M. ESTELA CAMPANELLA (nee PUCHULU)

EDUCATION

National University of Cordoba, Argentina.

     Biochemist (5 years degree)

National University of Buenos Aires, Argentina.

     Postgraduate studies: Hematology

Hematologist (applied basic biochemistry, cytochemistry and cytomorphology to the diagnosis of blood diseases)

PUBLICATIONS

1. Campanella M.E, Chu H. and Low P.L. (2005) Assembly and Regulation of a Glycolytic Enzyme Complex on the Human Erythrocyte Membrane. Proceedings of the National Academy of Sciences of the United States of America 102 (7): 2402-2407.

 2. Weber R. E., Voelter W, Fago A, Echner H, Campanella E and  Low PS (2004) Modulation of red cell glycolysis: interactions between vertebrate hemoglobins and cytoplasmic domains of band 3 red cell membrane proteins. Am J Physiol Regul Integr Comp Physiol. 287: R454-R464.

3. Low PS, Campanella E, Chu H. (2003) Regulation of glycolytic enzyme binding to the erythrocyte membrane. Blood 102 (11), 8a

4. Rettig M.P., Orendorff C.J., Campanella.E. and Low P.S. (2001) Effect of pH on the self- association of erythrocyte band 3 In Situ. Biochimica et Biophysica Acta, 151, 72-81..

5. Battersby J., Clark R., Hancock W., Puchulu-Campanella E., Haggarty N. Poll D. and Harding, D. (1996) Sustained Release Of Recombinant Human Growth Hormone From Dextran Via Hydrolysis Of An Imine Bond. Journal of Controlled Release, 42(2), 143-156.

6. Westerman M. P., Puchulu E., Schlegel R. A., Salameh M. and Williamson P. (1994) Intracellular Ca2+containing vesicles in sickle cell disorders. The Journal of Laboratory and ClinicalMedicine,124(3),416.

7. Puchulu-Campanella E., Haggarty N.W. and Harding, D.R.K. (1992) Design of low cost media for the isolation of commercially viable enzymes of high purity from various biological sources. Proceedings of the NZ Meat Research Institute, Hamilton, September 1992.

8. Williamson P., Puchulu, E., Penniston J., Westerman M.P., and Schlegel R.C.A. (1992) Ca2+ Accumulation and Loss by Aberrant Endocytic Vesicles in Sickle Erythrocytes. Journal ofCellularPhysiology,152,1-9.

9. Williamson P., Puchulu, E., Westerman M.P., and Schlegel, R.C.A. (1990) Erythrocyte Membrane Abnormalities in Sickle Cell Disease. Biotechnology and Applied Biochemistry, 12,523-528.

PRESENTATIONS & CONFERENCES

1- Low PS, Campanella ME, Chu H, Anong WA, Wandersee NJ Hillary CA, Chishti A. Characterization of Glycolytic Enzyme Complexes on Murine Erythrocyte Membranes. American Hematology Society, San Diego, December 2004.

2. Puchulu-Campanella M.E. and Low P.S. Regulation of glycolysis by tyrosine phosphorylation of band 3 in intact human red cells. Red Blood Cell Conference. Purdue University, West Lafayette, Indiana, October 2002.

3. Thresher,W.C., Campanella M.E., Boland M.J. and Hill J.P. Protein Processing: Relating chemical modifications to nutritional quality. European Dairy Experts Symposium. 15-18 September 1998, Arnhem, the Netherlands.

4. Boland M.J., Thresher, W.C. and Campanella M.E. Modeling the nutritional consequences of chemical modification of proteins. 25th International Dairy Congress, 21-24 September 1998, Aarhus, Denmark.

PATENTS

1. Boland MJ, Hill JP, Haggarty NW and Campanella ME Process for controlling Maillard-type glycation of whey proteins and products with enhanced functional properties. International Application No. PCT/NZ99/00163 on September 28 1999.

2. Campanella ME and Haggarty NW. Dairy Product and Process. New Zealand Application No 332080 on 28 September 1998.

PROJECTS

1. Organization and association of enzymes in the intact murine and human erythrocyte.

2. Mechanism of regulation of glycolysis.

3. Erythrocyte signal transduction pathways and their oxygenation dependence.

4. Autologous IgG binding to unmodified and modified red blood cells