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Sheldon Williams BS, Bemidji State University, Minnesota. Home town: Bemidji, Minnesota.

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Sheldon is investigating novel approaches to the design and use of enzyme- based biosensors. His research is currently focused on designing improved instruments and data processing methods for electrochemical analysis with reactor/sensor systems. These approaches, which are designed to predict the absolute charge produced by the electrochemical reaction of the analyte, rather than simply measure transient signals, should decrease the dependence of such systems on enzyme activity and, hence, the variables which affect enzyme activity. In the reactor/sensor system, the sensor is a conventional working electrode material, such as glassy carbon, and the reactor is an enzyme and/or chemical which reacts with a biomolecule, concomitantly producing free electrons and transporting them to the electrode surface. The reactor Sheldon is using is a poly(1-vinylimidizole) (PV1) polymer containing covalently linked glucose oxidase which oxidizes glucose and an osmium complex which transports electrons from the enzyme to the electrode surface.