Receptor-targeted imaging and therapeutics to inflammatory cells

Arthritis

Imaging of healthy and rheumatoid arthritic dogs with folate-targeted imaging agent

Rheumatoid arthritic patient’s feet imaged with EC20, a folate-targeted radioimaging agent.  Image is courtesy of Eric Matteson, Frank Prendergast and Val Lowe.

Rheumatoid arthritic patient’s hands imaged with EC20, a folate-targeted radioimaging agent.  Image is courtesy of Eric Matteson, Frank Prendergast and Val Lowe, Mayo Clinic

Folate-targeted therapy of collagen-induced arthritis in mouse

Osteoarthritic patient’s hands imaged with EC20, a folate-targeted imaging agent.  Image is provided by Eric Matteson, Frank Prendergast and Val Lowe, Mayo Clinic

Lupus

MRL-MpJ-Tnfrsf6lpr Lupus mice

Bowel Disease

Optical imaging of inflammatory bowel disease