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Records 1 to 13 of 13

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Han, C.; Kim, E. H.; Colby, D. A. Cleavage of Carbon−Carbon Bonds through the Mild Release of Trifluoroacetate: Generation of alpha,alpha-Difluoroenolates for Aldol Reactions J. Am. Chem. Soc. 2011 133 5802-5805
Riofski, M. V.; John, J. P.; Zheng, M. M.; Kirshner, J.; Colby, D. A. Exploiting the Facile Release of Trifluoroacetate for the alpha-Methylenation of the Sterically Hindered Carbonyl Groups on (+)-Sclareolide and (–)-Eburnamonine J. Org. Chem. 2011 76 3676–3683
Gunn, E. J.; Williams, J. T.; Huynh, D. T.; Iannotti, M. J.; Han, C.; Barrios, F. J.; Kendall, S.; Glackins, C. A.; Colby, D. A.; Kirshner, J. Leuk. The Natural Products Parthenolide and Andrographolide Exhibit Anticancer Stem Cell Activity in Multiple Myeloma Lymphoma 2011 52 1085–1097
Woods, J. R.; Mo, H.; Bieberich, A. A.; Alavanja, T.; Colby, D. A. Fluorinated Amino-Derivatives of the Sesquiterpene Lactone, Parthenolide, as 19F NMR Probes in Deuterium-Free Environments J. Med. Chem. 2011 54 7934–7941
John, J. P.; Colby, D. A. Synthesis of alpha-Halo-alpha,alpha-Difluoromethyl Ketones by a Trifluoroacetate Release/Halogenation Protocol J. Org. Chem. 2011 76 9163–9168
Mo., H.; Balko, K. M.; Colby, D. A. A Practical No-Deuterium NMR Method for the Rapid Determination of 1-Octanol/Water Partition Coefficients of Pharmaceutical Agents Bioorg. Med. Chem. Lett. 2010 20 6712–6715
Barrios, F. J.; Zhang, X.; Colby, D. A. Dialkylaluminum N,O-Dimethylhydroxylamine Complex as a Reagent to Mask Reactive Carbonyl Groups in situ from Nucleophiles Org. Lett. 2010 12 5588-5591
Ishikawa, H.; Colby, D. A.; Seto, S.; Va, P.; Tam, A.; Kakei, H.; Rayl, T. J.; Hwang, I.; Boger, D. L. Total Synthesis of Vinblastine, Vincristine, Related Natural Products, and Key Structural Analogues J. Am. Chem. Soc. 2009 131 4904-4916
Han, C.; Barrios, F. J.; Riofski, M. V.; Colby, D. A. Semisynthetic Derivatives of Sesquiterpene Lactones by Palladium-Catalyzed Arylation of the alpha-Methylene-gamma-lactone Substructure. J. Org. Chem. 2009 74 7176-7179
Ishikawa, H.; Colby, D. A.; Boger, D. L. Direct Coupling of Catharanthine and Vindoline to Provide Vinblastine: Total Synthesis of (+)- and ent-(-)- Vinblastine J. Am. Chem. Soc. 2008 130 420-421
Lawhorn, B. G.; Boga, S. B.; Wolkenberg, S. E.; Colby, D. A.; Guass, C. -M.; Swingle, M. R.; Amable, L.; Honkanen, R. E.; Boger, D. L. Total Synthesis and Evaluation of Cytostatin, its C10-C11 Diastereomers, and Additional Key Analogues: Impact on PP2A Inhibition J. Am. Chem. Soc. 2006 128 16720-16732
Colby, D. A.; Liu, W.; Sheppeck, J. E.; Huang, H.-B.; Nairn, A. C.; Chamberlin A. R. A New Model of the Tautomycin-PP1 Complex That Is Not Analogous to the Corresponding Okadaic Acid Structure Bioorg. Med. Chem. Lett. 2003 13 1601-1605
Liu, W.; Sheppeck, J. E.; Colby, D. A.; Huang, H.-B.; Nairn, A. C.; Chamberlin A. R. The Selective Inhibition of Phosphatases by Natural Toxins: the Anhydride Domain of Tautomycin is Not a Primary Factor in Controlling PP1/PP2A Selectivity Bioorg. Med. Chem. Lett. 2003 13 1597-1600