Sumith A Kularatne PhD student (Organic)

Department of Chemistry

Purdue University

WTHR 357A

765-494-5289

sumithk@purdue.edu

Thesis Advisor: Ralph C. Corley Distinguished Professor Philip S Low

MS in Organic Chemistry (2004)

Wichita State University Wichita KS USA

Current Projects (Purdue)

    Prostate Cancer: - Design & Synthesis of highly selective imaging agent for PC and potency drug for PC via targeted drug delivery.

    Flu Virus: - Design & Synthesis of Sialic acid derivatives for the immunotherapeutic approach to Flu Virus and Engineering SiO2 or Au surfaces for immunosensor detection of Flu Virus.

    Diabetes: - Targeting of folate receptors on macrophages in insulin dependent diabetes mellitus

    Arthritis: - Synthesis of di-and tri-nitrophenyl folate conjugates to investigate the Immunotherapeutic applications for FR-positive arthritis.

    Targeting Activated Macrophages: - Synthesis of folate conjugates TNF-α Inhibitors for in vitro / in vivo screenings for AM

AWARDS & HONORS

Honors

• The American Chemical Society recognition “Chemist of the year" - Honors for contributions to Chemistry (October 2004)

• National Science Honor Society (Phi Kappa Phi) Scholar

• National Society of Collegiate Scholars (NSCS)

• Phi Lambda Upsilon Scholar

Awards

Wichita State University

• Delano Maggard, Jr. Graduate Research Grant Award (2004)

• Dr. E. A. Talaty Fellowship Award ( 2003)

• B.L Parker Endowed Fellowship (2002)

PUBLICATIONS AND PRESENTATIONS

Purdue University

• “Synthesis and Activity of a Folate Peptide Camptothecin Prodrug” Walter A. Henne, Derek D. Doorneweerd, Andrew R. Hilgenbrink, Sumith A. Kularatne, and Philip S. Low*, Bioorg. Med. Chem. Lett., 16 (2006) 5350-5355.

Wichita State

• “Buried Solvent determines both Anion Binding Selectivity and Binding Stoichiometry with hydrogen bonding receptors”; Dennis H. Burns, Kenichi Caledron-Kawasaki, Sumith A. Kularatne, J. Org. Chem.; (Article); 2005; 70(7); 2803-2807.

• “Buried Solvent determines both Anion Binding Selectivity with hydrogen bonding receptors”; Sumith A. Kularatne ,Dennis H. Burns, Abstract of papers, 229th ACS National Meeting, San Diego, CA, United States, March 13-17, 2005, (2005), ORGN-867.

• “Synthesis of Endo-Metacyclopahnes utilizing Grubbs’ Catalyst while incorporating a porphyrin scaffold”; Charles L. Jayne, Sumith A. Kularatne and Dennis H. Burns, Abstracts, 39th Midwest Regional ACS Meeting, Manhattan, KS, United States, October 20-22 (2004).

• “Solvent is a determinant in Anion Binding Selectivity of Urea-Picket Porphyrin Receptors”,. Sumith A. Kularatne, Dennis H. Burns, Abstracts, 39th Midwest Regional ACS Meeting, Manhattan, KS, United States, October 20-22 (2004).

• “Novel Synthesis of Endo [N.M.N.M] Metacyclopahnes using 5, 10, 15, 20-meso-tetrakis (2-aminophenyl) porphyrin as a scaffold. (Poster Presentation)”, Dennis H. Burns, Charles L. Jayne and Sumith A. Kularatne, Abstract of papers, 228th ACS National Meeting, Philadelphia, PA, United States, August 22 - 26, 2004 (2004), ORGN-693.

• “Buried Solvent determines Anion Binding Selectivity with hydrogen bonding Receptor” Dennis H. Burns, Sumith A. Kularatne and Kenichi Caledron-Kawasaki, Proceedings of 2004, XIIIth International Symposium on Supramolecular Chemistry, Notre Dame, IN, United States, April 20-25,2004.

• Synthesis, Characterization and Elaboration of Endo [N.N.N.N](N>3) Metacyclopahnes” Sumith A. Kularatne, Charles L. Jayne, Dennis H. Burns, Abstracts , 38th Midwest Regional ACS Meeting, Columbia, MO, United States November 5-7 (2003).

• “Synthesis, Characterization and Elaboration of Endo [n.m.n.m] (n>3) Metacyclopahnes.” Dennis H. Burns, Charles L. Jayne, Sumith A. Kularatne, , Abstract of papers, 225th ACS National Meeting, New Orleans, LA, United States, March 23-27 2003 (2003) ORGN-584.