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Scott A. McLuckey
John A. Leighty Distinguished Professor—Analytical Chemistry
Email: mcluckey@purdue.edu
Phone: 765-494-5270
Office: BRWN B147A
For Professor McLuckey's individual Home Page click here.
Research in this laboratory is devoted to understanding the chemistry of gaseous macro-ions. These ions are typically derived via electrospray of proteins, oligonucleotides, synthetic polymers, and clusters. The major tools for studying the ions are various forms of mass spectrometry with particular emphasis on the quadrupole ion trap mass spectrometer. The goals are to understand the underlying phenomena that direct the dissociation of high mass ions and the reactions of these ions with neutral molecules and with ions of opposite charge. 
In realizing these goals, new approaches to the analysis of macro-molecules are enabled. A significant degree of effort is, therefore, also expended towards the exploitation of gaseous macro-ion chemistry in chemical analysis. This effort involves both the development of novel experimental procedures as well as the construction of novel instrumentation. Current areas of interest are the rapid identification of proteins in complex mixtures, sequencing DNA, and structural analysis of dendritic polymers.
Education
B.S. Westminster College, 1978; Ph.D. Purdue University, 1982.Recognitions
- Anachem Award presented by the National Federation of Analytical Chemistry and Spectroscopy , 2008
- Herbert Newby McCoy Award, 2008
- ACS Division of Analytical Chemistry Award in Chemical Instrumentation, 2007
- Curt Brunnee Research Award, International Mass Spectrometry Society, 2000
- Lockheed-Martin NOVA Award, 1999
- Oak Ridge National Laboratory Scientist of the Year, 1999
- Biemann Medal, American Society for Mass Spectrometry, 1997
- Research Staff, Oak Ridge National Laboratory, 1984-1999
- Wigner Fellow, Oak Ridge National Laboratory, 1983-1985
- Visiting Scientist - FOM Institute for Atomic and Molecular Physics, Amsterdam, 1983
Selected Publications
- Chanthamontri C.;Liu, J.;McLuckey, S. A., Charge state dependent fragmentation of gaseous alpha-synuclein cations via ion trap and beam-type collisional activation . International Journal of Mass Spectromet 2009 , 283 , 9-16.
- Han H. L.;Londry, F. A.;Erickson, D. E.;McLuckey, S. A., Tailored-waveform collisional activation of peptide ion electron transfer survivor ions in cation transmission mode ion/ion reaction experiments . Analyst 2009 , 134 , 681-689.
- Liu J.;Huang, T. Y.;McLuckey, S. A., Simultaneous Transmission Mode Collision-Induced Dissociation and Ion/Ion Reactions for Top-Down Protein Identification/Characterization Using a Quadrupole/Time-of-Flight Tandem Mass Spectrometer . Analytical Chemistry 2009 , 81 , 2159-2167.