Welcome to Xia Research Group

Book Chapters:

Scott A. Smith, Ruth Waddell Smith, Yu Xia, and Zheng Ouyang, “Chapter 1: An Introduction to Mass Spectrometry” in “Characterization of impurities and degradiants using mass spectrometry” edited by G. Cheng, John Wiley and Sons

Column Article:

Arnaud, C.H., 2016, "Pinpointing Double Bonds in Lipids", C&EN, 94(9), 11. Link to Article

Genetic Engineering and Biotechnology, 2016, "Lipidomics uses light touch to distinguish unsaturated isomers", Clinical Omics. Link to Article

Venere, E., 2016, New 'lipidomics' method could bring faster cancer diagnosis. Purdue University News. Link to Article

Yu Xia, Xiaoxiao Ma and Kate Yu, “Radical mass spectrometry as a new frontier for bio-analysis”, MS- the practical art, LC GC Europe 2014, 27 (7), 369-374.

Peer-reviewed Publications:

58. Xiaoxiao Ma, Xu Zhao, Junjie Li, Wenpeng Zhang, Ji-Xin Cheng, Zheng Ouyang*, and Yu Xia*, "Photochemical tagging for rapid quantitation of unsaturated fatty acids by mass spectrometry", Anal. Chem., 2016, accepted.

57. Ziqing Lin, Lei Tan, Yang Yang, Mingji Dai, František Tureček*, Zheng Ouyang*, and Yu Xia*, "Gas-Phase Reactions of Cyclopropenylidene with Protonated Alkyl Amines", Analyst, 2016, 141, 2412-2417. DOI: 10.1039/C6AN00235H

56. Y. Melodie Du, Ye Hu, Yu Xia, and Zheng Ouyang*, "Power Normalization for Mass Spectrometry Data Analysis and Analytical Method Assessment", Anal. Chem., 2016, 88, 3156-3163. DOI:10.1021/acs.analchem.5b04418

55. Xiaoxiao Ma, Leelyn Chong, Ran Tian, Riyi Shi, Tony Y. Hu, Zheng Ouyang*, and Yu Xia*, “Identification and quantitation of lipid C=C location isomers: a shotgun lipidomics approach enabled by photochemical reaction”, PNAS, 2016, 113(10), 2573-2578. DOI:10.1073/pnas.1523356113

54. Craig A. Stinson and Yu Xia*, “Method of coupling Paternò-Büchi reaction with direct infusion ESI-MS/MS for locating C=C bond in glycerophospholipids", Analyst, 2016, 141, 3696-3704. DOI: 10.1039/C6AN00015K

53. Chasity B. Love-Nkansah, Lei Tan, Joseph S. Francisco*, and Yu Xia*, "Gas-Phase Unimolecular Dissociation Reveals Dominant Base Property of Protonated Homocysteine Sulfinyl Radical Ions", Chem.-Eur. J., 2016, 22, 934-940. Featured as Inner Cover. DOI: 10.1002/chem.201502642

52. I.K. Chu, C. Siu, J. K. Lau, W. K. Tang, X. Mu, C. K. Lai, X. Guo, X. Wang, N. Li, Y. Xia, X. Kong, H. B. Oh, V. Ryzhov, F. Tureček, A.C. Hopkinson, K.W.M. Siu*, “Proposed nomenclature for peptide ion fragmentation”, Int. J. Mass Spectrom., 2015, 390, 24-27

51. Kirt L. Durand, Xiaoxiao Ma and Yu Xia, "Intra-molecular Reactions between Cysteine Sulfinyl Radical and a Disulfide Bond within Peptide Ions", Int. J. Mass Spectrom., 2015, 378, 246-254, DOI:10.1016/j.ijms.2014.08.027

50. Lei Tan, František Tureček, Joseph S. Francisco*, and Yu Xia*, "Probing the Radical and Base Dual Properties of Peptide Sulfinyl Radicals via Mass Spectrometry" , J. Phys. Chem. A, 2014, 118 (50), pp 11828–11835. DOI:10.1021/jp510362p

49. Craig A. Stinson and Yu Xia, “Reactions of Hydroxyalkyl Radicals with Cysteinyl Peptides in a NanoESI Plume”J. Am. Soc. Mass Spectrom.,2014, 25, 1192-1201. DOI:10.1007/s13361-014-0898-8

48. Chiharu Konda, Frank Londry, Brad Bendiak, and Yu Xia, "Assignment of the Stereochemistry and Anomeric Configuration of Sugars within Oligosaccharides via Overlapping Disaccharide Ladders using MSn ", J. Am. Soc. Mass Spectrom., 2014, 25, 1441-1450 DOI: 10.1007/s13361-014-0881-4

47. Xiaoxiao Ma and Yu Xia, “Pinpointing Double Bonds in Lipids by Paternò–Büchi Reactions and Mass Spectrometry”, Angew. Chem., Int. Ed, 2014, 53, 2592–2596 .DOI:10.1002/anie.201310699

46. Kirt L. Durand, Xiaoxiao Ma, and Yu Xia, "Intra-molecular Reactions as a New Approach to Investigate Bio-Radical Reactivity: A Case Study of Cysteine Sulfinyl Radical", Analyst, 2014, 139, 1327-1330, DOI:10.1039/C3AN02307A A

45. Lei Tan, Hanfeng Hu, Joseph S. Francisco*, and Yu Xia*, “A Mass Spectrometric Approach for Probing the Stability of Bioorganic Radicals", Angew. Chem., Int. Ed., 2014, 53, 1887-1890 “featured as front cover of issue 7, Feb 10, 2014” DOI:10.1002/anie.201310480

44. Chiharu Konda, Brad Bendiak, and Yu Xia, "Linkage Determination of Linear Oligosaccharides by MSn (n>2) Collision-Induced Dissociation of Z1 Ions in the Negative Ion Mode", J. Am. Soc. Mass Spectrom., 2014, 25, 248-257 DOI: 10.1007/s13361-013-0769-8

43. Ziqing Lin, Lei Tan, Sadilya Garimella, Linfan Li, Tsung-Chi Chen, Wei Xu, Yu Xia*, and Zheng Ouyang*, "Characterization of a DAPI-RIT-DAPI System for Gas-Phase Ion/Molecule and Ion/Ion Reactions", J. Am. Soc. Mass Spectrom., 2014, 25, 48-56 DOI: 1 0.1007/s13361-013-0757-z

42. Lei Tan, Kirt L. Durand, Xiaoxiao Ma, and Yu Xia, "Radical Cascades in Electron Transfer Dissociation (ETD) - Implications for Characterizing Peptide Disulfide Regio-Isomers", Analyst, 2013, 138, 6759-6765, DOI: 10.1039/C3AN01333B

41. Kirt L. Durand, Xiaoxiao Ma, Chelsea E. Plummer, and Yu Xia, "Tandem Mass Spectrometry (MSn) of Peptide Disulfide Regio-Isomers via Collision-Induced Dissociation: Utility and Limits in Disulfide Bond Characterization", Int. J. Mass Spectrom., 2013, 343-344, 50-57, DOI: 10.1016/j.ijms.2013.04.005

40. Craig A. Stinson and Yu Xia, “Radical Induced Disulfide Bond Cleavage within Peptides via Ultraviolet Irradiation of an Electrospray Plume”, Analyst, 2013, 138(10), 2840-2846, DOI: 10.1039/C3AN00303E

39. Chasity B. Love, Lei Tan, Joseph S. Francisco*, and Yu Xia*, “Competition of Charge- vs. Radical-Directed Fragmentation of Gas-Phase Protonated Cysteine Sulfinyl Radicals”, J. Am. Chem. Soc., 2013, 135, 6226-6233, DOI: 10.1021/ja4008744

38. Lei Tan and Yu Xia, "Gas-Phase Reactivity of Peptide Thiyl, Perthiyl, and Sulfinyl Radical Ions Formed from Atmospheric Pressure Ion/Radical Reactions", J. Am. Soc. Mass Spectrom., 2013, 24, 534-542, DOI: 10.1007/s13361-012-0548-y

37. Lei Tan and Yu Xia, "Gas-Phase Peptide Sulfinyl Radical Ions: Formation and Unimolecular Dissociation", J. Am. Soc. Mass Spectrom., 2012, 23, 2011-2019, DOI: 10.1007/s13361-012-0465-0

36. Chiharu Konda, Brad Bendiak, and Yu Xia, " Differentiation of the Stereochemistry and Anomeric Configuration for 1-3 Linked Disaccharides Via Tandem Mass Spectrometry and ¹⁸O-labeling", J. Am. Soc. Mass Spectrom., 2012, 23, 347-358, DOI: 10.1007/s13361-011-0287-5

35. Scott R. Cole, Xiaoxiao Ma, Xinrong Zhang, and Yu Xia, "Electron Transfer Dissociation (ETD) of Peptides Containing Intramolecular Disulfide Bonds", J. Am. Soc. Mass Spectrom., 2012, 23, 310-320, DOI: 10.1007/s13361-011-0300-z

34. Xiaoxiao Ma, Chasity B. Love, Xinrong Zhang, and Yu Xia, " Gas-Phase Fragmentation of [M + nH + OH]n•+ Ions Formed from Peptides Containing Intra-Molecular Disulfide Bonds", J. Am. Soc. Mass Spectrom., 2011, 22, 922-930, DOI: 10.1007/s13361-011-0104-1

33. W. Xu, N. Charipa, M. A. Kirleis, Y. Xia, and Z. Ouyang, "Study of Discontinuous Atmospheric Pressure Interfaces for Mass Spectrometry Instrumentation Developmenton", Anal. Chem., 2010, 82, 6584-6592, DOI: 10.1021/ac101002t

32. H. Wang, Z. Ouyang, Y. Xia, "Peptide Fragmentation during NanoElectrospray Ionization", Anal. Chem., 2010, 82, 6534-6541, DOI: 10.1021/ac100872x

Previous Publications:

31. I. Zhang, N. Talaty, A.B. Costa, Y. Xia, W. A. Tao, R. Bell, J.H. Callahan, R.G. Cooks “ Rapid direct lipid profiling of bacteria using desorption electrospray ionization mass spectrometry”, Int. J. Mass Spectrom., 2011, 301, 37-44.DOI:10.1016/j.ijms.2010.06.014

30. Y. Xia, R. G. Cooks, “Plasma Induced Oxidative Cleavage of Disulfide Bonds in Polypeptides during NanoElectrospray Ionization”, Anal. Chem., 2010, 82, 2 856-2864, DOI 10.1021/ac9028328

29. N. Na, Y. Xia, Z. Zhu, X. Zhang , R. G. Cooks, "Birch Reduction of Benzene in a Low-Temperature Plasma", Angew. Chem., Int. Ed., 2009, 48, 2017-2019, DOI 10.1002/anie.200805256

28. S. Kothari, Q. Song, Y. Xia, M. Fico, D. Taylor, J. W. Amy, G. Stafford, R. G. Cooks, “Multiplexed Four-Channel Rectilinear Ion Trap Mass Spectrometer”, Anal. Chem., 2009, 81, 1570-1579, DOI 10.1021/Ac8023284

27. Y. Xia, Z. Ouyang, R. G. Cooks, "Peptide Fragmentation Assisted by Surfaces Treated with a Low-Temperature Plasma in NanoESI”, Angew. Chem., Int. Ed., 2008, 47, 8646-8649, DOI 10.1002/anie.200803477

26. L. S. Eberlin, Y. Xia, H. Chen, R. G. Cooks "Atmospheric Pressure Thermal Dissociation of Phospho- and Sulfopeptides" J. Am. Soc. Mass Spectrom., 2008, 19, 1897-1905, DOI 10.1016/j.jasms.2008.07.019

25. D. M. Crizer, Y. Xia, S. A. McLuckey, “Transition Metal Complex Cations as Reagents for Gas-Phase Transformation of Multiply Deprotonated Polypeptides”, J. Am. Soc. Mass Spectrom., 2009, 20, 1718-1722, DOI 10.1016/j.jasms.2009.05.008

24. H. Han, Y. Xia, M. Yang, S. A. McLuckey “Rapidly Alternating Transmission Mode Electron Transfer Dissociation and Collisional Activation for the Characterization of Polypeptide Ions”, Anal. Chem., 2008, 80, 3492-3497, DOI 10.1021/Ac7022734

23. Y. Xia, H. Han, S. A. McLuckey “Activation of Intact Electron Transfer Products of Polypeptides and Proteins in Cation Transmission Mode Ion/Ion Reactions”, Anal. Chem., 2008, 80, 1111 -1117, DOI 10.1021/Ac702188q

22. C. K. Barlow, B. D. M. Hodges, Y. Xia, R. A. J. O'Hair, S. A. McLuckey “Gas-Phase Ion/Ion Reactions of Transition Metal Complex Cations with Multiply-Charged Oligodeoxynucleotide Anions”, J. Am. Soc. Mass Spectrom., 2008, 19, 281-293, DOI 10.1016/j.jasms.2007.10.017

21. Y. Xia, B. A. Thomson, S. A. McLuckey “Bi-directional Ion Transfer between Quadrupole Arrays: MSn Ion/Ion Reaction Experiments on a Quadrupole/Time-of-Flight Tandem Mass Spectrometer”, Anal. Chem., 2007, 79, 8199 – 8206, DOI 10.1021/Ac071448m

20. Y. Xia, H. P. Gunawardena, D. E. Erickson, S. A. McLuckey “Effects of Cation Charge Site Identity and Position on Electron Transfer Dissociation of Polypeptide Cations”, J. Am. Chem. Soc., 2007, 129, 12232-12243, DOI 10.1021/Ja0736764

19. H. Han, Y. Xia, S. A. McLuckey, “Ion Trap Collisional Activation of c and z• Ions Formed via Gas-Phase Ion/Ion Electron Transfer Dissociation”, J. Proteome. Res., 2007, 6, 3062-3069, DOI 10.1021/Pr070177t

18. Y. Xia, S. A. McLuckey, “Evolution of Instrumentation for the Study of Gas-Phase Ion/Ion Chemistry via Mass Spectrometry” J. Am. Soc. Mass Spectrom., 2008, 19, 173-189, DOI 10.1016/j.jasms.2007.10.018

17. H. Han, Y. Xia, S. A. McLuckey, “Beam-type Collisional Activation of Polypeptide Cations that Survive Ion/Ion Electron Transfer”, Rapid Commun. Mass Spectrom., 2007, 12, 1555-1622, DOI 10.1002/Rcm.2994

16. H. P. Gunawardena, L. Gorenstein, D. E. Erickson, Y. Xia, S. A. McLuckey, "Electron Transfer Dissociation of Multiply Protonated and Fixed Charge Disulfide Linked Polypeptides", Int. J. Mass Spectrom., 2007, 265, 130-138, DOI 10.1016/j.ijms.2007.01.017

15. X. Liang, H. Han, Y. Xia, S. A. McLuckey, “A Pulsed Triple Ionization Source for Sequential Ion/Ion Reactions in an Electrodynamic Ion Trap”, J. Am. Soc. Mass Spectrom., 2007, 18, 369-376, DOI 10.1016/j.jasms.2006.10.004

14. Y. Xia, P. Chrisman, S. J. Pitteri, D.E. Erickson, S. A. McLuckey “Ion/Molecule Reactions of Cation Radicals Formed from Protonated Polypeptides via Gas-Phase Ion/Ion Electron Transfer”, J. Am. Chem. Soc., 2006, 128, 11792-11798, DOI 10.1021/Ja063248i

13. Y. Xia, P. Chrisman, D. E. Erickson, J. Liu, X. Liang, F. A. Londry, M. Yang, S. A. McLuckey “Implementation of Ion/Ion Reactions in a Quadrupole/Time-of-Flight Tandem Mass Spectrometer", Anal. Chem., 2006, 78, 4146-4154, DOI 10.1021/Ac0606296

12. X. Liang, Y. Xia, S. A. McLuckey, "Alternately Pulsed Nano-electrospray Ionization/Atmospheric Pressure Chemical Ionization for Ion/Ion Reactions in an Electrodynamic Ion Trap", Anal. Chem., 2006, 78, 3208-3212, DOI 10.1021/Ac052288m

11. Y. Xia, X. Liang, S. A. McLuckey “Ion-Trap vs. Low Energy Beam-Type Collision-Induced Dissociation of Protonated Ubiquitin Ions”, Anal. Chem., 2006, 78, 1218-1227, DOI 10.1021/Ac051622b

10. Y. Xia, X. Liang, S. A. McLuckey “Pulsed Dual Electrospray Ionization for Ion/Ion Reactions”, J. Am. Soc. Mass Spectrom., 2005, 16, 1750-1756, DOI 10.1016/j.jasms.2005.07.013

9. Y. Xia, X. Liang, S. A. McLuckey “Sonic Spray as a Dual Polarity Ion Source for Ion/Ion Reactions”, Anal. Chem., 2005, 77, 3683-3689, DOI 10.1021/Ac0481811

8. Y. Xia, J. Wu, F. A. Londry, J. W. Hager, S. A. McLuckey “Mutual Storage Mode Ion/Ion Reaction in a Hybrid Linear Ion Trap”, J. Am. Soc. Mass Spectrom., 2005, 16, 71-81, DOI 10.1016/j.jasms.2004.09.017

7. J. Wu, J. W. Hager, Y. Xia, F. A. Londry, S.A. McLuckey “Positive Ion Transmission Mode Ion/Ion Reactions in a Hybrid Linear Ion Trap”, Anal. Chem., 2004, 76, 5006-5015, DOI 10.1021/Ac049359m

6. P. Pan, H. P. Gunawardena, Y. Xia, S. A. McLuckey “Nano-Electrospray Ionization of Protein Mixtures: Solution pH and Protein pI”, Anal. Chem., 2004, 76, 1165-1174, DOI 10.1021/Ac035209k

5. X. C. He, S. Feng, Z. F. Wang, Y. F. Shi, S. X. Zheng, Y. Xia, H. L. Jiang, X. C. Tang, D. L. Bai “Study on Dual-Site Inhibitors of Acetylcholinesterase: Highly Potent Derivatives of Bis- and Bifunctional Huperzine B”, Bioorg. Med. Chem., 2007, 15, 1394-1408.

4. S. Feng, Y. Xia, D. M. Han, C. Y. Zheng, X. C. He, X. C. Tang, D. L. Bai “Synthesis and Acetylcholinesterase Inhibition of Derivatives of Huperzine B”, Bioorg. Med. Chem. Lett., 2005, 15, 523-526.

3. S. Feng, Z. F. Wang, X. C. He, S. X. Zheng, Y. Xia, H. L. Jiang, X. C. Tang, D. L. Bai “Bis-Huperzine B: Highly Potent and Selective Acetylcholinesterase Inhibitors”, J. Med. Chem., 2005, 48, 655-657.

2. S. Feng, X. C. He, G. L. Yu, Y. Xia, D. Bai “Preparation of Methyl 2-Methoxycarbonylmethyl-6-Oxo-1,6-Dihydropyridine-3-Carboxylate”, Org. Prep. Proced. Int., 2004, 36, 129-133.

1. Y. Xia, X. S. Xiao, X. C. He, D. L. Bai “The Unexpected Reductive Products of Delta-Alkoxyenal by Sodium Borohydride in Methanol with a Trace of Magnesium Methoxide”, Chin. Chem. Lett., 2002, 13, 809-810.