Ji-ang Liu

resume

Education:

B.S. (Applied Chemistry), 1989, Peking University, Beijing, China M.Eng. (Chemical Engineering), 1992, Chinese Institute of Atomic Energy, China National Nuclear Corporation (CNNC), Beijing, China Ph.D. (Analytical Chemistry, Candidate), Department of Chemistry, Purdue University, West Lafayette, IN

Current Research:

The action of some powerful antitumor and antibiotic drugs is believed to be based on abstraction of hydrogen atoms from DNA strands by aromatic σ,σ-biradicals. However, the mechanisms for the interactions between the biradicals and DNA at molecular level and control of the chemical properties of the radical intermediate itself are not well understood, because of the highly reactive nature of the radicals and the complexity of the biological environment. Now I am using laser-induced acoustic desorption (LIAD) method to introduce neutral DNA components into FT-ICR and allow them to react with the charged phenyl radicals with different polarities generated in the FT-ICR, therefore the interactions of the phenyl radicals with DNA components are studied at molecular level and under a much cleaner condition. A better understanding the reactivity of phenyl radicals towards DNA components can help to design more efficient and less toxic drugs.

Previous Academic and Industrial Experience and Honor:

Visiting Scholar, Environmental Research Institute, University of Connecticut, Storrs, Connecticut, 1999-2000

Visiting Research Scientist, MITKEM Corporation, Warwick, RI, 1999-2000

Research Scientist, State Key Laboratory for Environmental Aquatic Chemistry (SKLEAC), Research Center for Eco-Environment of Chinese Academy of Sciences, Beijing, China, 1992-1999

Visiting Scholar, Department of Ecology and Ecotoxicology, Lund University, Lund, Sweden, 1999

Honor: Distinguished young graduate leader (Graduate School, China National Nuclear Corporation (CNNC), 1990)

Presentation and Selected Publications:

Oral presentation at the 42^nd American Society for Mass Spectrometry (ASMS) conference at Nashville, TN, May 23-27, 2004

Liu, Ji-ang and Hu, Huaizhong. Extraction Mechanism of Tritium in 30%TBP-HNO3 System. He Huaxue Yu Fangshe Huaxue (J. Nuclear Chem. & Radio Chem., in Chinese) 1997,19(2),16-21

Liu, Ji-ang; Wang, Wenhua and Wang, Zijian. Types and contents of persistent pollutants in the sediment samples of the Second Songhua River. Zhongguo Huanjing Kexue 1998, 18(6), 518-520

Liu, Ji-ang; Cao, Haifeng; Zhuang, Yahui; Kuschk, Peter; Eismann, Frank and Glindemann, Dietmar. Phosphine in the urban air of Beijing and its possible sources. Water, Air, and Soil Pollution 1999, 116(3-4), 597-604

Cao, Haifeng; Liu, Ji-ang; Zhuang, Yahui and Glindemann, Dietmar. Emission sources of atmospheric phosphine and simulation of phosphine formation. Science in China, Series B: Chemistry 2000, 43(2), 162-168

Han, Sheng-hui; Zhuang, Ya-hui; Liu, Ji-ang and Glindemann, Dietmar. Phosphorus cycling through phosphine in paddy fields. Science of the Total Environment 2000, 258(3), 195-203

Glindemann, Dietmar; Edwards, Marc; Liu, Ji-ang and Kuschk, Peter Phosphine (PH₃) occurrence in soils, sediments, biogases and in the atmosphere - a review. Ecological Engineering, 2005, accepted

Petzold, Christopher J.; Price, Jason M.; Stumpf, Chris L,; Ramirez-Arizmendi, Luis E.; Liu, Ji-ang; Crawford, Kenroy; Gilbert, Jared and Kenttämaa, Hilkka I. Intrinsic chemical properties of nucleobase radical cations, in preparation

Liu, Ji-ang; Huang, Yiqun; Petzold, Christopher; Ramirez-Arizmendi, Luis E.; Perez, James and Kenttämaa, Hilkka I. A gas-phase study of the reactivity of phenyl radicals toward DNA components, in preparation

Contact Information:

Email:liu30@purdue.edu

Telephone: (765)494-7040

Fax: (765)494-0359

Postal address:

560 Oval Dr., Box 578

Dept. of Chem., Purdue University

W. Lafayette, IN 47907-1393