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Research

Trevor Anderson

Biochemistry Education

Visualization in biochemistry education

 

Chittaranjan Das

Structural Biology, Deubiquitinating enzymes

The main focus of our lab is to understand the functional role deubiquitinating enzymes (deubiquitinases or DUBs) in cellular pathways, particularly the ones implicated in neurodegeneration (gradual loss of neurons), such as Alzheimer's disease (AD) and Parkinson's disease (PD).

 

Christine Hrycyna

Membrane biology, Cancer, Aging, Molecular targets, ABC transporters, Therapeutics

The overall goal of my research program is to understand the mechanisms and roles of important eukaryotic integral membrane proteins that are fundamental to human health and disease. My multidisciplinary work successfully integrates the tools of biochemistry, molecular biology, cell biology and biophysical chemistry to define how these membrane proteins recognize their substrates and how they operate at the molecular level.

 

Wen Jiang

Cryo-EM, Structural Biology, High-throughput imaging, 3-D reconstruction

We use cryo-EM to study the assembly, maturation, and infection mechanism of viruses including dsDNA tailed bacteriophages and noroviruses. We are also interested in the development of cryo-EM techniques including image processing algorithms, high-performance computing, data collection automation, and sample preparation.

 

Philip Low

Cancer, Red blood cells, Malaria, Targeted Imaging and Therapeutic agents, Inflammatory Disease, Autoimmune Disorders, Infectious Disease

Our laboratory focuses primarily on the development of ligand-targeted imaging and therapeutic agents for the diagnosis and treatment of important human diseases.

 

Angeline Lyon

Signal transduction, Structural biology, Cardiovascular disease, Drug design

Cardiovascular disease is the leading cause of death in the United States and a growing problem worldwide. Phospholipase C (PLC) enzymes are required for normal cardiovascular function as they regulate the concentration of intracellular calcium. My lab uses structural biology, biochemistry, and cell-based approaches to understand the molecular mechanisms of PLC regulation and activation.

 

Andrew Mesecar

Structural biology, Enzyme kinetics, Assay development and optimization, High-throughput Screening, Molecular modeling, Cheminformatics

The fundamental research interests of the Mesecar lab involve elucidating the molecular mechanisms and function of therapeutic enzymes and proteins. We wish to understand at the molecular level how enzymes and proteins recognize their substrates, catalyze their requisite chemical reactions, and trigger signal-transduction cascades. Our ultimate goal is to utilize this fundamental scientific knowledge to develop new therapeutics to treat cancer and infectious diseases.

 

Stefan Paula

The primary goal of our research is the discovery of novel bioactive compounds and a detailed characterization of the molecular interactions that they undergo with their protein receptors. Understanding the factors that determine a small molecule's ability to interact specifically with a protein receptor is critical for the elucidation of many biological processes as well as for the design of novel drugs.

 

Kavita Shah

Drug Discovery, Synthesis of chemical probes, Structure-based drug design, Clinical Targets, Proteomics, Kinases, G Proteins, Cancer, Alzheimer's Disease, Therapy

We have developed highly specific chemical probes for dissecting the functions of kinases and G-proteins on a proteome-wide scale. Our goal is to identify and validate disease-specific clinical targets and prognostic biomarkers in cancer and neurodegenerative diseases using a combination of chemical, genetic, genomics, proteomics and high-throughput screening approaches. We also use structure-based drug design to develop highly specific inhibitors of kinases involved in disease pathways.

 

Nikolai Skrynnikov

Protein NMR, MD simulations, protein structure, disordered proteins, protein dynamics, therapeutic peptides, cell line experiments, spin relaxation, chromatin, fibrils, x-ray structure refinement

We are interested in a broad range of problems in protein science - from MD simulations, to experimental characterization using a range of biophysical techniques, to structure analyses, to cell-line experiments. We specialize in developing NMR pulse sequences, as well as MD algorithms.

 

Mathew Tantama

Protein Engineering, Optical Tools

We engineer optical tools to both probe and perturb the biochemistry of living cells. One of our major goals is to develop genetically-encoded biosensors using fluorescent protein technology. We are developing biosensors that sense a wide range of analytes that are found both inside and outside the cell. In parallel, we engineer biosensors with a variety of spectral properties to expand their range of colors.

 

Zhong-Yin Zhang

Protein Phosphatases, Signaling, Activity-based and Interaction Proteomics, Drug Discovery

  • Structure and function studies of protein tyrosine phosphatases
  • Roles of protein phosphatases in signaling and diseases

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