Welcome to Xia Research Group

Assistant Professor, Purdue University, 2009 - present

42. Chiharu Konda, Frank Londry, Brad Bendiak, and Yu Xia, "Obtaining Stereo-Structural Information with Single-Sugar Resolution from Linear Oligosaccharides by Mass Spectrometry", submitted.

41. Kirt L. Durand, Xiaoxiao Ma, Chelsea E. Plummer, and Yu Xia, "Tandem Mass Spectrometry (MSn) of Peptide Disulfide Regio-Isomers via Collision-Induced Dissociation: Utility and Limits in Disulfide Bond Characterization", Int. J. Mass Spectrom., 2013, 343-344, 50-57, DOI: 10.1016/j.ijms.2013.04.005

40. Craig A. Stinson and Yu Xia, “Radical Induced Disulfide Bond Cleavage within Peptides via Ultraviolet Irradiation of an Electrospray Plume”, Analyst, 2013, 138(10), 2840-2846, DOI: 10.1039/C3AN00303E

39. Chasity B. Love, Lei Tan, Joseph S. Francisco*, and Yu Xia*, “Competition of Charge- vs. Radical-Directed Fragmentation of Gas-Phase Protonated Cysteine Sulfinyl Radicals”, J. Am. Chem. Soc., 2013, 135, 6226-6233, DOI: 10.1021/ja4008744

38. Lei Tan and Yu Xia, "Gas-Phase Reactivity of Peptide Thiyl, Perthiyl, and Sulfinyl Radical Ions Formed from Atmospheric Pressure Ion/Radical Reactions", J. Am. Soc. Mass Spectrom., 2013, 24, 534-542, DOI: 10.1007/s13361-012-0548-y

37. Lei Tan and Yu Xia, "Gas-Phase Peptide Sulfinyl Radical Ions: Formation and Unimolecular Dissociation", J. Am. Soc. Mass Spectrom., 2012, 23, 2011-2019, DOI: 10.1007/s13361-012-0465-0

36. Tammy T. Fang, Chiharu Konda, Yu Xia, and Brad Bendiak, "Unimolecular Dissociation of 2-linked Disaccharide Anions: Details of Localization of Fragmentation Events to Either Side of the Glycosidic Linkage as Revealed by ¹⁸O-labeling and Tandem Mass Spectrometry", submitted.

35. Chiharu Konda, Brad Bendiak, and Yu Xia, " Differentiation of the Stereochemistry and Anomeric Configuration for 1-3 Linked Disaccharides Via Tandem Mass Spectrometry and ¹⁸O-labeling", J. Am. Soc. Mass Spectrom., 2012, 23, 347-358, DOI: 10.1007/s13361-011-0287-5

34. Scott R. Cole, Xiaoxiao Ma, Xinrong Zhang, and Yu Xia, "Electron Transfer Dissociation (ETD) of Peptides Containing Intramolecular Disulfide Bonds", J. Am. Soc. Mass Spectrom., 2012, 23, 310-320, DOI: 10.1007/s13361-011-0300-z

33. Xiaoxiao Ma, Chasity B. Love, Xinrong Zhang, and Yu Xia, " Gas-Phase Fragmentation of [M + nH + OH]n•+ Ions Formed from Peptides Containing Intra-Molecular Disulfide Bonds", J. Am. Soc. Mass Spectrom., 2011, 22, 922-930, DOI: 10.1007/s13361-011-0104-1

32. W. Xu, N. Charipa, M. A. Kirleis, Y. Xia, and Z. Ouyang, "Study of Discontinuous Atmospheric Pressure Interfaces for Mass Spectrometry Instrumentation Developmenton", Anal. Chem., 2010, 82, 6584-6592, DOI: 10.1021/ac101002t

31. H. Wang, Z. Ouyang, Y. Xia, "Peptide Fragmentation during NanoElectrospray Ionization", Anal. Chem., 2010, 82, 6534-6541, DOI: 10.1021/ac100872x

Assistant Research Scientist in Aston Labs, Purdue University, 2007-2009

30. Y. Xia, R. G. Cooks, “Plasma Induced Oxidative Cleavage of Disulfide Bonds in Polypeptides during NanoElectrospray Ionization”, Anal. Chem., 2010, 82, 2856-2864, DOI 10.1021/ac9028328

29. N. Na, Y. Xia, Z. Zhu, X. Zhang , R. G. Cooks, "Birch Reduction of Benzene in a Low-Temperature Plasma", Angew. Chem., Int. Ed., 2009, 48, 2017-2019, DOI 10.1002/anie.200805256

28. S. Kothari, Q. Song, Y. Xia, M. Fico, D. Taylor, J. W. Amy, G. Stafford, R. G. Cooks, “Multiplexed Four-Channel Rectilinear Ion Trap Mass Spectrometer”, Anal. Chem., 2009, 81, 1570-1579, DOI 10.1021/Ac8023284

27. Y. Xia, Z. Ouyang, R. G. Cooks, "Peptide Fragmentation Assisted by Surfaces Treated with a Low-Temperature Plasma in NanoESI”, Angew. Chem., Int. Ed., 2008, 47, 8646-8649, DOI 10.1002/anie.200803477

26. L. S. Eberlin, Y. Xia, H. Chen, R. G. Cooks "Atmospheric Pressure Thermal Dissociation of Phospho- and Sulfopeptides" J. Am. Soc. Mass Spectrom., 2008, 19, 1897-1905, DOI 10.1016/j.jasms.2008.07.019

Ph.D. and Post-doc in MucLuckey group, Purdue University, 2002-2007

25. D. M. Crizer, Y. Xia, S. A. McLuckey, “Transition Metal Complex Cations as Reagents for Gas-Phase Transformation of Multiply Deprotonated Polypeptides”, J. Am. Soc. Mass Spectrom., 2009, 20, 1718-1722, DOI 10.1016/j.jasms.2009.05.008

24. H. Han, Y. Xia, M. Yang, S. A. McLuckey “Rapidly Alternating Transmission Mode Electron Transfer Dissociation and Collisional Activation for the Characterization of Polypeptide Ions”, Anal. Chem., 2008, 80, 3492-3497, DOI 10.1021/Ac7022734

23. Y. Xia, H. Han, S. A. McLuckey “Activation of Intact Electron Transfer Products of Polypeptides and Proteins in Cation Transmission Mode Ion/Ion Reactions”, Anal. Chem. 2008, 80, 1111 -1117, DOI 10.1021/Ac702188q

22. C. K. Barlow, B. D. M. Hodges, Y. Xia, R. A. J. O'Hair, S. A. McLuckey “Gas-Phase Ion/Ion Reactions of Transition Metal Complex Cations with Multiply-Charged Oligodeoxynucleotide Anions”, J. Am. Soc. Mass Spectrom., 2008, 19, 281-293, DOI 10.1016/j.jasms.2007.10.017

21. Y. Xia, B. A. Thomson, S. A. McLuckey “Bi-directional Ion Transfer between Quadrupole Arrays: MSn Ion/Ion Reaction Experiments on a Quadrupole/Time-of-Flight Tandem Mass Spectrometer”, Anal. Chem., 2007, 79, 8199 – 8206, DOI 10.1021/Ac071448m

20. Y. Xia, H. P. Gunawardena, D. E. Erickson, S. A. McLuckey “Effects of Cation Charge Site Identity and Position on Electron Transfer Dissociation of Polypeptide Cations”, J. Am. Chem. Soc., 2007, 129, 12232-12243, DOI 10.1021/Ja0736764

19. H. Han, Y. Xia, S. A. McLuckey, “Ion Trap Collisional Activation of c and z• Ions Formed via Gas-Phase Ion/Ion Electron Transfer Dissociation”, J. Proteome. Res.,2007, 6, 3062-3069, DOI 10.1021/Pr070177t

18. Y. Xia, S. A. McLuckey, “Evolution of Instrumentation for the Study of Gas-Phase Ion/Ion Chemistry via Mass Spectrometry” J. Am. Soc. Mass Spectrom., 2008, 19, 173-189, DOI 10.1016/j.jasms.2007.10.018

17. H. Han, Y. Xia, S. A. McLuckey, “Beam-type Collisional Activation of Polypeptide Cations that Survive Ion/Ion Electron Transfer”, Rapid Commun. Mass Spectrom., 2007, 12, 1555-1622, DOI 10.1002/Rcm.2994

16. H. P. Gunawardena, L. Gorenstein, D. E. Erickson, Y. Xia, S. A. McLuckey, "Electron Transfer Dissociation of Multiply Protonated and Fixed Charge Disulfide Linked Polypeptides", Int. J. Mass Spectrom., 2007, 265, 130-138, DOI 10.1016/j.ijms.2007.01.017

15. X. Liang, H. Han, Y. Xia, S. A. McLuckey, “A Pulsed Triple Ionization Source for Sequential Ion/Ion Reactions in an Electrodynamic Ion Trap”, J. Am. Soc. Mass Spectrom., 2007, 18, 369-376, DOI 10.1016/j.jasms.2006.10.004

14. Y. Xia, P. Chrisman, S. J. Pitteri, D.E. Erickson, S. A. McLuckey “Ion/Molecule Reactions of Cation Radicals Formed from Protonated Polypeptides via Gas-Phase Ion/Ion Electron Transfer”, J. Am. Chem. Soc., 2006, 128, 11792-11798, DOI 10.1021/Ja063248i

13. Y. Xia, P. Chrisman, D. E. Erickson, J. Liu, X. Liang, F. A. Londry, M. Yang, S. A. McLuckey “Implementation of Ion/Ion Reactions in a Quadrupole/Time-of-Flight Tandem Mass Spectrometer”, Anal. Chem., 2006, 78, 4146-4154, DOI 10.1021/Ac0606296

12. X. Liang, Y. Xia, S. A. McLuckey, "Alternately Pulsed Nano-electrospray Ionization/Atmospheric Pressure Chemical Ionization for Ion/Ion Reactions in an Electrodynamic Ion Trap", Anal. Chem., 2006, 78, 3208-3212, DOI 10.1021/Ac052288m

11. Y. Xia, X. Liang, S. A. McLuckey “Ion-Trap vs. Low Energy Beam-Type Collision-Induced Dissociation of Protonated Ubiquitin Ions”, Anal. Chem. 2006, 78, 1218-1227, DOI 10.1021/Ac051622b

10. Y. Xia, X. Liang, S. A. McLuckey “Pulsed Dual Electrospray Ionization for Ion/Ion Reactions”, J. Am. Soc. Mass Spectrom. 2005, 16, 1750-1756, DOI 10.1016/j.jasms.2005.07.013

9. Y. Xia, X. Liang, S. A. McLuckey “Sonic Spray as a Dual Polarity Ion Source for Ion/Ion Reactions”, Anal. Chem., 2005, 77, 3683-3689, DOI 10.1021/Ac0481811

8. Y. Xia, J. Wu, F. A. Londry, J. W. Hager, S. A. McLuckey “Mutual Storage Mode Ion/Ion Reaction in a Hybrid Linear Ion Trap”, J. Am. Soc. Mass Spectrom., 2005, 16, 71-81, DOI 10.1016/j.jasms.2004.09.017

7. J. Wu, J. W. Hager, Y. Xia, F. A. Londry, S.A. McLuckey “Positive Ion Transmission Mode Ion/Ion Reactions in a Hybrid Linear Ion Trap”, Anal. Chem., 2004, 76, 5006-5015, DOI 10.1021/Ac049359m

6. P. Pan, H. P. Gunawardena, Y. Xia, S. A. McLuckey “Nano-Electrospray Ionization of Protein Mixtures: Solution pH and Protein pI”, Anal. Chem., 2004, 76, 1165-1174, DOI 10.1021/Ac035209k

M.S. in Donglu Bai group at Shanghai Institute of Material Medica, 1999-2002

5. X. C. He, S. Feng, Z. F. Wang, Y. F. Shi, S. X. Zheng, Y. Xia, H. L. Jiang, X. C. Tang, D. L. Bai “Study on Dual-Site Inhibitors of Acetylcholinesterase: Highly Potent Derivatives of Bis- and Bifunctional Huperzine B”, Bioorg. Med. Chem., 2007, 15, 1394-1408.

4. S. Feng, Y. Xia, D. M. Han, C. Y. Zheng, X. C. He, X. C. Tang, D. L. Bai “Synthesis and Acetylcholinesterase Inhibition of Derivatives of Huperzine B”, Bioorg. Med. Chem. Lett., 2005, 15, 523-526.

3. S. Feng, Z. F. Wang, X. C. He, S. X. Zheng, Y. Xia, H. L. Jiang, X. C. Tang, D. L. Bai “Bis-Huperzine B: Highly Potent and Selective Acetylcholinesterase Inhibitors”, J. Med. Chem., 2005, 48, 655-657.

2. S. Feng, X. C. He, G. L. Yu, Y. Xia, D. Bai “Preparation of Methyl 2-Methoxycarbonylmethyl-6-Oxo-1,6-Dihydropyridine-3-Carboxylate”, Org. Prep. Proced. Int., 2004, 36, 129-133.

1. Y. Xia, X. S. Xiao, X. C. He, D. L. Bai “The Unexpected Reductive Products of Delta-Alkoxyenal by Sodium Borohydride in Methanol with a Trace of Magnesium Methoxide”, Chin. Chem. Lett., 2002, 13, 809-810.