Cancer and Inflammatory Diseases

Group Members

 

Please select a member's name to view pictures.  CV's are linked to a member's lab title.

Emanuela Ionela (Ligia) SegaPhD 12.2006 (BMB)

1997 BS Biophysics - University of Bucharest (Bucharest, Romania)

1997 - 1999 Research assistant - N. Simionescu Institute of Cellular Biology and Pathology (Romania)

    Studied the immunoglobulin G trafficking in human placental endothelial cells.

Current Project:

  • Folate-receptor targeted immunotherapy of cancer.

 

constane@purdue.edu

Erina Vlashi:  PhD 05.2006 (Biochemistry)

2ooo BA Chemistry - Hillsdale College (Hillsdale, MI)

    Minors:  Biology, French

Current Project:

  • Real time, non-invasive, and in vivo imaging of targeted drug accumulation in solid tumors via high affinity ligands: implications to improving targeted drug delivery.

 

vlashi@purdue.edu

Walt Henne, RN:  PhD 05.2006 (Biochemistry)

1996 BS Biology - Governor's State University (University Park, IL)

1999 MS Analytical Chemistry - Governor's State University (University Park, IL)

Current Project:

  • Disease detection and targeted drug delivery using high affinity low-molecular weight ligands.

 

whennejr@purdue.edu

Derek Doorneweerd:  PhD Candidate (Biochemistry)

2ooo BS Chemistry - Northern Illinois University (DeKalb, IL)

 

Current Projects:

  • Novel diagnostics for human pathogens.
  • Chemotherapeutics targeted to diseased tissue via folic acid.

 

doornewe@purdue.edu

Wei He:  PhD Candidate (BMB/PULSe)

2oo2 BS Life Sciences - University of Science and Technology of China (Hefei, China)

2oo2 Internship - GeneCore BioTechnologies Co. Ltd. (Shanghai, China)

2oo2 - 2oo3 Project Engineer - National Library and Information Center for Life Sciences (Shanghai, China)

 Current Project:

  • Developed a semi-automate and standard platform for in vivo, non-invasive, quantitative, and real-time detection of rare circulating tumor cells in circulation.
  • Developed an in vitro screening assay for diagnosis of ovarian cancer and evaluation of chemotherapy.

 

he11@purdue.edu

Wilfredo Ayala-López:  PhD Candidate (BMB/PULSe)

2oo1 BS Applied Microbiology - University of Puerto Rico (Humacao, PR)

2oo1 - 2oo2 Post-Baccalaureate Intramural Research Training Fellow - National Institute of Children's Health and Human Development (NICHD/NIH)

Current Projects:

  • Identification and development of anti-inflammatory drugs.
  • Characterization, imaging, and treatment of atherosclerosis using folate-targeting technology.
  • Elucidation of the mechanisms responsible for the efficacy of folate-targeted immunotherapy in arthritis.

 

wayalalo@purdue.edu

Wei Xia:  Graduate Student (PULSe)

2oo4 BS - Fudan University (Shanghai, China)

Current Project:

  • Characterization of FR+ macrophages/monocytes.

 

 

 

 

wxia@purdue.edu

Young-Su YiGraduate Student (PULSe)

2oo1 BS - SungKyunKwan University (Suwon, Korea)

2oo3 MS - Seoul National University (Seoul, Korea)

Current Projects:

  • Folate-receptor mediated immunotherapy of rheumatoid arthritis (RA).
  • Folate-receptor mediated immunotherapy of multiple sclerosis (MS).
  • Crystallization of folate-receptor beta.

 

yiy@purdue.edu

Sumith Kularatne:  Graduate Student (Organic Chemistry)

2oo4 MS Organic Chemistry - Wichita State University (Wichita, KS)

Current Projects:

  • Design and synthesis of highly selective imaging agent for PC and potency drug for PC via targeted drug delivery.
  • Design and synthesis of sialic acid derivatives for immunotherapeutic approach to flu virus; engineering SiO2 or Au surfaces for immunosensor detection of flu virus.
  • Targeting folate receptors on macrophages in insulin-dependent diabetes mellitus.
  • Synthesis of di- and tri-nitrophenyl folate conjugates to investigate the immunotherapeutic applications for FR+ arthritis.
  • Synthesis of folate conjugates TNF-α Inhibitors for in vitro / in vivo screenings for AM.

sumithk@purdue.edu

Ryan Rothenbuler, DVM:  Graduate Student (Comparative Biology - School of Veterinary Medicine)

2oo1 DVM - Purdue University (West Lafayette, IN)

2005 MS - Purdue University (West Lafayette, IN)

Current Projects:

  • Folate-targeted imaging and therapy for osteoarthritis.

 

 

 

 

 

ryanroth@purdue.edu

Balasubramanian (Bala) VaitilingamGraduate Student (Organic Chemistry)

1998 BPharmacy - Trivandum Medical College (University of Kerala, India)

2ooo MS Pharmacy and Medicinal Chemistry - National Institute of Pharmacy Education and Research (NIPER, India)

2ooo - 2oo5 Research scientist - Dr. Reddy's Laboratories Ltd. RDY-NYSE (India)

    Drug discovery.

Current Project:

  • Receptor-targeted therapeutics for diabetes, obesity, and rheumatoid arthritis.

balan@purdue.edu

Scott Poh:  Graduate Student (Organic Chemistry)

1996 BS Chemistry - California State University (Hayward, CA)

Current Project:

  • Design and synthesis of highly selective imaging agents.

 

 

 

 

 

spoh@purdue.edu

Judith Ronau:  Graduate Student (PULSe)

jronau@purdue.edu