Fiber and FIberless Laser-Induced Acoustic Desorption (LIAD)

    Some members of our group are involved in the development of laser desorption methods. We have examined laser-induced acoustic desorption (LIAD) as an evaporation method for analysis of neutral nonvolatile organic and biological molecules via chemical ionization. Besides LIAD, in this group we also have capabilities to perform reflection mode as well as transmission mode  Matrix Assisted Laser Desorption Ionization (MALDI). Our laser equipment includes two Nd:YAG lasers (Continuum Mini-Lite) and a nitrogen laser.     Figures below depict two types of laser set-ups used in our lab.

    Recently Ryan Shea in our group developed a novel LIAD technique called "Fiberless LIAD", which solved the power limitation problem to conventional LIAD. Under the optimized condition, polymers and biomolecules at high mass were evaporated into mass spectrometers without fragmentation successfully.