Tammy Munsch
Email: tmunsch@purdue.edu
Office: BRWN B125B
Office Phone: 765-494-7359
Lab: BRWN B125B Lab Phone: 765-494-7359
Education:
Ph.D. Student,
B.S. in Chemistry,
Awards:
Bilsland Dissertation Fellowship 2005-2006
Herbert C. Brown Organic Research Award 2005
ACS Division of Organic Chemistry Graduate Fellowship 2004-2005
Robert R. Squires Scholar 2003-2004
NSF-Research Experience for Undergraduates, University of Nebraska-Lincoln 2000
Phi Lambda Upsilon (PLU) Travis Miller Senior Award 2001
PLU Junior Award 2000
Current Research
Flowing
Afterglow Studies of Triradicals and Nitrene Radicals
Mass spectrometry can be used to study the
structure, energetics, and reactivity of reactive intermediates, such as biradicals
and triradicals. My research has focused on the reactivity and
thermochemistry of organic triradicals, as well as reactivity studies of
distonic diradical anions using flowing afterglow-triple quadrupole mass
spectrometry. More specifically, I have
determined the thermochemical properties of 5-dehydro-1,3-quinodimethane (DMX), 3 an
organic triradical with an “open-shell” doublet ground state. Although
low-spin, open-shell states can occur in molecules containing transition
metals, the ground states of organic molecules are rarely of this type.
Organic biradicals can have open-shell singlet ground states, depending on the
orbital structure, but DMX is the first example of an organic triradical
with an open-shell doublet ground state.
In addition, I characterized the electronic structure of its corresponding
biradical anion (DMX-)2 by using chemical reactivity studies.
Currently, I am investigating the
thermochemical properties of the dehydrophenylnitrenes. Calculations carried out by Bettinger and
Sander (JACS, 2003, 125, 9726) predict quartet ground states for the o-
and p-dehydrophenylnitrenes, whereas m-dehydrophenylnitrene is
predicted to have a doublet ground state.
In this project, we are working to develop an approach to experimentally
assess the electronic ground states of these triradicals.
Publications
1) Munsch, Tamara E.; Wenthold, Paul G.; "Organic Gas-Phase Ion Chemistry" Annu. Rep. Prog. Chem., Sect. B, 2004, 100, 377-405.
2) Munsch, Tamara E.; Slipchenko, Lyudmila V.; Krylov, Anna I.; Wenthold, Paul G. "Reactivity and Structure of the 5-Dehydro-m-xylylene Anion" J. Org. Chem. 2004, 69, 5735-5741.
3) Slipchenko, Lyudmila V.; Munsch, Tamara E.; Wenthold, Paul G.; Krylov, Anna I. "5-Dehydro-1,3-quinodimethane: A Hydrocarbon with an Open Shell Doublet State" Angew. Chem. Int. Ed. Eng., 2004, 43, 742-745.
4) Munsch, Tamara E.; Wenthold, Paul G. "Organic Gas-Phase Ion Chemistry" Annu. Rep. Prog. Chem., Sect. B, 2003, (99), 420-446.
5) Warmuth, R.; Munsch, T. E.; Stalker, R. A.; Li B.; Beatty, A. "Enantioselective synthesis of benzocyclic a,a-dialkyl-amino acids: new insight into the solvent dependent stereoselectivity of TMSCN addition to phenylglycinol derived imines" Tetrahedron, 2001, 57, 6383-6397.
6) Stalker, R. A.; Munsch, T. E.; Tran, J. D.; Nie, X.; Warmuth, R.; Beatty, A.; Aakeröy, C. B. "Asymmetric Synthesis of two new Conformationally Constrained Lysine Derivatives" Tetrahedron, 2002, 58, 4837-4849.