| 124. | CSTAT 1 Synthesis and Pharmacological Evaluation of Nonacyclic and Trisdecacyclic Pyrazines Related to Cephalostatin. Y. Pan, R. L. Merriman, L. R. Tanzer, P. L. Fuchs, Bioorg. & Med. Chem. Lett. 1992, 967-972. |
| 133. | CSTAT 2. Synthesis of a 17-Deoxy, C-14,15-Dihydro Derivative of the North Spiroketal Moiety of the Cephalostatins. Conversion to a (+)-Trisdecacyclic C2 Symmetrical Pyrazine. J. U. Jeong, P. L. Fuchs, J. Am. Chem. Soc. 1994, 116, 773-774. |
| 143. | CSTAT 3. Spiroketal Equilibration: Interconversion of 1,6-Dioxaspiro[4.4]nonanes and 1,6-Dioxaspiro[4.5]decanes. Implications for the Synthesis of Cephalostatin 7. J. U. Jeong, P. L. Fuchs, Tetrahedron Lett. 1994, 35, 5385-5388. |
| 146. | CSTAT 4. Application of the Reich Iodoso syn-Elimination for the Preparation of an Intermediate Appropriate for the Synthesis of both Hexacyclic Steroidal Units of Cephalostatin 7. S. Kim, P. L. Fuchs, Tetrahedron Lett. 1994, 35, 7163-7166. |
| 152. | CSTAT 5. Chromium [II]-Mediated Reductive Cleavage of a Tertiary Halide Bearing Three beta-alkoxy Groups. Synthesis of the North Hexacyclic Steroid Unit of the Cephalostatin Family. S. Kim, S. C. Sutton, P. L. Fuchs, Tetrahedron Lett. 1995, 36, 2427-2430. |
| 153. | CSTAT 6. Synthesis of the South Hexacyclic Steroid Unit of Cephalostatin 7. J. U. Jeong, P. L. Fuchs, Tetrahedron Lett. 1995, 36, 2431-2434. |
| 158. | CSTAT 7. Synthesis of a C14',15' Dihydro Derivative of the South Hexacyclic Steroid Unit of Cephalostatin 1. Part I: Regiospecific Rh[II]-Mediated Intermolecular Oxygen Alkylation of a Primary Neopentyl Alcohol. Bhandaru, S.; Fuchs, P. L., Tetrahedron Lett. 1995, 36, 8347-8350. |
| 159. | CSTAT 8. Synthesis of a C14',15' Dihydro Derivative of the South Hexacyclic Steroid Unit of Cephalostatin 1. Part II: Spiroketal Synthesis and Stereochemical Assignment by NMR Spectroscopy. Bhandaru, S.; Fuchs, P. L., Tetrahedron Lett. 1995, 36, 8351-8354. |
| 157. | CSTAT 9. Biomimetic Total Syntheses of (+)-Cephalostatin 7, (+)-Cephalostatin 12, and (+)-Ritterazine K. Jeong, J. U.; Sutton, S. C.; Kim, S.; Fuchs, P. L., J. Am. Chem. Soc. 1995, 117, 10157-10158. |
| 168. | CSTAT 10. An Efficient Protocol for the Synthesis of Unsymmetrical Pyrazines. Total Synthesis of Dihydrocephalostatin 1. Guo, C.; Bhandaru, S.; Fuchs, P. L. ; Boyd, M. R. J. Am. Chem. Soc. 1996, 118, 10672-10673. |
| 180. | CSTAT 11. Interphylal Product Splicing: The First Total Synthesis of Cephalostatin 1, the North Hemisphere of Ritterazine G, and the Highly Active Hybrid Analogue, Ritterostatin GN1N. LaCour, T.G.; Guo, C.; Bhandaru, S.; Boyd, M.R.; Fuchs, P.L. J. Am. Chem. Soc. 1998, 120, 692-707. |
| 179. | CSTAT 12. The First Synthesis of the Aglycone of the Potent Anti-Tumor Steroidal Saponin OSW-1. Guo, C; Fuchs, P.L. Tetrahedron Lett. 1998, 39, 1099-1102. |
| 184. | CSTAT 13. Synthesis of the North 1 Unit of the Cephalostatin Family from Hecogenin Acetate. Kim, S.; Sutton, S.C.; Guo, C.; LaCour, T.G.; Fuchs, P.L. J. Am. Chem. Soc. 1999, 121, 2056-2070. |
| 185. | CSTAT 14. Synthesis of the South Unit of the Cephalostatin 7. Total Synthesis of (+)-Cephalostatin 7, (+)-Cephalostatin 12, and (+)-Ritterazine K. Jeong, J.U.; Guo, C.; Fuchs, P.L. J. Am. Chem. Soc. 1999, 121, 2071-2084. |
| 183. | CSTAT 15. On the Relationship of OSW-1 to the Cephalostatins. Guo, C; LaCour, T.G.; Fuchs, P.L. Bioorg. Med. Chem. Lett. 1999, 9, 419-424. |
| 191. | CSTAT 16. On Topography and Functionality in the B-D Rings of Cephalostatin Cytotoxins. LaCour, T.G; Guo, C.; Ma, S.; Jeong, J.U.; Boyd, M.R.; Matsunaga, S; Fusetani, N.; Fuchs, P.L. Bioorg. Med. Chem. Lett. 1999, 9, 2587-2592. |
| 188. | CSTAT 17. Concurrent Ring Opening and Halogenation of Spiroketals. LaCour, T.G; Fuchs, P.L. Tetrahedron Lett. 1999, 40, 4655-4658. |
| 192. | CSTAT 18. Consequences of Acid Catalysis in Ring Opening and Halogenation of Spiroketals. LaCour, T.G.; Fuchs, P.L. Organic Lett. 1999, 1, 1815-1818. |
| 193. | CSTAT 19. Outer-Ring Stereochemical Modulation of Cytotoxicity in Cephalostatins. LaCour, T.G.; Fuchs, P.L. Organic Lett. 2000, 1, 33-36 |
| 200. | CSTAT 20. Redox Refunctionalization of Steroid Spiroketals. Structure Correction of Ritterazine M. Lee, Seongmin; LaCour, Thomas G.; Lantrip, D.A.; Fuchs, P.L. Organic Lett. 2002, 4, 313-316. |
| 201. | CSTAT 21. The First Total Synthesis of (Corrected) Ritterazine M. Lee, Seongmin; Fuchs, P.L. Organic Lett. 2002, 4, 317-318. |
| 202. | CSTAT 22. Dyotropic Rearrangement Facilitated Proximal Functionalization and Oxidative Removal of Angular Methyl Groups: Efficient Synthesis of 23'-Deoxy Cephalostatin 1 Analogues. Li, Wei; LaCour, Thomas G.; Fuchs, P.L. J. Am. Chem.Soc. 2002, 124, 4548-4549. |
| 205. | CSTAT 23. Chemospecific Chromium[VI] Catalyzed Oxidation of C-H Bonds at -40 C. Lee, S.; Fuchs, P.L. J. Am. Chem.Soc. 2002, 124, 13978-13979. |
| 207. | CSTAT 24. New Oxidative Tools for the Fucntionalization of the Cephalostatin North 1 Hemisphere. Lee, J.S.; Fuchs, P.L., Organic Lett. 2003, 5, 2247-2250. Dimethyldioxirane (DMDO) C-H oxidation of ketone 17 to hemiketal 18 (82%), bis-dehydration to vinyl ether 21 (77%), and DMDO again provides C-23 axial alcohol 23 (99%). Routine processing, including a double-stereoselective Sharpless AD reaction (de>98%), gives alcohols 7 and 32. C-23 deoxy substrate 7 undergoes Suarez hypoiodite oxidative cyclization to (natural) beta spiroketal 34, but compound 32, bearing a C-23 silyl ether, generates unnatural spiroketal 33. |
| 208. | CSTAT 26. An Efficient Synthesis of the C-23 Deoxy, 17alpha-Hydroxy South 1 Hemisphere and its Cephalostatin 1 Analog. Li, W.; Fuchs, P.L., Organic Lett. 2003, 5, 2849-2852. Methods for functionalization of the D ring of diene 1 were investigated. This study led to efficient syntheses of 3 and the subsequent 23'-deoxy,17'alpha-hydroxy cephalostatin 1 analog (4). The bioactivity data of 2 and 4 are in the low nanomolar range for a 10-cell-line minipanel. |
| 209. | CSTAT 27. A New Protocol of In-situ Dioxirane Reactions: Stiochiometric in Oxone and Catalytic in Fluoridated Acetophenones. Li, W.; Fuchs, P.L., Organic Lett. 2003, 5, 2853-2856. Dioxiranes made in situ from the commercially available tetrafluoroacetophenones (7, 8) and pentafluoroacetophenone (9) are reported for highly efficient epoxidation of olefins for the first time. Studies showed that ketone 7, 8, or 9 can be used in catalytic amount (0.2 equiv) with only 0.6 equiv of Oxone (equal to 1.2 equiv of peroxymonosulfate) to selectively oxidize diene 1 to epoxide 2. The epoxidation reactions of dioxiranes of fluoroacetophenones are compared with the recently described complementary aliphatic acyclic fluorinated ketones. |
| 211. | CSTAT 29. Polyphosphoric Acid Trimethylsilyl Ester Promoted Intramolecular Acylation of an Olefin by a Carboxylic Acid: Convenient Construction of C-18 Functionalized D14-Hecoginin Acetate. Li, W.; Fuchs, P.L. Organic Lett. 2003, 5, 4061-4064. |
| 212. | CSTAT 30. Trifluoroacetyl Trifluoromethanesulfonate (TFAT): An Efficient Agent for Ring Opening of Spiroketals. Lee, J.S.; Fuchs, P.L., Organic Lett. 2003, 5, 3619-3622. |
| 215. | CSTAT 31. An Efficient C-H Oxidation Protocol for the alpha-Hydroxylation of Cyclic Steroidal Ethers. Lee, S.M.; Fuchs, P.L. Organic Lett. 2004, 6, 1437-1440. |