Minou Bina                         email  

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• For studies of the Human Genome, we develop tools in Bioinformatics and theoretical models for making experimentally testable predictions. These efforts are interdisciplinary projects done in collaboration with scientists from the Department of Biology, Statistics, Computer Science and Electrical Engineering.

• For studies of the Human Genome, we have collected the sequences of the experimentally defined transcription factor binding sites.  The goal of this project is to resolve the redundancy problem encountered in the current databases of transcription factor binding elements.  

• We are developing computational and statistical models to locate the regulatory regions in human genomic DNA.  In collaborative work with E. Crowley and K. Roeder, we have developed a statistical model that often correctly locates Locus Control Regions (LCRs) and enhancer sequences in genomic DNA.   

• We are constructing a database of  a subset of the human regulatory genes, including transcription factors.  The goal of this project is to to reconstruct the regulatory networks that control the expression of human genes.

• We are constructing a database (Rosalind_Franklin.hsDAT) of potential regulatory codes in human DNA.  The goal of this project is to discover "the linguistics" of DNA defining the regulatory regions of human genes. 

• Our experimental systems include studies of regulation of a subset of human genes. These studies are done towards developing a framework for systematic identifications of control elements in human DNA.

• Our experimental systems include studies on the regulation of HIV-1 gene expression. We have identified several cellular transcription factors that interact selectively with DNA control elements in the HIV-1 long terminal repeat (LTR).