Research Publications (total of 242):

 

 

1.                         “Diastereoselection in Intramolecular Nitrile Oxide Cycloaddition  (NOC)   Reactions and Confirmation of the Antiperiplanar Effect  Through a Simple Synthesis  of  2-Deoxy-D-ribose"  A. P. Kozikowski and A. K. Ghosh, J. Am. Chem. Soc. 1982, 104, 5788-89.

 

2.                        "The Isoxazoline Route to a-Methylene Lactones"  A. P. Kozikowski and A. K. Ghosh, Tetrahedron Letters  1983, 24, 2623-26.

 

3.                        "Diastereofacial Selection in Nitrile Oxide Cycloaddition Reactions. The Anti-Directing Effect of an Allylic Oxygen and Some New Results on the Ring Metalation of Isoxazolines. A Synthesis of (±) Blastmycinone" A. P. Kozikowski and A. K. Ghosh, J. Org. Chem. 1984, 49, 2762-72.

 

4.                        "Methods for Pyranoannulation - An Approach to a New Class of Polyethers" A. P. Kozikowski and A. K. Ghosh, J. Org. Chem. 1985, 50, 3017-19.

 

5.                        "Mn(III)-Promoted Annulation of Enol Ethers to Fused or Spiro 2-Cyclopentanones" E. J. Corey and A. K. Ghosh, Tetrahedron Letters  1987,  28, 175-79.

 

6.                        "Two-step Synthesis of Furans by Mn(III)-Promoted Annulation of Enol Ethers" E. J. Corey and A. K. Ghosh, Chemistry Letters  1987, 223-26.

 

7.                        "Total Synthesis Of (±) Ginkgolide B"  E. J. Corey, M-C. Kang, M. C. Desai, A. K. Ghosh, and I. N. Houpis, J. Am. Chem. Soc. 1988, 110, 649-51.

 

8.                        "Total Synthesis Of (±) Ginkgolide A"  E. J. Corey and A. K. Ghosh,  Tetrahedron Letters 1988,  29, 3205-08.

 

9.                        "Total Synthesis Of (±) Ginkgolide B" M. C. Desai, A. K. Ghosh, M-C. Kang, and I. N. Houpis, Strategies and Tactics in Organic Synthesis, Academic Press, Edited by  T. Lindberg, 1991, 2, 89-119.

 

10.                    "Stereoselective Reduction of a-Hydroxy Oxime Ethers: A  Convenient Route to Cis-1,2-Amino Alcohols"  A. K. Ghosh, S. P. McKee, and W. M. Sanders, Tetrahedron  Letters  1991, 32, 4251-54.

 

11.                    "Di(2-Pyridyl) Carbonate Promoted Alkoxycarbonylation Of  Amines: A Convenient Synthesis of Functionalized Carbamates" A. K. Ghosh, T. T. Duong and S. P. McKee, Tetrahedron  Letters  1991, 32, 4251-54.

 

12.                    "Stereocontrolled Synthesis of HIV-1 Protease Inhibitors with C2-Axis of Symmetry" A. K. Ghosh, S. P. McKee, and W. J. Thompson,  Tetrahedron  Letters  1991, 32, 5729-33.

 

13.                    "An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors" A. K. Ghosh, S. P. McKee, and W. J. Thompson,  J. Org. Chem.  1991, 56, 6500-03.

 

14.                    "Intramolecular and Intermolecular Hydroxyl Reactivity Differences in Ginkgolides A, B and C and Their Chemical Applications" E. J. Corey, K. Srinivas Rao and A. K. Ghosh, Tetrahedron  Letters   1992, 33, 6955-58.     

 

15.                    "N,N'-Disuccinimidyl Carbonate: A Useful Reagent for Alkoxycarbonylation Of  Amines" A. K. Ghosh, T. T. Duong, S. P. McKee and W. J. Thompson, Tetrahedron  Letters 1992, 33, 2781-84.

 

16.                    "A Facile and Enantiospecific Synthesis of 2(S)- and 2(R)-[1'(S)-Azido-2-Phenylethyl]Oxirane" A. K. Ghosh, S. P. McKee, H. Y. Lee and W. J. Thompson,  J. Chem. Soc., Chem. Communication.  1992, 273-74.

 

17.                    "An Efficient Synthesis of Functionalized Urethanes from Azides" A. K. Ghosh, S. P. McKee, T. T. Duong and W. J. Thompson.  J. Chem. Soc., Chem. Communication.  1992, 1308-10.

 

18.                    "Highly Enantioselective Aldol Reaction : Development of a New Chiral Auxiliary from cis-1-amino-2-hydroxyindane" A. K. Ghosh, T. T. Duong, S. P. McKee,  J. Chem. Soc., Chem. Communication. 1992, 1673-74.

 

19.                    "HIV-1 Protease Inhibitors: Synthesis and biological Evalution of Glycopeptides"  A. K. Ghosh, S. P. McKee, W. M. Sanders, P. L. Darke, J. Zugay, E. M. Emini, J. R. Huff and P. S. Anderson ; Drug Design and Discovery 1993, 10, 77-86.

 

20.                    "Potent HIV-1 Protease Inhibitors : Stereoselective Synthesis of a New Dipeptide Mimic" A. K. Ghosh, S. P. McKee, W. J. Thompson, P. L. Darke, and J. Zugay; J. Org. Chem.  1993, 58, 1025-29.

 

21.                    "3'-tetrahydrofuranglycine  as a  Novel, Unnatural  Amino  Acid Surrogate  for Asparagine in the Design of Inhibitors of the HIV Protease" W. J. Thompson, A. K. Ghosh, M. K. Holloway, H. Y. Lee,  P. M. Munson,  J. E. Schwering, J. Wai,  P. L. Darke, J. Zugay,  E. A. Emini, W. A. Schleif, J. R. Huff and P. S. Anderson ;  J. Am. Chem. Soc. 1993, 115, 801-03.

 

22.                   "3- tetrahydrofuran  and  pyranyl  Urethanes  as High Affinity  P2-Ligands for HIV-1  Protease  Inhibitors"  A. K. Ghosh,  W. J.  Thompson,  S. P. McKee, T. T. Duong, T. A. Lyle,  J. C. Chen,  P. L. Darke, J. Zugay, E. A. Emini, W. A. Schleif, J. R. Huff and P. S. Anderson ; J. Med. Chem. 1993, 36,  292-94.

 

23.                    "Cyclic sulfones as novel and High Affinity P2-Ligands for HIV Protease Inhibitors" A. K. Ghosh,   W. J. Thompson, S. P. McKee, T. T. Duong, T. A. Lyle,  J. C. Chen,  P. L. Darke, J. Zugay,  E. A. Emini, W. A. Schleif, J. R. Huff and P.  S. Anderson ; J. Med. Chem. 1993, 36, 924-27.

 

24.                    "Potent HIV Protease Inhibitors: The Development of 3'-tetrahydrofuranglycine  as  P2-Ligands and substituted Pyrazine Derivatives as P3-Ligands " A. K. Ghosh, W. J. Thompson, S. P. McKee, T. T. Duong, M. K. Holloway, H. Y. Lee,  P. M. Munson, J. Wai,  P. L. Darke, J. Zugay,  E. A. Emini, W. A. Schleif, J. R. Huff and P. S. Anderson.  J. Med. Chem., 1993, 36, 2300-10.

 

25.                   "Structure Based Design of High Affinity Ligands for HIV-1 Protease Inhibitor: Replacements of Two Amides and a 10p Electron Aromatic System" A. K. Ghosh, W. J. Thompson, P. M.D. Fitzgerald, C. Culberson, S. P. McKee, J. R. Huff and P. S. Anderson. J. Med. Chem. 1994, 37, 2506-08.

 

26.                   "The Development of Cyclic Sulfolanes as Novel and High Affinity P2-Ligands for HIV-1 Protease Substrate Binding Site"  A. K. Ghosh, W. J. Thompson, C. Culberson, M. K. Holloway,  S. P. McKee, T. T. Duong,  P. M. Munson, P. L. Darke, J. Zugay,  E. A. Emini, W. A. Schleif, J. R. Huff and P. S. Anderson.  J. Med. Chem. 1994, 37, 1177-88.

 

27.                     "A Priori Prediction of Activity for HIV-1 Protease Inhibitors Employing Energy Minimization in the Active Site"  M. K. Holloway,  P. M.D. Fitzgerald, W. J. Thompson, A. K. Ghosh,  P. L. Darke, J. Zugay,  E. A. Emini, W. A. Schleif, J. M. Wai,  J. R. Huff and P. S. Anderson. J. Med. Chem., 1995,  38, 305-17.

 

28.                   "Synthesis and Optical Resolution of High Affinity P2-Ligands for HIV-1 Protease Inhibitors" A. K. Ghosh, Y. Chen. Tetrahedron Letters, 1995, 36, 505-08. 

 

29.                   "Cyclic Sulfone-3-Carboxamide as Novel P2-Ligands for HIV-1 Protease Inhibitors" A. K. Ghosh, W. J. Thompson, P. M. Munson, W. Liu, J. R. Huff. Bioorganic  and Med. Chem. Letters, 1995, 5,  83-88.

 

30.                    "Highly Stereoselective Reduction of a-keto Esters : Utility of Cis-1-Arylsulfonamido-2-Indanols as Chiral Auxiliaries", A. K. Ghosh Y. Chen. Tetrahedron Letters 1995, 36,  6811-14.

 

31.                   "Chiral Auxiliary Mediated Conjugate reduction and Asymmetric Protonation: Synthesis of High Affinity Ligands for HIV Protease Inhibitors",  A. K. Ghosh,  W. Liu, J. Org. Chem. 1995, 60, 6198-6201.

 

32.                    "Highly Diastereoselective Asymmetric Diels-Alder Reactions of Arylsulfonamido-2-Indanols derived Ligands" A. K. Ghosh, P. Mathivanan, Tetrahedron: Asymmetry,  1996, 7, 375-78.

 

33.                   "Nonpeptidal P2-Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis and Biological Evaluations " A. K. Ghosh, J. F. Kincaid, D. E. Walters, Y. Chen,  N. C. Chaudhuri, W. J. Thompson, C. Culberson, P. M.D. Fitzgerald,   S. P. McKee, P. M. Munson,  M. G. Axel, J. R. Huff; J. Med. Chem., 1996 39, 3278-90.

 

34.                    "A Convergent, Enantioselective Total Synthesis of Hapalosin with Multidrug-Resistance Reversing Activity"  A. K. Ghosh, W. M. Liu, Y. Xu, Z. Chen. Angew. Chem.  1996, 35, 74-76.

 

35.                  "Synthesis of Enantiomerically Pure Anti Aldols: A Highly Stereoselective Ester-Derived Titanium Enolate Aldol Reaction"  A. K. Ghosh, M. Onishi. J. Am. Chem. Soc. 1996, 118,  2527-28. 

 

36.                    "Conformationally Constrained Bis(oxazoline) Derived Chiral Catalyst: A Highly Effective Enantioselective-Catalytic Diels-Alder Reaction"  A. K. Ghosh, P. Mathivanan, J. Cappiello.  Tetrahedron Letters  1996, 37,  3815-18.

 

37.                   "Heteroatom Diels-Alder Reaction with Danishefsky Diene: Bis(oxazoline) Based Asymmetric Catalysis" A. K. Ghosh, P. Mathivanan, J. Cappiello.  Tetrahedron: Asymmetry, 1996, 7, 2165-68.

 

38.                   "Total Synthesis of (+)-Sinefungin" A. K. Ghosh, W-M. Liu. J. Org. Chem. 1996, 61, 6175-82.

 

39.                  "Asymmetric Alkylations and Aldol Reactions :  Optically Active  1, 2-aminocyclo-pentanol Derived New Chiral Auxiliaries"  A. K. Ghosh, H. Cho. Tetrahedron: Asymmetry,  1997, 8,  821-24. 

 

40.                   "A Convenient Enzymatic Route to Optically Active 1-Aminoindan-2-ol: Versatile Ligands for HIV-1 Protease Inhibitors and Asymmetric Syntheses" A. K. Ghosh, J. F. Kincaid and M. Haske. Synthesis  1997, 541-44.

 

41.                   "Synthetic studies of Antitumor Macrolide Laulimalide: Enantioselective Synthesis of the C1-C14 Segment by a Catalytic Hetero Diels-Alder Strategy" A. K. Ghosh, P. Mathivanan, J. Cappiello. Tetrahedron Letters 1997, 38, 2427-31.

 

42.                    "Asymmetric Aldol Route to Hydroxyethylamine Dipeptide Isostere: Convenient Synthesis of HIV Protease Inhibitor Saquinavir"   A. K. Ghosh, A. Hussain, S. Fidanze,  J. Org. Chem.  1997, 62,  6080-82.

 

43.                    "Ester Derived Titanium Enolate Aldol Reaction: Highly Diastereoselective Synthesis of Syn- and Anti-aldols"  A. K. Ghosh, S. Fidanze, M. Onishi, A. Hussain, Tetrahedron Letters ,  1997, 38, 7171-74.

 

44.                    "A Convergent, Enantioselective Total Synthesis of  Streptogramin Antibiotic (-)-Madumycin II" A. K. Ghosh and W-M.  Liu, J. Org. Chem. 1997, 62, 7908-09.

 

45.                    “C2-Symmetric Chiral Bis(oxazoline)-metal Complexes in Catalytic Asymmetric Synthesis” A. K. Ghosh, P. Mathivanan, J. Cappiello, Invited Review, Tetrahedron: Asymmetry,  1998, 9, 1-45.

 

46.                    “Chemoselective Reduction of Alkenes Using Lindlar Catalyst” A. K. Ghosh, K. Krishnan, Tetrahedron Letters, 1998, 39, 947-50.

 

47.                    “Structure Based Design: Novel Spirocyclic Ethers as Nonpeptidal P2-Ligands for HIV Protease Inhibitors”  A. K. Ghosh,  K. Krishnan, D. E. Walters, W. Cho, Y. Koo, H. Cho, L. Holland, J. Buthod, Bioorg. Med. Chem. Letters,  1998, 8, 979-982.

 

48.                    “Convenient Synthesis of Novel Macrocyclic Urethane: Alkoxycarbonylation of Amines and Ring-Closing Metathesis Strategy” A. K. Ghosh and K. A. Hussain, Tetrahedron Letters, 1998, 39, 1881-84.

 

49.                    “Potent HIV Protease Inhibitors Incorporating High Affinity P2-Ligands and (R)-Hydroxyethylaminosufonamide Isostere”  A. K. Ghosh,  J.  F. Kincaid, W. Cho, D. E. Walters, K. Krishnan, K. A. Hussain, Y. Koo, H. Cho, C. Rudall, L. Holland, J. Buthod, Bioorg. Med. Chem. Letters,  1998, 8,  687-90.

 

50.                    “Cis-1-aminindan-2-ol in Asymmetric Syntheses” A. K. Ghosh, S. Fidanze and C. H. Senanayake, Invited Review, Synthesis,  1998, 937-61.

 

51.                    “Ring-Closing Metathesis Strategy to a,b-unsaturated g- and d-Lactones: Synthesis of Hydroxyethylamine Isosteres for HIV Protease Inhibitors” A. K. Ghosh, J. Cappiello and D. Shin, Tetrahedron Letters,  1998, 8, 4651-54.

 

52.                    “Transition-State Mimetics for HIV Protease Inhibitors: Stereocontrolled Synthesis of Hydroxyethylene and Hydroxyethylamine Isosteres by Ester Derived Titanium Enolate Syn- and Anti-aldol Reactions” A. K. Ghosh and S. Fidanze, J. Org. Chem. 1998, 63, 6146-52.

 

53.                    "Constrained Bis(oxazoline) Derived Cationic Aqua Complexes: Highly Effective Catalysts for Enantioselective Diels-Alder Reactions” A. K. Ghosh, H. Cho and J. Cappiello, Tetrahedron : Asymmetry, 1998, 9,  3687-91.

 

54.                    “Stereoselective Synthesis of Protected Thymine Polyoxin C via   [2,3]-Wittig-Still Rearrangement of Ribose Derived Allylic Stannyl Ethers “ A. K. Ghosh and Y. Wang, J. Org. Chem. 1998, 63, 6735-38.

 

55.                    “Stereoselective Synthesis of Dihydroisocoumarin Moiety of Microbial Agent AI-77-B: A Diels-Alder Based Strategy” A. K. Ghosh and J. Cappiello, Tetrahedron Letters, 1998, 39, 8803-06.

 

56.                    “TiCl4 Promoted Three Component Coupling Reaction : A New Synthetic Method for the Functionalized Tetrahydrofuran and Tetrahydropyran“ A. K. Ghosh and R. Kawahama, Tetrahedron Letters,  1999, 40, 1083-86.

 

57.                    “Stereoselective Total Synthesis of Polyoxin J“ A. K. Ghosh and Y. Wang, J. Org. Chem. 1999, 64, 2789-95.

 

58.                    “TiCl4 Promoted Three Component Coupling Reaction:  an Efficient Method for the Substituted Tetrahydropyrilidene Acetates” A. K. Ghosh, R. Kawahama, Tetrahedron Letters 1999, 40, 4751-4754.

 

59.                 “Asymmetric Dihydroxylation Route to Dipeptide Mimetic for HIV Protease Inhibitors: Enantioselective Synthesis of the Core Unit of Ritonavir” A. K. Ghosh, D. Shin and P. Mathivanan, Chem. Commun.  1999, 1025-26.  

 

60.          “A Stereoselective Synthesis of (-)-Tetrahydrolipstatin” A. K. Ghosh and C. Liu, Chem. Comm. 1999, 1743-1744.

 

 61.      “Synthetic Studies of Nucleoside Antibiotics: A Formal Synthesis of (+)-Sinefungin” A. K. Ghosh and Y. Wang, J. Chem. Soc. Perkin Trans. 1 1999,  3597-01.

 

62.     “Stereoselective synthesis of 5-O-Carbamoylpolyoxamic Acid by [2,3]-Wittig-Still Rearrangement” A. K. Ghosh and Y. Wang, Tetrahedron  1999, 55, 13369-76.

 

63.    “Counterions of BINAP-Platinum and Palladium Complexes: Novel Catalysts for Highly Enantioselective Diels-Alder Reaction” A. K. Ghosh and H. Matsuda. Organic Letters 1999, 1, 2157-59.

 

64.     “A Stereoselective Synthesis of (+)-Boronolide”  A. K. Ghosh and G. Bilcer.  Tetrahedron Letters  2000, 41, 1003-06.

 

65.    “Design of Potent Inhibitors for Human Brain Memempsin 2 (b-Secretase)” A. K. Ghosh, D. Shin, D. Downs, G. Koelsch, X. Lin, J. Ermolieff and J. Tang, J. Am. Chem. Soc. 2000, 122, 3522-23.

 

66.     “An Enantioselective Synthesis of the C2-C16 Segment of Antitumor  Macrolide Laulimalide " A. K. Ghosh and Y. Wang, Tetrahedron Letters, 2000, 41, 2319-23.

 

67.    “Synthetic Studies of Antitumor Macrolide Laulimalide: A Stereoselective Synthesis of the C17-C28 Segment" A. K. Ghosh and Y. Wang, Tetrahedron Letters, 2000, 41, 4705-08.

 

68.    “Asymmetric Synthesis of (-)-Tetrahydrolipstatin: An Anti-Aldol Based Strategy " A. K. Ghosh and S. Fidanze, Organic Letters, 2000, 2, 2405-07.

 

69.     “A Short Synthesis of  (±)-Eburnamonine " A. K. Ghosh and R. Kawahama, J. Org. Chem. 2000, 65, 5433-35.

 

70.    “Enzymatic Acylation and Ring Closing Olefin-metathesis: A Convenient Strategy for the Lactone Moiety of Compactin and Mevinolin " A. K. Ghosh and H. Lei, J. Org. Chem.  2000, 65, 4779-81.

 

71.    “A Convergent Synthesis of (+)-Cryptophycin B, A potent Antitumor Macrolide from Nostoc sp. Cyanobacteria " A. K. Ghosh and A. Bischoff, Organic Letters,  2000, 2, 1573-75.

 

72.    “Total Synthesis of (+)-Laulimalide, A potent Antitumor Macrolide" A. K. Ghosh and Y. Wang, J. Am. Chem. Soc. 2000, 122, 11027-28.

 

73.     “Stereoselective Construction of Quaternary Carbon Centers by Three Component Coupling  Reactions”  A. K. Ghosh; R. Kawahama and D. Wink, Tetrahedron Letters, 2000, 44, 8425-29.

 

74.    “Structure of Memapsin 2 with Inhibitor, A Template to Design Drugs for Alzheimer’s Disease” L. Hong, G. Koelsch, X. Lin, S. Terzyan, A. K. Ghosh, X. C. Zhang and J. Tang, Science, 2000, 290 , 150-53.

 

75.    “Ester Derived Titanium Enolate Aldol Reaction : Chelation Controlled  Diastereoselective  Synthesis  of   Syn-Aldols” A. K. Ghosh and J-H. Kim, Tetrahedron Letters, 2001, 42 1227-31.

 

76.    “2,5-Anhydro Sugar Diacid and 2,5-Anhydro Sugar Diamine Based C2-Symmetric Peptidomimetics as Potential HIV-1 Protease Inhibitors" T. K. Chakraborty, S. Ghosh, M. H. V. Ramana Rao, A. C. Kunwar, H. Cho, A. K. Ghosh, Tetrahedron Letters 2001, 42, 10121-25.

 

77.    “Tartaric Acid and Tartrates in the Synthesis of Bioactive Molecule” A. K. Ghosh, E. Koltun, G. Bilcer, Synthesis, 2001, 1281-1301.

 

78.    “A Macrolactonization Strategy to Microtuble-Stabilizing Agent (-)-Laulimalide” A. K. Ghosh and Y. Wang, Tetrahedron Letters  2001, 42, 3399-01.

 

79.    “Structure-based Design of Nonpeptide HIV Protease Inhibitors” A. K. Ghosh, D. Shin, L. Swanson, K. Krishnan, H. Cho, K. A. Hussain, D. E. Walters,  L. Holland, J. Buthod, Farmaco  2001, 56, 29-32.

 

80.    “Total Synthesis of Antitumor Depsipeptide (-)-Doliculide" A. K. Ghosh and Chunfeng Liu, Organic Letters 2001, 3, 635-38.

 

81.    “Asymmetric Hetero Diels-Alder Route to Quaternary Carbon Centers: Synthesis of   (-)-Malyngolide” A. K. Ghosh and M. Shirai, Tetrahedron Letters  2001, 42, 6231-33.

 

82.    “Subsite Specificity of Memapsin 2 b-Secretase):  Implications for Inhibitor Design” R. Turner, G. Koelsch, L. Hong, P. Castenheira, A. K. Ghosh and J. Tang,  Biochemistry 2001, 40, 10001-06.

 

83.    “Stereoselective Synthesis of Pseudopeptide Microbial Agent AI-77B”A. K. Ghosh, A. Bischoff and J. Cappiello, Organic Letters  2001, 3, 2677-80.

 

84.    “Structure Based Design: Potent Inhibitors of Human Brain Memapsin 2 (b-Secretase)”A. K. Ghosh, G.  Bilcer, C. Harwood, R. Kawahama, D. Shin, K. A. Hussain, L. Hong, J. A. Loy, C. Nguyen, G. Koelsch, J. Ermolieff  and J. Tang, J. Med. Chem. 2001, 44, 2865-68.

 

85.    “Total Synthesis of Microtubule-stabilizing Agent (-)-Laulimalide” A. K. Ghosh, Y. Wang and J. T. Kim, J. Org. Chem. 2001, 66, 8973-82.

 

86.    “ Syntheses of FDA Approved HIV Protease Inhibitors” A. K. Ghosh, G. Bilcer and G. Schiltz, Synthesis, 2001, 2203-29.

 

87.    “Antiviral Activity of UIC-PI, a Novel Inhibitor of the Human Immunodeficiency Virus Type 1 Protease”  A. K. Ghosh, E. Pretzer, H. Cho, K. A. Hussain, N. Duzgunes, Antiviral  Research , 2002, 54, 29-36.

 

88.    “b-Secretase as a Therapeutic Target for Inhibitor Drugs”  A. K. Ghosh, L. Hong and J. Tang. Curr. Med. Chem. 2002,  9, 1135-44.

 

89.    “Stereoselective Synthesis of the C11-N26 Fragment of Griseoviridin” A. K. Ghosh, H. Lei, Synthesis, 2002, 371-74.

 

90     “A Potent HIV-1 Protease Inhibitor, UIC-94003:  (TMC-126), and Selection of a Novel (A28S) Mutation in the Protease Active Site” K. Yoshimura, R. Kato, M. K. Kavlick, A. Nguyen, V. Moroun, K. Maeda, K. A. Hussain, A. K. Ghosh, J. Erickson, H. Mitsuya, J. Virol.  2002, 76, 1349-58.

 

91.    “Novel Cyclourethane-Derived HIV Protease Inhibitors:  A Ring Closing Olefin Metathesis Based Strategy” A. K. Ghosh, L. M. Swanson,  C. Liu, K. A. Hussain, H. Cho, D. E. Walters, L. Holland,and J. Buthod,  Bioorg. Med. Chem. Lett.  2002, 12, 1993-96.

 

92.    “A Non-Antibacterial Oxazolidinone that inhibits Epithelial Cell Sheet Migration” K. T. Mchenry, S. V. Ankala, A. K. Ghosh, G. Fenteany, ChemBioChem, 2002, 3, 1105-11.

 

93.    “Specificity of Memapsin 1 and its Implications on the Design of Memapsin 2 (b-Secretase) Inhibitor Selectivity” R. T. Turner, J. A. Loy, C. Nguyen, T. Devasamudram, A. K. Ghosh, G. Koelsch, J. Tang, Biochemistry, 2002, 41, 8742-46.

 

94.    “Doliculide, a New Macrocyclic Desipeptide Enhancer of Actin Assembly” R. Bai, D. G. Covell, A. K. Ghosh, C. Liu, E. Hamel,  J.  Biol. Chem. 2002, 277, 32165-71.

 

95.     “Crystal Structure of Memapsin 2 (b-Secretase) in Complex with an Inhibitor OM00-3” L. Hong,  R. T. Turner, G. Koelsch, D. Shin, A. K. Ghosh, J. Tang, Biochemistry, 2002, 41, 10963-67.

 

96.    “Chelation Controlled Ester-Derived Titanium Enolate Aldol Reaction: Diastereoselective Syn-Aldols with Mono- and Bidentate Aldehydes” A. K Ghosh and J-H. Kim, Tetrahedron Letters 2002, 43, 5621-24.

 

97.     “Memapsin 2 (b-Secretase) as a therapeutic target” L. Hong,  R. T. Turner, G. Koelsch, A. K. Ghosh, J. Tang, Biochem. Soc. Trans.  2002, 30, 530-534.

 

98.    “Chelation-Controlled Reduction:  Stereoselective Formation of syn-1,3-diols and Synthesis of Compactin and Mevinolin Lactone” A. K. Ghosh and  H. Lei,  J. Org. Chem. 2002, 67, 8783-88.

 

99.    “The Microtubule Stabilizing Agent Laulimalide Does not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May not Require its Epoxide Moiety for Activity” D. E. Pryor, A. O’Brate, G. Bilcer, J. Fernando Diaz, Y. Wang, Y. Wang, M. Kabaki, M. K. Jung, J. M. Andreu, A. K. Ghosh, P. Giannakakou, E. Hamel, Biochemistry, 2002, 41, 9109-15.

 

100.    “Multicomponent Reactions: Synthesis of Spirocyclic Tetrahydropyran Derivatives by Prins Cyclization,” A. K. Ghosh, D. Shin and G. Schiltz,  Heterocycles, 2002, 58, 659-66.

 

101.    "Asymmetric Total Synthesis of the Gastroprotective Microbial Agent AI-77-B" A. K. Ghosh, A. Bischoff and J. Cappiello, Eur. J. Org. Chem. 2003, 5, 821-32.

 

102.    “A Enantioselective Synthesis of thecore unit of the Non-nucleoside Reverse Transcriptase Inhibitor Taurospongin  A” A. K. Ghosh and H. Lei. Tetrahedron: Asymm. 2003, 14, 629-34.

 

103.    “Highly Diastereoselective Anti-Aldol Reactions Utilizing Titanum Enolate of Cis-2-Arylsulfonamido -1-acenaphthenyl propionate” A. K. Ghosh, J.-H. Kim, Org. Lett. 2003, 6, 1063-66.

 

104.    “An Enantioselective Synthesis of the C1-C9 Segment of Antitumor  Macrolide Peloruside A” A. K. Ghosh, J.-H. Kim,  Tetrahedron. Lett. 2003, 44, 3967-70.

 

105.     “Enantioselective Total Synthesis of (+)-Amphidinolide T1” A. K. Ghosh, C. Liu,  J. Am. Chem. Soc. 2003, 125, 2374-75.

 

106.    “Study of memapsin 2 (b-secretase) and strategy of inhibitor design”  J. Tang, A. K. Ghosh, L. Hong, G. Koelsch, R. Turner, W. J. Chang, J.  Mol.  Neuroscience  2003,  20,  299-304.

 

107.    “Synthetic Studies of Microtubule Stabilizing Agent Peloruside A:  An Asymmetric  Synthesis of the C10-C24  Segment” A. K. Ghosh, J-H. Kim,  Tetrahedron. Lett. 2003, 44,  7659-7661.

 

108.    “A Novel bis-Tetrahydrofuranylurethane-containing Non-peptide Protease Inhibitor (PI) UIC-94017 (TMC114) Potent Against Multi-PI-Resistant HIV In Vitro" Y. Koh, H. Nakata, K. Maeda, H. Ogata, G. Bilcer, T. Devasamudram, J. K. Kincaid, P. Boross, Y. Tie P. Volarath, L. Gaddis, R. W. Harrison,  I. T. Weber,  A. K. Ghosh,. H. Mitsuya,  Antimicrobial Agents and Chemotherapy, 2003, 47,  3123-3129.

                                                                               

109.    “Memapsin 2, a drug target for Alzheimerís disease” in J. Saklatvala et al. (eds.) Protease and the Regulation of Biological Process” Portland Press.  G. Koelsch, R. T. Turner, 3rd, L. Hong, A.K. Ghosh, and J. Tang,  2003, 312-20.

 

110.    "Enantioselective Synthesis of (+)-Cryptophycin 52 (LY355703), A Potent Antimitotic Antitumor Agent"  A. K. Ghosh, L. Swanson,  J. Org. Chem.  2003, 68, 9823-26.

 

111.    “Memapsin 2 (b-secretase), a drug target for Alzheimer’s disease” G. Koelsch, R. Turner, L. Hong A. K. Ghosh, J. Tang,  Biochem. Soc. Symp.  2003,  70,  213-20.

 

112.    “The Development of Titanium Enolate Based Aldol Reaction” Edited by Rainer Mahrwald for 'Modern Aldol Reactions' A. K. Ghosh, M. Shevlin, WILEY-VCH, 2004, 63-121.

 

113.    "First Total Synthesis of (+)-Amphidinolide T1" A. K. Ghosh, C. Liu, Strategies and Tactics in Organic Synthesis, Academic Press, Edited by M. Harmata, 2004,  5, 255.

 

114.    “Asymmetric Syntheses of Potent Antitumor Macrolides Cryptophycin B and Arenastatin A” A. K. Ghosh and A. Bischoff, Eur. J. Org. Chem. 2004, 10,  2131-41.

 

115.    “High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) Active against Multi-Drug Resistant Clinical Strains” Y.  Tie, P. I. Boross, Y-F Wang, L. Gaddis, A. K. Hussain, S. Leshchenko, A. K. Ghosh, J. M. Louis, R. W. Harrison, I. T. Weber, J.  Mol.  Biol.  2004, 338, 341-52.

116.    “Laulimalide and PacliTaxel: A Comparison of Their Effects on Tubulin Assembly and Their Synergistic Action When Present Simultaneously” E. J. Gapud, R. Bai, A. K. Ghosh and E. Hamel,  Mol. Pharmacology,  2004,  66, 113-21.

117.    “In vivo inhibition of Ab production by memapsin 2 (b-secretase) inhibitors” W-P Chang, G. Koelsch, ,S. Wong,  D. Downs,  H. Da, V. Weerasena, B. Gordon, T. Devasamudram, G. Bilcer, A. K. Ghosh and J. Tang. J.  Neurochem.  2004,  89, 1409-16.

118.    “Oxazols: Synthesis, Reactions and spectroscopy of Chiral Bis(oxazolines)”,  Edited by D. Palmer for Heterocyclic Compounds series, A. K. Ghosh, S. Fidanze, G. Bilcer, Wiley Interscience,  2004,  60,  595-634. 

119.    “Assignment of Absolute Stereochemistry and Total synthesis of Spongidepsin”  A. K. Ghosh and X. Xu. Organic Letters 2004, 6, 2055-2058.

 

120.    "Stereoselective Chloroacetate Aldol Reaction: Synthesis of Acetate Aldol equivalents and Darzens Glycidic Esters” A. K. Ghosh, J.-H. Kim, Org. Lett. 2004, 6, 2725-8.

 

121.    “Total Synthesis and Structural Revision of (+)-Amphidinolide W” A. K. Ghosh and G. Gong,   J. Am. Chem. Soc. 2004, 126,  3704-05.

 

122.    “Stereoselective Photochemical 1,3-Dioxalene Addition to a,b Unsaturated–g-lactone: Synthesis of Bis-tetrahydrofuranyl Ligand for HIV Protease Inhibitor UIC-94-017 (TMC-114)” A. K. Ghosh,  S. Leshchenko and M. Noetzel, J. Org. Chem. 2004, 69, 7822-29.

 

123.    "TiCl4 Promoted Multicomponent Reaction:  a New Entry to the Functionalized -Amino Acids” A. K. Ghosh, C-X, Xu, D. Wink Org. Lett. 2005, 7, 7-10.

 

124.    “Memapsin 2 (b-Secretase) New Subsites S5, S6 and S7: Structural Locations and Functional Roles“ R. T. Turner, L. Hong, G. Koelsch, A. K. Ghosh and J. Tang,  Biochemistry, 2005, 44, 105-112.

 

125.    “Analysis of amyloid precursor protein processing protease -secretase: tools for memapsin 2 (b-secretase) inhibition studies” G. Koelsch, V. Weerasena, D. Shin, A. K. Ghosh, J. Tang, Amyloid Precursor Protein  2005, 41-50.

 

126.     “Structure Based Design of Cycloamide-urethane-Derived Novel Inhibitors of Human Brain Memapsin 2 (b-Secretase)” A. K. Ghosh, T. Devasamudram, L. Hong, C. DeZutter,  X. Xu, V. Weerasena, G. Koelsch, G.  Bilcer, and J. Tang, Bioorg. Med. Chem. Lett.  2005, 15, 15-20.

 

127.     “UIC-94017/TMC114: A Novel protease Inhibitors Containing bis-Tetrahydrofuranyl Urethane (bis-THF) Potent Against Multi-PI-Resistant HIV in vitro“ Y. Koh, A. K. Ghosh and H. Mitsuya, J. AIDS Res. 2005,  7, 17-21.

 

128.    “Cycloamide-based Protease Inhibitors Involving P1- and P2-ligands:  A Ring Closing    Olefin Metathesis Based Strategy” A. K. Ghosh, L. M. Swanson,  H. Cho, K. A. Hussain, S. Leschenko, S. Kay, D. E. Walters,and H. Mitsuya, J. Med. Chem. 2005,  48, 3576.

 

129.    “Recent Development of Structure-based b-Secretase Inhibitors for Alzheimer’s disease” A. K. Ghosh, K. Nagaswamy, J.  Tang.  Curr. Med. Chem. 2005, 16, 1609-22..

 

130.    “Conformations of Laulimalide in DMSO-d6”  P. Thepchatri, D. O. Cicero, E. Monteagudo, A. K. Ghosh, B. Cornett, E. R. Weeks, J. P. Snyder.  J. Am. Chem. Soc. 2005, 127, 12838-12846.

 

131.    “Design and Synthesis of Peptidomimetic SARS-3CLpro Inhibitors” A. K. Ghosh, K. Xi, K. Ratia, B. D. Santarsiero,  W. Fu, B. H. Harcourt,  P. A. Rota,  S. C. Baker,   M. E. Johnson and A.  D. Mesecar. J. Med. Chem. 2005, 48,  6767-70.

 

132.    “Susceptibility of an HIV-1 Protease Inhibitor (TMC-114) to Highly Drug Resistant Mutations D30N, I50V and L90M” A. Kovalevsky, Y. Tie, F. Liu, P. I. Boross, Y-F. Wang, S. Leshchenko, A. K. Ghosh  and I. T. Weber. J. Med. Chem.  2006, 49, 1379-87.

 

133.    “Altered HIV-1 gag Protein Interactions with Cyclophilin A (CypA) on the Acquisition of H219Qand H219P Substitutions in the CypA Binding Loop” H. Gatanaga, D. Das, Y. Suzuki, D. D. Yeh, M. F. Kavlick, K. A. Hussain, A. K. Ghosh, H. Mitsuya, J. Biol. Chem. 2006, 281, 1241-50.

 

134.    “Total synthesis and structural Revision of Amphidinolide W” A. K. Ghosh and G. Gong, J. Org. Chem.  2006, 71, 1085-93.

 

135.    “Design and Synthesis of Novel HIV-1 protease inhibitors incorporating oxindoles as the P'2-ligands” A. K. Ghosh, G. Schiltz, S. Leschenko, S. Kay, D. E. Walters,and H. Mitsuya, Bioorg. Med. Chem. Lett. 2006, 16,1869-73.

 

136.    "Bis-Tetrahydrofuran: A Privileged Ligand for Darunavir and  a New Generation of HIV-Protease Inhibitors That Combat Drug-Resistance" A. K. Ghosh, S. P. Ramu, N. Kumaragurubaran, Y. Koh, I. T. Weber, H. Mitsuya. ChemMedChem 2006, 1, 939-950.

 

137.    "Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance" A. K. Ghosh, S. P. Ramu, S. Leshchenko, A. K. Hussain, J. Li, A. Kovalevsky, D. E. Walters, J. E. Wedekind, V. Grum-Tokars, D. Das, Y. Koh, K. Maeda, H. Gatanaga, I. T. Weber, H. Mitsuya.  J. Med. Chem.  2006, 49(17),  5252-5261.  
 

138.    "A Stereoselective Anti-aldol Route to (3R,3aS,6aR)-Tetrahydro-2H-furo[2,3-b]furan-3-ol: A Key Ligand for a New Generation of HIV Protease Inhibitors" A. K. Ghosh, J. Li, S. P. Ramu. Synthesis 2006, 3015-3019.

 

139.    "Ultra-high Resolution Protein-ligand X-ray Structure of TMC 114: Identification of Novel Drug-binding sites" A. Y. Kovalevsky, F. Liu, S. Leshchenko, A. K. Ghosh, J. M. Louis, R. W. Harrison, I. T. Weber. J. Biol. Chem. 2006, 363, 161-173.

 

140.    "Asymmetric Multicomponent Reactions: Diastereoselective Synthesis of Substituted Pyrrolidines and Prolines" A. K. Ghosh, S. Kulkarni, C.-X. Xu, P. E. Fanwick. Organic Letters 2006, 8, 4509-4511.

 

141.    "Design, Synthesis and X-ray Structure of Protein-Ligand Complexes: Important Insight into Selectivity of Memapsin 2 (b -Secretase) Inhibitors" A. K. Ghosh, N. Kumaragurubaran, L. Hong, H. Lei, K. A. Hussain, C. Liu, T. Devasamudram, V. Weerasena, R. Turner, G. Koelsch, G. Bilcer, and J. Tang, J. Am. Chem. Soc. 2006, 128, 5310-5311

 

142.    "Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy" A. K. Ghosh, K. Xi, M. E. Johnson, S. C. Baker, A. D. Mesecar.  Ann. Rep. Med. Chem. 2006, 41, 183-196.

 

143.    "Synergistic Effects of Peloruside A and Laulimalide with Taxoid site Drugs, but not with Each other, on Tubulin Assembly" E. Hamel, B. W. Day, J. H. Miller, M. K. Jung, P. T. Northcote, A. K. Ghosh, D. P. Curan, M. Cushman, K. C. Nicolaou, I. Paterson, E. J. Sorenson. Mol. Pharmacology 2006, 70, 1555-64.

 

144.    "Atomic Resolution crystal Structures of HIV-1 Protease and MutantsV82A and I84V with Saquinavir" Y. Tie, A. Y. Kovalevsky, P. Boross, Y.-F. Wang, A. K. Ghosh, J. Tozser, R. W. Harrison, I. T. Weber. Proteins 2007, 67, 232-242.

 

145.    "Enantioselective Total Synthesis of Antitumor Macrolide Lasonolide A" A. K. Ghosh and G. Gong. Organic Letters 2007, 9, 1437.

 

146.    "Design, Synthesis and X-ray Structure of Potent Memapsin 2 (b-Secretase) Inhibitors with Functionalized Aromatic derivatives as the P2-P3-Ligands" A. K. Ghosh, N. Kumaragurubaran, L. Hong, S. Kulkarni, X. Xu, W. Chang, V. Weerasena, R. Turner, G. Koelsch, G. Bilcer, J. Tang. J. Med. Chem. 2007, 50, 2399.

 

147.    "Enantioselective Total Synthesis of (+)-Jasplakinolide" A. K. Ghosh, and D. K. Moon, Org. Lett. 2007, 9, 2425.

 

148.   "A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus in Vitro"  M. Amano, Y. Koh, D. Das, J. Li, S. Leschenko, Y.-F. Wang, P. I. Boross, I. T. Weber, A. K. Ghosh, H. Mitsuya. Antimicrob. Agents Chemother. 2007, 51, 2143.

 

149.    "Potent New Antiviral Compound Shows Similar inhibition and Structural Interactions with Drug Resistant Mutants and Wild Type HIV-1 Protease"  Y.-F. Wang, Y. Tie, P. I. Boross, J. Tozser, A. K. Ghosh, R. W. Harrison, I. T. Weber. J. Med. Chem. 2007, 50, 4509.

 

150.    "Memapsin 2 (Beta-Secretase) Inhibitor Drug, between Fantasy and Reality" A. K. Ghosh, G. Bilcer, L. Hong, G. Koelsch, J. Tang. Curr. Alz. Res. 2007, 4, 418.

 

151.    "Enantioselective Synthesis of (-)-Platensimycin Oxatetracyclic Core using an Intramolecular Diels Alder Reaction" A. K. Ghosh and  K. Xi. Org. Lett. 2007, 9, 4013.

 

152.    “Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors” A. K. Ghosh, K. Xi, V. Grum-Tokars, X. Xu, K. Ratia, W. Fu, K. V. Houser, S. C. Baker, M. E. Johnson, A. D. Mesecar. Bioorg. Med. Chem. Lett.  2007, 17, 5876.

 

153.   "Potent Inhibition of HIV-1 Replication by Novel Non-peptidyl Small Molecule Inhibitors of Protease Dimerization” Y. Koh, S. Matsumi, D. Das, M. Amano, D. A. Davis, J. Li, S. Leschenko, A. Baldridge, T. Shioda, R. Yarchoan, A. K. Ghosh, H. Mitsuya.   J. Biol. Chem.  2007, 282, 28709.

 

154.    "Darunavir, a Conceptually New HIV-1 Protease Inhibitor for the Treatment of Drug-resistant HIV”  A. K. Ghosh, Z. L. Dawson, H. Mitsuya.  Bioorg. Med. Chem.  2007, 15, 7576.

 

155.    "Development of Protease Inhibitors and the Fight with Drug-Resistant HIV-1 Variants” H. Mitsuya, K. Maeda, D. Das, A. K. Ghosh. Advances in Pharmacology, 2007, 56, 169-197.

 

156.    "Potent memapsin 2 (beta-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation" A. K. Ghosh, N. Kumaragurubaran, L. Hong, S. Kulkarni, X. Xu, H. B. Miller, D. S. Reddy, V. Weerasena, R. Turner, W. Chang, G. Koelsch, J. Tang. Bioorg. Med. Chem. Lett. 2008, 18,1031-1036.

 

157.    "Enantioselective total synthesis of Peloruside A, a potent Microtubule Stabilizer" A. K. Ghosh, X. Xu, J.-H. Kim, C.-X. Xu. Org. Lett. 2008, 10, 1001-1004.

 

158.    "Design of HIV Protease Inhibitors Targeting Protein Backbone: An Effective Strategy for Combating Drug Resistance" A. K. Ghosh, B. Chapsal, I. T. Weber, H. Mitsuya. Acc. Chem. Res. 2008, 41, 78-86.

 

159.    "Memapsin 2 (beta-secretase) inhibitors: drug development” A. K. Ghosh, N. Kumaragurubaran, L. Hong, G. Koelsh, J. Tang.  Curr. Alz. Res.  2008, 5, 121-131.

 

160.    "Enantioselective Synthesis of Cyclopentyltetrahydrofuran (Cp-THF), an Important High-Affinity P2-Ligand for HIV-1 Protease Inhibitors” A. K. Ghosh and J. Takayama. Tet. Lett. 2008, 49, 3409-2412. 

 

161.    "Asymmetric multi-component reactions: convenient access to acyclic stereocenters and functionalized cyclopentenoids" A. K. Ghosh, S. S. Kulkarni, C.-X. Xu, K. Shurrush, Tet. Asy. 2008, 19, 1020-1026.

 

162.   "Potent HIV-1 Protease Inhibitors Incorporating meso-Bicyclic Urethanes as P2-ligands: Structure-Based Design, Synthesis, Biological Evaluation and Protein-Ligand X-Ray Studies” A. K. Ghosh, S. Gemma, J. Takayama, A. Baldridge, S. Leshchenko-Yashchuk, H. B. Miller, Y.-F. Wang, A. Y. Kovalevsky, Y. Koh, I. T. Weber,  H. Mitsuya. Org. Biomol. Chem. 2008, 6, 3703-3713.

 

163.   "Beta-Secretase as a Therapeutic Target for Alzheimer’s Disease” A. K. Ghosh, S. Gemma, J. Tang. Neurotherapeutics, 2008, 5, 399-408.

 

164.   "Effect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and Darunavir" F. Liu, A. Y. Kovalevsky, Y. Tie, A. K. Ghosh, R. W. Harrison, I. T. Weber. J. Mol. Biol. 2008, 381, 102-115.   

 

165.    "Enantioselective Total Synthesis of (+)-Largazole, a Potent Inhibitor of Histone Deacetylase" A. K. Ghosh, S. Kulkarni. Org. Lett. 2008, 10, 3907-3909.

 

166.    "Total Synthesis of Potent Antitumor Agent (-)-Lasonolide A: a Cycloaddition-based Strategy" A. K. Ghosh and G. Gong. Chem. Asian J. 2008, 3, 1811-1823.

 

167.    "Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation and Protein-ligand X-ray Studies" A. K. Ghosh, S. Gemma, A. Baldridge, Y.-F. Wang, A. Y. Kovalevsky, Y. Koh, I. T. Weber, and H. Mitsuya. J. Med. Chem. 2008, 51, 6021-33.

 

168.    "Design, Synthesis and Antiviral Efficacy of a Series of Potent Chloropyridyl Ester-derived SARS-CoV 3CLpro Inhibitors” A. K. Ghosh, G. Gong, V. Grum-Tokars, D. C. Mulhearn, M. Coughlin, B. S. Prabhakar, K. Sleeman, S. C. Baker, M. E. Johnson, and A. D. Mesecar. Bioorg. Med. Chem. Lett. 2008, 18, 5684-5688.

 

169.    "Solution Kinetics Measurements Suggest HIV-1 Protease Has Two Binding Sites for Darunavir and Amprenavir” A. Y. Kovalevsky, A. K. Ghosh, I. T. Weber. J. Med. Chem. 2008, 51, 6599-6603.

 

170.    "A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication” K. Ratia, S. Pegan, J. Takayama, K. Sleeman, M. Coughlin, S. Baliji, R. Chaudhuri, W. Fu, B. S. Prabhakar, M. E. Johnson, S. C. Baker, A. K. Ghosh, and A. D. Mesecar, PNAS, 2008, 105, 16119-16124.

 

171.    "L-Selectride-Mediated Highly Diastereoselective Asymmetric Reductive Aldol Reaction: Access to an Important Subunit for Bioactive Molecules” A. K. Ghosh, J. Kass, D. D. Anderson, X. Xu and C. Marian, Org. Lett. 2008, 10, 4811-4814.

 

172.    "Structural Evidence for Effectiveness of Darunavir and Two Related Antiviral Inhibitors against HIV-2 Protease” A. Y. Kovalevsky, J. M. Louis, A. Aniana, A. K. Ghosh, I. T. Weber J. Mol. Biol. 2008, 384, 178-192.

 

173.   "Design and Synthesis of Stereochemically Defined Novel Spirocyclic P¬2-Ligands for HIV-1 Protease Inhibitors” A. K. Ghosh, B. D. Chapsal, A. Baldridge, K. Ide, Y. Koh, and H. Mitsuya, Org. Lett. 2008, 10, 5135-5138.

 

174.   "GRL-02031: A Novel Nonpeptide Protease Inhibitor (PI) Containing A Stereochemistry Defined Fused Cyclopentanyltetrahydrofuran (Cp-THF) Potent Against Multi-PI-Resistant HIV-1 In Vitro” Y. Koh, D. Das, S. Leshchenko, H. Nakata, H. Ogata-Aoki, M. Amano, M. Nakayama, A. K. Ghosh, and H. Mitsuya. Antimicrob. Agents Chemother. 2009, 53, 987-996.

 

175.   "Stereoselective synthesis of the C1-C12 segment of iriomoteolide-1a: a very potent macrolide antitumor agent” A. K. Ghosh, H. Yuan, Tet. Lett. 2009, 50, 1416-1418. 

 

176.    "Total Synthesis of (-)-Platensimycin, a Novel Antibacterial Agent” " A. K. Ghosh and K. Xi. J. Org. Chem. 2009, 74, 1163-1170.

 

177.    “Harnessing Nature’s Insight: Design of Aspartyl Protease Inhibitors from Treatment of Drug-Resistant HIV to Alzheimer’s Disease” A. K. Ghosh J. Med. Chem. 2009, 52(8), 2163-2176.

 

178.    "A Convergent  Synthesis of the Proposed Structure of Antitumor Depsipeptide, Stereocalpin A”" A. K. Ghosh and C.-X. Xu Org. Lett. 2009, 11,  1963-1966.

 

179.    "Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1’-Ligands to Enhance Backbone-binding interactions with Protease: Synthesis, Biological Evaluation and Protein-ligand X-ray Studies” A. K. Ghosh, S. Leshchenko-Yashchuk,  D. D. Anderson, A. Baldridge, M. Noetzel, H. B. Miller, Y. Tie, Y.-F. Wang, Y. Koh, I. T. Weber, and H. Mitsuya J. Med. Chem. 2009, 52, 3902-3914.

 

180.    "Asymmetric Synthesis of anti-Aldol Segments via a Nonaldol Route: Synthetic Applications to Statines and (-)-Tetrahydrolipstatin" A. K. Ghosh, K. Shurrush, S. Kulkarni J. Org. Chem. 2009, 74, 4508-4518.

 

181.    "A Symmetry-Based Concise Formal Synthesis of Platencin, a Novel Lead against "Superbugs" " A. K. Ghosh and K. Xi  Angew. Chem. Int. Ed. 2009, 48, 5372-5375.

 

182.    "Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome−Coronavirus Papain-Like Protease” A. K. Ghosh, J. Takayama, Y. Aubin, K. Ratia, R. Chaudhuri, Y. Baez, K. Sleeman, M. Coughlin, D. B. Nichols, D. C. Mulhearn, B. S. Prabhakar, S. C. Baker, M. E. Johnson and A. D. Mesecar J. Med. Chem. 2009, 52 (16), 5228-5240.

 

183.    "Synthesis of Bioactive Natural Products by Asymmetric syn- and anti-Aldol Reactions” A. K. Ghosh and Z. L. Dawson. Synthesis, 2009, 2992-3003.

 

184.    "An Asymmetric Total Synthesis of Brevisamide" A. K. Ghosh and J. Li.  Org. Lett. 2009, 11 (18), 4164–4167.

 

185.    "P-Glycoprotein Mediates Efflux Transport of Darunavir in Human Intestinal Caso-2 and ABCB1 Gene-Transfected Renal LLC-PK1 Cell Lines”  H. Fujimoto, M. Higuchi, H. Watanabe, Y. Koh, A. K. Ghosh, H. Mitsuya, N. Tanoue, A. Hamada and H. Saito. Biol. Pharm. Bull. 2009, 32, 1588-1593.

 

186.    "Design, Synthesis, Protein-Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance" A. K. Ghosh, S. Kulkarni, D. D. Anderson, L. Hong, A. Baldridge, Y.-F. Wang, A. A. Chumanevich, A. Y. Kovalevsky, Y. Tojo, M. Amano, Y. Koh, J. Tang, I. T. Weber and H. Mitsuya.  J. Med. Chem. 2009, 52 (23), 7689–7705.

 

187.    "Prediction of Potency of Protease Inhibitors Using Free Energy Simulations with Polarizable Quantum Mechanics-Based Ligand Charges and a Hybrid Water Molecule” D. Das, Y. Koh, Y. Tojo, A. K. Ghosh, and H. Mitsuya J. Chem. Info. Model, 2009, 49, 2851–2862.

 

188.    "Peloruside B, A Potent Antitumor Macrolide from the New Zealand Marine Sponge Mycale hentscheli: Isolation, Structure, Total Synthesis, and Bioactivity"  A. J. Singh, C.-X. Xu, X. Xu, L. M. West, A. Wilmes, A. Chan, E. Hamel, J. H. Miller, P. T. Northcote and A. K. Ghosh.  J. Org. Chem. 2010, 75, 2-10.

 

189.    "Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands”  A. K. Ghosh, S. Gemma, E. Simoni, A. Baldridge, D. E. Walters, K. Ide, Y. Tojo,  Y. Koh, M. Amano, and H. Mitsuya Bioog. Med. Chem. Lett. 2010, 20, 1241-1246.

 

190.    "Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction"  A. K. Ghosh and J. Kass ChemComm 2010, 46, 1218-1220.

 

191.    "Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases" M. A. Clementz, Z. Chen, B. S. Banach, Y. Wang, L. Sun, K. Ratia, Y. M. Baez-Santos, J. Wang, J. Takayama, A. K. Ghosh, K. Li, A. D. Mesecar, and S. C. Baker J. Virol. 2010, 84, 4619-4629.

 

192.    "Novel Protease Inhibitors (PIs) Containing Macrocyclic Components and 3(R),3a(S),6a(R)-bis-Tetrahydrofuranylurethane (bis-THF) That Are Potent Against Multi-PI-Resistant HIV-1 Variants In Vitro" Y. Tojo, Y. Koh, M. Amano, M. Aoki, D. Das, A. K. Ghosh, and H. Mitsuya Antimicrobial Agents and Chemotherapy, 2010, 54, 3460-3470.

 

193.    "Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation" A. K. Ghosh, J. Takayama, K. V. Rao, K. Ratia, R. Chaudhuri, D. C. Mulhearn, H. Lee, D. B. Nichols, S. Baliji, S. C. Baker, M. E. Johnson and A. D. Mesecar J. Med. Chem. 2010, 53, 4968–4979.

 

194.    "Enantioselective Syntheses of the Proposed Structures of Cytotoxic Macrolides Iriomoteolide-1a and -1b" A. K. Ghosh and H. Yuan. Org. Lett. 2010, 12, 3120–3123. 

 

195.    "Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine-CCR5 interactions" H. Nakata , M. Kruhlak, W. Kamata, H. Ogata-Aoki, J. Li, K. Maeda, A. K. Ghosh, H. Mitsuya.  Antivir. Ther. 2010, 15, 321-331.

 

196.    "Darunavir (Prezista): A HIV-1 Protease Inhibitor for Treatment of Multidrug-Resistant HIV"  A. K. Ghosh and C. D. Martyr in Modern Drug Synthesis, Wiley, Edited by J. J. Li and D. S. Johnson, 2010, 29-44.

 

197.    "Synthesis and Biological Evaluation of New Jasplakinolide (Jaspamide) Analogs" A. K. Ghosh, Z. L. Dawson, D. K. Moon, R. Bai, and E. Hamel.  Bioog. Med. Chem. Lett. 2010, 20, 5104-5107.

 

198.   "The FDA Approved HIV-1 Protease Inhibitors for Treatment of HIV/AIDS” A. K. Gosh, D. D. Anderson, H. Mitsuya in Burger’s Medicinal Chemistry, Drug Discovery and Development, Eds. D. J. Abraham and D. P. Rotella, Edition 7, Vol. 7, 2010, pp. 1-72.

 

199.   "Second-Generation Approved HIV Protease Inhibitors for the Treatment of HIV/AIDS” A. K. Ghosh, B. D. Chapsal in Aspartic Acid Proteases as Therapeutic Targets, Edited by A. K. Ghosh, Vol. 45, 2010, 169-195.

 

200.   "Darunavir, a New PI with Dual Mechanism: From a Novel Drug Design Concept to New Hope Against Drug-Resistant HIV” A. K. Ghosh, B. D. Chapsal, H. Mitsuya in Aspartic Acid Proteases as Therapeutic Targets, Edited by A. K. Ghosh, Vol. 45, 2010, 205-235.

 

201.   "Development of HIV-1 Protease Inhibitors, Antiretroviral Resistance, and Current Challenges of HIV/AIDS Management” H. Mitsuya, A. K. Ghosh in Aspartic Acid Proteases as Therapeutic Targets, Edited by A. K. Ghosh, Vol. 45, 2010, 245-259.

 

202.    "The Discovery of b-Secretase and Development Toward a Clinical Inhibitor for AD: An Exciting Academic Collaboration” J. Tang, L. Hong, A. K. Ghosh in Aspartic Acid Proteases as Therapeutic Targets, Edited by A. K. Ghosh,  Vol. 45, 2010, 413-438.

 

203.    "In Vitro Selection of Highly Darunavir-Resistant and Replication-Competent HIV-1 Variants by Using a Mixture of Clinical HIV-1 Isolates Resistant to Multiple Conventional Protease Inhibitors"  Y. Koh, M. Amano, T. Towata, M. Danish, S. Leshchenko-Yashchuk, D. Das, M. Nakayama, Y. Tojo, A. K. Ghosh, and H. Mitsuya.  J. Virol. 2010, 84, 11961-11969.

 

204.    "Probing Multidrug-Resistance and Protein–Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors" A. K. Ghosh, C.-X. Xu, K. V. Rao, A. Baldridge, J. Agniswamy, Y.-F. Wang, I. T. Weber, M. Aoki, S. G. P. Miguel, M. Amano, and H. Mitsuya.  ChemMedChem 2010, 5, 1850-1854.

 

205.    "Capturing the Essence of Organic Synthesis: From Bioactive Natural Products to Designed Molecules in Today’s Medicine" A. K. Ghosh. J. Org. Chem. 2010,  75, 7967-7989.

 

206.    "The Assembly-Inducing Laulimalide/Peloruside A Binding Site on Tubulin: Molecular Modeling and Biochemical Studies with [3H]Peloruside A" T. L. Nguyen, X. Xu, R. Gussio, A. K. Ghosh, and E. Hamel.  J. Chem. Inf. Model. 2010, 50, 2019-2028.

 

207.    "A Stereoselective Synthesis of (+)-Herboxidiene/GEX1A" A. K. Ghosh and J. Li Org. Lett. 2011, 13, 66-69.

 

208.    "Beta-Secretase Inhibitor GRL-8234 Rescues Age-Related Cognitive Decline in APP Transgenic Mice” W.-P. Chang, X. Huang, D. Downs, J. R. Cirrito, G. Koelsch, D. M. Holtzman, A. K. Ghosh, J. Tang.  FASEB J. 2011, 25, 775-784.

 

209.  "Design and Synthesis of Potent HIV-1 Protease Inhibitors Incorporating Hexahydrofuropyranol-Derived High Affinity P2 Ligands: Structure−Activity Studies and Biological Evaluation" A. K. Ghosh, B. D. Chapsal, A. Baldridge, M. P. Steffey, D. E. Walters, Y. Koh, M. Amano and H. Mitsuya. J. Med. Chem. 2011, 54, 622-634.

 

210.    "Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants"  K. Ide, M. Aoki, M. Amano, Y. Koh, R. S. Yedidi, D. Das, S. Leschenko, B. Chapsal, A. K. Ghosh and H. Mitsuya. Antimicrob. Agents Chemother. 2011, 55, 1717-1727.

 

211.    "Design, Synthesis, and X-ray Structure of Substituted Bis-tetrahydrofuran (Bis-THF)-Derived Potent HIV-1 Protease Inhibitors" A. K. Ghosh, C. D. Martyr, M. Steffey, Y.-F. Wang, J. Agniswamy, M. Amano, I. T. Weber and H. Mitsuya. ACS Medicinal Chemistry Letters 2011, 2, 298–302.

 

212.    "Treating transgenic Alzheimer mice with a β-secretase inhibitor, what have we learned?” J. Tang and A. K. Ghosh. Aging 2011, 3, 14-16.

 

213.    "Enantioselective Total Synthesis of (-)-Zampanolide, a Potent Microtubule-Stabilizing  Agent"  A. K. Ghosh and X. Cheng  Organic Letters 2011, 13, 4108-4111.

214.    "The Loss of Darunavir’s Protease Dimerization Inhibition Activity Is Associated with HIV-1 Acquisition of Resistance to Darunavir” Y. Koh, M. Aoki,  M. L. Danish, H. Aoki-Ogata, M. Amano, D. Das, R. W. Shafer, A. K. Ghosh, H. Mitsuya.  J. Virology, 2011, 85, 10079-10089.

215.    "Tetrahydrofuran and related heterocyclic derivatives as HIV protease inhibitors” A. K. Ghosh and D. D. Anderson.  Future Med. Chem. 2011, 3, 1181-1197.

 

216.   "Design of HIV-1 Protease Inhibitors with C3-Substituted Hexahydrocyclopentafuranyl Urethane as P2-Ligands: Synthesis, Biological Evaluations, and Protein-Ligand X-ray Crystal Structure” A. K. Ghosh, B. D. Chapsal, G. L. Parham, M. Steffey, J. Agniswamy, Y.-F. Wang, M. Amano, I. T. Weber, H. Mitsuya. J. Med. Chem. 2011, 54, 5890-5901.

 

217.    "Cu(II)-Catalyzed Olefin Migration and Prins Cyclization: Highly Diastereoselective Synthesis of Substituted Tetrahydropyrans” A. K. Ghosh and D. R. Nicponski.  Organic Letters, 2011, 13, 4328-4331.

218.    "Enhancing Protein Backbone Binding - A Fruitful Concept for Combating Drug-Resistant HIV” A. K. Ghosh, D. D. Anderson, I. T. Weber H. Mitsuya. Angew. Chem. Int. Ed. 2012, 51, 1778-1802.

219.    "Developing β-secretase inhibitors for treatment of Alzheimer’s disease” A. K. Ghosh, M. Brindisi and J. Tang. J. Neurochem. 2012, 120, 71-83.

220.    "A Stereoselective Synthesis of (-)-Viridiofungin A Utilizing a TiCl4-Promoted Asymmetric Multicomponent Reaction” A. K. Ghosh and  J. Kass. Organic Letters 2012, 14, 510-512.

221.    “Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors” Y. Tie, P. Boross, Y.-F. Wang, T.-Y. Chiu, A. K. Ghosh, J. Tozser, R. Harrison, I. Weber. Protein Science, 2012, 21, 339-350.

222.    “Enhancing backbone binding in the HIV-1 Protease Active site Using Substituted P2-Cyclopentyltetrahydrofuranyl Urethanes” A. K. Ghosh, B. D. Chapsal, M. Steffey, J. Agniswamy, Y.-F. Wang, M. Amano, I. T. Weber, H. Mitsuya.  Bioorg. Med. Chem. Lett. 2012, 22, 2308-2311.

223.    “Stereoselective Synthesis of Both Tetrahydropyran Rings of the Antitumor Macrolide, (-)-Lasonolide A” A. K. Ghosh and G.-B. Ren. J. Org. Chem. 2012, 77, 2559-2565.

224.    "A Tandem Olefin Migration and Prins Cyclization using Cu(OTf)2-Bisphosphine Complexes: An Improved Synthesis of Functionalized Tetrahydropyrans" A. K. Ghosh, D. R. Nicponski, J. Kass. Tetrahedron Lett. 2012, 53, 3699-3702.

225.    "Inhibition of anthrax lethal factor:  lability of hydroxamate as a chelating group” F. Li, I. Chvyrkova, S. Terzyan, N. Wakeham, R. Turner, A. K. Ghosh, X. C. Zhang, J. Tang. Appl. Microbiol. Biotechnol. 2012, 94, 1041-1049.

226.    "Structural Analysis of Multidrug-Resistant HIV-1 Protease Mutants in Comples with Potent Nonpeptidic inhibitor" Y-C. E. Chang, X-X. Yu, Y. Zhang, Y. Tie, Y.-F. Wang, S. Yashcuk, A. K. Ghosh, R. W. Harrison, I. T. Weber. J. Med. Chem. 2012, 55, 3387-3397.

227.    "TiCl4-Promoted Tandem Carbonyl or Imine Addition and Friedel-Crafts Cyclization: Synthesis of Benzo-fused Oxabicyclooctanes and Nonanes" A. K. Ghosh, C. D. Martyr, C.-X. Xu. Org. Lett. 2012, 14, 2002-2005.

228.    "Synthesis of Functionalized 4-Methylenetetrahydropyrans by Oxidative Activation of Cinnamyl or Benzyl Ethers" A. K. Ghosh and X. Cheng. Tetrahedron Lett. 2012, 53, 2568-2570. 

229.    "Total Synthesis of Potent Antitumor Macrolide (-)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy” A. K. Ghosh, X. Cheng, R. Bai, E. Hamel. Eur. J. Org. Chem. 2012, 4130-4139. 

230.    "Diastereoselective Synthesis of Substituted Tetrahydropyrans by Cu(II)-Bisphosphine Catalyzed Olefin Migration and Prins Cyclization", A. K. Ghosh, J. Kass, D. R. Nicponski, and C. Keyes. Synthesis. 2012, 44, 3579-3589.

231.    “Structure-based Design, Synthesis and Biological Evaluation of Dihydroquinazoline-Derived Potent b-Secretase Inhibitors” A. K. Ghosh, S. Pandey, S. Gangarajula, S. Kulkarni, D. D. Anderson, N. S Gavande, X. Xu, X. Huang, and J. Tang. Bioorg. Med. Chem. Lett. 2012, 22, 5460-5465.

232.   Lasonolide A, a potent and reversible inducer of chromosome condensation”  Y-W Zhang, A. K. Ghosh, Y. Pommier, Cell Cycle 2012, 11, 4424-4435.

233.    "Structure-Based Design of Highly Selective Beta-Secretase Inhibitors: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Crystal Structure" A. K. Ghosh, K. V. Rao, N. D. Yadav, D. D. Anderson, N. Gavande, X. Huang, S. Terzyan, and J. Tang. J. Med. Chem., 2012, 55, 9195-9207.

234.    "Enantioselective Total Synthesis of Pladienolide B:  A Potent Spliceosome Inhibitor" A. K. Ghosh and D. D. Anderson. Org. Lett. 2012, 14, 4730-4733.

235.    "Enantioselective Total Synthesis of (+)-Lithospermic Acid"  A. K. Ghosh, X. Cheng and B. Zhou.  Org. Lett. 2012, 14, 5046-5049.

 236.    “GRL-0519, A Novel Oxatricyclic-Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor (PI), Potently Suppresses the Replication of a Wide Spectrum of Multi-PI-Resistant HIV-1 Variants In Vitro” M. Amano, Y. Tojo, P. M. Salcedo-Gomez, J. R. Campbell, D. Das, M. Aoki, C-X. Xu, K. V. Rao, A. K. Ghosh and H. Mitsuya. Antimicrobial Agents and Chemotherapy 2013, 57, 2036-2046.   

237.    “Enantioselective Synthesis of Spiro [cyclohexane-1,3-indolin]-2¢-ones Containing Multiple Stereocenters via Organocatalytic Michael/Aldol Cascade Reactions” A. K. Ghosh and B. Zhou. Tetrahedron Lett. 2013, 54. 2311-2314.

238.    “Novel P2 Tris-tetrahydrofuran Group in Antiviral Compound 1 (GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease” H. Zhang, Y-F. Wang; C-H. Shen, J. Agniswamy, K. V. Rao, C. X. Xu, A. K. Ghosh, R. W. Harrison and I. T. Weber. J. Med. Chem. 2013, 56, 1074-1083.

239.    “Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs” H. Chen, L. Liu, S. A. Jones, N. Banavali, J. Kass, Z. Li, J. Zhang, L. D. Kramer, A. K. Ghosh and H. Li. Antiviral Research 2013, 97, 232-239.

240.    “Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism” H. Wu, D. Downs, K. Ghosh, A. K. Ghosh, P. Staib, M. Monod and J. Tang FASEB Journal, 2013, 27, 2132-2144.

241.    “Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1-pyrrolidinone or P2-tris-THF.’ J. Agniswamy, C. Shen, Y-F. Wang, A. K. Ghosh, K. V. Rao, C.-X. Xu, J. M. Sayer, J. M. Louis, and I. T. Weber. J. Med. Chem. 2013, 56, 4017-4027.

242.  “Bifunctional Cinchona Alkaloid-Squaramide-Catalyzed Highly Enantioselective aza-Michael Addition of Indolines to α, β-Unsaturated Ketones” A. K. Ghosh and B. Zhou. Tetrahedron Lett. 2013, 54, 3500-3502.