Lyon Lab

Purdue Science
Purdue University

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Publications

Intramolecular electrostatic interactions contribute to phospholipase Cβ3 autoinhibition. Esquina, C.M., Garland-Kuntz, E.E., Goldfarb, D., McDonald, E.K., Hudson, B.N., Lyon, A.M. Cell. Signal. [epublished ahead of print]. PMID: 31254604.

Quantifying acute fueld and respiration dependent pH homeostasis in live cells using the mCherryTYG mutant as a fluorescence lifetime sensor. Haynes, E.P., Rajendran, M., Henning, C.K., Mishra, A., Lyon, A.M., Tantama, M. Anal. Chem. 91(13), 8466-8475 (2019). PMID: 31247720.

High-resolution structure of RGS17 suggests a role for Ca2+ in promoting the GTPase-activating protein activity by RZ subfamily members. Sieng, M., Hayes, M.P., O'Brien, J.B., Fowler, C.A., Houtman, J.C., Roman, D.L., and Lyon, A.M. J. Biol. Chem. 294(20), 8148-8160 (2019). PMID: 30940727.

Direct obversation of conformational dyanmics of the PH domain in phospholipases Cε and β may contribute to subfamily-specific roles in regulation. Garland-Kuntz, E.E., Vago, F.S., Sieng, M., Van Camp, M., Chakravarthy, S., Blaine, A., Corpstein, C., Jiang, W., Lyon, A.M. J. Biol. Chem. 293(45), 17477-17490 (2018). PMID: 30242131.

G protein βγ subunits direct interact with and activation phospholipase Cε. Madukwe, J.C., Garland-Kuntz, E.E., Lyon, A.M., Smrcka, A.V. J. Biol. Chem. 293(17), 6387-6397 (2018). PMID: 29535186.

Defect in phosphoinositide signalling through a homozygous variant in PLCB3 causes a new form of spondylometaphyseal dysplasia with corneal dystrophy. Ben-Salem, S., Robbins, S.M., Sobreira, L.M., Lyon, A.M., Al-Shamsi, A.M., Islam, B.K., John, A., Thachillath, P., Al Hamed, S, Valle, D., Ali, B.R., and Al-Gazali, L. J. Med. Genet. 55(2), 122-130 (2017). PMID: 29122926.

Phospholipase Cβ3 membrane adsorption and activation is regulated by its C-terminal domains and PIP2. Hudson, B.N., Hyun, S.-H., Thompson, D.T., and Lyon, A.M. Biochemistry 56(41), 5604-5614 (2017). PMID: 28945350

Molecular Mechanisms of Phospholipase C β3 Autoinhibition. Lyon, A.M., Begley, J.A., Manett, T.M., and Tesmer, J.J.G. Structure 22, 1844-1854 (2014). PMID:25435326

Strike a Pose: Gαq Complexes at the Membrane. Lyon, A.M., Taylor, V.G., and Tesmer, J.J.G. Trends Pharmacol. Sci. 35(1), 23-30 (2014). PMID:24287282

Structural Insights into Phospholipase C-β Function. Lyon, A.M. and Tesmer, J.J.G. Mol. Pharm. 84(4), 488-500 (2013). PMID:23880553

Full-length Gαq-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain. Lyon, A.M., Dutta, S., Boguth, C.A., Skiniotis, G., and Tesmer, J.J.G. Nat. Struct. Mol. Biol. 20(3), 355-362 (2013). PMID:23377541

An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation. Lyon, A.M., Tesmer, V.M., Dhamsania, V.D., Thal, D.M., Gutierrez, J., Chowdhury, K.C., Northup, J.K., and Tesmer, J.J.G. Nat. Struct. Mol. Biol. 18(9), 999-1005 (2011). PMID: 21822282

Bruno protein contains an expanded RNA recognition motif. Lyon, A.M., Reveal, B.S., Macdonald, P.M., and Hoffman, D.W. Biochemistry 48(51), 12202-12212 (2009). PMID: 19919093

The structure of a eukaryotic translation initiation factor-4E from wheat reveals a novel disulfide bond. Monzingo, A.F., Dhaliwal, S., Dutt-Chaudhuri, A., Lyon, A., Sadow, J.H., Hoffman, D.W., Robertus, J.D., and Browning, K.S. Plant Physiol. 143(4), 1504-1518 (2007). PMID:17322339