The Ghosh Laboratories:
The Home of the Backbone Binding, Bioactive Natural Product Synthesis, and Nature-Inspired Molecular Design for Today's Medicine
About Professor Ghosh
- 2009-Present: Ian P. Rothwell Distinguished Professor, Purdue University
- 2005-2009: Professor, Department of Chemistry, Purdue University, West Lafayette, IN
- 2005-2009: Professor, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN
- 1998-2005: Professor, Department of Chemistry, University of Illinois at Chicago, Chicago, IL
- 1997-1998: Associate Professor, Department of Chemistry, University of Illinois at Chicago, Chicago, IL
- 1994-1997: Assistant Professor, Department of Chemistry, University of Illinois at Chicago, Chicago, IL
- 1988-1994: Research Fellow, Merck Research Laboratories, West Point, PA
- 1985-1988: Post-doctoral fellow (Professor E. J. Corey), Harvard University, Cambridge, MA
- 1981-1985: Ph.D. Organic Chemistry, Dept. of Chemistry, University of Pittsburgh
- 1979-1981: M.Sc. Organic Chemistry, Indian Institute of Technology, Kanpur, India
- 1979: B.Sc. (Hons), Calcutta University, India
Highlights of Research Accomplishments:
Structure-based innovative molecular design:
- Design and development of darunavir, an HIV-1 protease inhibitor drug approved for treating HIV-1 infection in treatment-naive and treatment-experienced patients.
- Developed novel tools and strategies for protein X-ray structure based molecular design to combat drug-resistance.
- Structure based design and synthesis of potent and selective BACE1 (memapsin) inhibitors (β-secretase) for the treatment of Alzheimer’s disease.
- Enzyme-inhibitor structure based design of selective BACE2 (memapsin 1) inhibitor for the treatment of type 2 diabetes.
- Design and synthesis of natural-product inspired ligands and templates for HIV protease inhibitors based upon X-ray crystal structure of HIVP-inhibitor complexes, synthesized dipeptide transition-state isosteres.
- Rational Design of peptidomimetic SARS-3CLPro inhibitors for SARS coronavirus.
Natural Products Total Synthesis and Biological Evaluation (66 total):
Synthesis of biologically important natural products with anticancer, antibacterial, antiviral, and antimalerial properties. Examples include the following:
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Acetylaspidoalbidine Amphidinolide T1 Amphidinolide W Amphirionin-4 Alloyohimbane Aetheramide A AI-77-B Amphidinolide W Amphirionin-4 Arenastatin A Boronolide Brevisamide Callyspongiolide Carambolaflavone A Cryptophycin 52 Cryptophycin B Decytospolide A |
Decytospolide B Doliculide Eburnamonine EBC-23 Fendleridine FR 252921 FR 901464 GEX1Q1 Griseoviridin Hapalosin Herboxidiene/GEX1A Irimoteolide 1A Irimoteolide 1B Jasplakinolide Lasonolide A Largazole Laulimalide |
Lithospermic Acid Lycibarbarine A Lycibarbarine B Madumycin II Malyngolide Hapalosin Monocerin Neopeltolide Nucleosides Sinefungin Tetrahydrolipstatin Peloruside A Peloruside B Pladienolide B Platencin Platensimycin Polyoxin C Polyoxin J Sinefungin |
Spliceostatin A Spliceostatin E Spliceostatin G Spliceostatin J Spongidepsin Stereocalpin A Madumycin Taurospongin A Tetrahydrolipstatin Thailanstatin A Vincamon Viridofungin A Yohimbane Zampanolide
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Development of New Reactions and Asymmetric Technologies for Carbon-Carbon and Carbon-Hetero Atom BondFormation:
- Stereoselective procedures for the asymmetric syn- and anti-Aldol reactions
- Catalytic enantioselective Diels-Alder and hetero Diels-Alder reactions
- Lewis-Acid mediated olefin migration and Prins cyclization to functionalized tetrahydropyrans
- Asymmetric Achmatowicz reactions in synthesis
- Novel methodologies for the multi-component coupling reactions
- Development of specific reagents for alkoxycarbonylation of amines
- Application of novel enzymatic reactions in synthesis
- Novel applications of ring closing olefin metathesis in synthesis
Office telephone: (765) 494-5323
e-mail: akghosh@purdue.edu
Administrative Associate: Yu-Tung Tsai
Office telephone: (765) 494-5300
e-mail: tsai224@purdue.edu