NMR is used to study molecules in solution and in the solid state. At Purdue, primary uses of NMR are in the support of these fields which are critical to drug discovery, energy research, nutrition and diagnostics:

• Synthetic chemistry
• Organic and natural products solution-state structure
• Protein and peptide structure and dynamics
• Metabolomics

Recent Publications

"Total Synthesis of (-)-Platensimycin, a Novel Antibacterial Agent," A. K. Ghosh and Kai Xi, J. Org. Chem. 2009, 74, 1163-1170.

"Visualization of Bile Homeostasis using 1H NMR Spectroscopy as a Route for Assessing Liver Diseases ," G. A. N. Gowda, N. Shanaiah, A. Cooper, M. Maluccio, and D. Raftery, Lipids 2009, 44, 27-35.

"Protein Side-Chain Dynamics As Observed by Solution- and Solid-State NMR Spectroscopy: A Similarity Revealed," Vipin Agarwal, Yi Xue, Bernd Reif and Nikolai R. Skrynnikov J. Am. Chem. Soc., 2008, 130 (49), pp 16611–16621

"Lateral Diffusion Coefficients of an Eicosanyl-Based Bisglycerophosphocholine Determined by PFG-NMR and FRAP," Wilma Febo-Ayala, David P. Holland, Scott A. Bradley, and David H. Thompson, Langmuir, 2007, 23 (11), pp 6276–6280

"Mechanistic Insight into Hydrosilylation Reactions Catalyzed by High Valent ReX (X = O, NAr, or N) Complexes:  The Silane (Si-H) Does Not Add across the Metal−Ligand Multiple Bond," Guodong Du, Phillip E. Fanwick, and Mahdi M. Abu-Omar, J. Am. Chem. Soc., 2007, 129 (16), pp 5180–5187

"Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling," Yajie Zhang, Hyunju Oh, Robert A. Burton, John W. Burgner, Robert L. Geahlen, and Carol Beth Post, PNAS, 2008 105:11760-11765

Staff

Instrumentation

Purdue Interdepartmental NMR Facility (PINMRF)