Prof. Scott McLuckey (Purdue) developed a combination of novel instrumentation and ion chemistry, which allows simplification of mass spectra, hence rapid protein identification
“Fingerprint” of the protein ubiquitin
Identification of the compounds is based on molecular weight and partial structural information derived from gaseous protein ions as shown in the following example:
Spectrum of dissociation products
At Indiana University, Prof. David Clemmer is making rapid identification of proteins a priority for today’s analytical instrumentation
One of the instruments developed by David Clemmer combines the advantages of a variety of instrumentation types resulting in capabilities such as high sensitivity ultra-fast analysis structural ID unattainable by other individual instruments:
