Chang KH, Vincent F, Shah K. (2012) Deregulated Cdk5 Triggers Aberrant Activation of Cell Cycle Kinases and Phosphatases Inducing Neuronal Death. J Cell Science (In Press).
Johnson EO, Chang KH, Ghosh S, Venkatesh C, Giger K, Low PS, Shah K. (2012) LIMK2 is a Crucial Regulator and Effector of Aurora A-Mediated Malignancy. J Cell Science 125 (Pt 5), 1204-16.
Kumar D, Kumar NM, Ghosh S, Shah K. (2012) Novel bis(indolyl)hydrazide-hydrazones as potent anticancer agents. Bioorg Med Chem Lett. 22(1), 212-5.
Kumar D, Kumar NM, Noel B, Shah K. (2012) A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles as potent cytotoxic agents. Eur J Med Chem. (In press).
Johnson EO, Chang KH, de Pablo Y, Ghosh S, Mehta R, Badve S, Shah K. (2011) PHLDA1 is a Crucial Negative Regulator and Effector of Aurora A Kinase in Breast Cancer. J Cell Science 124, 2711-2722.
Sun KH, Chang KH, Clawson S, Ghosh, S, Mirzaei H, Regnier, F, Shah K. (2011) Glutathione S-transferase P1 is a Critical Regulator of Cdk5 Kinase Activity. J Neurochem 118(5), 902-14.
Chang KH, Multani PS, Sun KH, Vincent F, de Pablo Y, Ghosh S, Gupta R, Lee HP, Lee HG, Smith MA, Shah K. (2011) Nuclear Envelope Dispersion Triggered by Deregulated Cdk5 Precedes Neuronal Death. Mol Biol Cell 22(9), 1452-62.
Kumar D, Patel G, Chavers A, Chang KH, Shah K. (2011) Synthesis of novel 1,2,4-oxadiazoles and analogues as potential anticancer agents. European Journal of Medicinal Chemistry 46(7), 3085-92.
Kumar D, Vadulla BR, Chang KH, Shah K. (2011) One-pot synthesis and anticancer studies of 2-arylamino-5-aryl-1,3,4-thiadiazoles. Bioorg Med Chem Lett 21(8), 2320-3.
Kumar D, Kumar NM, Chang KH, Shah K. (2011) Synthesis of Novel Indolyl-1,2,4-triazoles as Potent and Selective Anticancer Agents. Chem Biol Drug Design 77, 182-8.
Kumar D, Maruthi Kumar N, Chang KH, Shah K. (2010) Synthesis and anticancer activity of 5-(3-indolyl)-1,3,4-thiadiazoles. Eur J Med Chem. 45(10):4664-8.
Chang KH, Pablo Y, Lee H, Lee H, Smith M, Shah K. (2010) Cdk5 is a Major Regulator of p38 Cascade: Relevance to Neurotoxicity in Alzheimer’s Disease. J Neurochem 113(5):1221-9.
Kumar D, Kumar M, Sundaree S, Johnson E, Shah K. (2010) An expeditious synthesis and anticancer activity of novel 4-(3'-indolyl)oxazoles. Eur J Med Chem 45(3):1244-9.
Sun KH, Lee HG, Smith MA, Shah, K. (2009) Direct and Indirect Roles of Cdk5 as an Upstream Regulator in the JNK Cascade: Relevance to Neurotoxic Insults in Alzheimer’s Disease. Mol Biol Cell 20(21):4611-9.
Das M, Wiley DJ, Chen X, Shah K, Verde F. (2009) The conserved NDR kinase Orb6 controls polarized cell growth by spatial regulation of the small GTPase Cdc42. Current Biology 19, 1314-9.
Kumar D, Sundaree S, Johnson, E, Shah, K. (2009) An efficient synthesis and biological study of novel indolyl-1,3,4-oxadiazoles as potent anticancer agents. Bioorg Med Chem Lett. 19(15), 4492-4.
Kumar D, Patel G, Johnson, E, Shah, K. (2009) Synthesis and anticancer activities of novel 3,5-disubstituted-1,2,4-oxadiazoles. Bioorg Med Chem Lett, 19(10), 2739-41.
Sun KH, de Pablo Y, Vincent F, Shah K. (2008) Deregulated Cdk5 Promotes Oxidative Stress and Mitochondrial Dysfunction. J Neurochem. 107: 265-278.
Sun KH, de Pablo Y, Vincent F, Johnson EO, Chavers AK, Shah K. (2008) Novel Genetic Tools Reveal Cdk5's Major Role in Golgi Fragmentation in Alzheimer's Disease. Mol Biol Cell. 19(7):3052-69.
Vincent F, Cook S, Johnson EO, Emmert D, Shah K. (2007) Engineering Unnatural Nucleotide Specificity to Probe G protein Signaling. Chem Biol. 14(9), 1007-18. (Research Highlights: Stevens K. (2007) “Designer Modulators” Nature Methods 4(12): 988; Review: Erickson JW, Cerione RA.(2008) “A new tool for G protein analysis” ACS Chem Biol. 3(1):24-6.)
Oh H, Ozkirimli E, Shah K, Harrison ML, Geahlen RL (2007) Generation of an analog-sensitive Syk Tyrosine Kinase for Studying Signaling Dynamics from the B Cell Antigen Receptor. J Biol Chem 282, 33760-8.
Kim S & Shah K (2007) Dissecting Yeast HOG1 MAP Kinase Pathway Using a Chemical Genetic Approach. FEBS Lett. 581(6):1209-16.
Schauble S, King CC, Darshi M, Koller A, Shah K, Taylor SS (2007) Identification of ChChd3 as a novel substrate of PKA using an analog-sensitive catalytic subunit. J Biol Chem. 282(20):14952-9.
Endo S, Satoh Y, Shah K, Takishima K. (2006) A single amino-acid change in ERK1/2 makes the enzyme susceptible to PP1 derivatives. Biochem Biophys Res Commun. 341(1):261-5.
Juris SJ, Shah K, Shokat K, Dixon JE, Vacratsis PO (2006) Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry. FEBS Lett. 580(1):179-83.
Shah K., Vincent F. (2005) Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblasts. Mol Biol Cell. (11):5418-32.
Stauffer EA, Scarborough JD, Hirono M, Miller ED, Shah K, Mercer JA, Holt JR, Gillespie PG. (2005) Fast adaptation in vestibular hair cells requires myosin-1c activity. Neuron 47(4):541-53.
Shah K. (2005) Orthogonal Chemical Genetic Approaches for Unraveling Signaling Pathways. IUBMB Life 57(6):397-405.
Woodring PJ, Meisenhelder J, Johnson SA, Zhou GL, Field J, Shah K, Bladt F, Pawson T, Niki M, Pandolfi PP, Wang JYJ, Hunter T. (2004) c-Abl phosphorylates Dok-1 during filopodia formation. J Cell Biol 165(4):493-503.
Provance DW Jr, Gourley CR, Silan CM, Cameron LC, Shokat KM, Goldenring JR, Shah K, Gillespie PG, Mercer JA. (2004) Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic. Proc Natl Acad Sci U S A. 101(7):1868-73.
Hindley AD, Park S, Wang L, Shah K, Wang Y, Hu X, Shokat KM, Kolch W, Sedivy JM, Yeung KC. (2004) Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N(6) position FEBS Lett. 556(1-3):26-34.
Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow J, Shah K, Shokat KM, Morgan DO. (2003) Targets of cyclin-dependent kinase Cdk1 Nature 425: 859-64.
Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ. (2003) Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. J Biol Chem 278(17): 14926-35.
Shah K, Shokat KM. (2003) A Chemical Genetic Approach for the identification of direct substrates identification of protein kinases Protein Kinase C Protocols (Methods in Molecular Biology, edited by A.C. Newton, Humana Press, Totowa, NJ) 233:253-71.
Shah K, Shokat KM. (2002) A Chemical Genetic Screen for Direct v-Src substrates reveals Ordered Assembly of a Retrograde Signaling Pathway. Chemistry & Biology 9(1): 35-47.
Holt JR, Gillespie SKH, Provance Jr. W, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PG (2002) A Chemical-Genetic Strategy Demonstrates Myosin1c Mediates Adaptation by Hair Cells Cell 108(3):371-381.
Witucki LA , Huang X, Shah K, Liu L, Kyin S, Eck MJ, Shokat KM. (2002) Mutant Tyrosine Kinases with Unnatural Nucleotide Specificity Retain the Structure and Phospho-acceptor Specificity of the Wild-Type Enzyme Chemistry & Biology 9(1): 25-33.
Ting AY, Witte K, Shah K, Kraybill B, Shokat KM, Schultz PG. (2001) Phage Display Evolution of tyrosine kinases with altered nucleotide specificity. Biopolymers; 60(3): 220-8.
Wang Z, Shah K, Rana TM (2001) Probing Tat peptide-TAR RNA interactions by psoralen photo-cross-linking. Biochemistry 40(21): 6458-64.
Habelhah H, Shah K, Huang L, Burlingame AL, Shokat KM, Ronai Z. (2001) Identification of a new JNK substrate using ATP pocket mutant ADK and Corresponding ATP analogue. J Biol Chem. 276(21): 18090-5.
Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, Hentze MW, Ronai Z. (2001) ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition on mRNA translation. Nature Cell Biology 3: 325-330.
Liu Y, Witucki L, Shah K, Bishop AC, Shokat KM. (2000) Src-Abl Tyrosine Kinase Chimeras: Replacement of the Adenine Binding Pocket of c-Abl with v-Src to Swap Nucleotide and Inhibitor Specificities Biochemistry 39(47): 14400-8.
Ulrich S, Buzko O, Shah K, and Shokat KM (2000) Engineering a conditionally Orthogonal Protein Kinase/Nucleotide Triphosphate Pair. Tetrahedron 56: 9495-9502.
Bishop A, Buzko O, Heyeck-Dumas S, Jung I, Kraybill B, Liu Y, Shah K, Ulrich S, Witucki L, Yang F, Zhang C, and Shokat KM (2000) Unnatural Ligands For Engineered Proteins: New Tools for Chemical Genetics. Annu. Rev. Biophys. Biomolec. Struct. 29: 577-606.
Gillespie PG, Gillespie SKH, Mercer JA, Shah K, Shokat KM (1999) Engineering of the myosin-Ib nucleotide-binding pocket to create sensitivity to N6-modified ADP analogs. J. Biol. Chem., 274(44): 31373-31381.
Bishop AC, Kung C-Y, Shah K, Witucki L, Shokat KM, Liu Y. (1999) "Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J. Am. Chem. Soc., 121(4): 627-631.
Liu Y, Shah K, Yang F, Witucki L, & Shokat KM (1998) A Molecular Gate Which Controls Unnatural ATP Analog Recognition by the Tyrosine Kinase v-Src. Bioorganic & Medicinal Chemistry 6(8): 1219-25.
Liu Y, Shah K, Yang F, Witucki L, Shokat KM (1997) Engineering Src Family Protein Kinases with Unnatural Nucleotide Specificity. Chemistry & Biology 5(2): 91-102.
Bishop AC, Shah K, Liu Y, Witucki L, Kung C-Y, Shokat KM. (1997) Design of allele specific inhibitors to probe protein kinase signaling. Current Biology 8, 257-266.