Recent Research Publications (total of 242):

 

 

    

 

 

  • "Bifunctional Cinchona Alkaloid-Squaramide-Catalyzed Highly Enantioselective aza-Michael Addition of Indolines to α, β-Unsaturated Ketones” A. K. Ghosh and B. Zhou. Tetrahedron Lett. 2013, 54, 3500-3502.

  • “GRL-0519, A Novel Oxatricyclic-Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor (PI), Potently Suppresses the Replication of a Wide Spectrum of Multi-PI-Resistant HIV-1 Variants In Vitro” M. Amano, Y. Tojo, P. M. Salcedo-Gomez, J. R. Campbell, D. Das, M. Aoki, C-X. Xu, K. V. Rao, A. K. Ghosh and H. Mitsuya. Antimicrobial Agents and Chemotherapy 2013, 57, 2036-2046.

  • “Enantioselective Synthesis of Spiro [cyclohexane-1,3-indolin]-2¢-ones Containing Multiple Stereocenters via Organocatalytic Michael/Aldol Cascade Reactions” A. K. Ghosh and B. Zhou. Tetrahedron Lett. 2013, 54, 2311-2314.

  • “Novel P2 Tris-tetrahydrofuran Group in Antiviral Compound 1 (GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease” H. Zhang, Y-F. Wang; C-H. Shen, J. Agniswamy, K. V. Rao, C. X. Xu, A. K. Ghosh, R. W. Harrison and I. T. Weber. J. Med. Chem. 2013, 56, 1074-1083.

  • “Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs” H. Chen, L. Liu, S. A. Jones, N. Banavali, J. Kass, Z. Li, J. Zhang, L. D. Kramer, A. K. Ghosh and H. Li. Antiviral Research 2013, 97, 232-239.

  • “Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism” H. Wu, D. Downs, K. Ghosh, A. K. Ghosh, P. Staib, M. Monod and J. Tang FASEB Journal, 2013, 27(6), 2132-2144.

  •  “Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1-pyrrolidinone or P2-tris-THF.’ J. Agniswamy, C. Shen, Y-F. Wang, A. K. Ghosh, K. V. Rao, C.-X. Xu, J. M. Sayer, J. M. Louis, and I. T. Weber. J. Med. Chem. 2013, 56, 56(10), 4017-4027.

  • "Enantioselective Total Synthesis of Pladienolide B:  A Potent Spliceosome Inhibitor" A. K. Ghosh and D. D. Anderson. Org. Lett. 2012, 14, 4730-4733.

  • "Enantioselective Total Synthesis of (+)-Lithospermic Acid"  A. K. Ghosh, X. Cheng and B. Zhou.  Org. Lett. 2012, 14, 5046-5049.

  • "Enhancing Protein Backbone Binding - A Fruitful Concept for Combating Drug-Resistant HIV” A. K. Ghosh, D. D. Anderson, I. T. Weber, H. Mitsuya. Angew. Chem. Int. Ed. 2012, 51, 1778-1802.

  • “Lasonolide A, a potent and reversible inducer of chromosome condensation”  Y-W Zhang, A. K. Ghosh, Y. Pommier, Cell Cycle 2012, 11, 4424-4435.

  • “Developing β-secretase inhibitors for treatment of Alzheimer’s disease”, A. K. Ghosh, M. Brindisi and J. Tang. J. Neurochem. 2012, 120, 71-83.

  • “A Stereoselective Synthesis of (-)-Viridiofungin A Utilizing a TiCl4-Promoted Asymmetric Multicomponent Reaction”, A. K. Ghosh and J. Kass. Org. Lett. 2012, 14, 510-512.

  • “Substituent effects on P2-Cyclopentyltetrahydrofuranyl Urethanes: Design, Synthesis, and X-ray studies of potent HIV-1 Protease Inhibitors”, A. K. Ghosh, B. D. Chapsal, M. Steffey, J. Agniswamy, Y.-F. Wang, M. Amano, I. T. Weber, H. Mitsuya. Bioorg. Med. Chem. Lett. 2012, 22, 2308-2311.

  • “Stereoselective Synthesis of Both Tetrahydropyran Rings of the Antitumor Macrolide,   (-)-Lasonolide A”, A. K. Ghosh and G.-B. Ren. J. Org. Chem. 2012, 77, 2559-2565.

  • "Diastereoselective Synthesis of Substituted Tetrahydropyrans by Cu(II)-Bisphosphine Catalyzed Olefin Migration and Prins Cyclization", A. K. Ghosh, J. Kass, D. R. Nicponski, and C. Keyes. Synthesis. 2012, 44, 3579-3589.

  • “Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors”, Y. Tie, P. Boross, Y.-F. Wang, T.-Y. Chiu, A. K. Ghosh, J. Tozser, R. Harrison, I. Weber. Protein Science, 2012, 21, 339-350.

  • "Synthesis of Functionalized 4-Methylenetetrahydropyrans by Oxidative Activation of Cinnamyl or Benzyl Ethers" A. K. Ghosh and X. Cheng. Tetrahedron Lett. 2012, 53, 2568-2570.

  • "Potent Antiviral HIV-1 Protease Inhibitor GRL-02031 Adapts to the Structures of Drug Resistant Mutants with Its P1`-Pyrrolidinone Ring", Y-C. E. Chang, X-X. Yu, Y. Zhang, Y. Tie, Y.-F. Wang, S. Yashcuk, A. K. Ghosh, R. W. Harrison, I. T. Weber. J. Med. Chem. 2012, 55, 3387-3397.

  • "TiCl4-Promoted Tandem Carbonyl or Imine Addition and Friedel-Crafts Cyclization: Synthesis of Benzo-fused Oxabicyclooctanes and Nonanes" A. K. Ghosh, C. D. Martyr, C.-X. Xu. Org. Lett. 2012, 14, 2002-2005.

  • "A Tandem Olefin Migration and Prins Cyclization using Cu(OTf)2-Bisphosphine Complexes: An Improved Synthesis of Functionalized Tetrahydropyrans", A. K. Ghosh, D. R. Nicponski, J. Kass. Tetrahedron Lett. 2012, 53, 3699-3702.

  • "Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group”, F. Li, I. Chvyrkova, S. Terzyan, N. Wakeham, R. Turner, A. K. Ghosh, X. C. Zhang, J. Tang. Appl. Microbiol. Biotechnol. 2012, 94, 1041-1049.

  • “Structure-based Design, Synthesis and Biological Evaluation of Dihydroquinazoline-Derived Potent b-Secretase Inhibitors” A. K. Ghosh, S. Pandey, S. Gangarajula, S. Kulkarni, D. D. Anderson, N. S Gavande, X. Xu, X. Huang, and J. Tang. Bioorg. Med. Chem. Lett. 2012, 22, 5460-5465.

  • "Total Synthesis of Potent Antitumor Macrolide, (-)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy” A. K. Ghosh, X. Cheng, R. Bai, E. Hamel. Eur. J. Org. Chem. 2012, 4130-4139.

  • "Structure-Based Design of Highly Selective Beta-Secretase Inhibitors:  Synthesis, Biological Evaluation, and Protein-Ligand X-ray Crystal Structure" A. K. Ghosh, K. V. Rao, N. D. Yadav, D. D. Anderson, N. Gavande, X. Huang, S. Terzyan, and J. Tang. J. Med. Chem. 2012, 55, 9195-9207.

 

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