Yi, Young-Su

Education

Mar. 1994 – Feb. 2001            Department of Genetic Engineering, Sungkyunkwan University, Korea, BS

Mar. 2001 – Feb. 2003            School of Biological Sciences (Molecular Genetics) Seoul National University, Korea, MS

Aug. 2004 – Present                Department of Chemistry (PULSe program), Purdue University, IN

Research & professional experiences

Jan. 1996 – Mar. 1998        Military Obligation; 2XX  62FA-B  FDC, Won-Tong, Kangwon Province, Korea

Aug. 2001 – Dec. 2001 & Mar. 2002 – Jun. 2002      Teaching assistant; Seoul National University, Korea

Mar. 2003 – Jul. 2004        Researcher; Korea Institute of Radiological & Medical Sciences (KIRAMS), Korea

Research Experiences

1. Jan. 2001 – Feb. 2003; Laboratory of Molecular Genetics, Seoul National University , Korea

Regulation of gene expressions in the hepatocytes infected by human hepatitis B virus (HBV).

Differential gene expressions in HBV-infected human primary hepatocytes & human hepatoma cell lines were examined by cDNA microarray technology, and their roles relating to hepatocellular carcinomas (HCC) were investigated.

2. Mar. 2003 – Jul. 2004; Laboratory of Molecular Oncology, Korea Institute of Radiological & Medical Sciences (KIRAMS), Korea

Roles of SIRT1 relating to human cancers

Protein-protein interaction between SIRT1 and cellular proteins were examined by yeast two hybrid experiments. Gene regulation by SIRT1 and its roles relating to cancer development were investigated.

3. Aug. 2004 – Present; Purdue University , USA

1) Immunotherapy of human autoimmune diseases                            

Imaging of pathogenic lymphocytes in rheumatoid arthritis (RA) & multiple sclerosis

(MS) in animal models, and immunotherapy of RA & MS were investigated using animal models.

2) Development of highly specific & non-cross reactive monoclonal antibodies against human folate receptor beta (hFR-β)

Developing monoclonal antibodies against human folate receptor beta (hFR-β) by three strategies; 1) unique hFR-β peptides, 2) pre-B cell lines expressing hFR-β, & 3) intact hFR-β purified by baculovirus expression system

Honors & Awards

1. Prize for the research poster by Korean Society of Medical Biochemistry and Molecular Biology at fall 2001. The title of poster is “Gene expression analysis of human normal primary hepatocytes induced by human heptitis B virus.”

Publications

1. Yi YS, Park SG, Byeon SM, Kwon YG, Jung G.. Hepatitis B virus X protein induces TNF-alpha expression via down-regulation of selenoprotein P in human hepatoma cell line, HepG2. Biochim Biophys Acta. 2003 Jul 30;1638(3):249-56.

2. Ju YJ, Lee KH, Park JE, Yi YS, Yun MY, Ham YH, Kim TJ, Choi HM, Han GJ, Lee JH, Lee J, Han JS, Lee KM, Park GH. Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence. Exp Mol Med. 2006 Dec 31;38(6):686-93.

3. Yi YS, Ayala-Lopez W, Kularatne SA, Low PS. Comparative therapeutic efficacies of folate-dinitrophenol and -trinitrophenol conjugates in folate receptor-targeted immunotherapy of experimental rheumatoid arthritis. Manuscript in preparation.

Presentation

1. Differential gene regulation in hepatocytes infected by human hepatitis B virus. Park SG, Yi YS, Kim SH, Ryu YH, Lim SO, Jung G.. Annual meeting of BK21. Jun. 2001. (Poster)

2. HBx sensitizes HepG2 Cells to TNF-α induced apoptosis via down-regulation of selenoprotein P; Novel pathway of TNF-α induced-apoptosis by HBx. Yi YS, Jung G. Annual meeting of Korean Society for Biochemistry & Molecular Biology. Oct. 2002 (Poster)

3. Targeting of folate-conjugated nitrophenyl haptens show anti-inflammatory activity in rats with adjuvant-induced arthritis after hapten immunization. Yi YS, Ayala-López W, Kularatne SA, Low PS. the Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) . 2007 (Poster)