; Chmielewski, J., “Design and Use of Amphiphilic Peptides in Liposomes as pH-Triggered Releasing Agents”, Peptides: Chemistry, Structure and Biology, 1999, 15, 461-462.
  47. Yao, S.; Chmielewski, J., “A pH-Tunable Peptide Ligase” Biopolymers: Peptide Science, 1999, 8, 370-375.
  48. Shultz, M. D.; Bowman, M. J.; Ham, Y.-W.; Zhao, X.; Tora, G.; Chmielewski, J., “Small Molecule Dimerization Inhibitors of HIV-1 Protease”, Angewandte Chemie, 2000, 39,2710-2713.
  49. Zutshi, Reena; Chmielewski, Jean, “Targeting the Dimerization Interface for Irreversible Inhibition of HIV-1 Protease”, Bioorg. Med. Chem. Lett., 2000, 10, 1901-1903.
  50. Micklatcher, Cindy; Lutgring, Ray; Hart, Scott; Issac, Roy; Chmielewski, Jean, “Expanding the Repertoire of Helical Bundles: Stabilization of Five+ Helical Bundles” Peptides: Chemistry, Structure and Biology, 2000, 16, 496-497.
  51. Ragin, A.; Brickner, M.; Chmielewski, J. “Peptide Shuttles for Cytoplasmic and Nuclear Targeting” Peptides: Chemistry, Structure and Biology, 2000, 16, 212-213.
  52. Micklatcher, Cindy; Lutgring, Ray; Chmielewski, Jean, “Synthetic Steps Toward De Novo Designed Catalytic Five-Helix Bundle Proteins” Peptides: Chemistry, Structure and Biology, 2000, 16, 496-497.
  53. Ghosh, I.; Bishop, P.; Chmielewski, J. “DNA binding Properties of Tal and E47 Basic-Helix-Loop-Helix Fusion Proteins”, J. Pept. Res., 2001, 57, 354-360.
  54. Wang, H.; Kurimoto, M.; Kahr, B.; Chmielewski, J., “Lactose Monohydrate Single Crystals as Hosts for Matrix Isolation of Gust Biopolymers”, Bioorg. Med. Chem., 2001, 9, 2279-2283.
  55. Kurimoto, M.; Bastin, L.; Fredrickson, D.; Gustafson, P.; Jang, S.; Kaminsky, W.; Lovell, S.; Mitchell, C.; Chmielewski, J.; Kahr, B. “Intrasectoral Zoning of Proteins and Nucleotides in Simple Crystalline Hosts,” Morphology and Dynamics of Crystal Surfaces in Complex Molecular Systems, eds. J.J. De Yoreo, W.H. Casey, A.J. Malkin, E. Vlieg, and M.D. Ward, 2001, 620.
  56. Issac, R.; Ham, Y.-W.; Chmielewski, J., “The Design of Self-Replicating Helical Peptides”, Current Opinion in Structural Biology, 2001, 11, 458-463.
  57. Issac, R.; Chmielewski, J., “Approaching Exponential Growth with a Self Replicating Peptide”, J. Am. Chem. Soc, 2002, 124, 6808-6809.
  58. Turk, M. J.; Reddy, J. A.; Chmielewski, J.; Low, P. S. “Characterization of a Novel pH-Sensitive Peptide Which Enhances Folate-Targeted Liposomal Drug Delivery and Serum Stable Transfection of Cancer Cells”, Biochimica et Biophysica Acta, 2002, 1559, 56-68.
  59. Ragin, A.; Brickner, M.; Morgan, R.; Chmielewski, J., “Cellular Import Mediated by Nuclear Localization Signal Sequences”, Chemistry & Biology 2002, 8, 943-948.
  60. Bowman, M.; Chmielewski, J. “Novel Strategies for Targeting the Dimerization Interface of HIV Protease with Crosslinked Interfacial Peptides”, Biopolymers: Peptide Science, 2002, 66, 126-133.
  61. Li, X.; Chmielewski, J. “Highly Efficient Peptide Self Replication with a Proline Hinge”, J. Am. Chem. Soc. 2003, 125, 11820-11821.
  62. Zhao, L.; O’Reilly, M.; Shultz, M.; Chmielewski, J. “Interfacial Peptide Inhibitors of HIV-1 Integrase Activity and Dimerization” Bioorg. Med. Chem. Lett., 2003, 13, 1175-1177.
  63. Ragin, A.; Chmielewski, J. “Peptide Shuttles: Probing Role of Residues Essential for Cellular Uptake”, J. Pept. Res., 2003, 1221-1224.
  64. Chang, E.; Roberts, D.; Fillon, Y.; Chmielewski, J. “Synthesis of Modified Prolines for Peptidomimetic Use” Peptides: Genomics, Proteomics & Therapeutics, 2003, 227-228.
  65. Li, X.; Chmielewski, J. “Manipulating the Hydrophobic Core of a Coiled Coil Self Replicator” Peptides: Genomics, Proteomics & Therapeutics, 2003, 292-293.
  66. Zhao, L.; Chmielewski, J. “Aib Modified Dimerization Inhibitor of HIV-1 Integrase” Peptides: Genomics, Proteomics & Therapeutics, 2003, 337-338.
  67. Hwang, Y.S.; Chmielewski, J. “HIV-1 Protease Dimerization Inhibitors: Reversing the Southern Peptide” Peptides: Genomics, Proteomics & Therapeutics, 2003, 339-340.
  68. Lee, H.; Chmielewski, J. “Interactions Between the Lipid Bilayer and pH-Triggered Amphiphilic Peptides” Peptides: Genomics, Proteomics & Therapeutics, 2003, 789-790.
  69. Li, X.; Chmielewski, J. “Challenges in the Design of Self Replicating Peptides”, Organic and Biomolecular Chemistry, 2003, 1, 901-904.
  70. Shultz, M.; Lee, S.; Ham, Y.; Chmielewski, J. J. “Small Molecule Dimerization Inhibitors of Wild Type and Mutant HIV Protease: A Focused Library Approach”, J. Am. Chem. Soc. 2004, 126, 9886-9887.
  71. Nayak, S.; Lee, H.; Chmielewski, J.; Lyon, L. A. “Folate-Mediated Cell Targeting and Cytotoxicity Using Thermoresponsive Microgels” J. Am. Chem. Soc. 2004, 126, 10258-10259.
  72. Bowman, M.; Chmielewski, J. “Crucial Amides for Dimerization Inhibitors of HIV-1 Protease” Bioorg. Med. Chem. Lett., 2004, 14, 1395-1398.
  73. Ragin, A. D.; Chmielewski J. “Probing Essential Residues for Cellular Uptake with a Cationic Nuclear Localization Signal Sequence” J Pept. Res. 2004, 63, 155-160.
  74. Hwang, Y.S.; Chmielewski, J. “A Unidirectional Crosslinking Strategy for HIV-1 Protease Dimerization Inhibitors” Bioorg. Med. Chem. Lett., 2004, 14, 4297-4300.
  75. Ghosh, I.; Chmielewski, J. “Peptide Self-Assembly As a Model of Proteins in the Pre-Genomic World”, Current Opinion in Chemical Biology, 2004, 3, 640-644.
  76. Fillon, Y.; Anderson, J.; Chmielewski, J. “Cell Penetrating Agents Based on a Polyproline Scaffold” J. Am. Chem. Soc., 2005, 127, 11798-11803.
  77. Hwang, Y. S.; Chmielewski, J. “Development of Low Molecular Weight HIV-1 Protease Dimerization Inhibitors” J. Med. Chem., 2005, 48, 2239-2242.
  78. Lee. H. M.; Chmielewski, J. “Liposomal Cargo Unloading Induced By pH-Sensitive Peptides”, J. Pept. Res., 2005, 65, 355-363.
  79. Bowman, M.; Byrne, S.; Chmielewski, J. “Switching Between Allosteric and Dimerization Inhibition of HIV-1 Protease” Chemistry & Biology, 2005, 12, 439-444.
  80. Zhao, L.; Chmielewski, J. “Inhibiting Protein-Protein Interactions with Designed Molecules”, Current Opinion in Structural Biology, 2005, 15, 31-34.
  81. Lee, S.G.; Chmielewski, J. “Rapid Synthesis and In Situ Screening of Doubly Mutated HIV-1 Protease Dimerization Inhibitors” Chemistry & Biology, 2006, 13, 421-426.
  82. Pires, M.; Hrycyna, C.; Chmielewski, J. “Bivalent Probes of the Multidrug Transporter P-glycoprotein” Biochemistry, 2006, 45, 11695-11702.
  83. Ulysse, L.; Chmielewski, J. “A Light Activated β-Turn Scaffold within a Somatostatin Analog: NMR Structure and Biological Activity” Chemical Biology and Drug Design, 2006, 67, 127-136.
  84. Lee, S.-G.; Hershberger, S.; Chmielewski, J. “Scaffolds for Inhibiting Protein-Protein Interactions” Curr. Top. Med. Chem, 2007, 7, 928-942.
  85. Fillon, Y.; Verma, A.; Ghosh, P; Ernenwein, D.; Rotello, V.; Chmielewski, J. “Peptide Ligation Catalyzed by Functionalized Gold Nanoparticles” J. Am. Chem. Soc. 2007, 129, 6676-6677.
  86. Geisler, I; Chmielewski, J. “Probing Length Effects and Mechanism of Cell Penetrating Agents Mounted on a Polyproline Helix Scaffold” Bioorg. Med. Chem. Lett. 2007, 17, 2765-2768.
  87. Gaddis, B.; Avramova, L.; Chmielewski, J. “Inhibitors of Anthrax Lethal Factor” Bioorg. Med. Chem. Lett. 2007, 17, 4575-4578.
  88. Przybyla, D., Chmielewski, J. “Metal Triggered Radial Self Assembly of Collagen Peptide Fibers” J. Am. Chem. Soc. 2008, 130, 12610-12611.
  89. Lee, S.-G.; Lee, J.; Chmielewski, J. “Investigation of pH-Dependent Collagen Triple Helix Formation” Angewandte Chemie 2008, 47, 8429-8432.
  90. Pires, M.; Chmielewski, J. “Fluoresence Imaging of Cellular Glutathione Using a Latent Fluorophore” Org. Lett. 2008, 10, 837-840.
  91. Gaddis, B.; Rubert, C.; Chmielewski, J. “Inhibitors of Anthrax Lethal Factor Based on N-oleoyldopamine” Bioorg. Med. Chem. Lett. 2008, 18, 2467-2470.
  92. Zhu, H.; Coleman, D.; Dehen, C.; Geisler, I.; Chmielewski, J.; Simpson, G.; Wei, A. “Assembly of Dithiocarbamate-Anchored Monolayers on Gold Surfaces in Aqueous Solutions” Langmuir 2008, 24, 8660-8666.
  93. Pires, M. M.; Chmielewski, J. “Self Assembly of Collagen Peptides into Microflorettes via Metal Coordination” J. Am. Chem. Soc. 2009, 131, 2706-2712.
  94. Pires, M.; Hrycyna, C.; Chmielewski, J. “Inhibition of P-Glycoprotein-Mediated Taxol Resistance by Reversibly-Linked Quinine Homodimers” Molecular Pharmacology, 2009, 75, 92-100.
  95. Geisler, I, Chmielewski, J. “Cationic Amphiphilic Polyproline Helices (CAPHs): Side Chain Variations and Cell Specific Internalization” Chem. Biol. Drug Des. 2009, 73, 39-45.
  96. Bowman, M.; Chmielewski, J. “Sidechain Crosslinked Inhibitors of HIV Protease Dimerization and Activity” Bioorg. Med. Chem. 2009, 17, 967-976.
  97. Davis, D. A., Reynolds, I., Daniels, S., Stahl, S., Kaufman, J., Wingfield, P., Bowman, M., Chmielewski, J., Yarchoan, R. “Characterizing Dimerization Inhibition of a Multi-Drug Resistant HIV-1 Protease Using a Novel Size Exclusion Chromatographic Assay” Biochem. J. 2009, 419, 497-506.
  98. Pires, M. M.; Przybyla, D.; Chmielewski, J. “A Metal-Collagen Peptide Framework for 3-Dimernsional Cell Culture” Angewandte Chemie 2009, in press.
  99. Namanja, H.; Emmert. D.; Pires, M. M.; Hrycyna, C.; Chmielewski, J. “Inhibition of Human P-glycoprotein Transport and Substrate Binding Using a Galantamine Dimer” Biochem. Biophys. Res. Comm. 2009, in press.
  100. Chmielewski, J. “Protease Dimer Formation Disrupted” Nature Chem. Bio. 2009, in press.
  101. Pires, M. M.; Emmert, D.; Chmielewski, J.; Hrycyna, C. A. “ABCB1 and ABCG2: Deciphering the Role of Human Efflux Proteins in Cellular and Tissue Permeability” ABC Transporters In Human Health and Disease, World Scientific Press, eds. Linton K.; Holland B., 2009, in press.
  102. Przybyla, D., Chmielewski, J. “Collagen Peptide Fiber Formation Triggered by Metal Ions” Breaking Away: Proc. of the 21st American Peptide Symp. 2009, in press.
  103. Ernenwein, D., Chmielewski, J. “Manipulating Solvent Exposed Residues for the Formation of a pH-Dependent Coiled Coil Peptide” Breaking Away: Proc. of the 21st American Peptide Symp. 2009, in press.
  104. Lee, J., Chmielewski, J. “Strand exchange of charged collagen-based peptides” Breaking Away: Proc. of the 21st American Peptide Symp. 2009, in press.
  105. Li, L.; Chen, H.; Geisler, I.; Chmielewski, J.; Cheng, J.-X. “Mitochondrial Targeting of Cationic Amphiphilic Polyproline Helices” 2009, submitted.
  106. Ernenwein, D., Ghosh, P., Rotello, V., Chmielewski, J. “Gold Nanoparticle Self-Assembly Promoted by a Non-Covalent, Charge-Complemented Coiled-Coil Peptide” 2009, manuscript in preparation.
  107. Lee, J.; Chmielewski, J. “Nucleation Studies of pH-Dependent Collagen Peptides” 2009, manuscript in preparation.
  108. Przybyla, D.; Chmielewski, J. “Metal-Triggered Self Assembling Collagen Peptide Disks” 2009, manuscript in preparation.