---

Research interests can be grouped into three general categories including new developments in chemical instrumentation, kinetic aspects of analytical chemistry and problems related to clinical chemistry.

Areas of current interest include evaluation of imaging detectors such as charge injection devices (CID's) and charge coupled devices (CCD's) for analytical spectroscopy, novel data processing approaches for flow systems such as liquid chromatography, capillary zone electrophoresis and flow-injection systems, and novel measurement and data-processing methods applied to immunochemical systems, polymerase chain reactions used to amplify and detect DNA species and biosensors such as enzyme-based electrodes. Principal emphasis is on improvement of performance characteristics such as reduced dependencies on experimental variables. As an example, a novel data-processing approach has been used to reduced the dependency of liquid chromatographic results on injection volume by several hundred fold relative to peak-height and peak-area methods.

	Figure 1 New predictive steady-state approach to processing chromatographic data that is independent of variables such as sample volume, flow rate and capacity factors. (This figures shows that identical results are obtained for sample volumes between 25 and 45 uL.)
	Figure 2 Comparison of effects of sample volume on chromatographic results showing that the new predictive method (bottom plot) is more than 100-fold more rugged than peak-height (middle plot) and peak-area (top plot) methods.
	Figure 3 New approach to the design and use of enzyme-based biosensors. (The area under the response curve is proportional to the total amount of substrate that reacts and accordingly calibration plots are linear over very wide ranges and results are virtually independent of enzyme activity and variables that affect enzyme activity.)

---

[Pardue Group|| Chemistry Faculty|| Department of Chemistry|| Purdue University]
[Research Interests|| Publications|| Current Members|| Recent Graduates]