Yu Xia

Education:

2002-2006            Purdue University, West Lafayette , IN 47907  

                              Ph. D. in analytical chemistry, emphasizing gas phase ion/ion reactions in linear ion trap based mass spectrometers, under the direction of Prof. Scott A. McLuckey

1999-2002            Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai , P. R. China   

M.S. in organic chemistry

1995-1999            Lanzhou University, Lanzhou , Gansu Province, P.R. China

B.S. in chemistry

Research Experience:

2002- present       Characterization of DNAs and proteins using gas-phase ion/ion reactions

1999- 2002            Design and synthesis of (-)huperzine B derivatives as inhibitors of acetylcholinesterase

Honors and Awards: 

2007    M.G. Mellon Award in Analytical Chemisry

2006    Thomas W. Keough Graduate Scholar

2005    Merck Research Laboratories Fellowship in Analytical/Physical Chemistry

2002    Graduate Fellowship of Chinese Academy of Sciences

1999    Outstanding Graduate Award of Lanzhou University

1998     Baogang Undergraduate Fellowship

1998    Second Class Award of National Undergraduate Chemistry Experiment Competition

Publications:

Y. Xia, H. Han and S. A. McLuckey, Anal. Chem., 80 (2008), 1111-1117.
   "Activation of Intact Electron-Transfer Products of Polypeptides and Proteins in Cation Transmission Mode  Ion/Ion Reactions."

Y. Xia, B. A. Thomson, and S. A. McLuckey, Anal. Chem., 79 (2007), 8199 - 8206.
   "Bi-directional Ion Transfer between Quadrupole Arrays: MSⁿ Ion/Ion Reaction Experiments on a Quadrupole/Time-of-Flight Tandem Mass Spectrometer."

C. K. Barlow, B. D. M. Hodges, Y. Xia, R. A. J. O'Hair, and S. A. McLuckey, J. Am. Soc. Mass Spectrom.,  19 (2008), 281-293.
   "Gas-Phase Ion/Ion Reactions of Transition Metal Complex Cations with Multiply-Charged Oligodeoxynucleotide Anions."

Y. Xia, H. P. Gunawardena, D. E. Erickson, and S. A. McLuckey, J. Am. Chem. Soc, 129 (2007), 12232-12243.
   "Effects of Cation Charge Site Identity and Position on Electron Transfer Dissociation of Polypeptide Cations"

H. Han, Y. Xia, S.A. McLuckey, Rapid Commun. Mass Spectrom., 12 (2007) 1555-1622.
   "Beam-type Collisional Activation of Polypeptide Cations that Survive Ion/Ion Electron Transfer."

H. Han, Y. Xia, S.A. McLuckey, J. Proteome. Res., 6 (2007), 3062-3069.
   "Ion Trap Collisional Activation of c and z Ions Formed via Gas-Phase Ion/Ion Electron Transfer Dissociation."

Y. Xia, S.A. McLuckey, J. Am. Soc. Mass Spectrom., 19 (2008), 173-189.
   "Evolution of Instrumentation for the Study of Gas-Phase Ion/Ion Chemistry via Mass Spectrometry."

X. Liang, H. Han, Y. Xia, S. A. McLuckey, J. Am. Soc. Mass Spectrom., 18 (2007) 369-376.
    "A Pulsed Triple Ionization Source for Sequential Ion/Ion Reactions in an Electrodynamic Ion Trap."

Y. Xia, P. A. Chrisman, S.J. Pitteri, D. E. Erickson, S. A. McLuckey, J. Am. Chem. Soc., 128 (2006) 11792-11798.
     "Ion/Molecule Reactions of Cation Radicals Formed from Protonated Polypeptides via Gas-Phase Ion/Ion Electron Transfer."

Y. Xia, P. A. Chrisman, D. E. Erickson, J. Liu, X. Liang, F. A. Londry, M. J. Yang, S. A. McLuckey, Anal. Chem., 78 (2006) 4146-4154.
     "Implementation of Ion/Ion Reactions in a Quadrupole/Time-of-Flight."

X. Liang, Y. Xia, S.A. McLuckey, Ananl.Chem., 78 (2006) 3208-3212.
     "Alternately Pulsed Nano-electrospray Ionization/Atmospheric Pressure Chemical Ionization for Ion/Ion Reactions in an Electrodynamic Ion Trap."

Y. Xia, X. Liang, S.A. McLuckey, Anal. Chem., 78 (2006) 1218-1227.
      "Ion-Trap vs. Low Energy Beam-Type Collision-Induced Dissociation of Protonated Ubiquitin Ions."

Y. Xia, X. Liang, S.A. McLuckey, J.Am. Soc. Mass Spectrom., 16 (2005) 1750-1756.
      "Pulsed Dual Electrospray Ionization for Ion/Ion Reactions."

Y. Xia, X. Liang, S.A. McLuckey, Anal. Chem., 77 (2005) 3683-3689.
    "Sonic Spray as a Dual Polarity Ion Source for Ion/Ion Reactions."

Y. Xia, J. Wu, F.A. Londry, J.W. Hager, S.A. McLuckey, J. Am. Soc. Mass Spectrom., 16 (2005) 71-81.
    "Mutual Storage Mode Ion/Ion Reaction in Hybrid Linear Ion Trap."

J. Wu, J.W. Hager, Y. Xia, F.A. Londry, S.A. McLuckey, Anal. Chem., 76 (2004) 5006-5015..
    "Positive Ion Transmission Mode Ion/Ion Reactions in a Hybrid Linear Ion Trap." 

P. Pan, H.P. Gunawardena, Y. Xia, S.A. McLuckey, Anal. Chem., 76 (2004) 1165-1174.
    "Nano-Electrospray Ionization of Protein Mixtures: Solution pH and Protein pI."

G. Jin, Y. Xia, D. Bai, Yaoxue Xuebao., 37 (2002) 749-752.

    Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis.

Y. Xia, X. Xiao, X.C. He, D.L. Bai, Chinese Chemical Letters., 13 (2002) 809-810.

    The unexpected reduction products d-alkoxyenals by sodium borohydride in methanol with a trace of magnesium methoxid.