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Ei-ichi Negishi

A large number of organic reactions including biochemical processes are promoted by catalysts. Besides traditional Lewis acids and bases and biochemical catalysts, i.e., enzymes, transition metals and their complexes represent one of the most important groups of catalysts.

Our research is mainly directed toward (i) discovery and development of transition metal-catalyzed organic reactions, (ii) their application to those organic transformations which are of interest in the health- and energy-related areas, and (iii) development of polymer and materials chemistry based on organotransition metal chemistry.
Several specific examples described below are representative of our recent research.

Exploration, development, and application of organozirconium chemistry.

Our discovery and development of the Zr-catalyzed carboalumination and the Pd-catalyzed cross coupling provided a highly stereoselective synthesis of vitamin A (Equation 1).

The Zr-promoted bicylization reaction we have discovered and developed (Equation 2).

Our current efforts are focused on the development of catalytic and/or asymmetric reactions involving Zr (Equation 3).

Exploration, development, and application of organopalladium chemistry.

In addition to Pd-catalyzed cross coupling, and acylpalladation we earlier developed, we have recently developed a Azipper@-mode cascade carbopalladation which promises to be a powerful tool for cyclization (Equation 4) and preparation of oligo- and polyacetylenes as candidates for conductive polymers.

Education

  • Ph.D., 1963, University of Pennsylvania
  • B.S., 1958, University of Tokyo

Recognitions

  • Foreign Associate of the National Academy of Sciences, 2014
  • American Academy of Arts & Sciences, 2011
  • Sagamore of the Wabash, 2011
  • Order of the Griffin, 2011
  • ACS Award for Creative Work in Synthetic Organic Chemistry , 2010
  • The Order of Culture, Japan, 2010
  • Nobel Prize in Chemistry, 2010
  • Invited Lectureship, 4th Mitsui International Catalysis Symposium (MICS-4), Kisarazu, Japan, 2009
  • Gold Medal of Charles University, Prague, Czech Republic , 2007
  • Yamada-Koga Prize , 2007
  • Sigma Xi Award, Purdue University , 2003
  • Sir Edward Frankland Prize Lectureship , 2000
  • American Chemical Society Award for Organometallic Chemistry, 1998
  • Alexander von Humboldt Senior Researcher Award, 1998 - 2000
  • Herbert N. McCoy Award, 1998
  • Chemical Society of Japan Award, 1997
  • A. R. Day Award (ACS Philadelphia Section award), 1996
  • Guggenheim Fellowship, 1987
  • Assistant and Associate Professor, Syracuse University, 1972 - 1979
  • Harrison Fellowship at University of Pennsylvania, 1962 - 1963
  • Fulbright-Smith-Mund Fellowship, 1960 - 1961

Publications

Purdue University, West Lafayette, IN 47907 (765) 494-4600

Department of Chemistry, 560 Oval Drive, West Lafayette, Indiana 47907-2084 | Telephone: (765) 494-5200 | Fax: (765) 494-0239

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