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Ji-Xin Cheng
Associate Professor—Analytical and Physical Chemistry(Courtesy)
Email: jcheng@purdue.edu
Phone: 765-494-4335
Office: MJIS 2035
For Professor Cheng's individual Home Page click here.
Cheng and his group develop state-of-the-art optical imaging techniques and bionanotechnology to tackle compelling biomedical problems highly related to human health. Current research projects are:
1. New advances of nonlinear optical (NLO) microscopy.
NLO microscopy opens up a new window to watch the biological world with chemical selectivity and inherent 3D resolution. Our group develops (i) multimodality NLO microscopy that integrates coherent anti-Stokes Raman scattering (CARS), two-photon-excited fluorescence, and sum-frequency generation on the same platform; (ii) Intravital flow detection of tumor cells and nanoparticles; (iii) in vivo NLO imaging of small animals; (iv) CARS endoscopy for label-free diagnosis of cancer and cardiovascular diseases.
2. Biomedical and biophysical applications of NLO microscopy
We have demonstrated several successful applications through collaborations, including (i) demyelination in multiple sclerosis and spinal cord injury; (ii) molecular level understanding of obesity on cancer development; (iii) Label-free imaging of drug molecules; (iv) Multimodality NLO imaging of atherosclerotic plaques; (v) Probing molecular compositions of lipid domains.
3. Bionanotechnaology
Nanostructures often exhibit unique features that bulk materials do not possess. We identify those unique properties for better treatment of diseases. Two directions include (i) Gold nanorods for two-photon luminescence imaging and opto-thermal therapy; (ii) Polymeric micelles for membrane sealing in injured spinal cord. We also study the mechanisms involved in cell entry of drug delivery ligands and vehicles to develop highly efficient drug carriers.
Education
B.S., 1994, Department of Chemical Physics, University of Science and Technology of China; Ph. D., 1998, University of Science and Technology of China.Selected Publications
- Jung Y.;Tong, L.;Tanaudommongkon, A.;Cheng, J. X.;Yang, C., In Vitro and In Vivo Nonlinear Optical Imaging of Silicon Nanowires . Nano Letters 2009 , 9 , 2440-2444.
- Wang H. W.;Fu, Y.;Huff, T. B.;Le, T. T.;Wang, H. F.;Cheng, J. X., Chasing lipids in health and diseases by coherent anti-Stokes Raman scattering microscopy . Vibrational Spectroscopy 2009 , 50 , 160-167.
- Slipchenko M. N.;Le, T. T.;Chen, H. T.;Cheng, J. X., High-Speed Vibrational Imaging and Spectral Analysis of Lipid Bodies by Compound Raman Microscopy . Journal of Physical Chemistry B 2009 , 113 , 7681-7686.
- Zhu J. B.;Lee, B. G.;Buhman, K. K.;Cheng, J. X., A dynamic, cytoplasmic triacylglycerol pool in enterocytes revealed by ex vivo and in vivo coherent anti-Stokes Raman scattering imaging . Journal of Lipid Research 2009 , 50 , 1080-1089.