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Publications

142. Nambiar, M.; Wang, L. S.; Rotello, V.; Chmielewski, J. "Reversible Hierarchical Assembly of Trimeric Coiled-Coil Peptides into Banded Nano- and Microstructures" J. Am. Chem. Soc. 2018, 140, 13028-13033.

141. Nepal, M.; Mohamed, M.; Blade, R.; Eldedouky, H.; Anderson, T.; Seleem, M.N.; Chmielewski, J. "A Library Approach to Cationic Amphiphilic Polyproline Helices that Target Intracellular Pathogenic Bacteria" ACS Infectious Diseases 201841300–1305.

140. Schnoebelen, C.; Towns, M.T.; Chmielewski, J.; Hrycyna, C.A. "Design and Evaluation of a One-Semester General Chemistry Course for Undergraduate Life Science Majors" J. Chem. Educ. 2018, 95, 734-740.

139. Namanja-Magliano, H.A.; Bohn, K.; Agrawal, N.; Willoughby, M.E.; Hrycyna, C.A.; Chmielewski, J. "Dual Inhibitors of the Human Blood-brain barrier Drug Eflux Transporters P-gylcoprotein and ABCG2 Based on the Antiviral Azidothymidine" Bioorg Med Chem 2017, 25, 5128-5132.

138. Strauss, K.; Chmielewski, J. "Advances in the Design and Higher-order Assembly of Collagen Mimetic Peptides for Regenerative Medicine" Current Opinion in Biotechnology  2017, 46, 34-41.

137. Mohamed, M.F.; Brezden, A.; Mohammad, H.; Chmielewski, J.; Seleem, M.N. "A Short D-Enantiomeric Antimicrobial Peptide with Potent Immunomodulatory and Antibiofilm Activity against Multidrug-resistant Pseudomonas aeroginosa and Acinetobacter baumannii" Scientific Reports 2017, 7, 6953.

136. Mohamed, M.F.; Brezden, A.; Mohammad, H.; Chmielewski, J.; Seleem, M.N. "Targeting Biofilms and Persisters of ESKAPE pathogens with P14KanS, a Kanamycin Peptide Conjugate" Biochimica et Biophysica Acta 2017, 1861, 848-859.

135. Bohn, K.; Lange, A.; Chmielewski, J.; Hrycyna, C.A. "Dual Modulation of Human P-glycoprotein and ABCG2 with Prodrug Dimers of the Atypical Antipsychotic Agent Paliperidone in a Model of the Blood–brain Barrier" Molecular Pharmaceutics  2017, 14, 1107-1119.

134. Strauss, K.; Chmielewski, J. "Metal-promoted Assembly of Ttwo Collagen Mimetic Peptides into a Biofunctional 'Spiraled Horn' Scaffold" Materials 2016, 9, 838.

133. Nepal, M.; Sheeldo, M.; Das, C.; Chmielewski, J. "Accessing Three-Dimensional Crystals with Incorporated Guests through Metal-Directed Coiled-Coil Peptide Assembly" J. Am. Chem. Soc. 2016, 138, 11051-11057.

132. Brezden, A.; Mohamed, M. F.; Nepal, M.; Harwood, J. S.; Seleem, M.; Chmielewski, J. "Dual Targeting of Intracellular Pathogenic Bacteria with a Cleavable Conjugate of Kanamycin and an Antibacterial Cell-Penetrating Peptide" J. Am. Chem. Soc. 2016, 138, 10945-10949.

131. Gleaton, J.; Chmielewski, J. “Thermally Controlled Collagen Peptide Cages for Biopolymer Delivery” ACS Biomater. Sci. Eng. 2015, 1, 1002-1008.

130. Thangamani, S.; Nepal, M.; Chmielewski, J.; Seleem. M. “Antibacterial Activity and Therapeutic Efficacy of Fl-PRPRPL-5, a Cationic Amphiphilic Polyproline Helix, in a Mouse Model of Staphylococcal Skin Infection” Drug Design, Development and Therapy 2015, 9, 5749–5754.

129. Kotha, R.; Chmielewski, J. “Controlling the Morphology of Metal-Triggered Collagen Peptide Assemblies Through Ligand Alteration” Biopolymers: Pept. Sci. 2015, 104, 379-383.

128. Nepal. M.; Thangamani, S.; Seleem, M.; Chmielewski, J. “Targeting Intracellular Bacteria with an Extended Cationic Amphiphilic Polyproline Helix” Org. Biomol. Chem. 2015, 13, 5930-5936.

127. Hernandez, V.; Chmielewski, J. “Mimicking the extracellular matrix with functionalized, metal-assembled collagen peptide scaffolds”, Biomaterials 2014, 35, 7363-7373.

126. Rubert-Perez, C.; Rank, L; Chmielewski, J. “Tuning the thermosensitive properties of hybrid collagen peptide–polymer hydrogels” Chem. Comm. 2014, 50, 8174 – 8176.

125. Emmert, D.; Campos, C.; Ward, D.; Lu, P.; Namanja, H.; Bohn, K.; Miller, D.S.; Sharom, F.J.; Chmielewski, J.; Hrycyna, C.A. "Reversible Dimers of the Atypical Antipsychotic Quetiapine Inhibit P-glycoprotein-mediated Efflux in vitro with Increased Binding Affinity and in situ at the Blood Brain Barrier" ACS Chem. Neurosci. 2014, 5, 305-317.

124. Hrycyna, C.A.; Summers, R.; Lehane, A.M.;  Pires, M.M., Namanja, H., Bohn, K.; Kuriakose, J.; Ferdig, M.; Henrich, P.P.; Fiddock, D.A.; Kirk, K.; Chmielewski, J.; Martin, R.E.,  "Quinine Dimers Are Potent Inhibitors of the Plasmodium falciparum Chloroquine Resistance Transporter and Are Active Against Quinoline-Resistant P. falciparumACS Chem. Bio. 2014, 9, 722-730.

123. Hernandez, V.; Geisler, I.; Chmielewski, J. “Dimeric Unnatural Polyproline-rich Peptides with Enhanced Antibacterial Activity” Bioorg. Med. Chem. Lett. 2014, 24, 556-559.

122.  Kuriakose, J.; Hernandez, V.; Nepal, M.; Brezden, A.; Pozzi, V. Seleem, M,; Chmielewski, J. “Targeting Intracellular Pathogenic Bacteria with Unnatural Proline-rich Peptides:  Coupling Antibacterial Activity with Macrophage Penetration” Ang. Chem. 2013, 52, 9644-9667.

121. Przybyla, D.; Rubert Perez, C.; Gleaton, J.; Nandwana, V.; Chmielewski, J. “Hierarchical Assembly of Collagen Peptide Triple Helices into Curved Disks and Metal Ion-promoted Hollow Spheres” J. Am. Chem. Soc. 2013, 135, 3418-3422.

120. Gleaton, J.; Chmielewski, J. “Metal-ligand Interactions to Promote the Assembly of a Collagen Peptide into Fibrils”  Peptides 2013, 164-165.

119. Thompson, K.V.; Chmielewski, J.; Gaines, M.S.; Hrycyna, C.A.; LaCourse, W.R. “Competency-based Reforms of the Undergraduate Biology Curriculum:  Integrating the Physical and Biological Sciences” CRE-Life Sciences Education 2013, 12, 162-169.

118. Namanja, H.; Emmert, D.; Hrycyna, C.; Chmielewski, J. “Homodimers of the Antiviral Abacavir as Modulators of P-glycoprotein Transport in Cell Culture: Probing Tether Length” Med. Chem. Comm. 2013, 4, 1344-1349.

117. Zhao, L.; Chmielewski, J. “Inhibition of HIV-1 Integrase Dimerization and Activity with Crosslinked Interfacial Peptides” Bioorg. Med. Chem. 2013, 21, 4041-4044.

116. Kuriakose, J.; Hrycyna, C.; Chmielewski, J. “Click Chemistry-derived Bivalent Quinine Inhibitors of P-glycoprotein-mediated Cellular Efflux” Bioorg. Med. Chem. Lett. 2012, 22, 4410-4412.

115. Hrycyna, C.; Chmielewski, J. “Tools for Eradicating HIV Reservoirs:  Dimeric Prodrug Inhibitors of P-glycoprotein” Therapeutic Delivery 2012, 3, 689-692.

114. Kalafut, D.; Anderson, T.; Chmielewski, J. “Mitochondrial Targeting of a Cationic Amphiphilic Polyproline Helix” Bioorg. Med. Chem. Lett. 2012, 22, 561-563.

113. Pires, M.; Ernenwein, D.; Lee, J.; Chmielewski, J. “Controlling the Morphology of Metal-Promoted Higher Ordered Assemblies of Collagen Peptides with Varied Core Lengths” Langmuir 2012, 28, 1993-1997.

112. Rubert Pérez, C.; López-Pérez, D. Chmielewski, J.; Lipton, M. “Small Molecule Inhibitors of Anthrax Toxin-Induced Cytotoxicity Targeted Against Protective Antigen” Chem. Biol. Drug Des. 2012, 79, 260-269.

111. Namanja, H; Emmert, D.; Hrycyna, C.; Chmielewski, J. “Toward Eradicating HIV Reservoirs in the Brain: Inhibiting P-glycoprotein at the Blood-Brain Barrier Prodrug Abacavir Dimers” J. Am. Chem. Soc. 2012, 134, 2976-2980.

110. Pires, M. M.; Emmert, D.; Chmielewski, J.; Hrycyna, C. A. “ABCB1 and ABCG2: Deciphering the Role of Human Efflux Proteins in Cellular and Tissue Permeability” TheABC Transporters In Human Health and Disease: Genetics and Biochemistry of ATP Binding Cassette Transporters, edited eds. KJ Linton and IB Holland, 2011, pgs 85-126.

109. Geisler, I.; Chmielewski, J. “Dimeric Cationic Amphiphilic Polyproline Helices for Mitochondrial Targeting” Pharmaceutical Research 2011, 28, 2797-2807.

108. Rubert-Perez, C.; Pannitch, A.; Chmielewski, J. “A Collagen Peptide-based Physical Hydrogel for Cell Encapsulation” Macromolecular Biosciences 2011, 11, 1426-1431.

107. Pires, M.; Ernenwein, D.; Chmielewski, J. “Selective Decoration and Release of His-tagged Proteins from Metal-Assembled Collagen Peptide Microflorettes” Biomacromolecules 2011, 12, 2429-2433.

106. Pires, M. M.; Przybyla, D.; Rubert Perez, C.; Chmielewski, J. “Metal-Mediated Tandem Coassembly of Collagen Peptides into Banded Microstructures” J. Am. Chem. Soc. 2011, 133, 14469-14471.

105. Przybyla, D.; Chmielewski, J. “Higher Order Collagen Peptide Assembly into Nano- and Microscale Materials” Biochemistry 2010, 49, 4411-4419.

104. Przybyla, D.; Chmielewski, J. “Metal-Triggered Self Assembling Collagen Peptide Disks” J. Am. Chem. Soc. 2010, 132, 7866-7867.

103. Lee, S.-G.; Chmielewski, J.  “Crosslinked Peptoid-Based Dimerization Inhibitors of HHIV-1 Protease” ChemBioChem 2010, 11, 1513-1516.

102. Lee, J.; Chmielewski, J. “Nucleation Studies of pH-Dependent Collagen Peptides” Chem. Biol. Drug Des. 2010, 75, 161-168.

101. Ernenwein, D., Ghosh, P., Rotello, V., Chmielewski, J. “Gold Nanoparticle Self-Assembly Promoted by a Non-Covalent, Charge-Complemented Coiled-Coil Peptide” J. Mat. Chem. 2010, 20, 5608-5611.

100. Li, L.; Chen, H.; Geisler, I.; Chmielewski, J.; Cheng, J.-X. “Mitochondrial Targeting of Cationic Amphiphilic Polyproline Helices” J. Controlled Release 2010, 142, 259-266.

99. Namanja, H.; Emmert. D.; Pires, M. M.; Hrycyna, C.; Chmielewski, J. “Inhibition of Human P-glycoprotein Transport and Substrate Binding Using a Galantamine Dimer” Biochem. Biophys. Res. Comm. 2009, 388, 672-676.

98. Pires, M. M.; Przybyla, D.; Chmielewski, J. “A Metal-Collagen Peptide Framework for 3-Dimensional Cell Culture” Angewandte Chemie 2009, 48, 7813-7817.

97. Chmielewski, J. “Protease Dimer Formation Disrupted” Nature Chem. Bio. 2009, 5, 607-608.

96. Davis, D. A., Reynolds, I., Daniels, S., Stahl, S., Kaufman, J., Wingfield, P., Bowman, M., Chmielewski, J., Yarchoan, R. “Characterizing Dimerization Inhibition of a Multi-Drug Resistant HIV-1 Protease Using a Novel Size Exclusion Chromatographic Assay” Biochem. J. 2009, 419, 497-506.

95. Bowman, M.; Chmielewski, J. “Sidechain Crosslinked Inhibitors of HIV Protease Dimerization and Activity” Bioorg. Med. Chem. 2009, 17, 967-976.

94. Geisler, I, Chmielewski, J. “Cationic Amphiphilic Polyproline Helices (CAPHs): Side Chain Variations and Cell Specific Internalization” Chem. Biol. Drug Des. 2009, 73, 39-45.

93. Pires, M.; Hrycyna, C.; Chmielewski, J. “Inhibition of P-Glycoprotein-Mediated Taxol Resistance by Reversibly-Linked Quinine Homodimers” Molecular Pharmacology 2009, 75, 92-100.

92. Pires, M. M.; Chmielewski, J. “Self Assembly of Collagen Peptides into Microflorettes via Metal Coordination” J. Am. Chem. Soc. 2009, 131, 2706-2712.

91. Zhu, H.; Coleman, D.; Dehen, C.; Geisler, I.; Chmielewski, J.; Simpson, G.; Wei, A. “Assembly of Dithiocarbamate-Anchored Monolayers on Gold Surfaces in Aqueous Solutions” Langmuir 2008, 24, 8660-8666.

90. Gaddis, B.; Rubert, C.; Chmielewski, J. “Inhibitors of Anthrax Lethal Factor Based on N-oleoyldopamine” Bioorg. Med. Chem. Lett. 2008, 18, 2467-2470.

89. Pires, M.; Chmielewski, J. “Fluoresence Imaging of Cellular Glutathione Using a Latent Fluorophore” Org. Lett. 2008, 10, 837-840.

88. Lee, S.-G.; Lee, J.; Chmielewski, J. “Investigation of pH-Dependent Collagen Triple Helix Formation” Angewandte Chemie 2008, 47, 8429-8432.

87. Przybyla, D., Chmielewski, J. “Metal Triggered Radial Self Assembly of Collagen Peptide Fibers” J. Am. Chem. Soc. 2008, 130, 12610-12611.

86. Gaddis, B.; Avramova, L.; Chmielewski, J. “Inhibitors of Anthrax Lethal Factor” Bioorg. Med. Chem. Lett. 2007, 17, 4575-4578.

85. Geisler, I; Chmielewski, J. “Probing Length Effects and Mechanism of Cell Penetrating Agents Mounted on a Polyproline Helix Scaffold” Bioorg. Med. Chem. Lett. 2007, 17, 2765-2768.

84. Fillon, Y.; Verma, A.; Ghosh, P; Ernenwein, D.; Rotello, V.; Chmielewski, J. “Peptide Ligation Catalyzed by Functionalized Gold Nanoparticles” J. Am. Chem. Soc. 2007, 129, 6676-6677.

83. Lee, S.-G.; Hershberger, S.; Chmielewski, J. “Scaffolds for Inhibiting Protein-Protein Interactions” Curr. Top. Med. Chem 2007, 7, 928-942.

82. Ulysse, L.; Chmielewski, J. “A Light Activated b-Turn Scaffold within a Somatostatin Analog:  NMR Structure and Biological Activity” Chemical Biology and Drug Design 2006, 67, 127-136.

81. Pires, M.; Hrycyna, C.; Chmielewski, J. “Bivalent Probes of the Multidrug Transporter P-glycoprotein” Biochemistry 2006, 45, 11695-11702.

80. Lee, S.G.; Chmielewski, J. “Rapid Synthesis and In Situ Screening of Doubly Mutated HIV-1 Protease Dimerization Inhibitors” Chemistry & Biology 2006, 13, 421-426.

79. Zhao, L.; Chmielewski, J. “Inhibiting Protein-Protein Interactions with Designed Molecules”, Current Opinion in Structural Biology 2005, 15, 31-34.

78. Bowman, M.; Byrne, S.; Chmielewski, J. “Switching Between Allosteric and Dimerization Inhibition of HIV-1 Protease” Chemistry & Biology 2005, 12, 439-444.

77. Lee. H. M.; Chmielewski, J. “Liposomal Cargo Unloading Induced By pH-Sensitive Peptides”, J. Pept. Res. 2005, 65, 355-363.

76. Hwang, Y. S.; Chmielewski, J. “Development of Low Molecular Weight HIV-1 Protease Dimerization Inhibitors” J. Med. Chem. 2005, 48, 2239-2242.

75. Fillon, Y.; Anderson, J.; Chmielewski, J. “Cell Penetrating Agents Based on a Polyproline Scaffold” J. Am. Chem. Soc. 2005, 127, 11798-11803.

74. Ghosh, I.; Chmielewski, J. “Peptide Self-Assembly As a Model of Proteins in the Pre-Genomic World”, Current Opinion in Chemical Biology 2004, 3, 640-644.

73. Hwang, Y.S.; Chmielewski, J. “A Unidirectional Crosslinking Strategy for HIV-1 Protease Dimerization Inhibitors” Bioorg. Med. Chem. Lett. 2004, 14, 4297-4300.

72. Ragin, A. D.; Chmielewski J. “Probing Essential Residues for Cellular Uptake with a Cationic Nuclear Localization Signal Sequence” J Pept. Res. 2004, 63, 155-160.

71. Bowman, M.; Chmielewski, J. “Crucial Amides for Dimerization Inhibitors of HIV-1 Protease”  Bioorg. Med. Chem. Lett. 2004, 14, 1395-1398.

70. Nayak, S.; Lee, H.; Chmielewski, J.; Lyon, L. A. “Folate-Mediated Cell Targeting and Cytotoxicity Using Thermoresponsive Microgels” J. Am. Chem. Soc. 2004, 126, 10258-10259.

69. Shultz, M.; Lee, S.; Ham, Y.; Chmielewski, J. J. “Small Molecule Dimerization Inhibitors of Wild Type and Mutant HIV Protease:  A Focused Library Approach”, J. Am. Chem. Soc. 2004, 126, 9886-9887.

68. Li, X.; Chmielewski, J. “Challenges in the Design of Self Replicating Peptides”, Organic and Biomolecular Chemistry 2003, 1, 901-904

67. Li, X.; Chmielewski, J. “Highly Efficient Peptide Self Replication with a Proline Hinge”, J. Am. Chem. Soc. 2003, 125, 11820-11821.

66. Lee, H.; Chmielewski, J. “Interactions Between the Lipid Bilayer and pH-Triggered Amphiphilic Peptides” Peptides:  Genomics, Proteomics & Therapeutics 2003, 789-790.

65. Hwang, Y.S.; Chmielewski, J. “HIV-1 Protease Dimerization Inhibitors:  Reversing the Southern Peptide” Peptides:  Genomics, Proteomics & Therapeutics 2003, 339-340.

64. Zhao, L.; Chmielewski, J. “Aib Modified Dimerization Inhibitor of HIV-1 Integrase” Peptides:  Genomics, Proteomics & Therapeutics 2003, 337-338.

63. Li, X.; Chmielewski, J. “Manipulating the Hydrophobic Core of a Coiled Coil Self Replicator” Peptides:  Genomics, Proteomics & Therapeutics 2003, 292-293.

62. Chang, E.; Roberts, D.; Fillon, Y.; Chmielewski, J. “Synthesis of Modified Prolines for Peptidomimetic Use”  Peptides:  Genomics, Proteomics & Therapeutics 2003, 227-228.

61. Zhao, L.; O’Reilly, M.; Shultz, M.; Chmielewski, J. “Interfacial Peptide Inhibitors of HIV-1 Integrase Activity and Dimerization” Bioorg. Med. Chem. Lett. 2003, 13, 1175-1177.

60. Bowman, M.; Chmielewski, J. “Novel Strategies for Targeting the Dimerization Interface of HIV Protease with Crosslinked Interfacial Peptides”, Biopolymers:  Peptide Science 2002, 66, 126-133.

59. Ragin, A.; Brickner, M.; Morgan, R.; Chmielewski, J., “Cellular Import Mediated by Nuclear Localization Signal Sequences”, Chemistry & Biology 2002, 8, 943-948.

58. Turk, M. J.; Reddy, J. A.; Chmielewski, J.; Low, P. S. “Characterization of a Novel pH-Sensitive Peptide Which Enhances Folate-Targeted Liposomal Drug Delivery and Serum Stable Transfection of Cancer Cells”, Biochimica et Biophysica Acta 2002, 1559, 56-68.

57. Issac, R.; Chmielewski, J., “Approaching Exponential Growth with a Self Replicating Peptide”, J. Am. Chem. Soc. 2002, 124, 6808-6809.

56. Issac, R.; Ham, Y.-W.; Chmielewski, J., “The Design of Self-Replicating Helical Peptides”, Current Opinion in Structural Biology 2001, 11, 458-463.

55. Kurimoto, M.; Bastin, L.; Fredrickson, D.; Gustafson, P.; Jang, S.; Kaminsky, W.; Lovell, S.; Mitchell, C.; Chmielewski, J.; Kahr, B. “Intrasectoral Zoning of Proteins and Nucleotides in Simple Crystalline Hosts,” Morphology and Dynamics of Crystal Surfaces in Complex Molecular Systems, eds. J.J. De Yoreo, W.H. Casey,  A.J. Malkin, E. Vlieg, and M.D. Ward, 2001, 620.

54. Wang, H.; Kurimoto, M.; Kahr, B.; Chmielewski, J., “Lactose Monohydrate Single Crystals as Hosts for Matrix Isolation of Gust Biopolymers”, Bioorg. Med. Chem. 2001, 9, 2279-2283.

53. Ghosh, I.; Bishop, P.; Chmielewski, J. “DNA binding Properties of Tal and E47 Basic-Helix-Loop-Helix Fusion Proteins”, J. Pept. Res. 2001, 57, 354-360.

52. Micklatcher, Cindy; Lutgring, Ray; Chmielewski, Jean, “Synthetic Steps Toward De Novo Designed Catalytic Five-Helix Bundle Proteins” Peptides:  Chemistry, Structure and Biology 2000, 16, 496-497.

51. Ragin, A.; Brickner, M.; Chmielewski, J. “Peptide Shuttles for Cytoplasmic and Nuclear Targeting” Peptides:  Chemistry, Structure and Biology 2000, 16, 212-213.

50. Micklatcher, Cindy; Lutgring, Ray; Hart, Scott; Issac, Roy; Chmielewski, Jean, “Expanding the Repertoire of Helical Bundles:  Stabilization of Five+ Helical Bundles” Peptides:  Chemistry, Structure and Biology 2000, 16, 496-497.

49. Zutshi, Reena; Chmielewski, Jean, “Targeting the Dimerization Interface for Irreversible Inhibition of HIV-1 Protease”, Bioorg. Med. Chem. Lett. 2000, 10, 1901-1903.

48. Shultz, M. D.; Bowman, M. J.; Ham, Y.-W.; Zhao, X.; Tora, G.; Chmielewski, J., “Small Molecule Dimerization Inhibitors of HIV-1 Protease”, Angewandte Chemie 2000, 39,2710-2713.

47. Yao, S.; Chmielewski, J., “A pH-Tunable Peptide Ligase” Biopolymers:  Peptide Science 1999, 8, 370-375.

46. Brickner, M.; Yusuf, C.; Vogel, K.; Chmielewski, J., “Design and Use of Amphiphilic Peptides in Liposomes as pH-Triggered Releasing Agents”, Peptides:  Chemistry, Structure and Biology 1999, 15, 461-462.

45. Yao, S.; Ghosh, I.; Zutshi, R.; Chmielewski, J., “Natural Selection with Self-Replicating Peptides”, Peptides:  Chemistry, Structure and Biology 1999, 15, 366-368.

44. Yao, S.; Pares-Matos, E.; Brickner, M.; Chmielewski, J., “Inhibiting Dimerization and DNA Binding of c-Jun”, Peptides:  Chemistry, Structure and Biology 1999, 15, 751-52.

43. Micklatcher, Cindy; Chmielewski, Jean, “Helical Peptide and Protein Design”, Current Opinion in Chemical Biology 1999, 3, 724-729.

42. Ghosh, I.; Yao, S.; Chmielewski, J., “DNA Binding Peptides”, Comprehensive Natural Products Chemistry, Volume 7, 1999, 477-490.

41. Ghosh, I.; Issac, R.; Chmielewski, J. “Structure-Function Relationship in a Beta-Sheet Peptide Inhibitor of E47 Dimerization and DNA Binding”, Bioorg. Med. Chem. 1999, 7,61-66.

40. Shultz, Michael; Chmielewski, Jean, “Probing the Role of Interfacial Residues in Dimerization Inhibitors of HIV-1 Protease” Bioorg. Med. Chem. Lett. 1999, 9, 2431-2436.

39. Kurimoto, M.; Subramony, P.; Chmielewski, J.; Kahr, B., “Kinetic Stabilization of Biopolymers in Single Crystal Hosts:  Green Fluorescent Protein in alpha-Lactose Monohydrate”, J. Am. Chem. Soc. 1999, 29, 6952-6953.

38. Yao, S.; Ghosh, I.; Zutshi, R.; Chmielewski, J., “Selective Amplification via Auto- and Cross-Catalysis in a Replicating Peptide System”, Nature 1998, 396, 447-450.

37. Chmielewski, J. “Dimerization Inhibitors of HIV-1 Protease” SynLett. 1998, 1040-1044.

36. Chmielewski, J.; Zutshi, R.; Brickner, M.; “Inhibiting the Assembly of Protein-Protein Interfaces”, Current Opinion in Chemical Biology 1998, 2, 62-66.

35. Ulysse, L.; Chmielewski, J., “Restricting the Flexibility of Crosslinked, Interfacial Peptide Inhibitors of HIV-1 Protease”, Bioorg. Med. Chem. Lett. 1998, 8, 3281-3286.

34. Yao, S.; Brickner, M.; Pares-Matos, E.; Chmielewski, J. “Uncoiling c-Jun Coiled-Coils:  Inhibitory Effects of Truncated Fos Peptides on Jun Dimerization and DNA Binding” Biopolymers:  Peptide Science 1998, 47, 277-283.

33. Yao, Shao; Zutshi, Reena; Chmielewski, J., “Endothiopeptide Inhibitors of HIV-1 Protease”, Bioorganic and Med. Chem. Lett. 1998, 8, 699-704.

32. Ghosh, I.; Chmielewski, J. “A Beta-Sheet Peptide Inhibitor of IEB E47 Dimerization and DNA Binding”, Chemistry & Biology 1998, 5, 439-445.

31. Brickner, Michelle, Chmielewski, Jean, “Inhibition of the Dimerization of Eco RI” Chemistry & Biology 1998, 5, 339-343.

30. Yao, S.; Ghosh, I.; Zutshi, R.; Chmielewski, J., “A Self-Replicating Peptide under Ionic Control”, Angewandte Chemie Int. Ed. 1998, 37, 478-479.

29. Shultz, Michael; Chmielewski, Jean, “Hydrophobicity versus Hydrophilicity with Dimerization Inhibitors of HIV-1 Protease” Tetrahedron Asymmetry 1997, 8, 3881.

28. Chmielewski, J.; Lewis, J.; Lovell, S.; Zutshi, R.; Savickas, P.; Mitchell, C.; Subramony, A.; Kahr, B. “Single-Crystal Matrix Isolation of Biopolymers”, J. Am. Chem. Soc. 1997, 119, 10565-10566.

27. Yao, S.; Ghosh, I.; Zutshi, R.; Chmielewski, J., “A pH-Modulated, Self-Replicating Peptide”, J. Am. Chem. Soc. 1997, 119, 10559-10560.

26. Zutshi, Reena; Franciskovich, Jeff; Shultz, Mike; Schweitzer, Barbara; Bishop, Patricia; Wilson, Matt; Chmielewski, Jean, "Targeting the Dimerization Interface of HIV-1 Protease:  Inhibition with Crosslinked Interfacial Peptides", J. Am. Chem. Soc. 1997, 119, 4841-4845.

25. Ulysse, Luckner; Chmielewski, Jean, "Light Induced Conformational Switch in Cyclic Peptides", Peptides:  Chemistry, Structure and Biology 1996, 14, 203-204.

24. Vogel, Karen; Wang, Susan; Chmielewski, Jean; Low, Philip, "The Design of pH-Dependent Amphiphilic Helices to Trigger Cytoplasmic Release of Liposome Encapsulated Molecules", Peptides:  Chemistry, Structure and Biology 1996, 14, 577-578.

23. Zutshi, R.; Bishop, P.; Franciskovich, J.; Chmielewski, J., "Dissociation of Dimeric HIV-1 Protease:  A Novel Means of Enzyme Inhibition", Peptides:  Chemistry, Structure and Biology 1996, 14, 249-251.

22. Lutgring, Ray; Lipton, Mark; Chmielewski, Jean, “Differential Self-Assembly of Amphiphilic Helical Peptides”, Amino Acids 1996, 10, 295-304.

21. Vogel, Karen; Cooks, Julia;  Chmielewski, Jean, "Subtilisin-Catalyzed Religation of Proteolyzed Hen Egg-White Lysozyme:  Investigation of the Role of Disulfides", Chemistry & Biology 1996, 3, 295-299.

20. Vogel, Karen; Wang, Susan; Chmielewski, Jean; Low, Philip, "Peptide Mediated Endosomal Release of Folate-Targeted Liposomes" J. Am. Chem. Soc. 1996, 117, 1581-1586

19. Bishop, Patricia; Jones, Cory; Ghosh, Indraneel; Chmielewski, Jean, "The Basic-Helix-Loop-Helix Region of IEB E47:  Evaluation of Structure and DNA Affinity", Int. J. Pept. Prot. Res. 1995, 46, 149-154.

18. Ulysse, Luckner; Cubillos, Juanita; Chmielewski, Jean, "Photoregulation of Cyclic Peptide Conformation" J. Am. Chem. Soc. 1995, 117, 8466-8467.

17. Bishop, Pat; Ghosh, Indraneel; Jones, Cory; Chmielewski, Jean, "Basic-Helix-Loop-Helix Region of Tal:  Structure and DNA Binding" J. Am. Chem. Soc. 1995, 117, 8283-8284.

16. Ulysse, Luckner; Chmielewski, Jean, "The Synthesis of a Light-Switchable Amino Acid for Inclusion into Conformationally Mobile Peptides", Bioorganic and Medicinal Chemistry Letters 1994, 4, 2145-2146.

15. Chmielewski, Jean; Lipton, Mark, "The Rational Design of Highly Stable Amphiphilic Helical Peptides", Int. J. Peptide and Protein Res. 1994, 44, 152-157.

14. Chmielewski, Jean; Lutgring, Ray; Lewen Ken, "The Design of Associating Amphiphilic Helical Peptides", Peptides:  Chemistry, Structure and Biology 1994, 1054-1056.

13. Chmielewski, Jean; Franciskovich, Jeff; Wilson, Matt, "Inhibition of HIV-1 Protease by its C- and N-Terminal Peptides", Peptides:  Chemistry, Structure and Biology 1994, 595-597.

12. Vogel, Karen; Chmielewski, Jean, "A Rapid and Efficient Resynthesis of Proteolyzed Triose Phosphate Isomerase", J. Am. Chem. Soc. 1994, 116, 11163-11164.

11. Lutgring, Ray; Chmielewski, Jean, "A General Strategy for Covalently Stabilizing Helical Bundles:  A Disulfide Crosslinked Five Helix Bundle", J. Am. Chem. Soc. 1994, 116, 6451-6452.

10. Chmielewski, Jean; Lewen, Ken; Lutgring, Ray, "The Design of Coiled-Coil Peptides", Journal of Cellular Biochemistry 1993, Suppl. 17C, 214.

9. Bishop, Patricia; Jones, Cory; Chmielewski, Jean, "Dimethyl(methylthio)-sulfonium Tetrafluoroborate:  A Reagent for Disulfide Bond Formation in Peptides", Tetrahedron Lett. 1993, 34, 4469-4473.

8. Mihara, Hisakazu; Chmielewski, Jean; Kaiser, Emil T., "Synthesis of the 60 Amino Acid Homeo Domain and Smaller Fragments of the Drosophila  Gene Regulatory Protein Antennapedia by a Segment Synthesis-Condensation Approach", Journal of Organic Chemistry 1993, 58, 2209-2215.

7. Franciskovich, Jeff; Houseman, Kathryn; Mueller, Richard; Chmielewski, Jean, "A Systematic Evaluation of the Inhibition of HIV-1 Protease by its C- and N-Terminal Peptides", Bioorganic and Medicinal Chemistry Letters 1993, 3, 765-768.

6. Lutgring, Ray; Sujatha, K.; Chmielewski, Jean, "The Synthesis of Homologs of Cysteine Suitable for Peptide and Protein Crosslinking", Bioorganic and Medicinal Chemistry Letters 1993, 3, 739-742.

5. Bishop, Patricia; Chmielewski, Jean, "Cyanogen Iodide, A New Reagent for Disulfide Bond Formation in Peptides", Tetrahedron Lett. 1992, 33, 6263-6266.

4. Jackson, Dave; King, David; Chmielewski, Jean; Singh, Sunil; Schultz, Peter, "A General Approach to the Synthesis of Short Helical Peptides", J. Am. Chem. Soc. 1991, 113, 9391-9392.

3. Chmielewski, Jean; Schultz, Peter, "Monoclonal Antibodies with Sequence Specific Binding Affinity for a Stem - Loop Structure in DNA", Tetrahedron 1991, 47, 2563-2572.

2. Breslow, R.; Chmielewski, J.; Foley, D.; Johnson, B.; Kumabe, N.; Varney, M.;Mehra, R., "Optically Active Amino Acid Synthesis by Artificial Transaminase Enzymes", Tetrahedron 1988, 44, 5515-5524.

1. Chmielewski, Jean; Breslow, Ronald, "Racemase versus Transaminase Activity of Pyridoxal Analogs", Heterocycles 1987, 25, 533.

Patents

1.  “Pharmaceutical Materials and Methods for Their Preparation and Use”, Inventors: Jerry Lewis (Eli Lilly), Bart Kahr (Univ. of Washington), Jean Chmielewski (Purdue Univ.), P-99050.00.US, awarded 2006.

2. “Small Molecule Anthrax Anti-Toxins”, Inventors:  Jean Chmielewski, Mark Lipton, Brandon Gaddis, Larisa Avramova, U.S. Patent Application Serial Number 11/937,493, filed November 8, 2007.

3. “Collagen Peptide Conjugates and Uses Thereof” Inventors:  Jean Chmielewski, Marcos Pires, David Przybyla, US Patent Number US 8,575,311, issued Nov. 5, 2013.