Danzhou Yang, Martha and Fred Borch Chair in Cancer Therapeutics, Professor of Analytical Chemistry and Medicinal Chemistry and Molecular Pharmacology. Her research focuses on bioanalytical, structural and functional studies of cancer-specific DNA molecular targets and structure-based rational design of new anticancer drugs. In particular, her group works on the biologically relevant DNA G-quadruplexes found in human oncogene promoters and human telomeres. Research in her lab involves a variety of bioanalytical methods, particularly high-field NMR spectroscopy, UV and CD spectroscopy, and fluorescence spectroscopy, in combination with computational, biochemical and cell-based methods. Please see lab website for more information.
A REU student will be involved in the bioanalytical and biophysical characterization of biological G-quadruplexes and their interactions with small molecule ligands and proteins, using a combination of high-field NMR spectrometry, fluorescence spectroscopy, and UV and CD spectroscopy. The student will be mentored by a graduate student or a postdoctoral scholar in the group.