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Education:
Wayne State University, Detroit, MI 48202 1997-2002 Ph. D. in Analytical Chemistry Thesis advisor: Prof. Mary T. Rodgers Thesis title: Noncovalent Interactions between Metal Ions and Model Systems for Biologically Important Molecules: Threshold Collision Induced Dissociation and Theoretical Studies
GPA: 3.8 on 4.0 Wayne State University, Detroit, MI 48202 1995-1997 M.A. in Chemistry
University of Peradeniya, Peradeniya, Sri Lanka 1988-1992 B. Sc. (Hons.) in Chemistry GPA: 3.9 on 4 scale.
Research Experience:
Purdue University, West Lafayette, IN 47907 June 2002-February
2004 Post-doctoral associate with Professor Scott A. McLuckey. Application of Ion/Ion Reactions for "Top-Down" Protein Identification and Characterization Using Mass Spectrometry and Liquid Chromatography. Application of ion parking to the gas phase concentration, purification and identification of proteins from complex mixtures of Saccharomyces Cerevisiae. Study of the charge state dependent fragmentation behavior of multiply charged proteins.
Wayne State University, Detroit, MI 48202 August 1995 - May 2002 Graduate research assistant Energy Dependence of Collision Induced Dissociation Reactions of Metal Ion-Ligand Complexes Using Mass Spectrometry and Theory. Energy dependence of collision-induced dissociation (CID) reactions of metal ions bound biologically important model molecules was studied using a Guided Ion Beam Tandem Mass Spectrometer. These studies were performed focusing on development and application of quantitative threshold CID methods to obtain more accurate thermodynamic information on variety of biologically relevant metal ligand large complexes. Such reliable measurements allow the intrinsic interactions operative in biological systems to be examined in detail.
University of Peradeniya, Peradeniya, Sri Lanka January
1992 - November 1992
Investigation of Orientational Order Parameters of n-Cyano Biphenyl (n = 5)
Nematic Liquid Crystals. Selected Publications: (1) K.A. Newton, R. Amunugama, S.A. McLuckey. "Gas-Phase Ion/Ion Reactions of Multiply Protonated Polypeptides with Metal Containing Anions." J. Phys. Chem. A., 109, 3608-3616 (2005). (2) K.A. Newton, M. He., R. Amunugama, S.A. McLuckey, "Selective Cation Removal From Gaseous Polypeptide Ions: Proton versus Sodium Ion Abstraction via Ion/Ion Reactions." Phys. Chem. Chem. Phys., 6, 2710-2717 (2004). (3) R. Amunugama, J.M. Hogan, K.A. Newton, S.A. McLuckey; "Whole Protein Dissociation in a Quadrupole Ion Trap: Identification of an a priori Unknown Modified Protein." Anal. Chem., 76, 720-727 (2004). (4) R. Amunugama and M. T. Rodgers; “Cation-p Interactions with a Model for an Extended p Network: Absolute Binding Energies of Alkali Metal Cation-Naphthalene complexes determined by Threshold Collision-Induced Dissociation and Theoretical Studies” Intl. J. Mass Spectrom. accepted for publication. (5) R. Amunugama and M. T. Rodgers; “The Influence of Substituents on Cation-p Interactions 4: Absolute Binding Energies of Alkali Metal Cation-Phenol complexes determined by Threshold Collision-Induced Dissociation and Theoretical Studies.” J. Phys. Chem. A 106, 9718 (2002). (6) R. Amunugama and M. T. Rodgers; “The Influence of Substituents on Cation-p Interactions 1: Absolute Binding Energies of Alkali Metal Cation-Toluene complexes determined by Threshold Collision-Induced Dissociation and Theoretical Studies” J. Phys. Chem. A 106, 5529-5539 (2002). (7) G. Vitale, A. B. Valina, H. Huang, R. Amunugama and M. T. Rodgers; “Solvation of Copper Ions by Acetonitrile. Structures and Sequential Binding Energies of Cu+(CH3CN)x, x = 1-5 from Collision-Induced Dissociation and Theoretical Studies” J. Phys. Chem. A 105, 11351-11364 (2001). (8) A. B. Valina, R. Amunugama,
H. Huang and M. T. Rodgers; "Collision-Induced Dissociation and
Theoretical Studies of Na+—Acetonitrile Complexes” J. Phys.
Chem. A 105, 11057-11068 (2001). (9) R. Amunugama and M. T. Rodgers; "Periodic Trends in the Binding of Metal Ions to Pyrimidine Studied by Threshold Collision-Induced Dissociation and Density Functional Theory" J. Phys. Chem. A 105, 9883-9892 (2001). (10) M. T. Rodgers, J. R. Stanley and R. Amunugama; "Periodic Trends in the Binding of Metal Ions to Pyridine Studied by Threshold Collision-Induced Dissociation and Density Functional Theory" J. Am. Chem. Soc. 122, 10969-10978 (2000). (11) R. Amunugama and M. T. Rodgers; "Absolute Alkali Metal Ion Binding Affinities of Several Azines Determined by Threshold Collision-Induced Dissociation" Int. J. Mass. Spectrom. 195/196, 439-457 (2000).
Presentations: (1) S.A. McLuckey, R. Amunugama, K.A. Newton, J.M. Hogan, E.R. Badman, S.J. Pitteri, D.M. Watson, P. Pan and G.E. Reid; "Top-down Analysis of Protein Mixtures without a Magnet", Oral presentation at the 51st ASMS Conference on Mass Spectrometry and Allied Topics, Montreal, Canada, June 08 – 12, 2003. (2) R. Amunugama and M. T. Rodgers, “Substituent effects on Cation-p Interactions Between Alkali Metal Ions and Substituted Benzenes by Threshold Collision-Induced Dissociation”, Poster presentation at the 49th ASMS Conference on Mass Spectrometry and Allied Topics, Chicago, IL, May 27 – 31, 2001. (3) R. Amunugama and M. T. Rodgers, “Substituent effects on Cation-p Interactions Between alkali Metal Ions and Substituted Benzenes”, Poster presentation at the 6th Winter Gordon Conference on Structures, Energetics and Dynamics of Gaseous Ions, Ventura, CA, February 25 – March 2, 2001. (4) R. Amunugama and M. T. Rodgers, “A Gas Phase Study of the Influence of substitute on strength of Cation-p Interactions Between Alkali Metal Ions and Substituted Benzenes”, Ion Chemistry and Mass Spectrometry Conference, Lake Arrowhead, CA, January 26-28, 2001. (5) R. Amunugama and M. T. Rodgers, “Absolute Alkali Metal Ion Binding Affinities of Several Azines Determined by Threshold Collision-Induced Dissociation”, Poster presentation at the 1st annual Wayne State University Chemistry Graduate Symposium, Detroit, MI, August 1999.
Honors and
Awards: Student Travel Fellowship, 6th Winter Gordon Research Conference on Gaseous Ions: Structures, Energetics & Reactions, Ventura, CA, 2001. David F. Boltz Graduate Award in Analytical Chemistry, Wayne State University, 2001. Departmental Citation for Excellence in Teaching, Wayne State University, 2001. University Scholarship, University of Peradeniya, 1992. Hayleys’ Scholarship Award, University of Peradeniya, 1991. Professional Affiliations: American Society
for Mass Spectrometry Canadian Society for Mass Spectrometry American Chemical Society References: Professor Scott A. McLuckey Professor Mary T. Rodgers Purdue University Wayne State University
Department of
Chemistry
Department of Chemistry West Lafayette,
IN
47907-1393
Detroit, MI 48202 Tel: (765) 494 5270 Tel: (313) 577 2431
Professor David B. Rorabacher Wayne State University Department of Chemistry Detroit,
MI 4820 Tel:
(313) 577
260
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