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Last updated on 7/21/2021

Dr. Zhang’s



Ho, W. J., Croessmann, S., Lin, J., Phyo, Z., Charmsaz, S., Danilova, L., Mohan, A., Gross, N., Chen, F., Dong J., Aggarwal, D., Bai, Y., Wang, J., He, J., Leatherman, J., Yarchoan, M., Armstrong, T., Zaidi, N., Fertig, E. J., Denny, J. C., Park, B. H., Zhang, Z.-Y., and Jaffee, E. M. "Systemic inhibition of PTPN22 augments anticancer immunity", J. Clin. Invest., 131, in press (2021).


Xu, Y.-F., Chen, X., Yang, Z., Xiao, P., Liu, C.-H., Li, K.-S., Yang, X.-Z., Wang, Y.-J., Zhu, Z.-L., Xu, Z.-G., Zhang, S., Wang, C., Song, Y., Zhao, W.-D., Wang, C.-H., Ji, Z.-L., Zhang, Z.-Y., Cui, M., Sun, J.-P., and Yu, X. "PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates", EMBO Reports, 22, e52141 (2021).


Kim, W., LeBlanc, B., Matthews, W. L., Zhang, Z.-Y., and Zhang, Y. J. "Advancements in Chemical Biology Targeting the Kinases and Phosphatases of RNA Polymerase II-mediated Transcription", Current Opinion in Chemical Biology, 63, 68-77 (2021).


Ruddraraju, K. V., Aggarwal, D., and Zhang, Z.-Y. "Therapeutic Targeting of Protein Tyrosine Phosphatases from Mycobacterium tuberculosis", Microorganisms, 9, 14 (2021).


Chen, H., Libring, S., Ruddraraju, K. V., Miao, J., Solorio, L., Zhang, Z.-Y., and Wendt, M. K. "SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer", Oncogene, 39, 7166-7180 (2020).


Zhu, G., Xie, J., Kong, W., Xie, J., Li, Y., Du, L., Zheng, Q., Sun, L., Guan, M., Li, H., Zhu, T., He, H., Liu, Z., Xia, X., Kan, C., Tao, Y., Shen, H. C., Li, D., Wang, S., Yu, Y., Yu, Z.-H., Zhang, Z.-Y., Liu, C., and Zhu, J. "Phase separation of disease-associated SHP2 mutants underlies MAPK hyperactivation", Cell, 183, 490-502 (2020).


Ruddraraju, K. V., Aggarwal, D., Niu, C., Baker, E. A., Zhang, R.-Y., Wu, L., and Zhang, Z.-Y. "Highly Potent and Selective N-Aryl Oxamic Acid-Based Inhibitors for Mycobacterium Tuberculosis Protein Tyrosine Phosphatase B", J. Med. Chem., 63, 9212-9227 (2020).


Li, Q., Bai, Y., Lyle, L. T., Yu, G., Amarasinghe, O., Nguele Meke, F., Carlock, C., and Zhang, Z.-Y. "Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis", Proc. Natl. Acad. Sci. USA, 117, 20538-20548 (2020).


Zhang, R.-Y., Yu, Z.-H., Chen, L., Walls, C. D., Zhang, S., Wu, L., and Zhang, Z.-Y. "Mechanistic insights explain the transforming potential of the T507K substitution in the protein tyrosine phosphatase SHP2", J. Biol. Chem., 295, 6187-6201 (2020). PMC7196634


Wiede, F., Lu, K.-H., Liang, S., Hochheiser, K., Dodd, G. T., Goh, P., Kearny, C., Meyran, D., Beavis, P. A., Henderson, M. A., Park, S. L., Waithman, J., Zhang, S., Zhang, Z.-Y., Oliaro, J., Gebhardt, T., Darcy, P. K., and Tiganis, T. "PTPN2 deletion in T cells promotes anti-tumor immunity and CAR T cell efficacy in solid tumors", The EMBO J., 39(2): e103637 (2020).


Ruddraraju, K. V. and Zhang, Z.-Y. "Activity-based probes for profiling protein activities", Mass Spectrometry-based Chemical Proteomics (Eds. W. Andy Tao and Ying Zhang), Wiley New York, p.101-125 (2019).


Li, Y., Gardner, J. J., Fortney, K. R., Leus, I.V., Bonifay, V., Zgurskaya, H. I., Pletnev, A. A., Zhang, S., Zhang, Z.-Y., Gribble, G. W., Spinola, S. M., and Duerfeldt, A. S. "First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors", Bioorganic & Medicinal Chemistry Letters, 29, 1836-1841 (2019).


Sima, L. E., Yakubov, B., Zhang, S., Condello, S., Grigorescu, A. A., Nwani, N., Chen, L., Schiltz, G. E., Arvanitis, C., Zhang, Z.-Y., and Matei, D. "Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin", Molecular Cancer Therapeutics, 18, 1057-1068 (2019).


Kano, Y., Gebregiworgis, T., Marshall, C. B., Radulovich, N., Poon, B. P. K., St-Germain, J., Cook, J. D., Valencia-Sama, I., Grant, B. M. M., Herrera, S., Miao, J., Raught, B., Irwin, M. S., Lee, J. E., Yeh, J. J., Zhang, Z.-Y., Tsao, M.-S., Ikura, M., and Ohh, M. "Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation", Nature Communications, 10, 224 (2019).


Davis, D. C., Hoch, D. G., Wu, L., Abegg, D., Martin, B. S., Zhang, Z.-Y., Adibekian, A., and Dai, M. "Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids", J. Am. Chem. Soc., 140, 17465-17473 (2018).


Xu, J., Lee, S. S.-Y., Seo, H., Pang, L., Jun, Y., Zhang, R.-Y., Zhang, Z.-Y., Kim, P., Lee, W., Kron, S. J., and Yeo Y. "Quinic acid-conjugated nanoparticles enhance drug delivery to solid tumors via interactions with endothelial selectins", Small, 14, 1803601 (2018).


Dodd, G. T., Michael, N. J., Lee-Young, R. S., Mangiafico, S. P., Pryor, J. T., Munder, A. C., Simonds, S. E., Brüning, J. C., Zhang, Z.-Y., Cowley, M. A., Andrikopoulos, S., Horvath, T. L., Spanswick, D., and Tiganis, T. "Insulin regulates POMC neuronal plasticity to control glucose metabolism", eLife, 7, e38704 (2018).


Zehender, A., Huang, J., Györfi, A.-H., Matei, A.-E., Trinh-Minh, T., Xu, X., Li, Y.-N., Chen, C.-W., Lin, J., Dees, C., Beyer, C., Gelse, K., Zhang, Z.-Y., Bergmann, C., Ramming, A., Birchmeier, W., Distler, O., Schett, G., Distler, J. H. W. "The tyrosine phosphatase SHP2 controls TGFß-induced STAT3 signaling to regulate fibroblast activation and fibrosis", Nature Communications, 9, 3259 (2018).


Hsu, A. Y., Gurol, T., Sobreira, T. J., Zhang, S., Moore, N., Cai, C., Zhang, Z.-Y., and Deng, Q. "Development and characterization of an endotoxemia model in zebra fish", Frontiers in Immunology, 9, 607 (2018).


McQueeney, K. E., Salamoun, J. M., Burnett, J. C., Barabutis, N., Pekic, P., Lewandowski, S. L., Llaneza, D. C., Cornelison, R., Bai, Y., Zhang, Z.-Y., Catravas, J. D., Landen, Jr, C. N., Wipf, P., Lazo, J. S., and Sharlow, E. R. "Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor", Oncotarget, 9, 8223-8240(2018).


Yu, Z.-H., and Zhang, Z.-Y. "Regulatory mechanisms and novel therapeutic targeting strategies for protein tyrosine phosphatases", Chemical Reviews, 118, 1069-1091 (2018).


Prabhu, L., Chen, L., Wei, H., Safa, A., Zhang, Z.-Y., and Lu, T. "Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases", Molecular BioSystems, 13, 2509-2520 (2017).


Frankson, R., Yu, Z.-H., Bai, Y., Li, Q., Zhang, R.-Y., Zhang, Z.-Y. "Therapeutic targeting of oncogenic tyrosine phosphatases", Cancer Research, 77, 5701-5705 (2017).


Yamashita, N., Joshi, R., Zhang, S., Zhang, Z.-Y., and Kuruvilla, R. "Phospho-regulation of soma-to-axon transcytosis of neurotrophin receptors", Dev. Cell, 42, 626-639 (2017).


Sacchetti, C., Bai, Y., Stanford, S. M., Di Bebedetto, P., Cipriani, P., Santelli, E., Piera-Velazquez, S., Chernitskiy, V., Kiosses, W. B., Ceponis, A., Kaestner, K., Boin, F., Jimenez, S. A., Giacomelli, R., Zhang, Z.-Y., and Bottini, N. "PTP4A1 promotes TGFb signaling and fibrosis in systemic sclerosis", Nature Communications, 8 1060 (2017).


Heckman, C. A., Pandey, P., Cayer, M. L., Biswas, T., Zhang, Z.-Y., and Boudreau, N. S. "The Tumor Promoter-Activated Protein Kinase Cs are a System for Regulating Filopodia", Cytoskeleton, 74, 297-314 (2017).


Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z.-Y., Lu, T. "Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers", Oncotarget, 8, 39963-39977 (2017).


Ruddraraju, K. V. and Zhang, Z.-Y. "Covalent inhibition of protein tyrosine phosphatases", Molecular BioSystems, 13, 1257-1279 (2017).


Kobayashi, M., Chen, S., Bai, Y., Yao, C., Gao, R., Sun, X.-J., Mu, C., Twiggs, T., Yu, Z. H., Boswell, H. S., Yoder, M. C., Kapur, R., Mulloy, J. C., Zhang, Z.-Y., and Liu, Y. "Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia", Leukemia, 31, 1453-1457 (2017).


Kobayashi, M., Nabinger, S., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M. C., Kapur, R., Kaplan, M. H., Lacorazza, H. D., Zhang, Z.-Y., and Liu, Y. "Protein tyrosine phosphatase PRL2 mediates Notch and Kit signals in early T cell progenitors", Stem Cells, 35, 1053-1064 (2017).


Yu, T., Zuo, Y., Cai, R., Huang, X., Wu, S., Zhang, C., Chin, Y. E., Li. D., Zhang Z., Xia, N., Wang Q., Shen, H., Yao, X., Zhang, Z.-Y., Xue, S., Shen, L., and Cheng, J. "SENP1 regulates IFN-g-STAT1 signaling through STAT3-SOCS3 negative feedback loop", Journal of Molecular Cell Biology, 8, 144-153 (2017).


Kobayashi, M., Bai, Y., Chen, S., Gao, R., Yao, C., Cai, W., Cardoso, A. A., Croop, J., Zhang, Z.-Y., and Liu, Y. "Phosphatase PRL2 promotes oncogenic Notch1-induced T cell leukemia", Leukemia, 31, 751-754 (2017).


Zhang, Z.-Y. "Drugging the undruggable: therapeutic potential of targeting protein tyrosine phosphatases", Acc. Chem. Res., 50, 122-129 (2017).


Bai, S., Ingram, P., Chen, Y.-C., Deng, N., Pearson, A., Niknafs, Y., O’Hayer, P., Wang, Y., Zhang, Z.-Y., Boscolo, E., Bischoff, J., Yoon., E., and Buckanovich, R. "EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis ALDH+ Ovarian Cancer Cells", Cancer Res., 76, 6396-6409 (2016).


He, R., Wang, J., Yu, Z.-H., Zhang, R.-Y., Liu, S., Wu, L., and Zhang, Z.-Y. "Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism", J. Med. Chem., 59, 9094-9106 (2016).


Song, G. J., Kim, J., Kim, J.-H., Song, S., Park, H., Zhang, Z.-Y., and Suk, K. "Comparative analysis of protein tyrosine phosphatases regulating microglial activation", Experimental Neurobiology, 25, 252-261 (2016).


Bai, Y., Zhou, H.-M., Zhang, L., Dong, Y., Zeng, Q., Shou, W., and Zhang, Z.-Y. "Role of Phosphatase of Regenerating Liver 1 (PRL-1) in spermatogenesis", Scientific Reports, 6, 34211 (2016).


Zhang, R.-Y., Yu, Z.-H., Zeng, L.-F., Zhang, S., Bai, Y., Miao, J., Chen, L., Xie, J. and Zhang, Z.-Y. "SHP2 phosphatase as a novel target for melanoma treatment", Oncotarget, 7, 73817-73829 (2016).


Richine, B. M., Virts, E., Bowling, J. D., Ramdas, B., Mali, R., Naoye, R., Liu, Z., Zhang, Z.-Y., Boswell, H. S., Kapur, R. and Chan, R. J. "Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia", Leukemia, 30, 2094-2097 (2016).


He, R. and Zhang, Z.-Y. "Current status of PTP-based therapeutics", Current status of PTP-based therapeutics”, Protein Tyrosine Phosphatases in Cancer (Eds: Ben Neel and Nick Tonks), Springer New York, p. 335-353 (2016).


Bai, Y., Yu, Z.-H. and Zhang, Z.-Y. "Discovery and evaluation of PRL trimer disruptors for novel anticancer agents", Methods in Molecular Biology, 1447 121-138 (2016).


Li, Y., Xia, G., Guo, Q., Wu, L., Chen, S., Yang, Z., Wang, W., Zhang, Z.-Y., Zhou, X., and Jiang, Z.-X. "Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors", Med. Chem. Comm., 7, 1672-1680 (2016).


Bai, Y., Yu, Z., Liu, S., Zhang, L., Zhang, R.-Y., Zeng, L.-F., Zhang, S., and Zhang, Z.-Y. "Novel anticancer agents based on targeting the trimer interface of the PRL phosphatase", Cancer Res., 76, 4805-4815 (2016).


Maeshima, K., Stanford, S. M., Hammaker, D., Sacchetti, C., Zeng, L.-F., Ai, R., Zhang, V., Boyle, D. L., Aleman Muench, G. R., Feng, G.-F., Whitaker, J. W., Zhang, Z.-Y., Wang, W., Bottini, N., and Firestein, G. S. "Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation", JCI Insight, 1, e86580 (2016).


Wang, J., Mizui, M., Zeng, L-F., Bronson, R., Finnell, M., Terhorst, C., Kyttaris, V. C., Tsokos, G. C., Zhang, Z.-Y., and Kontaridis, M. "Inhibition of SHP2 Ameliorates the Pathogenesis of Systemic Lupus Erythematosus", J. Clin. Invest., 126, 2077-2092 (2016).


Song, G. J., Jung, M., Kim, J.-H., Park, H., Rahman, H., Zhang, S., Zhang, Z.-Y., Park, D. H., Kook, H., Lee, I.-K., and Suk, K. "A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation", Journal of Neuroinflammation, 13, 86 (2016).


Dutta, N. K., He, R., Pinn, M. L., He, Y., Burrows, F., Zhang, Z.-Y., and Karakousis, P. C. "Mycobacterial protein tyrosine phosphatases A and B inhibitors augment the bactericidal activity of standard anti-tuberculosis regimen", ACS Infectious Diseases, 2, 231-239 (2016).


Hamerman, J. A., Pottle, J., Ni, M., He, Y., Zhang, Z.-Y., and Buckner, J. H. "Negative regulation of TLR signaling in myeloid cells - Implications for autoimmune diseases", Immunological Reviews, 269, 212-227 (2016).


Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X.-Y., Broxmeyer, H., Zhang, Z.-Y., Liu, J.-Y., and Zhang, J.-T. "Small molecule inhibitors targeting the DNA-binding domain of STAT3 suppresses tumor growth, metastasis, and STAT3 target gene expression in vivo", Oncogene, 35, 783-792 (2016).


He, R., Yu, Z.-H., Zhang, R.-Y., Wu, L., Gunawan, A. M., and Zhang, Z.-Y. "Cefsulodin inspired potent and selective inhibitors of mPTPB, a virulent phosphatase from Mycobacterium tuberculosis", ACS Med. Chem. Lett. , 6, 1231-1235 (2015).


Bunda, S., Burrell, K., Heir, P., Zeng, L.-F., Alamsahebpour, A., Kano, Y., Raught, B., Zhang, Z.-Y., Zadeh, G., and Ohh, M. "Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis", Nature Communications, 6, 8859 (2015).


Zhu, H. H., Luo, X., Zhang, K., Cui, J., Zhao, H., Ji, Z.; Zhou, Z.; Yao, J.; Zeng, L., Ji, K., Gao, W.-Q., Zhang, Z.-Y., and Feng, G.-S. "Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals", Proc. Natl. Acad. Sci. USA, 112, 13342-13347 (2015).


Zhang, Z.-Y., Dodd, G. T., and Tiganis, T. "Protein Tyrosine Phosphatase in hypothalamic insulin and leptin signaling", Trends in Pharmacological Sciences, 36, 661-674 (2015).


He, R., Yu, Z.-H., Zhang, R.-Y., Wu, L., Gunawan, A., Lane, B. S., Shim, J. S., Zeng, L.-F., He, Y., Chen, L., Wells, C. D., Liu, J. O., and Zhang, Z.-Y. "Exploring the existing drug space for novel pTyr mimetic and SHP2 inhibitors", ACS Medicinal Chemistry Letter, 6, 782-786 (2015).


van Rensburg, J. J., Fortney, K. R., Chen, L., Kreiger, A., Lima, B. P., Wolfe, A. J., Katz, B. P., Zhang, Z.-Y., and Spinola, S. M. "Development and Validation of a High-throughput Cell-based Screen to Identify Activators of a Bacterial Two-component Signal Transduction System", Antimicrobial Agents and Chemotherapy, 59, 3789-3799 (2015).


He, Y., Guo, X., Yu, Z.-H., Wu, L., Gunawan, A. M., Zhang, Y., Dixon, J. E. and Zhang, Z.-Y. "A potent and selective inhibitor for the UBLCP1 proteasome phosphatase", Bioorganic and Medicinal Chemistry, 23, 2798-2809 (2015).


Dodd, G., Descherf, S., Loh, K., Simmonds, S., Wiede, F., Balland, E., Merry, T. L., Munzberg, H., Zhang, Z.-Y., Kahn, B. B., Neel, B. G., Bence, K. K., Andrews, Z. B., Cowley, M. A., and Tiganis, T. "Leptin and insulin act on POMC neurons to promote browning of white fat", Cell, 160, 88-104 (2015).


Xi, Y., Liu, S., Bettaieb, A., Matsuo, K., Matsuo, I., Hosein, E., Chahed, S., Wiede, F., Zhang, S., Zhang, Z.-Y., Kulkarni, R. N., Tiganis, T., and Haj, F. G. "Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta-cell function in mice", Diabetologia,58, 122-131 (2015).


Paudyal, M., Wu, L., Zhang, Z.-Y., Spilling, C. D., and Wong, C. F. "A New Class of Salicylic Acid Derivatives for Inhibiting YopH of Yersinia pestis", Bioorganic and Medicinal Chemistry, 22, 6781-6788 (2014).


Ozek, C., Kanoski, S. E., Zhang, Z.-Y., Grill H. J., and Bence, K. "Protein tyrosine phosphatase B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling", J. Biol. Chem., 289, 31682-31692 (2014).


Kobayashi, M., Chen, S., Gao, R. Bai, Y., Zhang, Z.-Y., and Liu, Y. "Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies", Cell Cycle, 13, 2827-2835 (2014).


He, R., Yu, Z.-H., Zhang, R.-Y., and Zhang, Z.-Y. "Protein tyrosine phosphatases as potential therapeutic targets", Acta Pharmacologica Sinica, 35, 1227-1246 (2014).


He, R., Bai, Y., Yu, Z.-H., Wu, L., Gunawan, A. M., and Zhang, Z.-Y. "Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis", Med. Chem. Commun., 5, 1496-1499 (2014).


Sharma, N., Everingham, S., Zeng, L.-F., Zhang, Z.-Y., Kapur, R., and Craig, A. W. B. "Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice", Oncotarget, 5, 6130-6141 (2014).


Zeng, L.-F., Zhang, R.-Y., Yu, Z.-H., Liu, S., Wu, L., Gunawan, A. M., Lane, B. S., Mali, R. S., Li, X., Chan, R. J., Kapur, R., Wells, C. D., and Zhang, Z.-Y. "Therapeutic potential of targeting oncogenic SHP2 phosphatase", J. Med. Chem., 57, 6594-6609 (2014).


Yu, Z.-H., Zhang, R.-Y., Walls, C., Chen, L., Zhang, S., Wu, L., Liu, S., and Zhang, Z.-Y. "Molecular Basis for Gain-of-Function LEOPARD Syndrome Associated SHP2 Mutations", Biochemistry, 53, 4136-4151 (2014).


Chen, X., Wang, H., Gewin, L., Hu, W., Mernaugh, G., Zhang, S. Zhang, Z.-Y., Fässler, R., Zent, R. and Pozzi, A. "Integrin-mediated type II TGF-ß receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling", Journal of Clinical Investigation, 124, 3295-3310 (2014).


Campbell, A. M. and Zhang, Z.-Y. "Phosphatase of Regenerating Liver, a Novel Target for Cancer Therapy", Expert Opinion on Therapeutic Targets, 18, 555-569 (2014).


Liao, J., Wu, C., Burlak, C., Zhang, S., Sahm, H., Wang, M., Zhang, Z.-Y., Vogel, K., Riddle, S., Federici, M., Nichols, J., Liu, D., Cookson, M., Stone, T. A. and Hoang, Q. Q. "The Parkinson's disease-associated mutation R1441H in LRRK2 prolongs the 'active-state' of its GTPase domain", Proc. Natl. Acad. Sci. USA, 111, 4055-4060 (2014).


Yakubov, B., Chen, L., Belkin, A., Zhang, S., Chelladurai , B., Zhang, Z.-Y., and Matei, D. "Small Molecule Inhibitors Target the Tissue Transglutaminase and Fibronectin Interaction", PLoS ONE, 9, e89285 (2014).


Kobayashi, M., Bai, Y., Dong, Y., Yu, H., Chen, S., Gao, R., Zhang, L. Yoder, M. C., Kapur, R., Zhang Z.-Y. and Liu, Y. "PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal", Stem Cells, 32, 1956-1967 (2014).


Zeng, L.-F., Zhang, R.-Y., Bai, Y., Wu, L., Gunawan, A. M., and Zhang, Z.-Y. "Hydroxyindole Carboxylic Acid Based Inhibitors for Receptor-Type Protein Tyrosine Protein Phosphatase Beta", Antioxidants & Redox Signaling, 20, 2130-2140 (2014).


Dong, Y., Zhang, L., Bai, Y., Zhou, H.-M., Campbell, A. M., Chen, H., Yong, W., Zhang, W., Zeng, Q., Shou, W., and Zhang Z.-Y. "Phosphatase of regenerating liver 2 (PRL2) deficiency impairs Kit signaling and spermatogenesis", J. Biol. Chem., 289, 3799-3810 (2014).


Selner, N. G., Luechapanichkul, R., Chen, X., Neel, B. G., Zhang, Z.-Y., Knapp, S., Bell, C. E., and Pei, D. "Diverse Levels of Sequence Selectivity and Catalytic Efficiency of Protein-Tyrosine Phosphatases", Biochemistry, 53, 397-412 (2014).


Walls, C., Iliuk, A., Bai, Y., Wang, M., Tao, A. and Zhang, Z.-Y. "Phosphatase of Regenerating Liver 3 (PRL3) Provokes a Tyrosine Phosphoproteome to Drive Pro-Metastatic Signal Transduction", Molecular and Cellular Proteomics, 12, 3759-3777 (2013).


Gan, Y., Zhang, Y., Buckels, A., Paterson, A. J., Jiang, J., Clemens, T. L., Zhang, Z.-Y., Du, K., Chang, Y., and Frank, S. J. "IGF-1R modulation of acute GH-induced STAT5 signaling: role of protein tyrosine phosphatase activity", Molecular Endocrinology, 27, 1969-1979 (2013).


Xu, J., Zeng, L.-F., Shen, W., Turchi, J. J., and Zhang, Z.-Y. "Targeting SHP2 for EGFR inhibitor resistant non small cell lung carcinoma", Biochem. Biophys. Res. Commun., 439, i586-590 (2013).


Dumaual, C. M., Steere, B. A., Walls, C. D., Wang, M., Zhang, Z.-Y., and Randall, S. K. "Integrated analysis of global mRNA and protein expression data in HEK293 cells overexpressing PRL-1", PLoS ONE, 8(9):e72977, doi:10.1371/journal.pone.0072977 (2013).


He, Y., Liu, S., Menon, A., Stanford, S., Oppong, E., Gunawan, A. M., Wu, L., Wu, D. J., Barrios, A. M., Bottini, N., Cato, A. C., and Zhang, Z.-Y. "A potent and selective small molecular inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases", J. Med. Chem., 56, 4990-5008 (2013).


Bettaieb, A., Bakke, J., Nagata, N., Matsuo, K., Xi, Y., Liu, S., AbouBechara, D., Melhem, R., Stanhope, K., Cummings, B., Graham, J., Bremer, A., Zhang, S., Lyssiotis, C. A., Zhang, Z.-Y., Cantley, L. C., Havel, P. J., and Haj, F. G. "Protein-Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation", J. Biol. Chem., 288, 17360-17371 (2013).


Zeng, L.-F., Xu, J., He, Y., He, R., Wu, L., Gunawan, A. M., and Zhang, Z.-Y. "A facile hydroxyindole carboxylic acid-based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B", ChemMedChem, 8, 904-908 (2013).


Tang, Y.-B., Lu, D., Chen, Z., Hu, C., Yang, Y., Tian, J.-Y., Ye, F., Wu, L., Zhang, Z.-Y., and Xiao, Z. "Design, synthesis and anti-diabetic activity of novel PTP1B inhibitors", Bioorg. Med. Chem. Lett., 23, 2313-2318 (2013).


Yu, Z.-H., Xu, J., Walls, C., Chen, L., Zhang, S., Zhang, R., Wu, L., Wang, L., Liu, S., and Zhang, Z.-Y. "Structural and mechanistic insights into LEOPARD syndrome associated SHP2 mutations", J. Biol. Chem., 288, 10472-10482 (2013).


He, Y., Xu, J., Yu, Z.-H., Gunawan A. M., Wu, L., Wang, L., and Zhang, Z.-Y. "Discovery and Evaluation of Novel Inhibitors of Mycobacterium Protein Tyrosine Phosphatase B from the 6-Hydroxy-Benzofuran-5-Carboxylic Acid Scaffold", J. Med. Chem., 56, 832-842 (2013).


He, R., Zeng, L.-F., He, Y., Wu, L., Gunawan, A. M., and Zhang, Z.-Y. "Organocatalytic Multicomponent Reaction for the Acquisition of a Potent and Selective Inhibitor of mPTPB, a Virulence Factor of Tuberculosis", Chem. Commun., 49, 2064-2066 (2013).


Nabinger, S. C., Li, X., Ramdas, B., He, Y., Zhang, X., Zeng, L.-F., Richine, B., Bowling, J. D., Fukuda, S., Goenka, S., Liu, Z., Feng, G.-S., Yu, M., Sandusky, G. E., Boswell, H. S., Zhang, Z.-Y., Kapur, R., and Chan, R. J. "The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Hematopoietic Progenitor Hyperproliferation and Malignant Disease In Vivo", Leukemia, 27, 398-408 (2013).


He, R., Zeng, L.-F., He, Y., Zhang, S. and Zhang, Z.-Y. "Small molecule tools for functional interrogation of protein tyrosine phosphatases", FEBS J., 280, 731-750 (2013).


Meng, F.-G. and Zhang, Z.-Y. "Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical", Biochimica et Biophysica Acta, 1834, 464-469 (2013).


Carbone, C. J., Zheng, H., Bhattacharya, S., Lewis, J. R., Reiter, A. M., Henthorn, P. S., Zhang, Z.-Y., Baker, D. P., Ukkiramapandian, R., Bence, K. K., and Fuchs, S. Y. "Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for anti-viral therapies", Proc. Natl. Acad. Sci., 109, 19226-19231 (2012).


Zhang, S., Liu, S., Tao, R., Wei, D., Chen, L., Shen, W., Yu, Z.-H., Wang, L., Jones, D. R., Dong, X. C. and Zhang, Z.-Y. "A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes", J. Am. Chem. Soc., 134, 18116-18124 (2012).   Access the recommendation on F1000Prime


Mali, R. S., Ma, P., Zeng, L.-F., Martin, H., Ramdas, B., He, Y., Sims, E., Nabinger, S., Ghosh, J., Sharma, N., Munugalavadla, V., Chatterjee, A., Li, S., Sandusky, G., Craig, A. W., Bunting, K. D., Feng, G.-S., Chan, R. J., Zhang, Z.-Y. and Kapur, R. "Role of SHP2 phosphatase in KIT induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT", Blood, 120, 2669-2678 (2012).


Dong, Y., Zhang, L., Zhang, S., Bai, Y., Chen, H., Sun, X., Yong, W., Li, W., Colvin, S. C., Rhodes, S. J., Shou, W., and Zhang, Z.-Y. "Phosphatase of regenerating liver 2 (PRL2) is essential for placenta development by downregulating PTEN (phosphatase and tensin homologue deleted on chromosome 10) and activating Akt protein", J. Biol. Chem., 287, 32172-32179 (2012).
This paper was selected as a Journal of Biological Chemistry "Paper of the Week."


Stanford, S. M., Panchal, R. G., Walker, L. M., Wu, D., Falk, M. D., Mitra, S., Damle, S., Ruble, D., Kaltcheva, T., Zhang, S., Zhang, Z.-Y., Bavari, S., Barrios, A., and Bottini, N. "High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active CD45 inhibitors", Proc. Natl. Acad. Sci., USA 109, 13972-13977 (2012).


Zhang, S., Chen, L., Lawrence, D. S. and Zhang, Z.-Y. "A combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors", Methods in Molecular Biology, 928, 53-65 (2012).


He, R., Zeng, L.-F., He, Y. and Zhang, Z.-Y. "Recent Advances in PTP1B Inhibitor Development for the Treatment of Type-2 Diabetes and Obesity", Royal Society of Chemistry ­ Drug Discovery Book Series No. 27, "New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches" (Edited by Robert M. Jones), p.142-176 (2012).


Sharma, N., Kumar, V., Everingham, S., Mali, R. S., Kapur, R., Zeng, L.-F., Zhang, Z.-Y., Feng, G.-S., Hartmann, K., Roers, A., and Craig, A. W. B. "SH2 Domain-Containing Phosphatase-2 is a Critical Regulator of Connective Tissue Mast Cell Survival and Homeostasis in Mice", Molecular and Cellular Biology, 32, 2653-2663 (2012).


Negro, R., Gobessi, S., Longo, P. G., He, Y., Zhang, Z.-Y., Laurenti, L. and Efremov, D. G. "Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated chronic lymphocytic leukemia cells by selectively activating the AKT pathway", Blood, 119, 6278-6287 (2012).


Martin, V. A., Wang, W.-H., Lipchik, A. M., Parker, L. L., He, Y., Zhang, S., Zhang, Z.-Y., Geahlen, R. L. "AKT2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores", Cellular Signaling, 24, 1064-1073 (2012).


He, Y., Zeng, L.-F., Yu, Z.-H., He, R., Liu, S. and Zhang, Z.-Y. "Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors", Bioorg. Med. Chem., 20, 1940-1946 (2012).


Zheng, L.-S., Zhang, Y.-Y., Wu, J.-W., Wu, Z., Zhang, Z.-Y., and Wang, Z.-X. "A continuous spectrophotometric assay for mitogen-activated protein kinase kinases", Anal. Biochem., 421, 191-197 (2012).


Loh, K., Merry, T., Galic, S., Wu, B. J., Watt, M. J., Zhang, S., Zhang, Z.-Y., Neel, B. G., and Tiganis, T. "TCPTP-deficiency in muscle does not alter insulin signaling and glucose homeostasis", Diabetologia,55, 468-478 (2012).


Bai, Y., Luo, Y., Liu, S., Zhang, L., Shen, K., Dong, Y., Walls, C. D., Quilliam, L. A., Wells, C. D., Cao, Y., and Zhang, Z.-Y. "PRL-1 protein promotes ERK1/2 and RhoA activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein", J. Biol. Chem.,286, 42316-42324 (2011).


Loh, K., Fukushima, A., Zhang, M., Briggs, D., Enriori, P., Galic, S., Sims, N., Weide, F., Bence, K. K, Zhang, S., Zhang, Z.-Y., Kahn, B. B., Neel, B. G., Andrews, Z. B., Cowley, M. A., and Tiganis, T. "Elevated hypothalamic TCPTP in obesity contributes to leptin resistance", Cell Metabolism,14, 684-699 (2011).


Kant, S., Swat, W., Zhang, S., Zhang, Z.-Y., Neel, B. G., Flavell, R. A. and Davis, R. J. "TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway", Genes & Development,25, 2069-2078 (2011).


Yu, X., Chen, M., Zhang, S., Yu, Z.-H, Sun, J.-P., Wang, L., Liu, S., Imasaki, T., Takagi, Y., and Zhang, Z.-Y. "Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate", J. Biol. Chem., 286, 30526-30534 (2011).    (Faculty of 1000 Biology "Must Read").


Yu, Z.-H., Chen, L. Wu, L., Liu, S., Wang, L. and Zhang, Z.-Y. "Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening", Bioorg. Med. Chem. Lett., 21, 4238-4242 (2011).


Li, H., Zhao, Z., Antalis, C., Zhao, Z., Emerson, R., Wei, G., Zhang, S., Zhang, Z-.Y. and Xu, Y. "Combinational therapy of an inhibitor of Group VIA phospholipase A2 with paclitaxel is highly effective in blocking ovarian cancer development", American Journal of Pathology, 452-461 (2011).


Stanford, S. M., Krishnamurthy, D., Falk, M. D., Messina, R., Debnath, B., Li, S., Liu, T., Kazemi, R., Dahl, R., He, Y., Yu, X., Chan, A. C., Zhang, Z.-Y., Barrios, A. M., Woods, V. L. Jr., Neamati, N., and Bottini, N "Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells", J. Med. Chem.,54, 1640-1054 (2011).


Piovan, L., Wu, L., Zhang, Z.-Y., and Andrade, L. H. "Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases", Organic & Biomolecular Chemistry,9, 1347-1351 (2011).


Liu, S., Yu, Z., Yu, X., Huang, S.-X., Luo, Y., Wu, L., Shen, W., Yang, Z., Wang, L., Gunawan, A. M., Chan, R. J., Shen, B., and Zhang, Z.-Y. "SHP2 is a Target of the Immunosuppressant Tautomycetin", Chemistry & Biology,18, 101-110 (2011).


He, R., Yu, Z., He, Y., Zeng, L.-F., Xu, J., Wu, L., Gunawan, A. M., Wang, L., Jiang, Z.-X., and Zhang, Z.-Y. "Double Click Reaction for the Acquisition of a Highly Potent and Selective mPTPB Inhibitor", ChemMedChem,5, 2051-2056 (2010).


Chen, L., Zhou, B., Zhang, S., Wu, L., Wang, Y., Franzblau, S. G. and Zhang, Z.-Y. "Identification and characterization of small molecule inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis", ACS Med. Chem. Lett.,1, 355-359 (2010).


Huang, Z., He, Y., Zhang, X., Gunawan, A., Wu, L., Zhang, Z.-Y., Wong, C. F. "Derivatives of Salicylic Acid as Inhibitors of YopH in Yersinia pestis", Chemical Biology and Drug Design,76, 85-99 (2010).


Zhang, X., He, Y., Liu, S., Yu, Z., Jiang, Z.-X., Yang, Z., Dong, Y., Nabinger, S. C., Wu, L., Gunawan, A. M., Wang, L., Chan, R. J., and Zhang, Z.-Y. "Salicylic acid-based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)", J. Med. Chem.,53, 2482-2493 (2010).


Zhou, B., He, Y., Zhang, X., Xu, J., Luo, Y., Wang, Y., Franzblau, S.G., Yang, Z., Chan, R. J., Liu, Y., Zheng, J. and Zhang, Z.-Y. "Targeting Mycobacterium Protein Tyrosine Phosphatase B for Anti-Tuberculosis Agents", Proc. Natl. Acad. Sci. USA,107, 4573-8 (2010).  (Faculty of 1000 Biology "Exceptional")  (Featured in C&EN Concentrates).


Long, S. A., Cerosaletti, K., Bollyky, P. L., Tatum, M., Shilling, H., Zhang, S., Zhang, Z.-Y., Pihoker, C., Sanda, S., Greenbaum, C., and Buckner, J. H. "Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4+CD25+ regulatory T cells of Type 1 Diabetic subjects", Diabetes,59, 407-415 (2010).   (Faculty of 1000 Biology "Recommended").


Zhang, Z.-Y. "Inhibitors of Protein Tyrosine Phosphatases", in Ralph Bradshaw and Edward Dennis, editors, Handbook of Cell Signaling, second edition, Oxford: Academic Press, Vol. 2, pp. 727-735 (2009).


Zhang, S., Chen, L., Luo, Y., Gunawan, A., Lawrence, D. S. and Zhang, Z.-Y. "Acquisition of a Potent and Selective TC-PTP Inhibitor from a Stepwise Fluorophore-tagged Combinatorial Synthesis and Screening Strategy", J. Am. Chem. Soc.,131, 13072-13079 (2009).


Zhang, W., Chan, R. J., Chen, H., Yang, Z., He, Y., Zhang, X., Luo, Y., Ying, F., Moh, A., Miller, L. C., Payne, R. M., Zhang, Z.-Y., Fu, X.-Y., and Shou, W. "Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and JMML", J. Biol. Chem.,284, 22353-22363 (2009).


Arias-Romero, L. E., Saha, S., Villamar-Cruz, O., Yip, S-C., Ethier, S.P., Zhang, Z.-Y., and Chernoff, J. "Activation of Src by protein tyrosine phosphatase 1B is required for ErbB2 transformation of human breast epithelial cells", Cancer Research, 69, 4582-4588 (2009).


Walls, C., Zhou, B. and Zhang, Z.-Y. "Activity-based protein profiling of protein tyrosine phosphatases", Methods in Molecular Biology,519, 417-429 (2009).


Arechiga, A. F., Habib, T., He, Y., Zhang, X., Zhang, Z.-Y., Funk, A., and Buckner, J. H. "Cutting Edge: The PTPN22 allelic variant associated with autoimmunity impairs B cell signaling", Journal of Immunology,182, 3343-3347 (2009).    (Faculty of 1000 Biology "Recommended").


Luo, Y., Liang, F., and Zhang, Z.-Y. "PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways", Biochemistry,48, 1838-1846 (2009).


Orrú, V., Tsai, S. J., Rueda, B., Fiorillo, E., Stanford, S. M., Dasgupta, J., Hartiala, J., Zhao, L., Ortego-Centeno, N., D¹Alfonso, S. & The Italian Collaborative Group, Arnett, F. C., Wu, H., Gonzalez-Gay, M. A., Tsao, B. P., Pons-Estel, B., Alarcon-Riquelme, M. E., He, Y., Zhang, Z.-Y., Allayee, H., Chen, X. S., Martin, J. and Bottini, N. "A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus", Human Molecular Genetics,18, 569-579 (2009).


Liu, S., Zeng, L.-F., Wu, L., Yu, X., Xue, T., Gunawan, A., Long, Y.-Q., and Zhang, Z.-Y. "Targeting Inactive Enzyme Conformation: Aryl Diketoacid Derivatives as a New Class of PTP1B Inhibitors", J. Am. Chem. Soc.,130, 17075-84 (2008).    (Faculty of 1000 Biology "Recommended").


Abdo, M., Liu, S., Zhou, B., Walls, C. D., Wu, L., Knapp, S. and Zhang, Z.-Y. "Seleninate in Place of Phosphate: Irreversible Inhibition of Protein Tyrosine Phosphatases", J. Am. Chem. Soc.,130, 13196-13197 (2008).    (Faculty of 1000 Biology "Recommended").


Boivin, B., Zhang, S., Arbiser, J. L., Zhang, Z.-Y., and Tonks, N. K. "A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells", Proc. Natl. Acad. Sci.,USA 105, 9959-9964 (2008).    (Faculty of 1000 Biology "Must Read").


Liu, S., Zhou, B., Yang, H., He, Y., Jiang, Z.-X., Kumar, S., Wu, L. and Zhang, Z.-Y. "Aryl vinyl sulfones and sulfonates as active site-directed and mechanism-based probes for protein tyrosine phosphatases", J. Am. Chem. Soc.,130, 8251-8260 (2008).    (Faculty of 1000 Biology "Must Read").


Jiang, Z.-X. and Zhang, Z.-Y. "Trgeting PTPs with small molecule inhibitors in cancer treatment", Cancer and Metastasis Reviews,27, 263-272 (2008).


Liang, F., Luo, Y., Dong, Y., Walls, C. D., Liang, J., Jiang, H.-Y., Sanford, J. R., Wek, R. C. and Zhang, Z.-Y. "Translational Control of C-terminal Src Kinase (Csk) Expression by PRL3 Phosphatase", J. Biol. Chem.,283, 10339-10346 (2008).


Cortesio, C. L., Chan, K. T., Perrin, B. J., Burton, N. O., Zhang, S., Zhang, Z.-Y., and Huttenlocher, A. "Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion", J. Cell Biology,180, 957-971 (2008).    (Faculty of 1000 Biology "Recommended").


Almo, S. C., Bonanno, J. B., Sauder, J. M., Emtage, S., Dilorenzo, T. P., Malashkevich, V., Wasserman, S. R., Swaminathan, S., Eswaramoorthy, S., Agarwal, R., Kumaran, D., Madegowda, M., Ragumani, S., Patskovsky, Y., Alvarado, J., Ramagopal, U. A., Faber-Barata, J., Chance, M. R., Sali, A., Fiser, A., Zhang, Z.-Y., Lawrence, D. S., and Burley, S. K. "Structural genomics of protein phosphatases", J. Struct. Funct. Genomics,8, 121-140 (2007).


Yu, X., Sun, J.-P., He, Y., Guo, X.-L., Liu, S., Zhou, B., Hudmon, A. and Zhang, Z.-Y. "Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases", Proc. Natl. Acad. Sci.,USA 104, 19767-19772 (2007).    (Faculty of 1000 Biology "Must Read").


Sun, J.-P., Luo, Y., Yu, X., Wang, W.-Q., Zhou, B., Liang, F., and Zhang, Z.-Y. "Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for the PRL1-mediated cell growth and migration", J. Biol. Chem.,282, 29043-29051 (2007).


Zhang, S., Chen, L., Kumar, S., Wu, L., Lawrence, D. S. and Zhang, Z.-Y. "An Affinity-based Fluorescence Polarization Assay for Protein Tyrosine Phosphatases", Methods,42, 261-267 (2007).   (Faculty of 1000 Biology "Recommended").


Zhou, B. and Zhang, Z.-Y. "Application of hydrogen/deuterium exchange mass spectrometry to study protein tyrosine phosphatase dynamics, ligand binding, and substrate specificity", Methods,42, 227-233 (2007).


Zhang, Z.-Y. "Emerging new techniques for studying protein phosphatases", Methods,42, 205-206 (2007).


Liang, F., Kumar, S., and Zhang, Z.-Y. "Proteomic Approaches to Studying Protein Tyrosine Phosphatases", Molecular BioSystems,3, 308-316 (2007).


Zhang, S. and Zhang, Z.-Y. "PTP1B as a drug target: recent development in PTP1B inhibitor discovery", Drug Discovery Today,12, 373-381 (2007).


Khajehpour, M., Wu, L., Liu, S., Zhadin, N., Zhang, Z.-Y. and Callender, R. "Loop Dynamics and ligand binding kinetics in the reaction catalyzed by the Yersinia protein tyrosine phosphatase", Biochemistry,46 4370-4378 (2007).


Liang, F., Liang, J., Wang, W.-Q., Sun, J.-P., Udho, E., and Zhang, Z.-Y. "PRL3 Promotes Cell Invasion and Proliferation by Down-regulation of Csk Leading to Src Activation", J. Biol. Chem.,282 5413-5419 (2007).     (Faculty of 1000 Biology "Recommended").


Boutselis, I. G., Yu, X., Zhang, Z.-Y., and Borch, R. "Synthesis and cell-based activity of a potent and selective PTP1B inhibitor prodrug", J. Med. Chem.,50, 856-864 (2007).


Morrison, C. D., White, C. L., Wang, Z., Lee, S.-Y., Lawrence, D. S., Cefalu, W. T., Zhang, Z.-Y., and Gettys, T. W. "Increased hypothalamic PTP1B contribute to leptin resistance with age", Endocrinology,148, 433-440 (2007).


Zhou, B., Zhang, J., Liu, S., Reddy, S., Wang, F., and Zhang, Z.-Y. "Mapping ERK2-MKP3 Binding Interfaces by Hydrogen/Deuterium Exchange Mass Spectrometry", J. Biol. Chem., 281, 38834-38844 (2006).


Kumar, S., Zhou, B., Liang, F., Yang, H., Wang, W.-Q., and Zhang, Z.-Y. "Global Analysis of Protein Tyrosine Phosphatase Activity with Ultra-Sensitive Fluorescent Probes", J. Proteome Res., 5, 1898-1905 (2006).    (Faculty of 1000 Biology "Must Read").


Cui, Y., Parra, I., Zhang, M., Hilsenbeck, S. G., Tsimelzon, A., Furukawa, T., Horii, A., Zhang, Z.-Y., Nicholson, R. I. and Fuqua, S. A. "Elevated Expression of Mitogen-Activated Protein Kinase Phosphatase 3 in Breast Tumors: A Mechanism of Tamoxifen Resistance", Cancer Research , 66, 5950-5959 (2006).


Liu, S., Sun, J.-P., Zhou, B. and Zhang, Z.-Y. "Structural basis of docking interaction between ERK2 and MAP kinase phosphatase 3", Proc. Natl. Acad. Sci. USA, 103, 5326-5331 (2006).


Xue, C., Wyckoff, J., Liang, F., Sidani, M., Violini, S., Tsai, K.-L., Zhang, Z.-Y., Sahai, E., Condeelis, J., and Segall J. E. "Epidermal Growth Factor Receptor Overexpression Results in Increased Tumor Cell Motility In vivo Coordinately with Enhanced Intravasation and Metastasis", Cancer Research, 66, 192-197 (2006).


Xue, C., Liang, F., Mahmood, R., Vuolo, M., Wyckoff, J., Qian, H., Tsai, K.-L., Kim, M., Locker, J., Zhang, Z.-Y., and Segall, J. E. "ErbB3-dependent motility and intravasation in breast cancer matastasis", Cancer Research 66, 1418-1426 (2006).


Lee, H., Xie, L., Luo, Y., Lee, S.-Y., Lawrence, D. S., Wang, X. B., Sotgia, F., Lisanti, M. P., and Zhang, Z.-Y. "Identification of Phospho-Caveolin-1 as a Novel PTP1B Substrate", Biochemistry, 45, 234-240 (2006).


Zhang, Z.-Y. "Functional Studies of Protein Tyrosine Phosphatases with Chemical Approaches", Biochim. Biophys. Acta 1754, 100-107 (2005).


Sun, J.-P., Wang, W.-Q., Yang, H., Liu, S., Liang, F., Fedorov, A. A., Almo, S. C. and Zhang, Z.-Y. "Structure and Biochemical Properties of PRL-1, a Phosphatase Implicated in Cell Growth, Differentiation, and Tumor Invasion", Biochemistry, 44, 12009-12021 (2005).


Lee, K., Boovanahalli, S. K., Nam, K.-Y., Kang, S.-U., Phan, J., Wu, L., Waugh, D. S., Zhang, Z.-Y., No, K. T., Lee, J.-J., and Burke, T. R. Jr. "Synthesis of tripeptides as potential Yersinia protein-tyrosine phosphatase inhibitors", Bioorg. Med. Chem. Lett., 15, 4037-4042 (2005)


Liang, F., Lee, S.-Y., Liang, J., Lawrence, D. S. and Zhang, Z.-Y. "The Role of PTP1B in integrin signaling", J. Biol. Chem. 280, 24857-24863 (2005).


Lee, S.-Y., Liang, F., Guo, X.-L., Xie, L., Cahill, S. M., Blumenstein, M., Yang, H., Lawrence, D. S. and Zhang, Z.-Y. "Design, Construction, and Intracellular Activation of An Intramolecularly Self-Silenced Signal Transduction Inhibitor", Angew. Chem. Int. Ed. 44, 4242-4244 (2005).


Kumar, S., Liang, F., Lawrence, D. S. and Zhang, Z.-Y. "Small Molecule Approach to Studying Protein Tyrosine Phosphatases", Methods, 35(1):9-21, (2005).


Huang, Z., Zhou, B. and Zhang, Z.-Y. "Molecular Determinants of Substrate Recognition in Hematopoietic Protein Tyrosine Phosphatase", J. Biol. Chem. 279, 52150-52159 (2004).


Chi, Y., Zhou, B., Wang, W.-Q., Chung, S.-K., Kwon, Y.-U., Ahn, Y.-H., Chang, Y.-T., Tsujishita, Y., Hurley, J. H., Zhang, Z.-Y. "Comparative Mechanistic and Substrate Specificity Study of Inositol Polyphosphate 5-phosphatases SPsynaptojanin and SHIP2", J. Biol. Chem. 279, 44987-44995 (2004).


Wang, W.-Q., Bembenek, J., Gee, K. R., Yu, H., Charbonneau, H. and Zhang, Z.-Y. "Kinetic and Mechanistic Studies of a Cell Cycle Protein Phosphatase Cdc14", J. Biol. Chem. 279, 30459-30468 (2004).


Kang, S. U., Gao, Y., Wu, L., Zhang, Z.-Y., and Burke, T. R. Jr. "Enantioselective Synthesis of (S)-3-Carboxy-4-((carboxy)difluoromethyl)phenylalanine in Protected Form and Incorporation into a PTP-1B-Directed Tripeptide", Chemistry Biodiversity, 1, 626-633 (2004).


McCain, D. F., Grzyska, P. K., Wu, L., Hengge, A. C. and Zhang, Z.-Y. "Mechanistic studies of protein tyrosine phosphatases YopH and Cdc25A with m-nitrobenzyl phosphate", Biochemistry, 43, 8256-8264 (2004).


Kumar, S., Zhou, B., Liang, F., Wang, W.-Q., Huang, Z., and Zhang, Z.-Y. "Activity-Based Probes for Protein Tyrosine Phosphatases", Proc. Natl. Acad. Sci. USA 101, 7943-7948 (2004).    (Faculty of 1000 Biology "Recommended").


McCain D.F., Wu L., Nickel P., Kassack M.U., Kreimeyer A., Gagliardi A., Collins D.C., Zhang Z.Y. "Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases.", J. Biol. Chem. 279, 14713-14725 (2004).


Zhang, X., Schwartz, J.-C. D., Guo, X.-L., Bhatia, S., Cho, E., Chen, L., Zhang, Z.-Y., Edidin, M. A., Nathenson, S. C., and Almo, S. C. "Structural and Functional Analysis of the Costimulatory Receptor Programmed Death-1", Immunity 20, 337-347(2004).


Pedersen, A. K., Guo, X.-L., Møller, K. B., Peters, G. H., Andersen, H. S., Kastrup, J. S.,Mortensen, S. B., Iversen, L. F., Zhang, Z.-Y., and Møller, N. P. H. "Residue 182 influences the second step of protein-tyrosine phosphatases-mediated catalysis", Biochemical Journal, 378, 421-433 (2004).


McCain, D. F. and Zhang, Z.-Y. "Tyrosine Phosphatases in Cancer: Targets for Therapeutic Intervention", Topics in Current Genetics, Vol. 5, Protein Phosphatases, (Joaquin Arino Denis Alexander, Eds.), Springer-Verlag Berlin Heidelberg, 359-374 (2004).


Vetter, S. W., and Zhang, Z.-Y. "Combinatorial Chemistry and Peptide Library Methods to Characterize Protein Phosphatases", Methods in Enzymology, 366, 260-282 (2003).


Zhou, B. and Zhang, Z.-Y. "Measuring Protein Phosphatase Activity with Physiological Substrates", Methods in Enzymology, 366, 34-43 (2003).


Goldberg, G. S., Alexander, D. B., Pellicena, P., Zhang, Z.-Y., Tsuda, H., Miller, W. T. "Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells.", J. Biol. Chem., 278, 46533-46540 (2003).


Xie, L., Lee, S.-Y. Anderson, J. N., Waters, S., Shen, K., Guo, X.-L., Moller, N. P. H., Olefsky, J. M., Lawrence, D. S., and Zhang, Z.-Y. "Cellular Effects of Small Molecule PTP1B Inhibitors on Insulin Signaling", Biolchemistry, 42, 12792-12804 (2003).


Zhang, Z.-Y. "Inhibitors of Protein Tyrosine Phosphatases", Handbook of Cell Signaling, (Ralph Bradshaw and Edward Dennis, Editors-in-Chief, Academic Press), 677-684 (2003).


Liang, F., Huang, Z., Lee, S.-Y., Liang, J., Ivanov, M. I., Alonso, A., Bliska, J. B., Lawrence, D. S., Mustelin, T., and Zhang, Z.-Y. "Aurintricarboxylic Acid Blocks in vitro and in vivo Activity of YopH, an Essential Virulent Factor of Yersinia pestis, the Agent of Plague", J. Biol. Chem., 278, 41734-41741 (2003).    (Faculty of 1000 Biology "Recommended").


Liu, D.-G., Gao, Y., Voigt, J. H., Lee, K., Nicklaus, M. C., Wu, L., Zhang, Z.-Y., and Burke, T. R. Jr. "Acylsulfonamide- containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration", Bioorg. Med. Chem. Lett. 13, 3005-3007 (2003).


Sun, J.-P., Wu, L., Fedorov, A. A., Almo, S. C. and Zhang, Z.-Y. "Crystal Structure of the Yersinia Protein-Tyrosine Phosphatase YopH Complexed with a Specific Small Molecule Inhibitor", J. Biol. Chem., 278, 33392-33399 (2003).


Zhang, J., Zhou, B., Zheng, C.-F., and Zhang, Z.-Y. "A Bipartite Mechanism for ERK2 Recognition by Its Cognate Regulators and Substrates", J. Biol. Chem., 278, 29901-29912, (2003).


Zhang, Z.-Y. "Mechanistic Studies on Protein Tyrosine Phosphatases", Progress in Nucleic Acid Research and Molecular Biology 73, 171-220 (2003).


Lee, K, Gao, Y., Yao, Z.-J., Phan, J., Wu, L., Liang, J., Waugh, D., Zhang, Z.-Y. and Burke, T. R. Jr. "Tripeptide Inhibitors of Yersinia Protein-Tyrosine Phosphatase", Bioorg. Med. Chem. Lett., 13, 2577-2581 (2003).


Zhang, Z.-Y. "Chemical and Mechanistic Approaches to the Study of Protein Tyrosine Phosphatases", Acc. Chem. Res., 36, 385-392 (2003).


Wang, W.-Q., Sun, J.-P. and Zhang, Z.-Y. "An Overview of the Protein Tyrosine Phosphatase Superfamily", Current Topics in Medicinal Chemistry, 3, 739-748 (2003).


Sun, J.-P., Fedorov, A. A., Lee, S.-Y., Guo, X.-L., Shen, K., Lawrence, D. S., Almo, S. C. and Zhang, Z.-Y. "Crystal Structure of PTP1B in Complex with a Potent and Selective Bidentate Inhibitor", J Biol Chem., 278(14), 12406-14 (2003).


Zhang, Z.-Y. and Lee, S-Y. "PTP1B Inhibitors as Potential Therapeutics in the Treatment of Type 2 Diabetes and Obesity", Expert Opinion on Investigational Drugs, 12, 223-233 (2003).


Guo, X.-L., Shen, K., Wang, F., Lawrence, D. S., and Zhang, Z.-Y. "Probing the Molecular Basis for Potent and Selective Protein Tyrosine Phosphatase 1B Inhibition", J. Biol. Chem., 277, 41014-41022 (2002).


Cheng, H., Nikolic-Hughes, I., Wang, J. H., Deng, H., O'Brien, P. J., Wu, L., Zhang, Z.-Y., Herschlag, D., and Callender, R. "Environmental Effects on Phosphoryl Group Bonding Probed by Vibrational Spectroscopy: Implications for Understanding Phosphoryl Transfer and Enzymatic Catalysis", J. Am. Chem. Soc., 124, 11295-11306 (2002).


Zhou, B., Wang, Z.-X., Zhao, Y., Brautigan, D. L. and Zhang, Z.-Y. "The Specificity of Extracellular Signal-Regulated Kinase 2 Dephosphorylation by Protein Phosphatases", J. Biol. Chem., 277, 31818-31825 (2002).


Vetter, S. W. and Zhang, Z.-Y. "Probing the Phosphopeptide Specificities of Protein Tyrosine Phosphatases, SH2 and PTB Domains with Combinatorial Library Methods", Current Protein Peptide Science, 3, 365-397 (2002).


Wang, Z.-X., Zhou, B., Wang, Q. M. and Zhang, Z.-Y. "A Kinetic Approach for the Study of Phosphatase-Catalyzed Regulation of Kinase Activity", Biochemistry, 41, 7849-7857 (2002).


Zhang, Z.-Y., Zhou, B. and Xie, L. "Modulation of Protein Kinase Signaling by Protein Phosphatases and Inhibitors", Pharmacology Therapeutics, 93, 307-317 (2002).


Deng, H., Callender, R., Huang, Z. and Zhang, Z.-Y. "Is PTPase-Vanadate a True Transition State Analog?", Biochemistry, 41, 5865-5872 (2002).    (Faculty of 1000 Biology "Recommended").


Zhou, B. and Zhang, Z.-Y. "The Activity of the Extracellular Signal-Regulated Kinase 2 Is Regulated by Differential Phosphorylation in the Activation Loop", J. Biol. Chem., 277, 13889-13899 (2002).


Zhao, Y. and Zhang, Z.-Y. "Control of Signaling by Tyrosine Phosphatases", in Hormone Signaling, (Eds: Vincent Goffin and Paul A. Kelly), Kluwer Academic Publishers, Norwell MA, p.21-36(2002).


McCain, D. F., Catrina, I. E., Hengge, A. C, and Zhang, Z.-Y. "The Catalytic Mechanism of Cdc25A Phosphatase", J. Biol. Chem., 277, 11190-11200 (2002).


Xie, L., Zhang, Y.-L. and Zhang, Z.-Y. "Design and Characterization of an Improved Protein Tyrosine Phosphatase Substrate-Trapping Mutant", Biochemistry, 41, 4032-4039 (2002).


Zhang, Z.-Y. "Protein Tyrosine Phosphatases: Structure and Function, Substrate Specificity, and Inhibitor Development", Annual Reviews of Pharmacology Toxicology, 42, 209-234 (2002).


McCain, D. F. and Zhang, Z.-Y. "Assays for Protein Tyrosine Phosphatases,", Methods in Enzymology, 345, 507-518 (2002).


Shen, K., Keng, Y.-F., Wu, L., Guo, X.-L., Lawrence, D. S., and Zhang, Z.-Y. "Acquisition of a Specific and Potent PTP1B Inhibitor from a Novel Combinatorial Library and Screening Procedure,", J. Biol. Chem., 276, 47311-47319 (2001).


Gao, Y., Voigt, J., Zhao, H., Pais, G. C. G., Zhang, X., Wu, L., Zhang, Z.-Y., and Burke, T. R., Jr. "Utilization of a Peptide Lead for the Discovery of a Novel PTP1B-Binding Motif,", J. Med. Chem., 44, 2869-2878 (2001).


Zhao, Y. and Zhang, Z.-Y. "The Mechanism of Dephosphorylation of Extracellular Signal-Regulated Kinase 2 by Mitogen-Activated Protein Kinase Phosphatase 3", J. Biol. Chem., 276, 32382-32391 (2001).


Zhang, Z.-Y. "Protein Tyrosine Phosphatases: Prospects for Therapeutics", Current Opinion in Chemical Biology, 5, 416-423 (2001).


Burke, T. R., Yao, Z.-J., Ye, B., Miyoshi, K., Otaka, A., Wu, L. and Zhang, Z.-Y. "Phospho-AzaTyrosine, a Less Effective Protein-Tyrosine Phosphatase Substrate than Phosphotyrosine", Bioorg. Med. Chem. Lett., 11, 1265-1268 (2001).


Zhou, B., Wu, L., Shen, K., Zhang, J., Lawrence, D. S. and Zhang, Z.-Y. "Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2", J. Biol. Chem., 276, 6506-6515 (2001).


Zhang, Y.-L., Yao, Z.-J., Sarmiento, M., Wu, L., Burke, T. R. Jr. and Zhang, Z.-Y. "Thermodynamic Study of Ligand Binding to Protein-Tyrosine Phosphatase 1B and Its Substrate-Trapping Mutants", J. Biol. Chem., 275, 34205-34212 (2000).


Sarmiento, M., Puius, Y. A., Vetter, S. W., Keng, Y.-F., Wu, L., Zhao, Y., Lawrence, D. S., Almo, S. C. Zhang, Z.-Y. "Structural Basis of Plasticity in Protein Tyrosine Phosphatase 1B Substrate Recognition", Biochemistry, 39, 8171-8179 (2000).


Gao, Y., Wu, L., Luo, J. H., Guo, R., Yang, D., Zhang, Z.-Y., and Burke, T. R., Jr. "Examination of Novel Non-Phosphorus-Containing Phosphotyrosyl Mimetics against Prpteon-Tyrosine Phosphatase-1B and Demonstration of Differential Affinities toward GRB2 SH2 Domains", Bioorg. Med. Chem. Lett., 10, 923-927 (2000).


Xian, M., Wang, K., Chen, X., Hou, Y., McGill, A., Zhou, B., Zhang, Z.-Y., Cheng, J. P. and Wang, G. P. "Inhibition of Protein Tyrosine Phosphatases by Low-Molecular-Weight S-Nitrosothiols and S-Nitrosylated Human Serum Albumin", Biochem. Biophys. Res. Commun., 268, 310-314 (2000).


Ibrahimi, O. A., Wu, L., Zhao, K. and Zhang, Z.-Y. " Synthesis and Characterization of a Novel Class of Protein Tyrosine Phosphatase Inhibitors", Bioorg. Med. Chem. Lett., 10, 457-460 (2000).


Sarmiento, M., Wu, L., Keng, Y.-F., Song, L., Luo, Z., Huang, Z., Wu, G.-Z., Yuan, A. K. and Zhang, Z.-Y. "Structure-Based Discovery of Small Molecule Inhibitors Targeted to Protein Tyrosine Phosphatase 1B", J. Med. Chem., 43, 146-155 (2000).


Vetter, S. W., Keng, Y.-F., Lawrence, D. S. and Zhang, Z.-Y. "Assessment of Protein Tyrosine Phosphatse 1B Substrate Specificity Using "Inverse Alanine Scanning"", J. Biol. Chem., 275, 2265-2268 (2000).


Hoff, R. H., Hengge, A. C., Wu, L., Keng, Y.-F., and Zhang, Z.-Y. "The Effects on General Acid Catalysis from Mutations of the Invariant Tryptophan and Arginine Residues in the Protein-Tyrosine Phosphatase from Yersinia", Biochemistry, 39, 46-54 (2000).


Zhou, B. and Zhang, Z.-Y. "Mechanism of Mitogen-activated Protein Kinase Phosphatase-3 Activation by ERK2", J. Biol. Chem., 274, 35526-35534 (1999).


Barrett, W. C., DeGnore, J. P., Keng, Y.-F., Zhang, Z.-Y., Yim, M.-B., and Chock, P. B. "Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein Tyrosine Phosphatase 1B", J. Biol. Chem., 274, 34543-34546 (1999).


Hoff, R. H., Wu, L., Zhou, B. Zhang, Z.-Y. and Hengge, A. C. "Does Positive Charge at the Active site of a Phosphatase Cause a Change in Mechanism? The Effect of the Conserved Arginine on the Transition State for Enzymatic Phosphoryl Transfer in the Protein-Tyrosine Phosphatase from Yersinia", J. Am. Chem. Soc., 121, 9514-9521 (1999).


Zhang, Y.-L., Hollfelder, F., Gordon, S. J., Chen, L., Keng, Y.-F., Wu, L., Herschlag, D. and Zhang, Z.-Y. "Impaired Transition State Complementarity in the Hydrolysis of O-Arylphosphorothioates by Protein-Tyrosine Phosphatases", Biochemistry, 38, 12111-12123 (1999).


Wrobel, J., Sredy, J., Moxham, C., Dietrich, A., Li, Z., Sawicki, D. R., Seestaller, L., Wu, L., Katz, A., Sullivan, D. Tio, C. and Zhang, Z.-Y. "PTP1B Inhibition and Antihyperglycemic Activity of Novel 11-Aryl-benzo[b]naphtho[2,3-d]furans and 11-Aryl-benzo[b]naphtho[2,3-d]thiophenes", J. Med. Chem., 42, 3199-3202 (1999).


Barrett, W. C., DeGnore, J. P., König, S., Fales, H. M., Keng, Y.-F., Zhang, Z.-Y., M.-B. Yim and Chock, P. B. "Regulation of PTP1B via Glutathionylation of the Active Site Cysteine 215", Biochemistry, 38, 6699-6705 (1999).


Taing, M., Keng, Y.-F., Shen, K., Wu, L., Lawrence, D. S., Zhang, Z.-Y. "Potent and Highly Selective Inhibitors of the Protein Tyrosine Phosphatase 1B", Biochemistry, 38, 3793-3803 (1999).


Keng, Y.-F., Wu, L. Zhang, Z.-Y. "Probing the Function of the Invariant Tryptophan in the Flexible Loop of the Yersinia Protein-Tyrosine Phosphatase", Eur. J. Biochem., 259, 809-814 (1999).


Buist, A., Zhang, Y.-L., Keng, Y.-F., Wu, L., Zhang, Z.-Y., and den Hertog, J. "Restoration of Potent Protein-Tyrosine Phosphatase Activity into the Membrane-Distal Domain of Receptor Protein-Tyrosine Phosphatase a", Biochemistry, 38, 914-922 (1999).


Chen, H., Cong, L.-N., Li, Y., Yao, Z.-J., Wu, L., Zhang, Z.-Y., Burke, T. R., Quon, M. J. "A Phosphotyrosyl Mimetic Peptide Reverses Impairment of Insulin Stimulated Translocation of GLUT4 Caused by Overexpression of PTP1B in Rat Adipose Cells", Biochemistry, 38, 384-389 (1999).


Yao, Z.-J., Ye, B., Wu, X.-W., Wang, S., Wu, L., Zhang, Z.-Y. Burke, T. R. "Structure-Based Design and Synthesis of Small Molecule Protein-Tyrosine Phosphatase 1B Inhibitors", Bioorganic Medicinal Chemistry, 6, 1799-1810 (1998).


Burke, T. R. Jr., Zhang, Z.-Y. "Protein Tyrosine Phosphatases: Structure, Mechanism and Inhibitor Discovery", Biopolymers (Peptide Science), 47, 225-241 (1998).


Wang, F., Li, W., Emmett, M. R., Hendrickson, C. L., Marshall, A. G., Zhang, Y.-L., Wu, L., Zhang, Z.-Y. "Conformational and Dynamic Changes of Yersinia Protein Tyrosine Phosphatase Induced by Ligand Binding and Active Site Mutation and Revealed by H/D Exchange and Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry", Biochemistry, 37, 15289-15299 (1998).


Sarmiento, M., Zhao, Y., Gordon, S. J. Zhang, Z.-Y. "Molecular Basis of Substrate Specificity of Protein Tyrosine Phosphatase 1B", J. Biol. Chem., 273, 26368-26374 (1998).


Roller, P. P., Wu, L., Zhang, Z.-Y., Burke, T. R. "Potent Inhibition of Protein-tyrosine Phosphatase 1B Using the Phosphotyrosyl Mimetic Fluoro-O-malonyl Tyrosine (FOMT)", Bioorg. Med. Chem. Lett., 8, 2149-2150 (1998).


Zhang, Y.-L. Zhang, Z.-Y. "Low-Affinity Binding Determined by Titration Calorimetry Using a High-Affinity Coupling Ligand: A Thermodynamic Study of Ligand Binding to Protein Tyrosine Phosphatase 1B", Anal. Biochem., 261, 139-148 (1998).


Burke, T. R. Jr., Yao, Z.-J., Zhao, H., Milne, G. W. A., Wu, L., Zhang, Z.-Y. Voigt, J. H. "Enantioselective Synthesis of Nonphosphorus-Containing Phosphotyrosyl Mimetics and Their Use in the Preparation of Tyrosine Phosphatase Inhibitory Peptides", Tetrahedron 54, 9981-9994 (1998).


Zhang, Y.-L., Keng, Y.-F., Zhao, Y., Wu, L. Zhang, Z.-Y. "Suramin Is an Active Site- Directed, Reversible, and Tight-Binding Inhibitor of Protein-Tyrosine Phosphatases", J. Biol. Chem., 273, 12281-12287 (1998).


lhambra, C., Wu, L., Zhang, Z.-Y. Gao, J. "Walden-Inversion Enforced Transition State Stabilization in a Protein Tyrosine Phosphatase", J. Am. Chem. Soc., 120, 3858-3866 (1998).


Zhang, Z.-Y. "Protein-Tyrosine Phosphatases: Biological Function, Structural Characteristics, and Mechanism of Catalysis", Critical Reviews in Biochemistry and Molecular Biology, 33, 1-52 (1998).


Zhao, Y., Wu, L. Noh, S. J., Guan, K.-L., Zhang, Z.-Y. "Altering the Nucleophile Specificity of a Protein-Tyrosine Phosphatase-Catalyzed Reaction: Probing the Function of the Invariant Glutamine Residues", J. Biol. Chem., 273, 5484-5492 (1998).


Sarmiento, M., Gordon, S. J. and Zhang, Z.-Y. "Protein Tyrosine Phosphatases: Modulators of Signal Transduction", Einstein Quarterly J. Biol. Med., 14, 140-156 (1997).


Puius, Y. A., Zhao, Y., Sullivan, M., Lawrence, D. S., Almo, S. C. Zhang, Z.-Y. "Identification of a Second Aryl Phosphate-Binding Site in Protein-Tyrosine Phosphatase 1B: A Paradigm for Inhibitor Design", Proc. Natl. Acad. Sci. USA, 94, 13420-13425 (1997).


Hengge, A. C., Zhao, Y., Wu, L. Zhang, Z.-Y. "Examination of the Transition State of the Low-Molecular Mass Tyrosine Phosphatase 1. Comparisons with Other Protein Phosphatases", Biochemistry, 36, 7928-7936 (1997).


Zhang, Z.-Y. "Structure, Mechanism and Specificity of Protein-Tyrosine Phosphatases", Current Topics in Cellular Regulation, 35, 21-68 (1997).


Wu, L., Buist, A., den Hertog, J. Zhang, Z.-Y. "Comparative Kinetic Analysis and Substrate Specificity of the Tandem Catalytic Domains of the Receptor-like Protein- Tyrosine Phosphatase a", J. Biol. Chem., 272, 6994-7002 (1997).


Juszczak, L. J., Zhang, Z.-Y., Wu, L., Gottfried, D. S., Eads, D. D. "Rapid Loop Dynamics of Yersinia Protein Tyrosine Phosphatases", Biochemistry, 36, 2227-2236 (1997).


Akamatsu, M., Roller, P. P., Chen, L., Zhang, Z.-Y., Ye, B. Burke, T. R. "Potent Inhibition of Protein-Tyrosine Phosphatase by Phosphotyrosine-Mimic Containing Cyclic Peptides", Bioorganic Medicinal Chemistry, 5, 157-163 (1997).


Zhang, Z.-Y. Wu, L. "The Single Sulfur to Oxygen Substitution in the Active Site Nucleophile of the Yersinia Protein-Tyrosine Phosphatase Leads to Substantial Structural and Functional Perturbations", Biochemistry, 36, 1362-1369 (1997).


Burke, T. R. Jr., Ye, B., Yan, X., Wang, S., Jia, Z., Chen, L., Zhang, Z.-Y., Barford, D. "Small Molecule Interactions with Protein-Tyrosine Phosphatase PTP1B and Their Use in Inhibitor Design", Biochemistry, 35, 15989-15996 (1996).


Taylor, W. P., Zhang, Z.-Y., Widlanski, T. S. "Quiescent Affinity Inactivators of Protein Tyrosine Phosphatases", Bioorganic Medicinal Chemistry, 4, 1515-1520 (1996).


Zhao, Y. Zhang, Z.-Y. "Reactivity of Alcohols Toward the Phosphoenzyme Intermediate in the Protein-Tyrosine Phosphatase-Catalyzed Reaction: Probing the Transition State of the Dephosphorylation Step", Biochemistry, 35, 11797-11804 (1996).


Chen, L., Montserat, J., Lawrence, D. S. Zhang, Z.-Y. "VHR and PTP1 Protein Phosphatases Exhibit Remarkably Different Active Site Specificities Toward Low Molecular Weight Nonpeptidic Substrates", Biochemistry, 35, 9349-9354 (1996).


Wu, L. Zhang, Z.-Y. "Probing the Function of Asp128 in the Low Molecular Weight Protein-Tyrosine Phosphatase Catalyzed Reaction. A Pre-Steady-State and Steady-State Kinetic Investigation", Biochemistry, 35, 5426-5434 (1996).


Montserat, J., Chen, L., Lawrence, D. S. Zhang, Z.-Y. "Potent Low Molecular Weight Substrates for Protein-Tyrosine Phosphatase", J. Biol. Chem., 271, 7868-7872 (1996).


Zhang, Z.-Y., Walsh, A. B., Wu, L., McNamara, D. J., Dobrusin, E. M., Miller, W. T. "Determinants of Substrate Recognition in the Protein-Tyrosine Phosphatase, PTP1", J. Biol. Chem., 271, 5386-5392 (1996).


Dunn, D., Chen, L., Lawrence, D. S. Zhang, Z.-Y. "The Active-Site Specificity of the Yersinia Protein-Tyrosine Phosphatase", J. Biol. Chem., 271, 168-173 (1996).


Zhang, Z.-Y., Palfey, B. A., Wu, L. Zhao, Y. "Catalytic Function of the Conserved Hydroxyl Group in the Protein-Tyrosine Phosphatase Signature Motif", Biochemistry, 34, 16389-16396 (1995).


Zhang, Z.-Y., Wu, L. Chen, L. "Transition State and Rate-Limiting Step of the Reaction Catalyzed by the Human Dual Specificity Phosphatase, VHR", Biochemistry, 34, 16088-16096 (1995).


Chen, L., Wu, L., Otaka, A., Smyth, M. S., Roller, P. P., Burke, T. R., den Hertog, J. Zhang, Z.-Y. "Why Is Phosphono-difluoromethyl Phenylalanine a More Potent Inhibiting Moiety Than Phosphonomethyl Phenylalanine toward Protein-Tyrosine Phosphatases?", Biochem. Biophys. Res. Commun., 216, 976-984 (1995).


Hengge, A. C., Sowa, G, Wu, L. Zhang, Z.-Y. "Nature of the Transition State of the Protein-Tyrosine Phosphatase-Catalyzed Reaction", Biochemistry, 34, 13982-13987 (1995).


Zhang, Z.-Y., Zhou, G., Denu, J. M., Wu, L., Tang, X., Mondesert, O., Russell, P., Butch, E. Guan, K.-L. "Purification and Characterization of the Low M olecular Weight Protein Tyrosine Phosphatase, Stp1, from the Fission Yeast S. pombe", Biochemistry, 34, 10560-10568 (1995).


Zhang, Z.-Y. "Are Protein-Tyrosine Phosphatases Specific for Phosphotyrosine?", J. Biol. Chem., 270, 16052-16055 (1995).


Zhang, Z.-Y. "Kinetic and Mechanistic Characterization of a Mammalian Protein Tyrosine Phosphatase, PTP1", J. Biol. Chem., 270, 11199-11204 (1995).


Yu, L., McGill, A., Ramirez, J., Wang, P. G. Zhang, Z.-Y. "Synthesis and Bioassay of a Protein Tyrosine Phosphatase Inhibitor, Dephostatin", Bioorganic Medicinal Chemistry Letters 5, 1003-1006 (1995).


Zhang, Z.-Y., Wang, Y., Wu, L., Fauman, E., Stuckey, J. A., Schubert, H. L., Saper, M. A. Dixon, J. E. "The Cys(X)5Arg Catalytic Motif in Phosphoester Hydrolysis", Biochemistry, 33, 15266-15270 (1994).


Stuckey, J. A., Schubert, H. L., Fauman, E., Zhang, Z.-Y., Dixon, J. E. Saper, M. A. "Crystal Structure of Yersinia Protein Tyrosine Phosphatase at 2.5 Å and the Complex with Tungstate", Nature, 370, 571-575 (1994).


Zhang, Z.-Y., Malachowski, W. P., Van Etten, R. L. Dixon, J. E. "The Nature of the Rate-determining Steps of the Yersinia Protein Tyrosine Phosphatase-catalyzed Reactions", J. Biol. Chem., 269, 8140-8145 (1994).


Zhang, Z.-Y., Maclean, D., McNamara, D. J., Sawyer, T. K. Dixon, J. E. "Protein Tyrosine Phosphatase Substrate Specificity: the Minimum Size of the Peptide and the Positioning of the Phosphotyrosine", Biochemistry, 33, 2285-2290 (1994).


Zhang, Z.-Y., Wang, Y. Dixon, J. E. "Dissecting the Catalytic Mechanism of Protein Tyrosine Phosphatases", Proc. Natl. Acad. Sci. USA, 91, 1624-1627 (1994).


Zhang, Z.-Y. Dixon, J. E. " Protein Tyrosine Phosphatases: Mechanism of Catalysis and Substrate Specificity", Advances in Enzymology 68, 1-36 (1994).


Maclean, D., Sefler, A., McNamara, D. J., Zhang, Z.-Y., Zhu, G., Dobrusin, E. M., McMichael, A., Fry, D. W., Decker, S. J., Dixon, J. E., Saltiel, A. R., Sawyer, T. K. Bristol, J. A. "Phosphorylated Fragments of the Epidermal Growth Factor Receptor: Sequence Specificity for Binding to Phospholipase C-g-1 SH2 Domains, and for Kinase and Phosphatase Activity", Peptides: Chemistry, Structure and Biology, (Hodges, R. S. Smith, J. A., Eds.) ESCOM, Leiden, The Netherlands, p.948-950 (1994).


Milarski, K. L., Zhu, G., Pearl, C. G., McNamara, D. J., Dobrusin, E. M., Maclean, D., Thieme-Sefler, A., Zhang, Z.-Y., Sawyer, T., Decker, S. J., Dixon, J. E. Saltiel, A. R. "Sequence Specificity in Recognition of the Epidermal Growth Factor by Protein Tyrosine Phosphatase 1B", J. Biol. Chem., 268, 23634-23639 (1993).


Zhang, Z.-Y. Dixon, J. E. "Active Site Labeling of the Yersinia Protein Tyrosine Phosphatase: The Determination of the pKa of the Active Site Cysteine and the Function of the Conserved Histidine 402", Biochemistry, 32, 9340-9345 (1993).


Zhang, Z.-Y., Maclean, D., Thieme-Sefler, A. M., McNamara, D., Dobrusin, E. M., Sawyer, T. K. Dixon, J. E. "Substrate Specificity of the Protein Tyrosine Phosphatases", Proc. Natl. Acad. Sci. USA, 90, 4446-4450 (1993).


Zhang, Z.-Y., Thieme-Sefler, A. M., Maclean, D., Roeske, R. Dixon, J. E. "A Continuous Spectrophotometric and Fluorimetric Assay for Protein Tyrosine Phosphatase Using Phosphotyrosine Containing Peptides", Anal. Biochem., 211, 7-15 (1993).


David, M., Romero, G., Zhang, Z.-Y., Dixon, J. E. Larner, A. C. "In Vitro Activation of the Transcription Factor ISGF3 by Interferon a Involves a Membrane Associated Tyrosine Phosphatase and Tyrosine Kinase", J. Biol. Chem., 268, 6593-6599 (1993).


Maggiora, L. L., Smith, C. W. Zhang, Z.-Y. "A General Method for the Preparation of Internally Quenched Fluorogenic Protease Substrates Using Solid-Phase Peptides Synthesis", J. Med. Chem., 35, 3727-3730 (1992).


Zhang, Z.-Y., Clemens, J. C., Schubert, H. L., Stuckey, J. A., Fischer, M, W. F., Hume, D. M., Saper, M. A. Dixon, J. E. "Expression, Purification, and Physicochemical Characterization of a Recombinant Yersinia Protein Tyrosine Phosphatase", J. Biol. Chem., 267, 23759-23766 (1992).


Wo, Y.-Y. P., Zhou, M.-M., Stevis, P., Davis, J. P., Zhang, Z.-Y. Van Etten, R. L. "Cloning, Expression, and Catalytic Mechanism of a Low Molecular Weight Phosphotyrosyl Protein Phosphatase from Bovine Heart", Biochemistry, 31, 1712-1721 (1992).


Zhang, Z.-Y., Davis, J. P. Van Etten, R. L. "Covalent Modification and Active Site- Directed Inactivation of a Low Molecular Weight Phosphotyrosyl Protein Phosphatase", Biochemistry, 31, 1701-1711 (1992).


Zhang, Z.-Y. Van Etten, R. L. "Leaving Group Dependence and Proton Inventory Studies of the Phosphorylation of a Cytoplasmic Phosphotyrosyl Protein Phosphatase from Bovine Heart", Biochemistry, 30, 8954-8959 (1991).


Zhang, Z.-Y., Reardon, I. M., Hui, J. O., O'Connell, K., Poorman, R. A., Tomasselli, A. G. Heinrikson, R. L. "Zinc Inhibition of Renin and the Protease from HIV-1", Biochemistry, 30, 8717-8721 (1991).


Zhang, Z.-Y., Poorman, R. A., Maggiora, L. L., Heinrikson, R. L. Kézdy, F. J. "Dissociative Inhibition of Dimeric Enzymes: Kinetic Characterization of the Inhibition of HIV-1 Protease by Its C-Terminal Peptide", J. Biol. Chem., 266, 15591-15594 (1991).


Zhang, Z.-Y. Van Etten, R. L. "Pre-steady-state and Steady-state Kinetic Analysis of the Low Molecular Weight Phosphotyrosyl Protein Phosphatase from Bovine Heart", J. Biol. Chem., 266, 1516-1525 (1991).


Zhang, Z.-Y. Van Etten, R. L. "Purification and Characterization of a Low Molecular Weight Acid Phosphatase - A Major Phosphotyrosyl-Protein Phosphatase from Bovine Heart", Arch. Biochem. Biophys., 282, 39-49 (1990).

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