Professional experience:                 

2005-

 

 

Professor, Dept. of Chemistry,  Purdue University, West Lafayette, IN

1999-

     

 

 

Professor, Dept. of Chemistry, University of  Illinois at Chicago,  Chicago, IL

1997-

 

 

 

Associate Professor, Dept. of Chemistry, University of Illinois at Chicago, Chicago, IL

1994-

 

 

 

Assistant Professor, Dept. of Chemistry, University of Illinois at Chicago, Chicago, IL

   

1988-1994       Research Fellow, Merck Research Laboratories, West Point, PA.

1985-1988       Post-doctoral fellow (Professor E. J. Corey), Harvard University, Cambridge, MA

1981-1985              Ph.D. Organic Chemistry, Dept. of Chemistry, University of Pittsburgh.

1979-1981       M.Sc. Organic Chemistry, Indian Institute of Technology, Kanpur, India.

1979                 B.Sc. (Hons), Calcutta University, India.

 

Highlights of Research Accomplishments:

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Structure based design and synthesis of potent and selective Memapsin inhibitors (b-secretase) for the treatment of Alzheimer’s disease

•

Design and synthesis of potent HIV protease inhibitors based upon X-ray crystal structure of HIVP-inhibitor complexes, synthesized dipeptide transition-state isosteres

•

Rational Design of peptidomimetic SARS-3CLPro inhibitor for SARS coronavirus.

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Synthesis of biologically important natural products with anticancer, antibacterial, antiviral, and antimalerial properties. Recent examples, Laulimalide, Amphidinolide T, Cryptophysin B and Doliculide; MDR-inhibitor Hapalosin, Streptogramin antibiotic Madumycin, pancreatic lipase inhibitor, Tetrahydrolipstatin,  Nuclosides Sinefungin, Polyoxin-J, Malyngolide, Vincamon and Turospongin

 

 

 

•

Stereoselective procedures for the asymmetric syn- and anti-Aldol reactions

•

Catalytic enantioselective Diels-Alder and hetero Diels-Alder reactions

•

Novel methodologies for the multi-component coupling reactions

•

Development of specific reagents for alkoxycarbonylation of amines

•

Application of novel enzymatic reactions in synthesis

•

Novel applications of ring closing olefin metathesis in synthesis

 

Office telephone: 765-494-5323
Laboratory telephone: 765-494-0310, 765-496-8325
Fax: 765-496-1612
Electronic mail: akghosh@purdue.edu