1. Quelle, F. W., Smith, R. V., Hrycyna, C.A., Kaliban,T. D., Crooks, J. A., and O'Brien, J. M.: [³H]Dexamethasone Binding to Plasma Membrane Enriched Fractions from Liver of Non-Adrenalectomized Rats, Endocrinology 123: 1642 - 1651, 1988.
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2. Hrycyna, C.A. and Clarke S.: Farnesyl-cysteine C-terminal Methyltransferase Activity is Dependent upon the STE14 Gene Product in Saccharomyces cerevisiae, Mol. Cell. Biol. 10: 5071 - 5076, 1990.
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3. Hrycyna, C.A., Sapperstein, S. K., Clarke, S., and Michaelis, S.: The Saccharomyces cerevisiae STE14 Gene Encodes a Methyltransferase that Mediates C-terminal Methylation of a-factor and RAS Proteins, EMBO J. 10: 1699 - 1709, 1991.
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4. Hrycyna, C.A. and Clarke, S.: Maturation of Isoprenylated Proteins in Saccharomyces cerevisiae: Multiple Activities Catalyze the Cleavage of the Three Carboxyl-Terminal Amino Acids from Farnesylated Substrates in vitro, J. Biol. Chem. 267: 10457 - 10464, 1992.
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5. Hrycyna, C.A. and Clarke, S.: Purification and Characterization of a Novel Metalloendopeptidase from Saccharomyces cerevisiae, Biochemistry 32: 11293 - 11301, 1993.
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6. Hrycyna, C.A. and Clarke, S.: Modification of Eukaryotic Signaling Proteins by C-terminal Methylation Reactions, Pharmacol. Ther. 59: 281 - 300, 1993.
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7. Hrycyna, C.A., Yang, M., and Clarke, S.: Protein Carboxyl Methylation in Saccharomyces cerevisiae: Evidence for STE14-Dependent and STE14-Independent Pathways, Biochemistry 33: 9806 - 9812, 1994.
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8. Sugimoto, Y., Hrycyna, C.A., Aksentijevich, I., Pastan, I., and Gottesman, M. M.: Co-expression of a Multidrug Resistance Gene (MDR1) and Herpes Simplex Virus Thymidine Kinase Gene as Part of a Bicistronic mRNA in a Retrovirus Vector Allows Selective Killing of MDR1-Transduced Cells, Clin. Cancer Res. 1: 447 - 457, 1995.
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9. Evans, G. L., Ni, B., Hrycyna, C.A., Chen, D., Ambudkar, S. V., Pastan, I., Germann, U. A., and Gottesman, M. M.: Heterologous Expression Systems for P-glycoprotein: E. coli, Yeast and Baculovirus, J. Bioenerg. Biomembr. 27: 43 - 52, 1995.
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10. Hrycyna, C.A., Wait, S., Backlund, P. S. Jr., and Michaelis, S.: Use of the Yeast STE14 Methyltransferase, Expressed as a TrpE-STE14 Fusion Protein in Escherichia coli, for in vitro Carboxylmethylation of Isoprenylated Polypeptides, Methods in Enzymology 250: 251 - 266, 1995.
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11. Gottesman, M. M., Hrycyna, C.A., Schoenlein, P. V., Germann, U. A., and Pastan, I.: Genetic Analysis of the Multidrug Transporter, Annu. Rev. Genet. 29: 607 - 649, 1995.
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12. Hwang, M., Ahn, C.-H., Pine, P. S., Yin, J.-J., Hrycyna, C.A., Licht, T., and Aszalos, A.: Effect of Combination of Suboptimal Concentrations of P-glycoprotein Blockers on the Proliferation of MDR1 Expressing Cells, Int. J. Cancer 65: 389 - 397, 1996.
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13. Ramachandra, M., Ambudkar, S. V., Gottesman, M. M., Pastan, I., and Hrycyna, C.A.: Functional Characterization of a Glycine 185 to Valine 185 Substitution in Human P-glycoprotein using a Vaccinia Based Transient Expression System, Molecular Biology of the Cell 7: 1485 - 1498, 1996.
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14. Hrycyna, C.A., Zhang, S., Ramachandra, M., Ni, B., Pastan, I., and Gottesman, M. M.: Functional and Molecular Characterization of the Human Multidrug Transporter. in Multidrug Resistance in Cancer Cells: Cellular, biochemical, molecular, and biological aspects, eds. S. Gupta and T. Tsuruo, 1996, 29 - 38.
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15. Ramachandra, M., Ambudkar, S. V., Chen, D., Hrycyna, C.A., Dey, S., Gottesman, M. M., and Pastan, I.: Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state, Biochemistry, 37: 5010 - 5019, 1998.
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16. Hrycyna, C.A., Ambudkar, S. V., Ramachandra, M., Ko, Y. H., Pedersen, P. L., Pastan, I., and Gottesman, M. M.: Mechanism of Action of Human P-glycoprotein ATPase Activity. Photochemical Cleavage During a Catalytic Transition State using Orthovanadate Reveals Cross-talk between the Two ATP sites, J. Biol. Chem., 273: 16631 - 16634, 1998.
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17. Hrycyna, C.A., Airan, L. E., Germann, U. A., Pastan, I., and Gottesman, M. M.: Structural Flexibility of the Linker Region of Human P-glycoprotein Permits ATP Hydrolysis and Drug Transport, Biochemistry, 37: 13660 - 13673, 1998.
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18. Russ, G., Ramachandra, M., Hrycyna, C.A., Gottesman, M. M., Pastan, I, Bennink, J. R., and Yewdell, J. W.: P-glycoprotein Plays an Insignificant Role in the Presentation of Antigenic Peptides to CD8+ T Cells, Cancer Research, 58: 4688 - 4693, 1998.
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19. Hafkemeyer, P., Dey, S., Ambudkar, S. V., Hrycyna, C.A., Pastan, I, and Gottesman, M.M. Contribution to Substrate Specificity and Transport of Non-Conserved Residues in Transmembrane Domain 12 of Human P-glycoprotein, Biochemistry, 37: 16400 - 16409, 1998.
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20. Hrycyna, C.A., Ramachandra, M., Pastan, I., and Gottesman, M. M.: Rapid and Transient Functional Expression of Human P-glycoprotein from Plasmids using a Vaccinia Virus-Bacteriophage T7 RNA Polymerase System, Methods in Enzymology, 292: 456 - 473, 1998.
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21. Hrycyna, C.A. and Gottesman, M.M.: Multidrug ABC Transporters from Bacteria to Man: An Emerging Hypothesis for the Universality of Molecular Mechanism and Function, Drug Resistance Updates, 1: 81 - 83, 1998.
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22. Hrycyna, C.A., Ramachandra, M., Germann, U. A, Wu, P., Pastan, I., and Gottesman, M. M.: Both ATP Sites of Human P-glycoprotein are Essential but not Symmetric, Biochemistry, 38: 13887 - 13899, 1999.
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23. Ambudkar, S. V., Dey, S., Hrycyna, C.A., Ramachandra, M., , Pastan, I., and Gottesman, M. M.: Biochemical, Cellular and Pharmacological Aspects of the Multidrug Transporter, Annual Review of Pharmacology and Toxicology, 39: 361 - 398, 1999.
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24. Gribar, J. J., Ramachandra, M., Hrycyna, C.A., Dey, S., and Ambudkar, S. V.: Functional Characterization of Glycosylation-Deficient Human P-glycoprotein using a Vaccinia Virus Expression System, J. Membrane Biology, 173: 203 - 214, 2000.
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25. Gottesman, M. M., Licht, T., Zhou, Y, Lee, C. G. L., Shoshani, T., Hafkemeyer, P., Hrycyna, C.A., and Pastan, I.: Selectable Markers for Gene Therapy. In Lasic, D. and Templeton, N. S. (Eds.): Gene Therapy: Therapeutic Mechanisms and Strategies. Ch. 16. New York, Marcel Dekker, Inc., 2000, pp. 333 - 352.
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26. Lamensdorf, I., Hrycyna, C.A., Li Ping, H., Nechushtan, A., Tjurmina, O., Harvey-White, J., and Kopin, I. J.: Acidic Dopamine Metabolites are Actively Extruded from PC12 Cells by a Novel Sulfonylurea-sensitive Transporter, Arch Pharmacol., 361: 654 - 664, 2000.
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27. Honjo, Y., Hrycyna, C.A., Yan, Q-W., Medina-Perez, W. Y., Robey, R. W., van de Laar, A., Litman, T., Dean, M. and Bates, S. E: Acquired Mutations in the MXR/BCRP/ABCP Gene Alter Substrate Specificity in MXR/BCRP/ABCP-overexpressing Cells, Cancer Research, 61: 6659 - 6666, 2001.
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28. Hrycyna, C.A.*: Molecular Genetic Analysis and Biochemical Characterization of Mammalian P-glycoproteins, Semin. Cell Dev. Biol., 12: 247 - 256, 2001.
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29. Ejendal, K. F. and Hrycyna, C.A.*: Multidrug Resistance and Cancer: The Role of the Human ABC Transporter ABCG2, Current Protein and Peptide Science, 3: 503 - 511, 2002.
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30. Corrigan, D. P., Kuszczak, D., Rusinol, A. E., Thewke, D. P., Hrycyna, C.A.*, Michaelis, S. and Sinensky, M. S.: Prelamin A Endoproteolytic Processing In Vitro by Recombinant Zmpste24, Biochemical Journal, 387:129 - 138, 2005.
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31. Ejendal, F. K. and Hrycyna, C.A.*: Differential Sensitivities of the Human ABC Transporters ABCG2 and P-glycoprotein to Cyclosporin A, Molecular Pharmacology, 67: 902 - 911, 2005.
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32. Anderson, J. A., Frase, H., Michaelis, S., and Hrycyna, C.A.*: Purification and Functional Reconstitution and Characterization of the Ste14p Isoprenylcysteine Methyltransferase, J. Biol. Chem 280: 7336 - 7345, 2005. PDF Download

"Paper of the Week" ranked in the top 1% of all papers (~6600) published in J. Biol. Chem. for the year 2005 - J. Biol. Chem., Vol. 280, Issue 8, 99906, February 25, 2005)

33. Diop, N. K. and Hrycyna, C.A.*: N-linked Glycosylation of the Human ABC Transporter ABCG2 on Asparagine 596 is Not Essential for Expression, Transport Activity or Trafficking to the Plasma Membrane, Biochemistry, 44:5420 - 5429, 2005.
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34. Wang, C., Leffler, L., Thompson, D. T. and Hrycyna, C.A.*: A General Fluorescence-based Coupled Assay for S-Adenosylmethionine-dependent Methyltransferases, Biochem. Biophys. Res. Comm., 331: 351 - 356, 2005.
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35. Hodges, H. B., Zhou, M., Anderson, J. L., Thompson, D. T. and Hrycyna, C.A.*: Inhibition of Membrane-Spanning Metalloproteins by Hydrophobic Metal Chelators, Bioconjugate Chemistry, 16: 490 - 493, 2005.
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36. Tarasova, N. I., Rishi S., Tarasov, S. G., Kosakowska-Cholody, T., Hrycyna, C.A.*, Gottesman, M. M. and Michejda, C. J.: Transmembrane inhibitors of P-glycoprotein, an ABC transporter, J. Med. Chem., 48: 3768 - 3775, 2005.
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37. Anderson, J. A., Henriksen, B., Gibbs, R. and Hrycyna, C.A.*: The Isoprenoid Substrate Specificity of Isoprenylcysteine Carboxylmethyltransferase: Development of Novel Inhibitors, J. Biol. Chem., 280: 29454 - 29461, 2005.
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38. Bhatia, A., SchÃefer, H. J., and Hrycyna, C.A.*: Oligomerization of the Human ABC Transporter, ABCG2: Evaluation of the Native Protein and Chimeric Dimers, Biochemistry, 44: 10893 - 10904, 2005.
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39. Geisler, M. , Blakeslee, J. J. , Bouchard, R. , Lee, O.R. , Vincenzetti, V. , Bandyopadhyay, A., Peer, W.A. , Bailly, A. , Richards, E. L. , Ejendal, K. F. K. , Smith, A. P., Baroux, C. , Grossniklaus, U. , Müller, A. , Hrycyna, C. A, R. Dudler, Murphy, A. S. and Martinoia, E.: Active export of auxin by MDR-type ATP-binding cassette transporters of Arabidopsis thaliana, The Plant Journal, 44:179-194, 2005.
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40. Henriksen, B., Anderson, J. L., Hrycyna, C.A.*, and Gibbs, R. A.: Synthesis of Desthio Prenylcysteine Analogs: Sulfur is Important for Biological Activity, Bioorganic & Medicinal Chemistry Letters, 15:5080 – 5083, 2005.
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41. Anderson, J. A. and Hrycyna, C.A.*: Structure and Biological role of the Isoprenylcysteine Protein Carboxyl Methyltransferase, The Enzymes, Vol. 24, Protein methyltransferases. Steven G. Clarke and Fuyuhiko Tamanoi, eds., Chapter 9: 245 - 272, 2006.

42. Ejendal, F. K., Diop, N. K., Schweiger, L. C., and Hrycyna, C.A.*: The Nature of Amino Acid 482 of Human ABCG2 is Important for Substrate Transport and ATPase Activity but not for Substrate Binding, Protein Science, 15:1597 - 1607, 2006.
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43. Donelson, J. L., Hodges, H. B., MacDougall, D. D., Hrycyna, C.A.*, and Gibbs, R. A.*: Synthesis and Biological Evaluation of Amine-Modified Farnesyl Cysteine Analogs as Isoprenylcysteine Methyltransferase Inhibitors, Bioorganic and Medicinal Chemistry Letters, 2006.
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44. Pires, M., Hrycyna, C.A.*, and Chmielewski, J. A.*: Bivalent Inhibitors of the Human Multidrug Transporter P-glycoprotein, Biochemistry, 45:11695-11702, 2006.
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45. Gelb, M. H.*, S. Michaelis, Hrycyna, C.A., Waldman, H. Brunsveld, L., Tamanoi, F. and Van Voorhis, W.: Therapeutic intervention based on protein prenylation and associated modifications, Nature Chemical Biology, 2:518 - 528, 2006.
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46. Febo-Ayala, W., Morera-Felix, Hrycyna, C.A.*, and Thompson, D. T.*: Functional Reconstitution of the Integral Membrane Enzyme, Isoprenylcysteine Carboxyl Methyltransferase, in Synthetic Bolalipid Vesicles, Biochemistry, 45:14683 - 14694, 2006.
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47. Takenaka, K., Morgan, J. A., Krishnamurthy, P., Lan, L., Adachi, M., Stewart, C. F., Sun, D., Leggas, M., Ejendal, K. F. K., Hrycyna, C.A., and Schuetz, J. D.*: Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analog Drug Cytotoxicity and Tissue Distribution, Cancer Research, 67:6965-6972, 2007.
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48. Coffinier, C.*, Hudon, S., Farber, E., Chang, S. Y., Hrycyna, C.A.*, Young, S. G.*, and Fong, L. G.*: From the Cover: HIV Protease Inhibitors Block the Zinc Metalloproteinase ZMPSTE24 and Lead to an Accumulation of Prelamin A in Cells, Proc. Natl. Acad. Sci., 33: 13432-13437, 2007.
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Accompanying Commentary: Clarke, S. G.: HIV Protease Inhibitors and Nuclear Lamin Processing: Getting the Right Bells and Whistles, Proc. Natl. Acad. Sci., 35: 13857-13858, 2007.
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49. Coffinier, C., Hudon, S.E., Lee, R., Farber, E.A., Nobumori, C., Miner, J.H., Andres, D.A., Spielmann, H.P., Hrycyna, C.A., Fong, L.G., and Young, S.G.*: A Potent HIV Protease Inhibitor, Darunavir, Does not Inhibit ZMPSTE24 or Lead to an Accumulation of Farnesyl-Prelamin A in Cells, J. Biol. Chem., 15: 9797-804, 2008.
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50. Hudon, S.E., Coffinier, C., Michaelis, S., Fong, L.G., Young, S.G., and Hrycyna, C.A.*: HIV Protease Inhibitors Block the Enzymatic Activity of Purified Ste24p, Biochem. Biophys. Res. Comm. 374: 365-368, 2008.
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51. Pires, M.M., Emmert, D., Hrycyna, C.A.*, and Chmielewski, J.*: Inhibition of P-glycoprotein-Mediated Taxol Resistance by Reversibly-Linked Quinine Homodimers, Molecular Pharmacology, 75: 92 - 100, 2009.
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52. Donelson, J.L., Hodges-Loaiza, H.B., Henriksen, B.S., Hrycyna, C.A., and Gibbs, R.A.: Solid Phase Synthesis of Prenylcysteine Analogs, J. Org. Chem., 74: 2975 - 2981, 2009.
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53. Namanja, H.A., Emmert, D., Pires, M.M., Hrycyna, C.A.*, and Chmielewski, J.*: Inhibition of Human P-glycoprotein Transport and Substrate Binding Using a Galantamine Dimer, Biochem. Biophys. Res. Comm., 388: 672 - 676, 2009.
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54. Griggs, A.M., Hahne, K., and Hrycyna, C.A.*: Functional Oligomerization of the Saccharomyces cerevisiae Isoprenylcysteine Carboxyl Methyltransferase, Ste14p, J. Biol. Chem., in press, 2010. 
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