Research Publications (total of 173):

 

 

1.                         “Diastereoselection in Intramolecular Nitrile Oxide Cycloaddition  (NOC)   Reactions and Confirmation of the Antiperiplanar Effect  Through a Simple Synthesis  of  2-Deoxy-D-ribose"  A. P. Kozikowski and A.K. Ghosh, J. Am. Chem. Soc. 1982, 104, 5788-89.

 

2.                        "The Isoxazoline Route to a-Methylene Lactones"  A. P. Kozikowski and A. K. Ghosh, Tetrahedron Letters  1983, 24, 2623-26.

 

3.                        "Diastereofacial Selection in Nitrile Oxide Cycloaddition Reactions. The Anti-Directing Effect of an Allylic Oxygen and Some New Results on the Ring Metalation of Isoxazolines. A Synthesis of (±) Blastmycinone" A. P. Kozikowski and A. K. Ghosh, J. Org. Chem. 1984, 49, 2762-72.

 

4.                        "Methods for Pyranoannulation - An Approach to a New Class of Polyethers" A. P. Kozikowski and A. K. Ghosh, J. Org. Chem. 1985, 50, 3017-19.

 

5.                        "Mn(III)-Promoted Annulation of Enol Ethers to Fused or Spiro 2-Cyclopentanones" E. J. Corey and A. K. Ghosh, Tetrahedron Letters  1987,  28, 175-79.

 

6.                        "Two-step Synthesis of Furans by Mn(III)-Promoted Annulation of Enol Ethers" E. J. Corey and A. K. Ghosh, Chemistry Letters  1987, 223-26.

 

7.                        "Total Synthesis Of (±) Ginkgolide B"  E. J. Corey, M-C. Kang, M. C. Desai, A. K. Ghosh, and I. N. Houpis, J. Am. Chem. Soc. 1988, 110, 649-51.

 

8.                        "Total Synthesis Of (±) Ginkgolide A"  E. J. Corey and A. K. Ghosh,  Tetrahedron Letters 1988,  29, 3205-08.

 

9.                        "Total Synthesis Of (±) Ginkgolide B" M. C. Desai, A. K. Ghosh, M-C. Kang, and I. N. Houpis, Strategies and Tactics in Organic Synthesis, Academic Press, Edited by  T. Lindberg, 1991, 2, 89-119.

 

10.                    "Stereoselective Reduction of a-Hydroxy Oxime Ethers: A  Convenient Route to Cis-1,2-Amino Alcohols"  A. K. Ghosh, S. P. McKee, and W. M. Sanders, Tetrahedron  Letters  1991, 32, 4251-54.

 

11.                    "Di(2-Pyridyl) Carbonate Promoted Alkoxycarbonylation Of  Amines: A Convenient Synthesis of Functionalized Carbamates" A. K. Ghosh, T. T. Duong and S. P. McKee, Tetrahedron  Letters  1991, 32, 4251-54.

 

12.                    "Stereocontrolled Synthesis of HIV-1 Protease Inhibitors with C2-Axis of Symmetry" A. K. Ghosh, S. P. McKee, and W. J. Thompson,  Tetrahedron  Letters  1991, 32, 5729-33.

 

13.                    " An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors" A. K. Ghosh, S. P. McKee, and W. J. Thompson,  J. Org. Chem.  1991, 56, 6500-03.

 

14.                    "Intramolecular and Intermolecular Hydroxyl Reactivity Differences in Ginkgolides A, B and C and Their Chemical Applications" E. J. Corey, K. Srinivas Rao and A. K. Ghosh, Tetrahedron  Letters   1992, 33, 6955-58.     

 

15.                    "N,N'-Disuccinimidyl Carbonate: A Useful Reagent for Alkoxycarbonylation Of  Amines" A. K. Ghosh, T. T. Duong, S. P. McKee and Wayne J. Thompson, Tetrahedron  Letters 1992, 33, 2781-84.

 

16.                    "A Facile and Enantiospecific Synthesis of 2(S)- and 2(R)-[1'(S)-Azido-2-Phenylethyl]Oxirane" A. K. Ghosh, S. P. McKee, H. Y. Lee, and W. J. Thompson,  J. Chem Soc., Chem. Communication.,  1992, 273-75.

 

17.                    "An Efficient Synthesis of Functionalized Urethanes from Azides" A. K. Ghosh, S. P. McKee, T. T. Duong and W. J. Thompson ; J. Chem Soc., Chem. Communication.  1992, 1308-10.

18.                    "Highly Enantioselective Aldol Reaction : Development of a New Chiral Auxiliary from cis-1-amino-2-hydroxyindane" A. K. Ghosh, T. T. Duong, S. P. McKee,  J. Chem Soc., Chem. Communication. 1992, 2833-35.

 

19.                    "HIV-1 Protease Inhibitors: Synthesis and biological Evalution of Glycopeptides"  A. K. Ghosh, S. P. McKee, W. M. Sanders, P. L. Darke, J. Zugay, E. M. Emini, J. R. Huff and P. S. Anderson ; Drug Design and Discovery 1993, 10, 77-86.

 

20.                    "Potent HIV-1 Protease Inhibitors : Stereoselective Synthesis of a New Dipeptide Mimic" A. K. Ghosh, S. P. McKee, W. J. Thompson, P. L. Darke, and J. Zugay; J. Org. Chem.  1993, 58, 1025-32.

 

21.                    "Synthetic studies of Antitumor Macrolide Laulimalide: Enantioselective Synthesis of the C1-C14 Segment by a Catalytic Hetero Diels-Alder Strategy" A. K. Ghosh, P. Mathivanan; J. Cappiello; Tetrahedron Letters 1997, 38, 2427-31.

 

22.                    "3'-tetrahydrofuranglycine  as a  Novel, Unnatural  Amino  Acid Surrogate  for Asparagine in the Design of Inhibitors of the HIV Protease" W. J. Thompson, A. K. Ghosh, M. K. Holloway, H. Y. Lee,  P. M. Munson,  J. E. Schwering, J. Wai,  P. L. Darke,J. Zugay,  E. A. Emini, W. A. Schleif, J. R. Huff and P. S. Anderson ;  J. Am. Chem. Soc. 1993, 115, 801-02.

 

23.                    "3- tetrahydrofuran  and  pyranyl  Urethanes  as High Affinity  P2-Ligands for HIV-1  Protease  Inhibitors"  A. K. Ghosh,  W. J.  Thompson,  S. P. McKee, T. T. Duong, T. A. Lyle,  J. C. Chen,  P. L.Darke, J. Zugay, E. A. Emini, W. A. Schleif, J. R. Huff and P. S. Anderson ; J. Med. Chem. 1993, 36,  292-94.

 

24.                    "Cyclic sulfones as novel and High Affinity P2-Ligands for HIV Protease Inhibitors" A. K. Ghosh,   W. J. Thompson, S. P. McKee, T. T. Duong, T. A. Lyle,  J. C. Chen,  P. L.Darke,J. Zugay,  E. A. Emini, W. A. Schleif, J. R. Huff and P.  S. Anderson ; J. Med. Chem. 1993, 36, 924-27.

 

25.                    "Potent HIV Protease Inhibitors: The Development of 3'-tetrahydrofuranglycine  as  P2-Ligands and substituted Pyrazine Derivatives as P3-Ligands " A. K. Ghosh, W. J. Thompson, S. P. McKee, T. T. Duong, M. K. Holloway, H. Y. Lee,  P. M. Munson, J. Wai,  P. L. Darke,J. Zugay,  E. A. Emini, W. A. Schleif, J. R. Huff and P. S. Anderson ;  J. Med. Chem., 1993, 36, 2300-10.

 

26.                    "Structure Based Design of High Affinity Ligands for HIV-1 Protease Inhibitor: Replacements of Two Amides and a 10p Electron Aromatic System" A. K. Ghosh, W. J. Thompson, P. M.D. Fitzgerald, C. Culberson, S. P. McKee, J. R. Huff and P. S. Anderson ; J. Med. Chem. 1994, 37, 2506-08.

 

27.                    "The Development of Cyclic Sulfolanes as Novel and High Affinity P2-Ligands for HIV-1 Protease Substrate Binding Site"  A. K. Ghosh, W. J. Thompson, C. Culberson, M. K. Holloway,  S. P. McKee, T. T. Duong,  P. M. Munson, P. L. Darke,J. Zugay,  E. A. Emini, W. A. Schleif, J. R. Huff and P. S. Anderson ;  J. Med. Chem. 1994, 37, 1177-86.

 

28.                    "A Simple Method for Predicting the Activity of HIV-1 Protease Inhibitors"  M. K. Holloway,  P. M.D. Fitzgerald, W. J. Thompson, A. K. Ghosh,  P. L. Darke,J. Zugay,  E. A. Emini, W. A. Schleif, J. M. Wai,  J. R. Huff and P. S. Anderson ; J. Med. Chem., 1995,  38, 305-12.

 

29.                    "Synthesis and Optical Resolution of High Affinity P2-Ligands for HIV-1 Protease Inhibitors" A. K. Ghosh, Y. Chen; Tetrahedron Letters, 1995, 36, 505-08.

 

30.                    "Cyclic Sulfone-3-Carboxamide as Novel P2-ligands for HIV-1 Protease Inhibitors" A. K. Ghosh, W. J. Thompson, P. M. Munson, W. Liu, J. R. Huff; Bioorganic  and Med. Chem. Letters, 1995, 5,  83-88.

 

31.                    "Highly Stereoselective Reduction of a-keto Esters : Utility of Cis-1-Arylsulfonamido-2-Indanols as Chiral Auxiliaries", A. K. Ghosh Y. Chen; Tetrahedron Letters 1995, 36,  6811-14.

 

32.                    "Chiral Auxiliary Mediated Conjugate reduction and Asymmetric Protonation: Synthesis of High Affinity Ligands for HIV Protease Inhibitors",  A. K. Ghosh,  W. Liu, J. Org. Chem. 1995, 60, 6198-6201.

 

33.                    "Highly Diastereoselective Asymmetric Diels-Alder Reactions of Arylsulfonamido-2-Indanols derived Ligands" A. K. Ghosh, P. Mathivanan; Tetrahedron: Asymmetry,  1996, 7, 375-78.

 

34.                    "Nonpeptidal P2-Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis and Biological Evaluations " A. K. Ghosh, J. F. Kincaid, D. E. Walters, Y. Chen,  N. C. Chaudhuri, W. J. Thompson, C. Culberson, P. M.D. Fitzgerald,   S. P. McKee, P. M. Munson,  M. G. Axel, J. R. Huff; J. Med. Chem., 1996 39, 3278-90.

 

35.                    "A Convergent, Enantioselective Total Synthesis of Hapalosin with Multidrug-Resistance Reversing Activity,"  A. K. Ghosh, Wein Ming Liu, Yibo Xu, Zhidong Chen; Angewandte Chemie,  1996, 35, 74-76.

 

36.                    "Synthesis of Enantiomerically Pure Anti Aldols: A Highly Stereoselective Ester-Derived Titanium Enolate Aldol Reaction,"  A. K. Ghosh, M. Onishi; J. Am. Chem. Soc., 1996, 118,  2527-28.

 

37.                    "Conformationally Constrained Bis(oxazoline) Derived Chiral Catalyst: A Highly Effective Enantioselective-Catalytic Diels-Alder Reaction"  A. K. Ghosh, P. Mathivanan, J. Cappiello;  Tetrahedron Letters  1996, 37,  3815-18.

 

38.                    "Heteroatom Diels-Alder Reaction with Danishefsky Diene: Bis(oxazoline) Based Asymmetric Catalysis" A. K. Ghosh, P. Mathivanan, J. Cappiello;  Tetrahedron: Asymmetry, 1996, 7, 2165-68.

 

39.                    "Enantioselective Total Synthesis of (+)-Sinefungin" A. K. Ghosh, W-M. Liu; J. Org. Chem. 1996, 61, 6175-82.

 

40.                    "Asymmetric Alkylations and Aldol Reactions :  Optically Active  1, 2-aminocyclo-pentanol Derived New Chiral Auxiliaries"  A. K. Ghosh, H. Cho; Tetrahedron: Asymmetry,  1997, 8,  821-24.

 

41.                    "Synthesis and Enzymatic Resolution of 1-Amino-2-Indanols: Versatile Ligands for HIV-1 Protease Inhibitors and Asymmetric Syntheses" A. K. Ghosh, J. F. Kincaid and M. Haske; Synthesis  1997, 541-44.

 

42.                    "Asymmetric Aldol Route to Hydroxyethylamine Dipeptide Isostere: Convenient Synthesis of HIV Protease Inhibitor Saquinavir"   A. K. Ghosh, A, Hussain, S. Fidanze,  J. Org. Chem.  1997, 62,  6080-82.

 

43.                    "Ester Derived Titanium Enolate Aldol Reaction: Highly Diastereoselective Synthesis of Syn- and Anti-aldols"  A. K. Ghosh, S. Fidanze, M. Onishi, A, Hussain, Tetrahedron Letters ,  1997, 38, 7171-74.

 

44.                    "A Convergent, Enantioselective Total Synthesis of  Streptogramin Antibiotic (-)-Madumycin II" A. K. Ghosh and W-M.  Liu, J. Org. Chem. 1997, 62, 7908-09.

 

45.                    “C2-Symmetric Chiral Bis(oxazoline)-metal Complexes in Catalytic Asymmetric Synthesis” A. K. Ghosh, P. Mathivanan; J. Cappiello, Invited Review,Tetrahedron: Asymmetry,  1998, 9, 1-45.

 

46.                    “Chemoselective Reduction of Alkenes Using Lindlar Catalyst” A. K. Ghosh; K. Krishnan, Tetrahedron Letters, 1998, 39, 947-50.

 

47.                    “Structure Based Design: Novel Spirocyclic Ethers as Nonpeptidal P2-Ligands for HIV Protease Inhibitors”  A. K. Ghosh,  K. Krishnan, D. E. Walters, W. Cho, Y. Koo, H. Cho, L. Holland, J. Buthod, Bioorganic  and Med. Chem. Letters,  1998, 8, 687-90.

 

48.                    “Convenient Synthesis of Novel Macrocyclic Urethane: Alkoxycarbonylation of Amines and Ring-Closing Metathesis Strategy” A. K. Ghosh and K. A. Hussain, Tetrahedron Letters, 1998, 39, 1881-84.

 

49.                    “Potent HIV Protease Inhibitors Incorporating High Affinity P2-Ligands and (R)-Hydroxyethylaminosufonamide Isostere”  A. K. Ghosh,  J.  F. Kincaid, W. Cho, D. E. Walters, K. Krishnan, K. A. Hussain, Y. Koo, H. Cho, C. Rudall, L. Holland, J. Buthod, Bioorganic  and Med. Chem. Letters,  1998, 8,  979-82.

 

50.                    “Cis-1-aminindan-2-ol in Asymmetric Syntheses” A. K. Ghosh, S. Fidanze and C. H. Senanayake, Invited Review, Synthesis,  1998, 937-61.

 

51.                    “Ring-Closing Metathesis Strategy to a,b-unsaturated g- and d-Lactones: Synthesis of Hydroxyethylamine Isosteres for HIV Protease Inhibitors” A. K. Ghosh, J. Cappiello and D. Shin, Tetrahedron Letters,  1998, 8, 4651-54.

 

52.                    “Transition-State Mimetics for HIV Protease Inhibitors: Stereocontrolled Synthesis of Hydroxyethylene and Hydroxyethylamine Isosteres by Ester Derived Titanium Enolate Syn- and Anti-aldol Reactions” A. K. Ghosh and S. Fidanze, J. Org. Chem. 1998, 63, 6146-52.

 

53.                    "Constrained Bis(oxazoline) Derived Cationic Aqua Complexes: Highly Effective Catalysts for Enantioselective Diels-Alder Reactions” A. K. Ghosh, H. Cho and J. Cappiello, Tetrahedron : Asymmetry, 1998, 9,  3688-91.

 

54.                    “Stereoselective Synthesis of Protected Thymine Polyoxin C via   [2,3]-Wittig-Still Rearrangement of Ribose Derived Allylic Stannyl Ethers “ A. K. Ghosh and Y. Wang, J. Org. Chem. 1998, 63, 6735-38.

 

55.                    “Stereoselective Synthesis of Dihydroisocoumarin Moiety of Microbial Agent AI-77-B: A Diels-Alder Based Strategy” A. K. Ghosh and J. Cappiello, Tetrahedron Letters, 1998, 39, 8803-06.

 

56.                    “TiCl4 Promoted Three Component Coupling Reaction : A New Synthetic Method for the Functionalized Tetrahydrofuran and Tetrahydropyran“ A. K. Ghosh and R. Kawahama, Tetrahedron Letters,  1999, 40, 1083-86.

 

57.                    “Stereoselective Total Synthesis of Polyoxin J“ A. K. Ghosh and Y. Wang, J. Org. Chem. 1999, 64, 2789-95.

 

58.                    “Asymmetric Dihydroxylation Route to Dipeptide Mimetic for HIV Protease Inhibitors: Enantioselective Synthesis of the Core Unit of Ritonavir”, A. K. Ghosh;  D. Shin and P. Mathivanan, Chem. Commun.  1999, 1025-26.

 

59.                    “A Stereoselective Synthesis of (-)-Tetrahydrolipstatin”, A. K. Ghosh and C. Liu, Chem. Commun. 1999, 1764-65.

 

60.                    “Synthetic Studies of Nucleoside Antibiotics: A Formal Synthesis of (+)-Sinefungin”, A. K. Ghosh and Y. Wang, J. Chem. Soc. Perkin Trans. 1 1999,  3597-01.

 

61.                    “Stereoselective synthesis of 5-O-Carbamoylpolyoxamic Acid by [2,3]-Wittig-Still Rearrangement”, A. K. Ghosh and Y. Wang, Tetrahedron  1999, 55, 13369-76.

 

62.                    “BINAP-Platinum and Palladium Complexes: Effective Catalysts for Enantioselective Diels-Alder Reaction”, A. K. Ghosh and H. Matsuda, Organic Letters 1999, 1 2157-60.

 

63.                    “A Stereoselective Synthesis of (+)-Boronolide”  A. K. Ghosh, and G. Bilcer  Tetrahedron Letters  2000, 41, 1003-07.

 

64.              “Potent and Selective Inhibitors for Human Brain Memempsin 2 (b-Secretase)” A. K. Ghosh, D. Shin, D. Downs, G. Koelsch, X. Lin, J. Ermolieff and J. Tang, J. Am. Chem. Soc. 2000, 122, 3522-23.

 

65.             “An Enantioselective Synthesis of the C2-C16 Segment of Antitumor  Macrolide Laulimalide " A. K. Ghosh and Y. Wang, Tetrahedron Letters, 2000, 41, 2319-23.

 

66.                    “An Enantioselective Synthesis of the C2-C16 Segment of Antitumor Macrolide         Laulimalide " A. K. Ghosh and Y. Wang, Tetrahedron Letters, 2000, 41, 4705-08.

 

67.                    “Asymmetric Synthesis of (-)-Tetrahydrolipstatin: An Anti-Aldol Based Strategy " A. K. Ghosh and S. Fidanze, Organic Letters, 2000, 2, 2405-08.

 

68.                    “A Short Synthesis of  (±)-Eburnamonine " A. K. Ghosh and R. Kawahama, J. Org. Chem. .  2000, 65, 5433-35.

 

69.                    “Enzymatic Acylation and Ring Closing Olefin-metathesis: A Convenient Strategy for the Lactone Moiety of Compactin and Mevinolin " A. K. Ghosh and H. Lei, J. Org. Chem.  2000, 65, 4779-81.

 

70.            “A Convergent Synthesis of (+)-Cryptophycin B, A potent Antitumor Macrolide from Nostoc sp. Cyanobacteria " A. K. Ghosh and A. Bischoff, Organic Letters,  2000, 2, 1573-76.

 

71.            “Total Synthesis of (+)-Laulimalide, A potent Antitumor Macrolide." A. K. Ghosh and Yong Wang, J. Am. Chem. Soc. 2000, 122, 11027-28.

 

72.            “Stereoselective Construction of Quaternary Carbon Centers by Three Component Coupling  Reactions”  A. K. Ghosh; R. Kawahama and D. Wink , Tetrahedron Letters, 2000, 44, 8425-28.

 

73.             “Structure of Memapsin 2 with Inhibitor, A Template to Design Drugs for Alzheimer’s Disease” L. Hong; G. Koelsch; X. Lin; S. Terzyan; A. K. Ghosh; X. C. Zhang and J. Tang, Science, 2000, 290 , 150-53.

 

74.             “Ester Derived Titanium Enolate Aldol Reaction : Chelation Controlled  Diastereoselective  Synthesis  of   Syn-Aldols” A. K. Ghosh and J-H. Kim, Tetrahedron Letters, 2001, 42 1227-31.

 

75.             “2,5-Anhydro Sugar Diacid and 2,5-Anhydro Sugar Diamine Based C2-Symmetric Peptidomimetics as Potential HIV-1 Protease Inhibitors" T. K. Chakraborty, S. Ghosh, M. H. V. Ramana Rao, A. C. Kunwar, H. Cho, A. K. Ghosh, Tetrahedron Letters 2001, 42, 10121-24.

 

76.               “Tartaric Acid and Tartrates in the Synthesis of Bioactive Molecule” A. K. Ghosh; E. Koltun; G. Bilcer, Synthesis, 2001, 1281-01.

 

77.           “A Macrolactonization Strategy to Microtuble-Stabilizing Agent (-)-Laulimalide” A. K. Ghosh and Y. Wang, Tetrahedron Letters  2001, 42, 3399-04.

 

78.          “Structure-based Design of Nonpeptide HIV Protease Inhibitors” A. K.   Ghosh, D. Shin, L. Swanson, K. Krishnan, H. Cho, K. A. Hussain, D. E. Walters,  L. Holland, J. Buthod, Farmaco  2001, 56, 29-32.

 

79.              “Total Synthesis of Antitumor Depsipeptide (-)-Doliculide" A. K. Ghosh and Chunfeng Liu, Organic Letters 2001, 3, 635-39.

 

80.            “Asymmetric Hetero Diels-Alder Route to Quaternary Carbon Centres: Synthesis of   (-)-Malynolide” A. K. Ghosh and M. Shirai, Tetrahedron Letters  2001, 42, 6231-34.

 

81.           “Subsite Specificity of Memapsin 2 b-Secretase):  Implications for Inhibitor Design”R. Turner, G. Koelsch, L. Hong, P. Castenheira, A. K. Ghosh and J. Tang,  Biochemistry 2001, 40, 10001-06.

 

82.              “Stereoselective Synthesis of Pseudopeptide Microbial Agent AI-77B”A. K. Ghosh, A. Bischoff and J. Cappiello, Organic Letters  2001, 3, 2677-81.

 

83.                    “Structure Based Design: Potent Inhibitors of Human Brain Memapsin 2 (b-Secretase)”A. K. Ghosh, G.  Bilcer, C. Harwood, R. Kawahama, D. Shin, K. A. Hussain, L. Hong, J. A. Loy, C. Nguyen, G. Koelsch, J. Ermolieff  and J. Tang, J. Med. Chem. 2001, 44, 2865-68.

 

84.                    “Total Synthesis of Microtubule-stabilizing Agent (-)-Laulimalide” A. K. Ghosh, Y. Wang and J. T. Kim, J. Org. Chem. 2001, 66, 8973-82.

 

85.                    “ Syntheses of FDA Approved HIV Protease Inhibitors” A. K. Ghosh, G. Bilcer and G. Schiltz, Synthesis, 2001, 2203-29.

 

86.                    “Antiviral Activity of UIC-PI, a Novel Inhibitor of the Human Immunodeficiency Virus Type 1 Protease,”  A. K. Ghosh, E. Pretzer, H. Cho, K. A. Hussain, N. Duzgunes, Antiviral  Research , 2002, 54, 29-36.

 

87.                    “b-Secretase as a Therapeutic Target for Inhibitor Drugs”  A. K. Ghosh, L. Hong and J. Tang. Curr. Med. Chem. 2002,  9, 1135-44.

 

88.                    “Stereoselective Synthesis of the C11-N26 Fragment of Griseoviridin” A. K. Ghosh, H. Lei, Synthesis, 2002, 371-74.

 

89.                    “UIC-94003: A Potent Protease Inhibitor (PI) That Inhibits Multi-PI-Resistant HIV-1 Peplication in vitro” K. Yoshimura, R. Kato, M. K. Kavlick, A. Nguyen, V. Moroun, K. Maeda, K. A. Hussain, A. K. Ghosh, J. Erickson, H. Mitsuya, J. Virol.  2002, 76, 1349-58.

 

90.                    “Novel Cyclourethane-Derived HIV Protease Inhibitors:  A Ring Closing Olefin Metathesis Based Strategy”A. K. Ghosh, L. M. Swanson,  C. Liu, K. A. Hussain, H. Cho, D. E. Walters, L. Holland,and J. Buthod,  Bioorg. Med. Chem. Lett.  2002, 12, 1993-96.

 

91.                    “A Non-Antibacterial Oxazolidinone that inhibits Epithelial Cell Sheet Migration” K. T. Mchenry, S. V. Ankala, A. K. Ghosh, G. Fenteany, ChemBioChem, 2002, 3, 1105-11.

 

92.                    “Specificity of Memapsin 1 and its Implications on the Design of Memapsin 2 (b-Secretase) Inhibitor Selectivity” R. T. Turner, J. A. Loy, C. Nguyen, T. Devasamudram, A. K. Ghosh, G. Koelsch, J. Tang, Biochemistry, 2002, 41, 8742-46.

 

93.                    “Doliculide, a New Macrocyclic Desipeptide Enhancer of Actin Assembly” R. Bai, D. G. Covell, A. K. Ghosh, C. Liu, E. Hamel,  J.  Biol. Chem. 2002, 277, 32165-71.

 

94.                    “Crystal Structure of Memapsin 2 (b-Secretase) in Complex with an Inhibitor OM00-3” L. Hong,  R. T. Turner, G. Koelsch, D. Shin, A. K. Ghosh, J. Tang, Biochemistry, 2002, 41, 10963-67.

 

95.                    “Chelation Controlled Ester-Derived Titanium Enolate Aldol Reaction: Diastereoselective Syn-Aldols with Mono- and Bidentate Aldehydes” A. K Ghosh and J-H. Kim, Tetrahedron Letters 2002, 43, 5621-24.

 

96.                    “Memapsin 2 (b-Secretase as a therapeutic target”, L. Hong,  R. T. Turner, G. Koelsch, A. K. Ghosh, J. Tang, Biochem. Soc. Trans  2002, 30, 530-34.

 

97.                    “Stereoselective Synthesis of syn-1,3-diol Derivatives and Application to the Lactone Moiety of Compactin and Mevinolin” A. K. Ghosh and  H. Lei,  J. Org. Chem. 2002, 67, 8783-88.

 

98.                    “The Microtubule Stabilizing Agent Laulimalide Does not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May not Require its Epoxide Moiety for Activity” D. E. Pryor, A. O’Brate, G. Bilcer, J. Fernando Diaz, Y. Wang, Y. Wang, M. Kabaki, M. K. Jung, J. M. Andreu, A. K. Ghosh, P. Giannakakou, E. Hamel, Biochemistry, 2002, 41, 9109-15.

 

99.                    “Multicomponent Reactions: Synthesis of Spirocyclic Tetrahydropyran Derivatives by Prins Cyclization,” A. K. Ghosh, D. Shin and G. Schiltz,  Heterocycles, 2002, 58, 659-66.

 

100.                "Asymmetric Total Synthesis of the Gastroprotective Microbial Agent AI-77-B" A. K. Ghosh, A. Bischoff and J. Cappiello, Eur. J. Org. Chem. 2003, 5, 821-32.

 

101.                “A Formal Synthesis of the Non-nucleoside Reverse Transcriptase Inhibitor Taurospongin  A” A. K. Ghosh and H. Lei. Tetrahedron: Asymm. 2003, 14, 629-34.

 

102.                “Highly Diastereoselective Anti-Aldol Reactions Utilizing Titanum Enolate of Cis-2-Arylsulfonamido -1-acenaphthenyl propionate” A. K. Ghosh, Jae-hun Kim, Org. Lett. 2003, 6, 1063-66.

 

103.                “An Enantioselective Synthesis of the C1-C9 Segment of Antitumor  Macrolide Peloruside A” A. K. Ghosh, Jae-hun Kim,  Tetrahedron. Lett. 2003, 44, 3967-70.

 

104.                “Enantioselective Total Synthesis of (+)-Amphidinolide T1” A. K. Ghosh, Chunfeng Liu,  J. Am. Chem.Soc. 2003, 125, 2374-75.

 

105.                “Study of memapsin 2 (b-secretase) and strategy of inhibitor design.”  J. Tang, A. K. Ghosh, L. Hong, G. Koelsch, R. Turner, Chang, W.  J.  Mol.  Neuroscience  2003,  20,  299-304.

 

106.                “Synthetic Studies of Microtubule Stabilizing Agent Peloruside A:  An Asymmetric  Synthesis of the C10-C24  Segment” A. K. Ghosh, Jae-hun Kim,  Tetrahedron. Lett. 2003, 44,  7659-7661.

 

107.                “A Novel bis-Tetrahydrofuranylurethane-containing Non-peptide Protease Inhibitor (PI) UIC-94017 (TMC114) Potent Against Multi-PI-Resistant HIV In Vitro" Y. Koh, H. Nakata, K. Maeda, H. Ogata, G. Bilcer, T. Devasamudram, J. K. Kincaid, P. Boross, Y. Tie P. Volarath, L. Gaddis, R. W. Harrison,  I. T. Weber,  A. K. Ghosh,. H. Mitsuya,  Antimicrobial Agents and Chemotherapy,. 2003, 47,  3123-3129. .                                                                               

 

108.                “Memapsin 2, a drug target for Alzheimerís disease” in J. Saklatvala et al. (eds.) Protease and the Regulation of Biological Process”. Portland Press.  G. Koelsch, R. T. Turner, 3rd, L. Hong, A.K. Ghosh, and J. Tang,  2003, 312-20.

 

109.                "An Enantioselective Synthesis of (+)-Cryptophycin 52 (LY355703), A Potent Antimitotic Antitumor Agent",  A. K. Ghosh, L. Swanson,  J. Org. Chem.  2003, 68, 9823-26.

 

110.                “Memapsin 2 (b-secretase), a drug target for Alzheimer’s disease” G. Koelsch, R. Turner, L. Hong A. K. Ghosh, J. Tang,  Biochem. Soc. Symp.  2003,  70,  213-20.

 

111.                “The Development of Titanium Enolate Based Aldol Reaction”', Edited by Rainer      Mahrwald for 'Modern Aldol Reactions' A. K. Ghosh, M. Shevlin, WILEY-VCH, 2004, 63-121.

 

112.                "First Total Synthesis of (+)-Amphidinolide T1" A. K. Ghosh, C. Liu, Strategies and Tactics in Organic Synthesis, Academic Press, Edited by M. Harmata, 2004,  5, 255.

 

113.                “Asymmetric Syntheses of Potent Antitumor Macrolides Cryptophycin B and Arenastatin A” A. K. Ghosh and A. Bischoff, Eur. J. Org. Chem. 2004, 10,  2131-41.

 

114.                “High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) Active against Multi-Drug Resistant Clinical Strains” Y.  Tie, P. I. Boross, Y-F Wang, L. Gaddis, A. K. Hussain, S. Leshchenko, A. K. Ghosh, J. M. Louis, R. W. Harrison, I. T. Weber, J.  Mol.  Biol.  2004, 338, 341-52.

 

115.                “Laulimalide and PacliTaxel: A Comparison of Their Effects on Tubulin Assembly and Their Synergistic Action When Present Simultaneously” E. J. Gapud, R. Bai, A. K. Ghosh and E. Hamel,  Mol. Pharmacology,  2004,  66, 113-121.

116.                “In vivo inhibition of Ab production by memapsin 2 (b-secretase) inhibitors” W-P Chang, G. Koelsch, ,S. Wong,  D. Downs,  H. Da, V. Weerasena, B. Gordon, T. Devasamudram, G. Bilcer, A. K. Ghosh and J. Tang. J.  Neurochem.  2004,  89, 1409-16.

117.                “Oxazols: Synthesis, Reactions and spectroscopy of Chiral Bis(oxazolines)”,  Edited by D. Palmer for Heterocyclic Compounds series, A. K. Ghosh, S. Fidanze, G. Bilcer, Wiley Interscience,  2004,  60,  595-634.

 

118.                “Determination of Absolute Stereochemistry and Total synthesis of Spongidepsin”  A. K. Ghosh and X. Xu. Organic Letters 2004, 6, 2055.

 

119.                Stereoselective Chloroacetate Aldol Reaction: Synthesis of Acetate Aldol equivalents and Darzens Glycidic Esters” A. K. Ghosh, Jae-hun Kim, Org. Lett. 2004, 6, 2725-8.

 

120.                “Total Synthesis and Structural Revision of (+)-Amphidinolide W” A. K. Ghosh and Gangli Gong,   J. Am. Chem. Soc. 2004, 126,  3704-05.

 

121.                “Stereoselective Photochemical 1,3-Dioxalene Addition to a,b Unsaturated–g-lactone: Synthesis of Bis-tetrahydrofuranyl Ligand for HIV Protease Inhibitor UIC-94-017 (TMC-114)” A. K. Ghosh,  S. Leshchenko and M. Noetzel, J. Org. Chem. 2004, 69, 7822-29.

 

122.                "TiCl4 Promoted Multicomponent Reaction:  a New Entry to the Functionalized -Amino Acids” A. K. Ghosh, C-X, Xu, D. Wink Org. Lett. 2005, 7, 7-10.

 

123.                “Memapsin 2 (b-Secretase) New Subsites S5, S6 and S7: Structural Locations and Functional Roles “ R. T. Turner, L. Hong, G. Koelsch, A. K. Ghosh and J. Tang,  Biochemisry, 2005, 44, 105-112.

 

124.                “Analysis of amyloid precursor protein processing protease -secretase: tools for memapsin 2 (b-secretase) inhibition studies” G. Koelsch, V. Weerasena, D. Shin, A. K. Ghosh, J. Tang, Amyloid Precursor Protein  2005,    41-50.

 

125.                 “Structure Based Design of Cycloamide-urethane-Derived Novel Inhibitors of Human Brain Memapsin 2 (b-Secretase)” A. K. Ghosh, T. Devasamudram, L. Hong, C. DeZutter,  X. Xu, V. Weerasena, G. Koelsch, G.  Bilcer, and J. Tang, Bioorg. Med. Chem. Lett.  2005, 15, 15-20.

 

126.                “UIC-94017/TMC114: A Novel protease Inhibitors Containing bis-Tetrahydrofuranyl Urethane (bis-THF) Potent Against Multi-PI-Resistant HIV in vitro“ Y. koh, A. K. Ghosh and H. Mitsuya, J. AIDS Res. 2005,  7, 17-21.

 

127.                “Cycloamide-based Protease Inhibitors Involving P1- and P2-ligands:  A Ring Closing    Olefin Metathesis Based Strategy”A. K. Ghosh, L. M. Swanson,  H. Cho, K. A. Hussain, S. Leschenko, S. Kay, D. E. Walters,and H. Mitsuya, J. Med. Chem. 2005,  48, 3576.

 

128.                “Recent Development of Structure-based b-Secretase Inhibitors for Alzheimer’s disease” A. K. Ghosh, K. Nagaswamy, J.  Tang.  Curr. Med. Chem. 2005, 16, 1609-22..

 

129.                “Conformations of Laulimalide in DMSO-d6”  P. Thepchatri, D. O. Cicero, E. Monteagudo, A. K. Ghosh, B. Cornett, E. R. Weeks, J. P. Snyder.  J. Am. Chem. Soc. 2005, 127, 12838-12846.

 

130.                “Design and Synthesis of Peptidomimetic SARS-3CLpro Inhibitors” A. K. Ghosh, K. Xi, K. Ratia, B. D. Santarsiero,  W. Fu, B. H. Harcourt,  P. A. Rota,  S. C. Baker,   M. E. Johnson and A.  D. Mesecar. J. Med. Chem. 2005, 48,  6767-70.

 

131.          “Susceptibility of an HIV-1 Protease Inhibitor (TMC-114) to Highly Drug Resistant Mutations D30N, I50V and L90M” A. Kovalevsky, Y. Tie, F. Liu, P. I. Boross, Y-F. Wang, S. Leshchenko, A. K. Ghosh  and I. T. Weber. J.  Med.  Chem.  2006, 49, 1379.

 

132.          “Altered HIV-1 gag Protein Interactions with Cyclophilin A (CypA) on the Acquisitionof H219Qand H219P Substitutios in the CypA Binding Loop” H. Gatanaga; D. Das, Y. Suzuki, D. D. Yeh; M. F. Kavlick, K. A. Hussain; A. K. Ghosh; H. Mitsuya, J. Biol. Chem. 2006, 281, 1241.