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 Dr. Ei-ichi
Negishi
Herbert
C. Brown Distinguished Professor ¡ª Organic and Organometallic Chemistry
Ei-ichi Negishi, H. C. Brown Distinguished Professor of
Chemistry, Purdue University, grew up in Japan and received
his Bachelor's degree from the University of Tokyo (1958). He then joined a chemical company, Teijin. In 1960 he came to the University of
Pennsylvania on a Fulbright- Smith-Mund All-Expense
Scholarship and obtained his Ph.D. degree (under Prof. A. R.
Day) in 1963. He returned to Teijin but
decided to pursue an academic career.
In 1966, he joined
Professor H. C. Brown's Laboratories at Purdue as a Postdoctoral Associate
and began investigating various C¡ªC bond forming reactions of organoboranes. He was appointed
Assistant to Professor Brown in 1968. It was during the following few years
that he began feeling the need for some catalytic ways of
promoting organoborane reactions.
Negishi went to
Syracuse University as Assistant Professor in 1972 and began his life-long
investigations of transition metal-catalyzed organometallic reactions
for organic synthesis. His initial and largely unsuccessful
attempts to develop a Cu-catalyzed conjugate addition or substitution
reaction of organoboranes soon led him to adopt a then novel strategy of
considering all 60 or so non-radioactive metals as components of both
stoichiometric reagents and catalysts. During the 1976-1978 period he
published about 10 papers describing the Pd- or Ni-catalyzed cross-coupling
reactions of various organometals including those of Mg, Zn, B, Al, Sn, and
Zr. Today, those involving Zn, Al, and Zr are called the Negishi
coupling. His success in developing the Pd- or Ni-catalyzed
alkenylzirconiums was the beginning of many series of his subsequent
investigations of organozirconium chemistry leading to the discoveries and
developments of the Zr-catalyzed alkyne carboalumination often called the Negishi
alkyne carboalumination (1978- ), the Zr-catalyzed asymmetric alkene
carboalumination (ZACA reaction) (1995- ), and the chemistry
of low-valent zirconocenes generated via "Bu2ZrCp2
and other dialkylzirconocenes widely known as the Negishi reagents
(1985- ).
Negishi
was promoted to Associate Professor at Syracuse University in 1976 and
invited hack to Purdue University as Full Professor in 1979. In 1999
he was appointed the inaugural H. C. Brown Distinguished Professor of
Chemistry. Various awards he has received include Guggenheim
Fellowship (1987), the 1996 A. R. Day Award, a 1996 Chemical Society of
Japan Award, the 1998 ACS Organometallic Chemistry Award, a Humboldt Senior
Researcher Award, Germany (1998 - 2001), the 2000 RSC Sir E. Frankland
Prize Lectureship, the 2007 Yamada-Koga Prize, Japan, and Gold Medal of
Charles University, Prague, Czech Republic (2007). At Purdue
University, he was the recipient of the 1998 McCoy Award and the 2003 Sigma
Xi Award. Negishi has published over 400
publications including two books, one of which is Handbook of
Organopalladium Chemistry for Organic Synthesis, 2 Vols., Negishi, E.,
Ed., Wiley-Interscience, New York, 2002, 3279 pp., and several
patents. Collectively, these publications have been cited well over
17,000 times. Negishi has been cited in Marquis Who's Who in American
and Marquis Who's Who in the World.
- Publication of approximately
375 research papers (cf. List of Publications), ca. 30 essays
and miscellaneous chemistry-related papers, several
patents, and 2 books including
Handbook
of Organopalladium Chemistry for Organic Synthesis, 2
Vols., Negishi, E., Ed., Wiley-Interscience, New York, 2002, 3279
pp.
¡¤
Research Accomplishments
See
attached descriptions.
¡¤
Some Notable Awards and Recognitionsa
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