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Records 21 to 40 of 59

Authors Title Journal Year

Vol.

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Pages

Anderson J. L.;Frase, H.;Michaelis, S.;Hrycyna, C. A. Purification, functional reconstitution, and characterization of the Saccharomyces cerevisiae isoprenylcysteine carboxylmethyltransferase Ste14p Journal of Biological Chemistry 2005 280 - 7336-7345
Ejendal K. F. K.;Hrycyna, C. A. Differential sensitivities of the human ATP-binding cassette transporters ABCG2 and P-glycoprotein to cyclosporin A Molecular Pharmacology 2005 67 - 902-911
Henriksen B. S.;Anderson, J. L.;Hrycyna, C. A.;Gibbs, R. A. SAR studies of AFC-based icmt inhibitors. Abstracts of Papers of the American Chem 2004 227 - U28-U28
Anderson J. L.;Frase, H.;Laurence, J.;Michaelis, S.;Hrycyna, C. A. Molecular mechanisms of Ras isoprenylcysteine carboxyl methyltransferase (ICMT) Mol. Biol. Cell 2002 13 - 499A-499A
Ejendal K. F. K.;Hrycyna, C. A. Multidrug resistance and cancer: The role of the human ABC transporter ABCG2 Curr. Protein Pept. Sci. 2002 3 - 503-511
Honjo Y.;Hrycyna, C. A.;Yan, Q. W.;Medina-Perez, W. Y.;Robey, R. W.;van de Laar, A.;Litman, T.;Dean, M.;Bates, S. E. Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells Cancer Res. 2001 61 - 6635-6639
Hrycyna C. A. Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance Semin. Cell Dev. Biol. 2001 12 - 247-256
Tarasova N. I.;Amadei, G.;Seth, R.;Hrycyna, C.;Gottesman, M.;Michejda, C. New paradigm for the development of inhibitors of ABC transporters and other polytopic membrane proteins Clin. Cancer Res. 2001 7 - 3738S-3738S
Lamensdorf I.;Hrycyna, C.;He, L. P.;Nechushtan, A.;Tjurmina, O.;Harvey-White, J.;Eisenhofer, G.;Rojas, E.;Kopin, I. J. Acidic dopamine metabolites are actively extruded from PC12 cells by a novel sulfonylurea-sensitive transporter Naunyn-Schmiedebergs Arch. Pharmacol. 2000 361 - 654-664
Gribar J. J.;Ramachandra, M.;Hrycyna, C. A.;Dey, S.;Ambudkar, S. V. Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system J. Membr. Biol. 2000 173 - 203-214
Ambudkar S. V.;Dey, S.;Hrycyna, C. A.;Ramachandra, M.;Pastan, I.;Gottesman, M. M. Biochemical, cellular, and pharmacological aspects of the multidrug transporter Annu. Rev. Pharmacol. Toxicol. 1999 39 - 361-398
Hrycyna C. A.;Ramachandra, M.;Germann, U. A.;Cheng, P. W.;Pastan, I.;Gottesman, M. M. Both ATP sites of human P-glycoprotein are essential but not symmetric Biochemistry 1999 38 - 13887-13899
Hrycyna C. A.;Ramachandra, M.;Ambudkar, S. V.;Ko, Y. H.;Pedersen, P. L.;Pastan, I.;Gottesman, M. M. Mechanism of action of human P-glycoprotein ATPase activity - Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites J. Biol. Chem. 1998 273 - 16631-16634
Hrycyna C. A.;Gottesman, M. M. Multidrug ABC transporters from bacteria to man: an emerging hypothesis for the universality of molecular mechanism and function Drug Resist. Update 1998 1 - 81-83
Hrycyna C. A.;Ramachandra, M.;Pastan, I.;Gottesman, M. M. Functional expression of human P-glycoprotein from plasmids using vaccinia virus bacteriophage T7 RNA polymerase system
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1998 292 - 456-473
Hafkemeyer P.;Dey, S.;Ambudkar, S. V.;Hrycyna, C. A.;Pastan, I.;Gottesman, M. M. Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein Biochemistry 1998 37 - 16400-16409
Hrycyna C. A.;Airan, L. E.;Germann, U. A.;Ambudkar, S. V.;Pastan, I.;Gottesman, M. M. Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport Biochemistry 1998 37 - 13660-13673
Ramachandra M.;Ambudkar, S. V.;Chen, D.;Hrycyna, C. A.;Dey, S.;Gottesman, M. M.;Pastan, I. Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state Biochemistry 1998 37 - 5010-5019
Gottesman M. M.;Hrycyna, C. A.;Hafkemeyer, P.;Dey, S.;Zhou, Y.;Shoshani, T.;Pastan, I. Molecular dissection of the multidrug transporter Naunyn-Schmiedebergs Arch. Pharmacol. 1998 358 - R24-R24
Russ G.;Ramachandra, M.;Hrycyna, C. A.;Gottesman, M. M.;Pastan, I.;Bennink, J. R.;Yewdell, J. W. P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells Cancer Res. 1998 58 - 4688-4693