|
|
|
|
|
|
Recent Research Publications (total of 165): |
|
|
|
|
|
|
l
"Total Synthesis of Potent Antitumor Agent (-)-Lasonolide A: a
Cycloaddition-based Strategy" Arun Ghosh and Gangli
Gong, Chem. Asian J. 2008, ASAP. l
"Enantioselective Total Synthesis of (+)-Largazole, a Potent
Inhibitor of Histone Deacetylase" Arun K. Ghosh, Sarang Kulkarni, Org. Lett.
2008, ASAP. l "Effect of Flap
Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and
Darunavir" Fengling Liu, Andrey Y. Kovalevsky, Yunfeng Tie, Arun K. Ghosh,
Robert W. Harrison, Irene T. Weber, J. Mol. Biol. 2008, 381,
102-115.
l
“Beta-Secretase as a
Therapeutic Target for Alzheimer’s Disease” Arun K. Ghosh, Sandra l
“Potent HIV-1 Protease Inhibitors Incorporating meso-Bicyclic
Urethanes as P2-ligands: Structure-Based Design, Synthesis, Biological
Evaluation and Protein-Ligand X-Ray Studies”
Arun K. Ghosh, Sandra Gemma, Jun Takayama, Abigail
Baldridge, Sofiya Leshchenko-Yashchuk, Heather B Miller, Yuan-Fang Wang,
Andrey Yu. Kovalevsky, Yashiro Koh, Irene T. Weber, and Hiroaki Mitsuya, Org. Biomol. Chem., 2008, in Press. l
"Asymmetric multi-component reactions: convenient access
to acyclic stereocenters and functionalized cyclopentenoids" Arun K.
Ghosh, Sarang S. Kulkarni, l
“Enantioselective Synthesis of Cyclopentyltetrahydrofuran
(Cp-THF), an Important High-Affinity P2-Ligand for HIV-1 Protease Inhibitors” Arun K. Ghosh and Jun Takayama, Tet. Lett. 2008, 49, 3409-3412. l
“Memapsin 2 (beta-secretase) inhibitors: drug development.” A. K. Ghosh, N. Kumaragurubaran, L.
Hong, G. Koelsh, J. Tang. Curr. Alz. Res. 2008,
5, 121. l
"Design of HIV Protease Inhibitors
Targeting Protein Backbone: An Effective Strategy for Combating Drug
Resistance" Arun Ghosh, l
"Enantioselective
total synthesis of Peloruside A, a potent Microtubule Stabilizer" Arun Ghosh, l
"Potent
memapsin 2 (beta-secretase) inhibitors: Design, synthesis, protein-ligand
X-ray structure, and in vivo evaluation" Arun K. Ghosh, Nagaswamy Kumaragurubaran, Lin Hong,
Sarang Kulkarni, l
“Development of
Protease Inhibitors and the Fight with Drug-Resistant HIV-1 Variants” Hiroaki Mitsuya, Kenji Maeda, Debananda Das, and Arun K.
Ghosh. Advances in Pharmacology, 2007, 56, 169-197. l
“Darunavir, a Conceptually New
HIV-1 Protease Inhibitor for the Treatment of Drug-resistant HIV” A. K. Ghosh, Z. L. Dawson, H. Mitsuya. Bioorg. Med.
Chem. 2007, 15, 7576. l
“Potent Inhibition of HIV-1 Replication by Novel Non-peptidyl
Small Molecule Inhibitors of Protease Dimerization” Y. Koh, S. Matsumi, D. Das,
M. Amano, D. A. Davis, J. Li, S. Leschenko, A. Baldridge, T. Shioda, R.
Yarchoan, A. K. Ghosh, H. Mitsuya. J. Biol. Chem.
2007, 282, 28709. l
“Structure-based design, synthesis, and biological evaluation of
peptidomimetic SARS-CoV 3CLpro inhibitors” A. K. Ghosh, K. Xi,
V. Grum-Tokars, X. Xu, K. Ratia, W. Fu, K. V. Houser, S. C. Baker, M. E.
Johnson, A. D. Mesecar. Bioorg. Med. Chem. Lett. 2007, 17,
5876. l
"Enantioselective
Synthesis of (-)-Platensimycin Oxatetracyclic Core using an Intramolecular
Diels Alder Reaction" l
“Potent New Antiviral Compound Shows Similar inhibition and
Structural Interactions with Drug Resistant Mutants and Wild Type HIV-1
Protease" Yuan-Fang Wang, Yunfeng Tie, Peter I. Boross, Jozsef
Tozser, Arun K. Ghosh, Robert W. Harrison, and Irene T. Weber, J. Med.
Chem. 2007, 50, 4509. l "Memapsin 2 (Beta-Secretase) Inhibitor Drug, between Fantasy and Reality" Arun K. Ghosh, Geoffrey Bilcer, Lin Hong, Gerald Koelsch and Jordan Tang, Curr. Alz. Res., 2007, 4, 418.
l "A Novel Bis-Tetrahydrofuranylurethane-Containing
Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against
Multiple-PI-Resistant Human Immunodeficiency Virus in Vitro" Masayuki Amano, Yasuhiro Koh, Debananda Das,
l "Design, Synthesis and X-ray Structure of Potent Memapsin 2 (b-Secretase) Inhibitors with Functionalized Aromatic derivatives as the P2-P3-Ligands" A. K. Ghosh, N. Kumaragurubaran, L. Hong, S. Kukarni, X. Xu, W. Chang, V. Weerasena, R. Turner, G. Koelsch, G. Bilcer, J. Tang. J. Med. Chem. 2007, 50, 2399.
l "Enantioselective Total Synthesis of Antitumor Macrolide Lasonolide A" A. K. Ghosh and G. Gong. Organic Letters 2007, 9, 1437.
l "Atomic Resolution crystal Structures of HIV-1 Protease and MutantsV82A and I84V with Saquinavir" Yunfeng Tie, Andrey Y. Kovalevsky, Peter Boross, Yuan-Fang Wang, Arun K. Ghosh, Jozsef Tozser, Robert W. Harrison, Irene T. Weber. Proteins 2007, 67, 232-242.
|
|
|
|
|
