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Ei-ichi Negishi

Ei-ichi Negishi

A large number of organic reactions including biochemical processes are promoted by catalysts. Besides traditional Lewis acids and bases and biochemical catalysts, i.e., enzymes, transition metals and their complexes represent one of the most important groups of catalysts.

Our research is mainly directed toward (i) discovery and development of transition metal-catalyzed organic reactions, (ii) their application to those organic transformations which are of interest in the health- and energy-related areas, and (iii) development of polymer and materials chemistry based on organotransition metal chemistry.
Several specific examples described below are representative of our recent research.

Exploration, development, and application of organozirconium chemistry.

Our discovery and development of the Zr-catalyzed carboalumination and the Pd-catalyzed cross coupling provided a highly stereoselective synthesis of vitamin A (Equation 1).

The Zr-promoted bicylization reaction we have discovered and developed (Equation 2).

Our current efforts are focused on the development of catalytic and/or asymmetric reactions involving Zr (Equation 3).

Exploration, development, and application of organopalladium chemistry.

In addition to Pd-catalyzed cross coupling, and acylpalladation we earlier developed, we have recently developed a Azipper@-mode cascade carbopalladation which promises to be a powerful tool for cyclization (Equation 4) and preparation of oligo- and polyacetylenes as candidates for conductive polymers.

Education

  • B.S., University of Tokyo, 1958
  • Ph.D., University of Pennsylvania, 1963

Recognitions

  • A. R. Day Award (ACS Philadelphia Section award), 1996
  • ACS Award for Creative Work in Synthetic Organic Chemistry , 2010
  • Alexander von Humboldt Senior Researcher Award, 1998
  • American Academy of Arts & Sciences, 2011
  • American Chemical Society Award for Organometallic Chemistry, 1998
  • Assistant and Associate Professor, Syracuse University, 1972
  • Chemical Society of Japan Award, 1997
  • Foreign Associate of the National Academy of Sciences, 2014
  • Fulbright-Smith-Mund Fellowship, 1960
  • Gold Medal of Charles University, Prague, Czech Republic , 2007
  • Guggenheim Fellowship, 1987
  • Harrison Fellowship at University of Pennsylvania, 1962
  • Herbert N. McCoy Award, 1998
  • Invited Lectureship, 4th Mitsui International Catalysis Symposium (MICS-4), Kisarazu, Japan, 2009
  • Nobel Prize in Chemistry, 2010
  • Order of the Griffin, 2011
  • Sagamore of the Wabash, 2011
  • Sigma Xi Award, Purdue University , 2003
  • Sir Edward Frankland Prize Lectureship , 2000
  • The Order of Culture, Japan, 2010
  • Yamada-Koga Prize , 2007

Publications

Purdue University, West Lafayette, IN 47907 (765) 494-4600

Department of Chemistry, 560 Oval Drive, West Lafayette, Indiana 47907-2084 | Telephone: (765) 494-5200 | Fax: (765) 494-0239

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