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"Targeting SHP2 for EGFR inhibitor resistant non small cell lung carcinoma",
Biochem. Biophys. Res. Commun.,
439, i586-590 (2013).
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197. |
Dumaual, C. M., Steere, B. A., Walls, C. D., Wang, M., Zhang, Z.-Y., and Randall, S. K.
"Integrated analysis of global mRNA and protein expression data in HEK293 cells overexpressing PRL-1",
PLoS ONE,
8(9):e72977, doi:10.1371/journal.pone.0072977 (2013).
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196. |
He, Y., Liu, S., Menon, A., Stanford, S., Oppong, E., Gunawan, A. M., Wu, L., Wu, D. J., Barrios, A. M., Bottini,
N., Cato, A. C., and Zhang, Z.-Y.
"A potent and selective small molecular inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a
target associated with autoimmune diseases",
J. Med. Chem.,
56, 4990-5008 (2013).
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195. |
Bettaieb, A., Bakke, J., Nagata, N., Matsuo, K., Xi, Y., Liu, S., AbouBechara, D., Melhem, R., Stanhope, K.,
Cummings, B., Graham, J., Bremer, A., Zhang, S., Lyssiotis, C. A., Zhang, Z.-Y., Cantley, L. C., Havel, P. J.,
and Haj, F. G.
"Protein-Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation",
J. Biol. Chem.,
288, 17360-17371 (2013).
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194. |
Zeng, L.-F., Xu, J., He, Y., He, R., Wu, L., Gunawan, A. M., and Zhang, Z.-Y.
"A facile hydroxyindole carboxylic acid-based focused library approach for potent and selective inhibitors of
Mycobacterium protein tyrosine phosphatase B",
ChemMedChem,
8, 904-908 (2013).
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193. |
Tang, Y.-B., Lu, D., Chen, Z., Hu, C., Yang, Y., Tian, J.-Y., Ye, F., Wu, L., Zhang, Z.-Y., and Xiao, Z.
"Design, synthesis and anti-diabetic activity of novel PTP1B inhibitors",
Bioorg. Med. Chem. Lett.,
23, 2313-2318 (2013).
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192. |
Yu, Z.-H., Xu, J., Walls, C., Chen, L., Zhang, S., Zhang, R., Wu, L., Wang, L., Liu, S., and Zhang, Z.-Y.
"Structural and mechanistic insights into LEOPARD syndrome associated SHP2 mutations",
J. Biol. Chem.,
288, 10472-10482 (2013).
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191. |
He, Y., Xu, J., Yu, Z.-H., Gunawan A. M., Wu, L., Wang, L., and Zhang, Z.-Y.
"Discovery and Evaluation of Novel Inhibitors of Mycobacterium Protein Tyrosine Phosphatase B from the
6-Hydroxy-Benzofuran-5-Carboxylic Acid Scaffold",
J. Med. Chem.,
56, 832-842 (2013).
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190. |
He, R., Zeng, L.-F., He, Y., Wu, L., Gunawan, A. M., and Zhang, Z.-Y.
"Organocatalytic Multicomponent Reaction for the Acquisition of a Potent and Selective Inhibitor of mPTPB, a
Virulence Factor of Tuberculosis",
Chem. Commun.,
49, 2064-2066 (2013).
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189. |
Nabinger, S. C., Li, X., Ramdas, B., He, Y., Zhang, X., Zeng, L.-F., Richine, B., Bowling, J. D., Fukuda, S.,
Goenka, S., Liu, Z., Feng, G.-S., Yu, M., Sandusky, G. E., Boswell, H. S., Zhang, Z.-Y., Kapur, R., and Chan, R. J.
"The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Hematopoietic Progenitor
Hyperproliferation and Malignant Disease In Vivo",
Leukemia,
27, 398-408 (2013).
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188. |
He, R., Zeng, L.-F., He, Y., Zhang, S. and Zhang, Z.-Y.
"Small molecule tools for functional interrogation of protein tyrosine phosphatases",
FEBS J.,
280, 731-750 (2013).
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187. |
Meng, F.-G. and Zhang, Z.-Y.
"Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical",
Biochimica et Biophysica
Acta, 1834, 464-469 (2013).
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186. |
Carbone, C. J., Zheng, H., Bhattacharya, S., Lewis, J. R., Reiter, A. M., Henthorn, P. S., Zhang, Z.-Y., Baker,
D. P., Ukkiramapandian, R., Bence, K. K., and Fuchs, S. Y.
"Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for anti-viral
therapies",
Proc. Natl. Acad. Sci.,
109, 19226-19231 (2012).
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185. |
Zhang, S., Liu, S., Tao, R., Wei, D., Chen, L., Shen, W., Yu, Z.-H., Wang, L., Jones, D. R., Dong, X. C. and
Zhang, Z.-Y.
"A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes",
J. Am. Chem. Soc.,
134, 18116-18124 (2012).
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184. |
Mali, R. S., Ma, P., Zeng, L.-F., Martin, H., Ramdas, B., He, Y., Sims, E., Nabinger, S., Ghosh, J., Sharma, N.,
Munugalavadla, V., Chatterjee, A., Li, S., Sandusky, G., Craig, A. W., Bunting, K. D., Feng, G.-S., Chan, R. J.,
Zhang, Z.-Y. and Kapur, R.
"Role of SHP2 phosphatase in KIT induced transformation: identification of SHP2 as a druggable target in
diseases involving oncogenic KIT",
Blood,
120, 2669-2678 (2012).
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183. |
Dong, Y., Zhang, L., Zhang, S., Bai, Y., Chen, H., Sun, X., Yong, W., Li, W., Colvin, S. C., Rhodes, S. J.,
Shou, W., and Zhang, Z.-Y.
"Phosphatase of regenerating liver 2 (PRL2) is essential for placenta development by downregulating PTEN
(phosphatase and tensin homologue deleted on chromosome 10) and activating Akt protein",
J. Biol. Chem.,
287, 32172-32179 (2012).
This paper was selected as a Journal of Biological Chemistry "Paper of the Week."
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182. |
Stanford, S. M., Panchal, R. G., Walker, L. M., Wu, D., Falk, M. D., Mitra, S., Damle, S., Ruble, D.,
Kaltcheva, T., Zhang, S., Zhang, Z.-Y., Bavari, S., Barrios, A., and Bottini, N.
"High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active
CD45 inhibitors",
Proc. Natl. Acad. Sci.,
USA 109, 13972-13977 (2012).
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181. |
Zhang, S., Chen, L., Lawrence, D. S. and Zhang, Z.-Y.
"A combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase
inhibitors",
Methods in Molecular Biology,
928, 53-65 (2012).
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180. |
He, R., Zeng, L.-F., He, Y. and Zhang, Z.-Y.
"Recent Advances in PTP1B Inhibitor Development for the Treatment of Type-2 Diabetes and Obesity",
Royal Society of Chemistry Drug Discovery Book Series No. 27, "New Therapeutic Strategies for
Type 2 Diabetes: Small Molecule Approaches" (Edited by Robert M. Jones),
p.142-176 (2012).
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179. |
Sharma, N., Kumar, V., Everingham, S., Mali, R. S., Kapur, R., Zeng, L.-F., Zhang, Z.-Y., Feng, G.-S., Hartmann,
K., Roers, A., and Craig, A. W. B.
"SH2 Domain-Containing Phosphatase-2 is a Critical Regulator of Connective Tissue Mast Cell Survival and
Homeostasis in Mice",
Molecular and Cellular Biology,
32, 2653-2663 (2012).
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178. |
Negro, R., Gobessi, S., Longo, P. G., He, Y., Zhang, Z.-Y., Laurenti, L. and Efremov, D. G.
"Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated
chronic lymphocytic leukemia cells by selectively activating the AKT pathway",
Blood,
119, 6278-6287 (2012).
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177. |
Martin, V. A., Wang, W.-H., Lipchik, A. M., Parker, L. L., He, Y., Zhang, S., Zhang, Z.-Y., Geahlen, R. L.
"AKT2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular
stores",
Cellular Signaling,
24, 1064-1073 (2012).
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176. |
He, Y., Zeng, L.-F., Yu, Z.-H., He, R., Liu, S. and Zhang, Z.-Y.
"Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors",
Bioorg. Med. Chem.,
20, 1940-1946 (2012).
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175. |
Zheng, L.-S., Zhang, Y.-Y., Wu, J.-W., Wu, Z., Zhang, Z.-Y., and Wang, Z.-X.
"A continuous spectrophotometric assay for mitogen-activated protein kinase kinases",
Anal. Biochem.,
421, 191-197 (2012).
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174. |
Loh, K., Merry, T., Galic, S., Wu, B. J., Watt, M. J., Zhang, S., Zhang, Z.-Y., Neel, B. G., and Tiganis, T.
"TCPTP-deficiency in muscle does not alter insulin signaling and glucose homeostasis",
Diabetologia,55, 468-478 (2012).
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173. |
Bai, Y., Luo, Y., Liu, S., Zhang, L., Shen, K., Dong, Y., Walls, C. D., Quilliam, L. A., Wells, C. D., Cao, Y., and Zhang, Z.-Y.
"PRL-1 protein promotes ERK1/2 and RhoA activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein",
J. Biol. Chem.,286, 42316-42324 (2011).
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172. |
Loh, K., Fukushima, A., Zhang, M., Briggs, D., Enriori, P., Galic, S., Sims, N., Weide, F., Bence, K. K, Zhang, S.,
Zhang, Z.-Y., Kahn, B. B., Neel, B. G., Andrews, Z. B., Cowley, M. A., and Tiganis, T.
"Elevated hypothalamic TCPTP in obesity contributes to leptin resistance",
Cell Metabolism,14, 684-699 (2011).
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171. |
Kant, S., Swat, W., Zhang, S., Zhang, Z.-Y., Neel, B. G., Flavell, R. A. and Davis, R. J.
"TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway",
Genes & Development,25, 2069-2078 (2011).
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170. |
Yu, X., Chen, M., Zhang, S., Yu, Z.-H, Sun, J.-P., Wang, L., Liu, S., Imasaki, T., Takagi, Y., and Zhang, Z.-Y.
"Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src
kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate",
J. Biol. Chem.,
286, 30526-30534 (2011).
(Faculty of 1000 Biology "Must Read").
|
169. |
Yu, Z.-H., Chen, L. Wu, L., Liu, S., Wang, L. and Zhang, Z.-Y.
"Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening",
Bioorg. Med. Chem. Lett.,
21, 4238-4242 (2011).
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168. |
Li, H., Zhao, Z., Antalis, C., Zhao, Z., Emerson, R., Wei, G., Zhang, S., Zhang, Z-.Y. and Xu, Y.
"Combinational therapy of an inhibitor of Group VIA phospholipase A2 with paclitaxel is highly effective in blocking ovarian cancer development",
American Journal of Pathology,
452-461 (2011).
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167. |
Stanford, S. M., Krishnamurthy, D., Falk, M. D., Messina, R., Debnath, B., Li, S., Liu, T., Kazemi, R., Dahl, R., He, Y., Yu, X., Chan, A. C., Zhang, Z.-Y., Barrios, A. M., Woods, V. L. Jr., Neamati, N., and Bottini, N
"Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells",
J. Med. Chem.,54, 1640-1054 (2011).
|
166. |
Piovan, L., Wu, L., Zhang, Z.-Y., and Andrade, L. H.
"Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases",
Organic & Biomolecular Chemistry,9, 1347-1351 (2011).
|
165. |
Liu, S., Yu, Z., Yu, X., Huang, S.-X., Luo, Y., Wu, L., Shen, W., Yang, Z., Wang, L., Gunawan, A. M., Chan, R. J., Shen, B., and Zhang, Z.-Y.
"SHP2 is a Target of the Immunosuppressant Tautomycetin",
Chemistry & Biology,18, 101-110 (2011).
|
164. |
He, R., Yu, Z., He, Y., Zeng, L.-F., Xu, J., Wu, L., Gunawan, A. M., Wang, L., Jiang, Z.-X., and Zhang, Z.-Y.
"Double Click Reaction for the Acquisition of a Highly Potent and Selective mPTPB Inhibitor",
ChemMedChem,5, 2051-2056 (2010).
|
163. |
Chen, L., Zhou, B., Zhang, S., Wu, L., Wang, Y., Franzblau, S. G. and Zhang, Z.-Y.
"Identification and characterization of small molecule inhibitors of mPTPB, an essential virulent phosphatase
from Mycobacterium tuberculosis",
ACS Med. Chem. Lett.,1, 355-359 (2010).
|
162. |
Huang, Z., He, Y., Zhang, X., Gunawan, A., Wu, L., Zhang, Z.-Y., Wong, C. F.
"Derivatives of Salicylic Acid as Inhibitors of YopH in Yersinia pestis",
Chemical Biology and Drug Design,76, 85-99 (2010).
|
161. |
Zhang, X., He, Y., Liu, S., Yu, Z., Jiang, Z.-X., Yang, Z., Dong, Y., Nabinger, S. C., Wu, L., Gunawan, A. M., Wang, L., Chan, R. J.,
and Zhang, Z.-Y.
"Salicylic acid-based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine
phosphatase-2 (SHP2)",
J. Med. Chem.,53, 2482-2493 (2010).
|
160. |
Zhou, B., He, Y., Zhang, X., Xu, J., Luo, Y., Wang, Y., Franzblau, S.G., Yang, Z., Chan, R. J., Liu, Y., Zheng, J. and Zhang, Z.-Y.
"Targeting Mycobacterium Protein Tyrosine Phosphatase B for Anti-Tuberculosis Agents",
Proc. Natl. Acad. Sci. USA,107, 4573-8 (2010). (Faculty of 1000 Biology "Exceptional")
(Featured in C&EN Concentrates).
|
159. |
Long, S. A., Cerosaletti, K., Bollyky, P. L., Tatum, M., Shilling, H.,
Zhang, S., Zhang, Z.-Y., Pihoker, C., Sanda, S., Greenbaum, C., and Buckner, J. H.
"Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4+CD25+ regulatory T cells of
Type 1 Diabetic subjects",
Diabetes,59, 407-415 (2010).
(Faculty of 1000 Biology "Recommended").
|
158. |
Zhang, Z.-Y.
"Inhibitors of Protein Tyrosine Phosphatases",
in Ralph Bradshaw and Edward Dennis, editors, Handbook of Cell Signaling, second edition, Oxford: Academic Press,
Vol. 2, pp. 727-735 (2009).
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157. |
Zhang, S., Chen, L., Luo, Y., Gunawan, A., Lawrence, D. S. and Zhang, Z.-Y.
"Acquisition of a Potent and Selective TC-PTP Inhibitor from a Stepwise Fluorophore-tagged Combinatorial Synthesis and Screening Strategy",
J. Am. Chem. Soc.,131, 13072-13079 (2009).
|
156. |
Zhang, W., Chan, R. J., Chen, H., Yang, Z., He, Y., Zhang, X., Luo, Y., Ying, F., Moh, A., Miller, L. C., Payne, R. M., Zhang, Z.-Y., Fu, X.-Y., and Shou, W.
"Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and JMML",
J. Biol. Chem.,284, 22353-22363 (2009).
|
155. |
Arias-Romero, L. E., Saha, S., Villamar-Cruz, O., Yip, S-C., Ethier, S.P., Zhang, Z.-Y., and Chernoff, J.
"Activation of Src by protein tyrosine phosphatase 1B is required for ErbB2 transformation of human breast epithelial cells",
Cancer Research, 69, 4582-4588 (2009).
|
154. |
Walls, C., Zhou, B. and Zhang, Z.-Y.
"Activity-based protein profiling of protein tyrosine phosphatases",
Methods in Molecular Biology,519, 417-429 (2009).
|
153. |
Arechiga, A. F., Habib, T., He, Y., Zhang, X., Zhang, Z.-Y., Funk, A., and Buckner, J. H.
"Cutting Edge: The PTPN22 allelic variant associated with autoimmunity impairs B cell signaling",
Journal of Immunology,182, 3343-3347 (2009).
(Faculty of 1000 Biology "Recommended").
|
152. |
Luo, Y., Liang, F., and Zhang, Z.-Y.
"PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways",
Biochemistry,48, 1838-1846 (2009).
|
151. |
Orrú, V., Tsai, S. J., Rueda, B., Fiorillo, E., Stanford, S. M., Dasgupta, J., Hartiala, J., Zhao, L., Ortego-Centeno, N., D¹Alfonso, S. &
The Italian Collaborative Group, Arnett, F. C., Wu, H., Gonzalez-Gay, M. A., Tsao, B. P., Pons-Estel, B., Alarcon-Riquelme, M. E., He, Y., Zhang, Z.-Y.,
Allayee, H., Chen, X. S., Martin, J. and Bottini, N.
"A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus",
Human Molecular Genetics,18, 569-579 (2009).
|
150. |
Liu, S., Zeng, L.-F., Wu, L., Yu, X., Xue, T., Gunawan, A., Long, Y.-Q., and Zhang, Z.-Y.
"Targeting Inactive Enzyme Conformation: Aryl Diketoacid Derivatives as a New Class of PTP1B Inhibitors",
J. Am. Chem. Soc.,130, 17075-84 (2008).
(Faculty of 1000 Biology "Recommended").
|
149. |
Abdo, M., Liu, S., Zhou, B., Walls, C. D., Wu, L., Knapp, S. and Zhang, Z.-Y.
"Seleninate in Place of Phosphate: Irreversible Inhibition of Protein Tyrosine Phosphatases",
J. Am. Chem. Soc.,130, 13196-13197 (2008).
(Faculty of 1000 Biology "Recommended").
|
148. |
Boivin, B., Zhang, S., Arbiser, J. L., Zhang, Z.-Y., and Tonks, N. K.
"A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells",
Proc. Natl. Acad. Sci.,USA 105, 9959-9964 (2008).
(Faculty of 1000 Biology "Must Read").
|
147. |
Liu, S., Zhou, B., Yang, H., He, Y., Jiang, Z.-X., Kumar, S., Wu, L. and Zhang, Z.-Y.
"Aryl vinyl sulfones and sulfonates as active site-directed and mechanism-based probes for protein tyrosine phosphatases",
J. Am. Chem. Soc.,130, 8251-8260 (2008).
(Faculty of 1000 Biology "Must Read").
|
146. |
Jiang, Z.-X. and Zhang, Z.-Y.
"Trgeting PTPs with small molecule inhibitors in cancer treatment",
Cancer and Metastasis Reviews,27, 263-272 (2008).
|
145. |
Liang, F., Luo, Y., Dong, Y., Walls, C. D., Liang, J., Jiang, H.-Y., Sanford, J. R., Wek, R. C. and Zhang, Z.-Y.
"Translational Control of C-terminal Src Kinase (Csk) Expression by PRL3 Phosphatase",
J. Biol. Chem.,283, 10339-10346 (2008).
|
144. |
Cortesio, C. L., Chan, K. T., Perrin, B. J., Burton, N. O., Zhang, S., Zhang, Z.-Y., and Huttenlocher, A.
"Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion",
J. Cell Biology,180, 957-971 (2008).
(Faculty of 1000 Biology "Recommended").
|
143. |
Almo, S. C., Bonanno, J. B., Sauder, J. M., Emtage, S., Dilorenzo, T. P., Malashkevich, V., Wasserman, S. R., Swaminathan, S.,
Eswaramoorthy, S., Agarwal, R., Kumaran, D., Madegowda, M., Ragumani, S., Patskovsky, Y., Alvarado, J., Ramagopal, U. A., Faber-Barata, J.,
Chance, M. R., Sali, A., Fiser, A., Zhang, Z.-Y., Lawrence, D. S., and Burley, S. K.
"Structural genomics of protein phosphatases",
J. Struct. Funct. Genomics,8, 121-140 (2007).
|
142. |
Yu, X., Sun, J.-P., He, Y., Guo, X.-L., Liu, S., Zhou, B., Hudmon, A. and Zhang, Z.-Y.
"Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases",
Proc. Natl. Acad. Sci.,USA 104, 19767-19772 (2007).
(Faculty of 1000 Biology "Must Read").
|
141. |
Sun, J.-P., Luo, Y., Yu, X., Wang, W.-Q., Zhou, B., Liang, F., and Zhang, Z.-Y.
"Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for the PRL1-mediated
cell growth and migration",
J. Biol. Chem.,282, 29043-29051 (2007).
|
140. |
Zhang, S., Chen, L., Kumar, S., Wu, L., Lawrence, D. S. and Zhang, Z.-Y.
"An Affinity-based Fluorescence Polarization Assay for Protein Tyrosine Phosphatases",
Methods,42, 261-267 (2007).
(Faculty of 1000 Biology "Recommended").
|
139. |
Zhou, B. and Zhang, Z.-Y.
"Application of hydrogen/deuterium exchange mass spectrometry to study protein tyrosine phosphatase dynamics,
ligand binding, and substrate specificity",
Methods,42, 227-233 (2007).
|
138. |
Zhang, Z.-Y.
"Emerging new techniques for studying protein phosphatases",
Methods,42, 205-206 (2007).
|
137. |
Liang, F., Kumar, S., and Zhang, Z.-Y.
"Proteomic Approaches to Studying Protein Tyrosine Phosphatases",
Molecular BioSystems,3, 308-316 (2007).
|
136. |
Zhang, S. and Zhang, Z.-Y.
"PTP1B as a drug target: recent development in PTP1B inhibitor discovery",
Drug Discovery Today,12, 373-381 (2007).
|
135. |
Khajehpour, M., Wu, L., Liu, S., Zhadin, N., Zhang, Z.-Y. and Callender, R.
"Loop Dynamics and ligand binding kinetics in the reaction catalyzed by the Yersinia protein tyrosine phosphatase",
Biochemistry,46 4370-4378 (2007).
|
134. |
Liang, F., Liang, J., Wang, W.-Q., Sun, J.-P., Udho, E., and Zhang, Z.-Y.
"PRL3 Promotes Cell Invasion and Proliferation by Down-regulation of Csk Leading to Src Activation",
J. Biol. Chem.,282 5413-5419 (2007).
(Faculty of 1000 Biology "Recommended").
|
133. |
Boutselis, I. G., Yu, X., Zhang, Z.-Y., and Borch, R.
"Synthesis and cell-based activity of a potent and selective PTP1B inhibitor prodrug",
J. Med. Chem.,50, 856-864 (2007).
|
132. |
Morrison, C. D., White, C. L., Wang, Z., Lee, S.-Y., Lawrence, D. S., Cefalu, W. T., Zhang, Z.-Y., and Gettys, T. W.
"Increased hypothalamic PTP1B contribute to leptin resistance with age",
Endocrinology,148, 433-440 (2007).
|
131. |
Zhou, B., Zhang, J., Liu, S., Reddy, S., Wang, F., and Zhang, Z.-Y.
"Mapping ERK2-MKP3 Binding Interfaces by Hydrogen/Deuterium Exchange Mass Spectrometry",
J. Biol. Chem., 281, 38834-38844 (2006).
|
130. |
Kumar, S., Zhou, B., Liang, F., Yang, H., Wang, W.-Q., and Zhang, Z.-Y.
"Global Analysis of Protein Tyrosine Phosphatase Activity with Ultra-Sensitive
Fluorescent Probes",
J. Proteome Res., 5, 1898-1905 (2006).
(Faculty of 1000 Biology "Must Read").
|
129. |
Cui, Y., Parra, I., Zhang, M., Hilsenbeck, S. G., Tsimelzon, A., Furukawa, T., Horii, A.,
Zhang, Z.-Y., Nicholson, R. I. and Fuqua, S. A.
"Elevated Expression of Mitogen-Activated Protein Kinase Phosphatase 3 in Breast Tumors:
A Mechanism of Tamoxifen Resistance",
Cancer Research , 66, 5950-5959 (2006).
|
128. |
Liu, S., Sun, J.-P., Zhou, B. and Zhang, Z.-Y.
"Structural basis of docking interaction between ERK2 and MAP kinase phosphatase 3",
Proc. Natl. Acad. Sci. USA, 103, 5326-5331 (2006).
|
127. |
Xue, C., Wyckoff, J., Liang, F., Sidani, M., Violini, S., Tsai, K.-L., Zhang, Z.-Y., Sahai, E., Condeelis, J., and Segall J. E.
"Epidermal Growth Factor Receptor Overexpression Results in Increased Tumor Cell
Motility In vivo Coordinately with Enhanced Intravasation and Metastasis",
Cancer Research, 66, 192-197 (2006).
|
126. |
Xue, C., Liang, F., Mahmood, R., Vuolo, M., Wyckoff, J., Qian, H., Tsai, K.-L., Kim, M., Locker, J., Zhang, Z.-Y., and Segall, J. E.
"ErbB3-dependent motility and intravasation in breast cancer matastasis",
Cancer Research 66, 1418-1426 (2006).
|
125. |
Lee, H., Xie, L., Luo, Y., Lee, S.-Y., Lawrence, D. S., Wang, X. B., Sotgia, F., Lisanti, M. P., and Zhang, Z.-Y.
"Identification of Phospho-Caveolin-1 as a Novel PTP1B Substrate",
Biochemistry, 45, 234-240 (2006).
|
124. |
Zhang, Z.-Y.
"Functional Studies of Protein Tyrosine Phosphatases with Chemical Approaches",
Biochim. Biophys. Acta 1754, 100-107 (2005).
|
123. |
Sun, J.-P., Wang, W.-Q., Yang, H., Liu, S., Liang, F., Fedorov, A. A., Almo, S. C. and Zhang, Z.-Y.
"Structure
and Biochemical Properties of PRL-1, a Phosphatase Implicated in Cell Growth, Differentiation, and Tumor Invasion",
Biochemistry, 44, 12009-12021 (2005).
|
122. |
Lee, K., Boovanahalli, S. K., Nam, K.-Y., Kang, S.-U., Phan, J., Wu, L., Waugh, D. S., Zhang, Z.-Y., No, K. T., Lee, J.-J., and
Burke, T. R. Jr.
"Synthesis of tripeptides as potential Yersinia protein-tyrosine phosphatase inhibitors",
Bioorg. Med. Chem. Lett., 15, 4037-4042 (2005)
|
121. |
Liang, F., Lee, S.-Y., Liang, J., Lawrence, D. S. and Zhang, Z.-Y.
"The Role of PTP1B in integrin signaling",
J. Biol. Chem. 280, 24857-24863 (2005).
|
120. |
Lee, S.-Y., Liang, F., Guo, X.-L., Xie, L., Cahill, S. M., Blumenstein, M., Yang, H., Lawrence, D. S. and Zhang, Z.-Y.
"Design, Construction, and
Intracellular Activation of An Intramolecularly Self-Silenced Signal Transduction Inhibitor",
Angew. Chem. Int. Ed. 44, 4242-4244 (2005).
|
119. |
Kumar, S., Liang, F., Lawrence, D. S. and Zhang, Z.-Y.
"Small Molecule Approach to Studying Protein Tyrosine Phosphatases",
Methods, 35(1):9-21, (2005).
|
118. |
Huang, Z., Zhou, B. and Zhang, Z.-Y.
"Molecular Determinants of Substrate Recognition in Hematopoietic Protein Tyrosine Phosphatase",
J. Biol. Chem. 279, 52150-52159 (2004).
|
117. |
Chi, Y., Zhou, B., Wang, W.-Q., Chung, S.-K., Kwon, Y.-U., Ahn, Y.-H., Chang, Y.-T., Tsujishita, Y., Hurley, J. H., Zhang, Z.-Y.
"Comparative Mechanistic and Substrate Specificity Study of Inositol Polyphosphate 5-phosphatases SPsynaptojanin and SHIP2",
J. Biol. Chem. 279, 44987-44995 (2004).
|
116. |
Wang, W.-Q., Bembenek, J., Gee, K. R., Yu, H., Charbonneau, H. and Zhang, Z.-Y.
"Kinetic and Mechanistic Studies of a Cell Cycle Protein Phosphatase Cdc14",
J. Biol. Chem. 279, 30459-30468 (2004).
|
115. |
Kang, S. U., Gao, Y., Wu, L., Zhang, Z.-Y., and Burke, T. R. Jr.
"Enantioselective Synthesis of (S)-3-Carboxy-4-((carboxy)difluoromethyl)phenylalanine
in Protected Form and Incorporation into a PTP-1B-Directed Tripeptide",
Chemistry Biodiversity, 1, 626-633 (2004).
|
114. |
McCain, D. F., Grzyska, P. K., Wu, L., Hengge, A. C. and Zhang, Z.-Y.
"Mechanistic studies of protein tyrosine phosphatases YopH and Cdc25A with m-nitrobenzyl phosphate",
Biochemistry, 43, 8256-8264 (2004).
|
113. |
Kumar, S., Zhou, B., Liang, F., Wang, W.-Q., Huang, Z., and Zhang, Z.-Y.
"Activity-Based Probes for Protein Tyrosine Phosphatases",
Proc. Natl. Acad. Sci. USA 101, 7943-7948 (2004).
(Faculty of 1000 Biology "Recommended").
|
112. |
McCain D.F., Wu L., Nickel P., Kassack M.U., Kreimeyer A., Gagliardi A., Collins D.C., Zhang Z.Y.
"Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases.",
J. Biol. Chem. 279, 14713-14725 (2004).
|
111. |
Zhang, X., Schwartz, J.-C. D., Guo, X.-L., Bhatia, S., Cho, E., Chen, L., Zhang, Z.-Y., Edidin, M. A., Nathenson, S. C., and Almo, S. C.
"Structural and Functional Analysis of the Costimulatory Receptor Programmed Death-1",
Immunity 20, 337-347(2004).
|
110. |
Pedersen, A. K., Guo, X.-L., Møller, K. B., Peters, G. H., Andersen, H. S., Kastrup, J. S.,Mortensen, S. B., Iversen, L. F., Zhang, Z.-Y., and Møller, N. P. H.
"Residue 182 influences the second step of protein-tyrosine phosphatases-mediated catalysis",
Biochemical Journal, 378, 421-433 (2004).
|
109. |
McCain, D. F. and Zhang, Z.-Y.
"Tyrosine Phosphatases in Cancer: Targets for Therapeutic Intervention",
Topics in Current Genetics, Vol. 5, Protein Phosphatases, (Joaquin Arino Denis Alexander, Eds.), Springer-Verlag Berlin Heidelberg, 359-374 (2004).
|
108. |
Vetter, S. W., and Zhang, Z.-Y.
"Combinatorial Chemistry and Peptide Library Methods to Characterize Protein Phosphatases",
Methods in Enzymology, 366, 260-282 (2003).
|
107. |
Zhou, B. and Zhang, Z.-Y.
"Measuring Protein Phosphatase Activity with Physiological Substrates",
Methods in Enzymology, 366, 34-43 (2003).
|
106. |
Goldberg, G. S., Alexander, D. B., Pellicena, P., Zhang, Z.-Y., Tsuda, H., Miller, W. T.
"Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells.",
J. Biol. Chem., 278, 46533-46540 (2003).
|
105. |
Xie, L., Lee, S.-Y. Anderson, J. N., Waters, S., Shen, K., Guo, X.-L., Moller, N. P. H., Olefsky, J. M., Lawrence, D. S., and Zhang, Z.-Y.
"Cellular Effects of Small Molecule PTP1B Inhibitors on Insulin Signaling",
Biolchemistry, 42, 12792-12804 (2003).
|
104. |
Zhang, Z.-Y.
"Inhibitors of Protein Tyrosine Phosphatases",
Handbook of Cell Signaling, (Ralph Bradshaw and Edward Dennis, Editors-in-Chief, Academic Press), 677-684 (2003).
|
103. |
Liang, F., Huang, Z., Lee, S.-Y., Liang, J., Ivanov, M. I., Alonso, A., Bliska, J. B., Lawrence, D. S., Mustelin, T., and Zhang, Z.-Y.
"Aurintricarboxylic Acid Blocks in vitro and in vivo Activity of YopH, an Essential Virulent Factor of Yersinia pestis, the Agent of Plague",
J. Biol. Chem., 278, 41734-41741 (2003).
(Faculty of 1000 Biology "Recommended").
|
102. |
Liu, D.-G., Gao, Y., Voigt, J. H., Lee, K., Nicklaus, M. C., Wu, L., Zhang, Z.-Y., and Burke, T. R. Jr.
"Acylsulfonamide- containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration",
Bioorg. Med. Chem. Lett. 13, 3005-3007 (2003).
|
101. |
Sun, J.-P., Wu, L., Fedorov, A. A., Almo, S. C. and Zhang, Z.-Y.
"Crystal Structure of the Yersinia Protein-Tyrosine
Phosphatase YopH Complexed with a Specific Small Molecule Inhibitor",
J. Biol. Chem., 278, 33392-33399 (2003).
|
100. |
Zhang, J., Zhou, B., Zheng, C.-F., and Zhang, Z.-Y.
"A Bipartite Mechanism for ERK2 Recognition by Its Cognate Regulators and Substrates",
J. Biol. Chem., 278, 29901-29912, (2003).
|
99. |
Zhang, Z.-Y.
"Mechanistic Studies on Protein Tyrosine Phosphatases",
Progress in Nucleic Acid Research and Molecular Biology 73, 171-220 (2003).
|
98. |
Lee, K, Gao, Y., Yao, Z.-J., Phan, J., Wu, L., Liang, J., Waugh, D., Zhang, Z.-Y. and Burke, T. R. Jr.
"Tripeptide Inhibitors of Yersinia Protein-Tyrosine Phosphatase",
Bioorg. Med. Chem. Lett., 13, 2577-2581 (2003).
|
97. |
Zhang, Z.-Y.
"Chemical and Mechanistic Approaches to the Study of Protein Tyrosine Phosphatases",
Acc. Chem. Res., 36, 385-392 (2003).
|
96. |
Wang, W.-Q., Sun, J.-P. and Zhang, Z.-Y.
"An Overview of the Protein Tyrosine Phosphatase Superfamily",
Current Topics in Medicinal Chemistry, 3, 739-748 (2003).
|
95. |
Sun, J.-P., Fedorov, A. A., Lee, S.-Y., Guo, X.-L., Shen, K., Lawrence, D. S., Almo, S. C. and Zhang, Z.-Y.
"Crystal Structure of PTP1B in Complex with a Potent and Selective Bidentate Inhibitor",
J Biol Chem., 278(14), 12406-14 (2003).
|
94. |
Zhang, Z.-Y. and Lee, S-Y.
"PTP1B Inhibitors as Potential Therapeutics in the Treatment of Type 2 Diabetes and Obesity",
Expert Opinion on Investigational Drugs, 12, 223-233 (2003).
|
93. |
Guo, X.-L., Shen, K., Wang, F., Lawrence, D. S., and Zhang, Z.-Y.
"Probing the Molecular Basis for Potent and Selective Protein
Tyrosine Phosphatase 1B Inhibition",
J. Biol. Chem., 277, 41014-41022 (2002).
|
92. |
Cheng, H., Nikolic-Hughes, I., Wang, J. H., Deng, H., O'Brien, P. J., Wu, L., Zhang, Z.-Y., Herschlag, D., and Callender, R.
"Environmental Effects on
Phosphoryl Group Bonding Probed by Vibrational Spectroscopy: Implications for Understanding Phosphoryl Transfer and Enzymatic Catalysis",
J. Am. Chem. Soc., 124, 11295-11306 (2002).
|
91. |
Zhou, B., Wang, Z.-X., Zhao, Y., Brautigan, D. L. and Zhang, Z.-Y.
"The Specificity of Extracellular Signal-Regulated Kinase 2 Dephosphorylation by Protein Phosphatases",
J. Biol. Chem., 277, 31818-31825 (2002).
|
90. |
Vetter, S. W. and Zhang, Z.-Y.
"Probing the Phosphopeptide Specificities of Protein Tyrosine Phosphatases, SH2 and PTB Domains with Combinatorial Library Methods",
Current Protein Peptide Science, 3, 365-397 (2002).
|
89. |
Wang, Z.-X., Zhou, B., Wang, Q. M. and Zhang, Z.-Y.
"A Kinetic Approach for the Study of Phosphatase-Catalyzed Regulation of Kinase Activity",
Biochemistry, 41, 7849-7857 (2002).
|
88. |
Zhang, Z.-Y., Zhou, B. and Xie, L.
"Modulation of Protein Kinase Signaling by Protein Phosphatases and Inhibitors",
Pharmacology Therapeutics, 93, 307-317 (2002).
|
87. |
Deng, H., Callender, R., Huang, Z. and Zhang, Z.-Y.
"Is PTPase-Vanadate a True Transition State Analog?",
Biochemistry, 41, 5865-5872 (2002).
(Faculty of 1000 Biology "Recommended").
|
86. |
Zhou, B. and Zhang, Z.-Y.
"The Activity of the Extracellular Signal-Regulated Kinase 2 Is Regulated by Differential Phosphorylation in the Activation Loop",
J. Biol. Chem., 277, 13889-13899 (2002).
|
85. |
Zhao, Y. and Zhang, Z.-Y.
"Control of Signaling by Tyrosine Phosphatases", in
Hormone Signaling, (Eds: Vincent Goffin and Paul A. Kelly), Kluwer Academic Publishers, Norwell MA, p.21-36(2002).
|
84. |
McCain, D. F., Catrina, I. E., Hengge, A. C, and Zhang, Z.-Y.
"The Catalytic Mechanism of Cdc25A Phosphatase",
J. Biol. Chem., 277, 11190-11200 (2002).
|
83. |
Xie, L., Zhang, Y.-L. and Zhang, Z.-Y.
"Design and Characterization of an Improved Protein Tyrosine Phosphatase Substrate-Trapping Mutant",
Biochemistry, 41, 4032-4039 (2002).
|
82. |
Zhang, Z.-Y.
"Protein Tyrosine Phosphatases: Structure and Function, Substrate Specificity, and Inhibitor Development",
Annual Reviews of Pharmacology Toxicology, 42, 209-234 (2002).
|
81. |
McCain, D. F. and Zhang, Z.-Y.
"Assays for Protein Tyrosine Phosphatases,",
Methods in Enzymology, 345, 507-518 (2002).
|
80. |
Shen, K., Keng, Y.-F., Wu, L., Guo, X.-L., Lawrence, D. S., and Zhang, Z.-Y.
"Acquisition of a Specific and Potent PTP1B Inhibitor
from a Novel Combinatorial Library and Screening Procedure,",
J. Biol. Chem., 276, 47311-47319 (2001).
|
79. |
Gao, Y., Voigt, J., Zhao, H., Pais, G. C. G., Zhang, X., Wu, L., Zhang, Z.-Y., and Burke, T. R., Jr.
"Utilization of a Peptide Lead
for the Discovery of a Novel PTP1B-Binding Motif,",
J. Med. Chem., 44, 2869-2878 (2001).
|
78. |
Zhao, Y. and Zhang, Z.-Y.
"The Mechanism of Dephosphorylation of Extracellular Signal-Regulated Kinase 2 by Mitogen-Activated Protein Kinase Phosphatase 3",
J. Biol. Chem., 276, 32382-32391 (2001).
|
77. |
Zhang, Z.-Y.
"Protein Tyrosine Phosphatases: Prospects for Therapeutics",
Current Opinion in Chemical Biology, 5, 416-423 (2001).
|
76. |
Burke, T. R., Yao, Z.-J., Ye, B., Miyoshi, K., Otaka, A., Wu, L. and Zhang, Z.-Y.
"Phospho-AzaTyrosine, a Less Effective
Protein-Tyrosine Phosphatase Substrate than Phosphotyrosine",
Bioorg. Med. Chem. Lett., 11, 1265-1268 (2001).
|
75. |
Zhou, B., Wu, L., Shen, K., Zhang, J., Lawrence, D. S. and Zhang, Z.-Y.
"Multiple Regions of MAP Kinase Phosphatase 3 Are
Involved in Its Recognition and Activation by ERK2",
J. Biol. Chem., 276, 6506-6515 (2001).
|
74. |
Zhang, Y.-L., Yao, Z.-J., Sarmiento, M., Wu, L., Burke, T. R. Jr. and Zhang, Z.-Y.
"Thermodynamic Study of Ligand Binding to
Protein-Tyrosine Phosphatase 1B and Its Substrate-Trapping Mutants",
J. Biol. Chem., 275, 34205-34212 (2000).
|
73. |
Sarmiento, M., Puius, Y. A., Vetter, S. W., Keng, Y.-F., Wu, L., Zhao, Y., Lawrence, D. S., Almo, S. C. Zhang, Z.-Y.
"Structural
Basis of Plasticity in Protein Tyrosine Phosphatase 1B Substrate Recognition",
Biochemistry, 39, 8171-8179 (2000).
|
72. |
Gao, Y., Wu, L., Luo, J. H., Guo, R., Yang, D., Zhang, Z.-Y., and Burke, T. R., Jr.
"Examination of Novel Non-Phosphorus-Containing Phosphotyrosyl Mimetics
against Prpteon-Tyrosine Phosphatase-1B and Demonstration of Differential Affinities toward GRB2 SH2 Domains",
Bioorg. Med. Chem. Lett., 10, 923-927 (2000).
|
71. |
Xian, M., Wang, K., Chen, X., Hou, Y., McGill, A., Zhou, B., Zhang, Z.-Y., Cheng, J. P. and Wang, G. P.
"Inhibition of Protein Tyrosine Phosphatases by
Low-Molecular-Weight S-Nitrosothiols and S-Nitrosylated Human Serum Albumin",
Biochem. Biophys. Res. Commun., 268, 310-314 (2000).
|
70. |
Ibrahimi, O. A., Wu, L., Zhao, K. and Zhang, Z.-Y.
" Synthesis and Characterization of a Novel Class of Protein Tyrosine Phosphatase Inhibitors",
Bioorg. Med. Chem. Lett., 10, 457-460 (2000).
|
69. |
Sarmiento, M., Wu, L., Keng, Y.-F., Song, L., Luo, Z., Huang, Z., Wu, G.-Z., Yuan, A. K. and Zhang, Z.-Y.
"Structure-Based
Discovery of Small Molecule Inhibitors Targeted to Protein Tyrosine Phosphatase 1B",
J. Med. Chem., 43, 146-155 (2000).
|
68. |
Vetter, S. W., Keng, Y.-F., Lawrence, D. S. and Zhang, Z.-Y.
"Assessment of Protein Tyrosine Phosphatse 1B Substrate Specificity Using "Inverse Alanine Scanning"",
J. Biol. Chem., 275, 2265-2268 (2000).
|
67. |
Hoff, R. H., Hengge, A. C., Wu, L., Keng, Y.-F., and Zhang, Z.-Y.
"The Effects on General Acid Catalysis from Mutations of the
Invariant Tryptophan and Arginine Residues in the Protein-Tyrosine Phosphatase from Yersinia",
Biochemistry, 39, 46-54 (2000).
|
66. |
Zhou, B. and Zhang, Z.-Y.
"Mechanism of Mitogen-activated Protein Kinase Phosphatase-3 Activation by ERK2",
J. Biol. Chem., 274, 35526-35534 (1999).
|
65. |
Barrett, W. C., DeGnore, J. P., Keng, Y.-F., Zhang, Z.-Y., Yim, M.-B., and Chock, P. B.
"Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein Tyrosine Phosphatase 1B",
J. Biol. Chem., 274, 34543-34546 (1999).
|
64. |
Hoff, R. H., Wu, L., Zhou, B. Zhang, Z.-Y. and Hengge, A. C.
"Does Positive Charge at the Active site of a Phosphatase Cause a Change in Mechanism?
The Effect of the Conserved Arginine on the Transition State for Enzymatic Phosphoryl Transfer in the Protein-Tyrosine Phosphatase from Yersinia",
J. Am. Chem. Soc., 121, 9514-9521 (1999).
|
63. |
Zhang, Y.-L., Hollfelder, F., Gordon, S. J., Chen, L., Keng, Y.-F., Wu, L., Herschlag, D. and Zhang, Z.-Y.
"Impaired Transition
State Complementarity in the Hydrolysis of O-Arylphosphorothioates by Protein-Tyrosine Phosphatases",
Biochemistry, 38, 12111-12123 (1999).
|
62. |
Wrobel, J., Sredy, J., Moxham, C., Dietrich, A., Li, Z., Sawicki, D. R., Seestaller, L., Wu, L., Katz, A., Sullivan, D. Tio, C. and Zhang, Z.-Y.
"PTP1B Inhibition and Antihyperglycemic Activity of Novel 11-Aryl-benzo[b]naphtho[2,3-d]furans and 11-Aryl-benzo[b]naphtho[2,3-d]thiophenes",
J. Med. Chem., 42, 3199-3202 (1999).
|
61. |
Barrett, W. C., DeGnore, J. P., König, S., Fales, H. M., Keng, Y.-F., Zhang, Z.-Y., M.-B. Yim and Chock, P. B.
"Regulation of PTP1B via
Glutathionylation of the Active Site Cysteine 215",
Biochemistry, 38, 6699-6705 (1999).
|
60. |
Taing, M., Keng, Y.-F., Shen, K., Wu, L., Lawrence, D. S., Zhang, Z.-Y.
"Potent and Highly Selective Inhibitors of the Protein Tyrosine Phosphatase 1B",
Biochemistry, 38, 3793-3803 (1999).
|
59. |
Keng, Y.-F., Wu, L. Zhang, Z.-Y.
"Probing the Function of the Invariant Tryptophan in the Flexible Loop of the Yersinia Protein-Tyrosine Phosphatase",
Eur. J. Biochem., 259, 809-814 (1999).
|
58. |
Buist, A., Zhang, Y.-L., Keng, Y.-F., Wu, L., Zhang, Z.-Y., and den Hertog, J.
"Restoration of Potent Protein-Tyrosine Phosphatase
Activity into the Membrane-Distal Domain of Receptor Protein-Tyrosine Phosphatase a",
Biochemistry, 38, 914-922 (1999).
|
57. |
Chen, H., Cong, L.-N., Li, Y., Yao, Z.-J., Wu, L., Zhang, Z.-Y., Burke, T. R., Quon, M. J.
"A Phosphotyrosyl Mimetic Peptide Reverses
Impairment of Insulin Stimulated Translocation of GLUT4 Caused by Overexpression of PTP1B in Rat Adipose Cells",
Biochemistry, 38, 384-389 (1999).
|
56. |
Yao, Z.-J., Ye, B., Wu, X.-W., Wang, S., Wu, L., Zhang, Z.-Y. Burke, T. R.
"Structure-Based Design and Synthesis of Small Molecule Protein-Tyrosine Phosphatase 1B Inhibitors",
Bioorganic Medicinal Chemistry, 6, 1799-1810 (1998).
|
55. |
Burke, T. R. Jr., Zhang, Z.-Y.
"Protein Tyrosine Phosphatases: Structure, Mechanism and Inhibitor Discovery",
Biopolymers (Peptide Science), 47, 225-241 (1998).
|
54. |
Wang, F., Li, W., Emmett, M. R., Hendrickson, C. L., Marshall, A. G., Zhang, Y.-L., Wu, L., Zhang, Z.-Y.
"Conformational and Dynamic Changes of Yersinia Protein Tyrosine Phosphatase Induced by Ligand Binding and Active Site
Mutation and Revealed by H/D Exchange and Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry",
Biochemistry, 37, 15289-15299 (1998).
|
53. |
Sarmiento, M., Zhao, Y., Gordon, S. J. Zhang, Z.-Y.
"Molecular Basis of Substrate Specificity of Protein Tyrosine Phosphatase 1B",
J. Biol. Chem., 273, 26368-26374 (1998).
|
52. |
Roller, P. P., Wu, L., Zhang, Z.-Y., Burke, T. R.
"Potent Inhibition of Protein-tyrosine Phosphatase 1B Using the Phosphotyrosyl Mimetic
Fluoro-O-malonyl Tyrosine (FOMT)",
Bioorg. Med. Chem. Lett., 8, 2149-2150 (1998).
|
51. |
Zhang, Y.-L. Zhang, Z.-Y.
"Low-Affinity Binding Determined by Titration Calorimetry Using a High-Affinity Coupling Ligand: A
Thermodynamic Study of Ligand Binding to Protein Tyrosine Phosphatase 1B",
Anal. Biochem., 261, 139-148 (1998).
|
50. |
Burke, T. R. Jr., Yao, Z.-J., Zhao, H., Milne, G. W. A., Wu, L., Zhang, Z.-Y. Voigt, J. H.
"Enantioselective Synthesis of
Nonphosphorus-Containing Phosphotyrosyl Mimetics and Their Use in the Preparation of Tyrosine Phosphatase Inhibitory Peptides",
Tetrahedron 54, 9981-9994 (1998).
|
49. |
Zhang, Y.-L., Keng, Y.-F., Zhao, Y., Wu, L. Zhang, Z.-Y.
"Suramin Is an Active Site- Directed, Reversible, and Tight-Binding Inhibitor of Protein-Tyrosine Phosphatases",
J. Biol. Chem., 273, 12281-12287 (1998).
|
48. |
lhambra, C., Wu, L., Zhang, Z.-Y. Gao, J.
"Walden-Inversion Enforced Transition State Stabilization in a Protein Tyrosine Phosphatase",
J. Am. Chem. Soc., 120, 3858-3866 (1998).
|
47. |
Zhang, Z.-Y.
"Protein-Tyrosine Phosphatases: Biological Function, Structural Characteristics, and Mechanism of Catalysis",
Critical Reviews in Biochemistry and Molecular Biology, 33, 1-52 (1998).
|
46. |
Zhao, Y., Wu, L. Noh, S. J., Guan, K.-L., Zhang, Z.-Y.
"Altering the Nucleophile Specificity of a Protein-Tyrosine
Phosphatase-Catalyzed Reaction: Probing the Function of the Invariant Glutamine Residues",
J. Biol. Chem., 273, 5484-5492 (1998).
|
45. |
Sarmiento, M., Gordon, S. J. and Zhang, Z.-Y.
"Protein Tyrosine Phosphatases: Modulators of Signal Transduction",
Einstein Quarterly J. Biol. Med., 14, 140-156 (1997).
|
44. |
Puius, Y. A., Zhao, Y., Sullivan, M., Lawrence, D. S., Almo, S. C. Zhang, Z.-Y.
"Identification of a Second Aryl Phosphate-Binding Site in Protein-Tyrosine Phosphatase 1B: A Paradigm for Inhibitor Design",
Proc. Natl. Acad. Sci. USA, 94, 13420-13425 (1997).
|
43. |
Hengge, A. C., Zhao, Y., Wu, L. Zhang, Z.-Y.
"Examination of the Transition State of the Low-Molecular Mass Tyrosine Phosphatase 1. Comparisons with Other Protein Phosphatases",
Biochemistry, 36, 7928-7936 (1997).
|
42. |
Zhang, Z.-Y.
"Structure, Mechanism and Specificity of Protein-Tyrosine Phosphatases",
Current Topics in Cellular Regulation, 35, 21-68 (1997).
|
41. |
Wu, L., Buist, A., den Hertog, J. Zhang, Z.-Y.
"Comparative Kinetic Analysis and Substrate Specificity of the Tandem Catalytic Domains of the Receptor-like Protein- Tyrosine Phosphatase a",
J. Biol. Chem., 272, 6994-7002 (1997).
|
40. |
Juszczak, L. J., Zhang, Z.-Y., Wu, L., Gottfried, D. S., Eads, D. D.
"Rapid Loop Dynamics of Yersinia Protein Tyrosine Phosphatases",
Biochemistry, 36, 2227-2236 (1997).
|
39. |
Akamatsu, M., Roller, P. P., Chen, L., Zhang, Z.-Y., Ye, B. Burke, T. R.
"Potent Inhibition of Protein-Tyrosine Phosphatase by Phosphotyrosine-Mimic Containing Cyclic Peptides",
Bioorganic Medicinal Chemistry, 5, 157-163 (1997).
|
38. |
Zhang, Z.-Y. Wu, L.
"The Single Sulfur to Oxygen Substitution in the Active Site Nucleophile of the Yersinia
Protein-Tyrosine Phosphatase Leads to Substantial Structural and Functional Perturbations",
Biochemistry, 36, 1362-1369 (1997).
|
37. |
Burke, T. R. Jr., Ye, B., Yan, X., Wang, S., Jia, Z., Chen, L., Zhang, Z.-Y., Barford, D.
"Small Molecule Interactions with Protein-Tyrosine Phosphatase PTP1B and Their Use in Inhibitor Design",
Biochemistry, 35, 15989-15996 (1996).
|
36. |
Taylor, W. P., Zhang, Z.-Y., Widlanski, T. S.
"Quiescent Affinity Inactivators of Protein Tyrosine Phosphatases",
Bioorganic Medicinal Chemistry, 4, 1515-1520 (1996).
|
35. |
Zhao, Y. Zhang, Z.-Y.
"Reactivity of Alcohols Toward the Phosphoenzyme Intermediate in the Protein-Tyrosine Phosphatase-Catalyzed
Reaction: Probing the Transition State of the Dephosphorylation Step",
Biochemistry, 35, 11797-11804 (1996).
|
34. |
Chen, L., Montserat, J., Lawrence, D. S. Zhang, Z.-Y.
"VHR and PTP1 Protein Phosphatases Exhibit Remarkably Different Active Site
Specificities Toward Low Molecular Weight Nonpeptidic Substrates",
Biochemistry, 35, 9349-9354 (1996).
|
33. |
Wu, L. Zhang, Z.-Y.
"Probing the Function of Asp128 in the Low Molecular Weight Protein-Tyrosine Phosphatase Catalyzed Reaction. A
Pre-Steady-State and Steady-State Kinetic Investigation",
Biochemistry, 35, 5426-5434 (1996).
|
32. |
Montserat, J., Chen, L., Lawrence, D. S. Zhang, Z.-Y.
"Potent Low Molecular Weight Substrates for Protein-Tyrosine Phosphatase",
J. Biol. Chem., 271, 7868-7872 (1996).
|
31. |
Zhang, Z.-Y., Walsh, A. B., Wu, L., McNamara, D. J., Dobrusin, E. M., Miller, W. T.
"Determinants of Substrate Recognition in the Protein-Tyrosine Phosphatase, PTP1",
J. Biol. Chem., 271, 5386-5392 (1996).
|
30. |
Dunn, D., Chen, L., Lawrence, D. S. Zhang, Z.-Y.
"The Active-Site Specificity of the Yersinia Protein-Tyrosine Phosphatase",
J. Biol. Chem., 271, 168-173 (1996).
|
29. |
Zhang, Z.-Y., Palfey, B. A., Wu, L. Zhao, Y.
"Catalytic Function of the Conserved Hydroxyl Group in the Protein-Tyrosine Phosphatase Signature Motif",
Biochemistry, 34, 16389-16396 (1995).
|
28. |
Zhang, Z.-Y., Wu, L. Chen, L.
"Transition State and Rate-Limiting Step of the Reaction Catalyzed by the Human Dual Specificity Phosphatase, VHR",
Biochemistry, 34, 16088-16096 (1995).
|
27. |
Chen, L., Wu, L., Otaka, A., Smyth, M. S., Roller, P. P., Burke, T. R., den Hertog, J. Zhang, Z.-Y.
"Why Is Phosphono-difluoromethyl Phenylalanine a
More Potent Inhibiting Moiety Than Phosphonomethyl Phenylalanine toward Protein-Tyrosine Phosphatases?",
Biochem. Biophys. Res. Commun., 216, 976-984 (1995).
|
26. |
Hengge, A. C., Sowa, G, Wu, L. Zhang, Z.-Y.
"Nature of the Transition State of the Protein-Tyrosine Phosphatase-Catalyzed Reaction",
Biochemistry, 34, 13982-13987 (1995).
|
25. |
Zhang, Z.-Y., Zhou, G., Denu, J. M., Wu, L., Tang, X., Mondesert, O., Russell, P., Butch, E. Guan, K.-L.
"Purification and Characterization of the Low M
olecular Weight Protein Tyrosine Phosphatase, Stp1, from the Fission Yeast S. pombe",
Biochemistry, 34, 10560-10568 (1995).
|
24. |
Zhang, Z.-Y.
"Are Protein-Tyrosine Phosphatases Specific for Phosphotyrosine?",
J. Biol. Chem., 270, 16052-16055 (1995).
|
23. |
Zhang, Z.-Y.
"Kinetic and Mechanistic Characterization of a Mammalian Protein Tyrosine Phosphatase, PTP1",
J. Biol. Chem., 270, 11199-11204 (1995).
|
22. |
Yu, L., McGill, A., Ramirez, J., Wang, P. G. Zhang, Z.-Y.
"Synthesis and Bioassay of a Protein Tyrosine Phosphatase Inhibitor, Dephostatin",
Bioorganic Medicinal Chemistry Letters 5, 1003-1006 (1995).
|
21. |
Zhang, Z.-Y., Wang, Y., Wu, L., Fauman, E., Stuckey, J. A., Schubert, H. L., Saper, M. A. Dixon, J. E.
"The Cys(X)5Arg Catalytic Motif in Phosphoester Hydrolysis",
Biochemistry, 33, 15266-15270 (1994).
|
20. |
Stuckey, J. A., Schubert, H. L., Fauman, E., Zhang, Z.-Y., Dixon, J. E. Saper, M. A.
"Crystal Structure of Yersinia Protein Tyrosine Phosphatase at 2.5 Å and the Complex with Tungstate",
Nature, 370, 571-575 (1994).
|
19. |
Zhang, Z.-Y., Malachowski, W. P., Van Etten, R. L. Dixon, J. E.
"The Nature of the Rate-determining Steps of the Yersinia
Protein Tyrosine Phosphatase-catalyzed Reactions",
J. Biol. Chem., 269, 8140-8145 (1994).
|
18. |
Zhang, Z.-Y., Maclean, D., McNamara, D. J., Sawyer, T. K. Dixon, J. E.
"Protein Tyrosine Phosphatase Substrate Specificity:
the Minimum Size of the Peptide and the Positioning of the Phosphotyrosine",
Biochemistry, 33, 2285-2290 (1994).
|
17. |
Zhang, Z.-Y., Wang, Y. Dixon, J. E.
"Dissecting the Catalytic Mechanism of Protein Tyrosine Phosphatases",
Proc. Natl. Acad. Sci. USA, 91, 1624-1627 (1994).
|
16. |
Zhang, Z.-Y. Dixon, J. E.
" Protein Tyrosine Phosphatases: Mechanism of Catalysis and Substrate Specificity",
Advances in Enzymology 68, 1-36 (1994).
|
15. |
Maclean, D., Sefler, A., McNamara, D. J., Zhang, Z.-Y., Zhu, G., Dobrusin, E. M., McMichael, A., Fry, D. W., Decker, S. J.,
Dixon, J. E., Saltiel, A. R., Sawyer, T. K. Bristol, J. A.
"Phosphorylated Fragments of the Epidermal Growth Factor Receptor:
Sequence Specificity for Binding to Phospholipase C-g-1 SH2 Domains, and for Kinase and Phosphatase Activity",
Peptides: Chemistry, Structure and Biology, (Hodges, R. S. Smith, J. A., Eds.) ESCOM, Leiden, The Netherlands, p.948-950 (1994).
|
14. |
Milarski, K. L., Zhu, G., Pearl, C. G., McNamara, D. J., Dobrusin, E. M., Maclean, D., Thieme-Sefler, A., Zhang, Z.-Y.,
Sawyer, T., Decker, S. J., Dixon, J. E. Saltiel, A. R.
"Sequence Specificity in Recognition of the Epidermal Growth Factor by Protein Tyrosine Phosphatase 1B",
J. Biol. Chem., 268, 23634-23639 (1993).
|
13. |
Zhang, Z.-Y. Dixon, J. E.
"Active Site Labeling of the Yersinia Protein Tyrosine Phosphatase:
The Determination of the pKa of the Active Site Cysteine and the Function of the Conserved Histidine 402",
Biochemistry, 32, 9340-9345 (1993).
|
12. |
Zhang, Z.-Y., Maclean, D., Thieme-Sefler, A. M., McNamara, D., Dobrusin, E. M., Sawyer, T. K. Dixon, J. E.
"Substrate Specificity of the Protein Tyrosine Phosphatases",
Proc. Natl. Acad. Sci. USA, 90, 4446-4450 (1993).
|
11. |
Zhang, Z.-Y., Thieme-Sefler, A. M., Maclean, D., Roeske, R. Dixon, J. E.
"A Continuous Spectrophotometric and Fluorimetric Assay for Protein Tyrosine Phosphatase Using Phosphotyrosine Containing Peptides",
Anal. Biochem., 211, 7-15 (1993).
|
10. |
David, M., Romero, G., Zhang, Z.-Y., Dixon, J. E. Larner, A. C.
"In Vitro Activation of the Transcription Factor ISGF3 by Interferon a Involves a Membrane Associated Tyrosine Phosphatase and Tyrosine Kinase",
J. Biol. Chem., 268, 6593-6599 (1993).
|
9. |
Maggiora, L. L., Smith, C. W. Zhang, Z.-Y.
"A General Method for the Preparation of Internally Quenched Fluorogenic Protease Substrates Using Solid-Phase Peptides Synthesis",
J. Med. Chem., 35, 3727-3730 (1992).
|
8. |
Zhang, Z.-Y., Clemens, J. C., Schubert, H. L., Stuckey, J. A., Fischer, M, W. F., Hume, D. M., Saper, M. A. Dixon, J. E.
"Expression, Purification, and Physicochemical Characterization of a Recombinant Yersinia Protein Tyrosine Phosphatase",
J. Biol. Chem., 267, 23759-23766 (1992).
|
7. |
Wo, Y.-Y. P., Zhou, M.-M., Stevis, P., Davis, J. P., Zhang, Z.-Y. Van Etten, R. L.
"Cloning, Expression, and Catalytic Mechanism of a Low Molecular Weight Phosphotyrosyl Protein Phosphatase from Bovine Heart",
Biochemistry, 31, 1712-1721 (1992).
|
6. |
Zhang, Z.-Y., Davis, J. P. Van Etten, R. L.
"Covalent Modification and Active Site- Directed Inactivation of a Low Molecular Weight Phosphotyrosyl Protein Phosphatase",
Biochemistry, 31, 1701-1711 (1992).
|
5. |
Zhang, Z.-Y. Van Etten, R. L.
"Leaving Group Dependence and Proton Inventory Studies of the Phosphorylation of a Cytoplasmic Phosphotyrosyl Protein Phosphatase from Bovine Heart",
Biochemistry, 30, 8954-8959 (1991).
|
4. |
Zhang, Z.-Y., Reardon, I. M., Hui, J. O., O'Connell, K., Poorman, R. A., Tomasselli, A. G. Heinrikson, R. L.
"Zinc Inhibition of Renin and the Protease from HIV-1",
Biochemistry, 30, 8717-8721 (1991).
|
3. |
Zhang, Z.-Y., Poorman, R. A., Maggiora, L. L., Heinrikson, R. L. Kézdy, F. J.
"Dissociative Inhibition of Dimeric Enzymes: Kinetic Characterization of the
Inhibition of HIV-1 Protease by Its C-Terminal Peptide",
J. Biol. Chem., 266, 15591-15594 (1991).
|
2. |
Zhang, Z.-Y. Van Etten, R. L.
"Pre-steady-state and Steady-state Kinetic Analysis of the Low Molecular Weight Phosphotyrosyl Protein Phosphatase from Bovine Heart",
J. Biol. Chem., 266, 1516-1525 (1991).
|
1. |
Zhang, Z.-Y. Van Etten, R. L.
"Purification and Characterization of a Low Molecular Weight Acid Phosphatase - A Major Phosphotyrosyl-Protein Phosphatase from Bovine Heart",
Arch. Biochem. Biophys., 282, 39-49 (1990).
|
|