We are conducting a research study to determine the relative effectiveness of different methods for teaching molecular geometry to General Chemistry students. The instructional methods we are studying include both 2D and 3D visualization during lectures with either no corresponding lab, a computer simulation lab, or a physical models lab. The 2D lecture visualization consist of textbook depictions and chalkboard drawings, whereas the 3D visualization lectures have the professor manipulate 3D structures on a projected computer screen as a supplement to the traditional 2D depictions. Are 3D instruction methods necessarily more helpful when learning 3D concepts? Do students need to be involved in manipulating 3D structures themselves, or is watching enough?