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David R. McMillin
Platinum(II) Polypyridines as Luminescent Probes and DNA Binders
The family of polypyridine complexes of platinum(II) are of interest in part because
they undergo DNA-binding interactions and show potential for therapeutic activity. Our
focus is on luminescent systems. The 2,2';6',2"-terpyridine (trpy) ligand offers
advantages and disadvantages in this regard. Introduction of electron donating groups at
the 4' position of the trpy ligand enhance the emission yield and the lifetime because the
emitting excited state takes on intraligand charge-transfer character. More recently, we
have begun to investigate a fused-ring analogue, php =
2-(2'-pyridyl)-1,10-phenenathroline. In dichloromethane the Pt(php)Cl+ complex
exhibits a structured emission with a lifetime of 230 ns. Positionally dependent
ring-substitution effects are profound and yield excited-state lifetimes of many
microseconds. Moreover, the emission signals are quite sensitive to DNA binding
interactions and reveal changes in the mode of binding.
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