Instrument development of Ion Soft-Landing Systems
Nano-DESI imaging of isomeric lipids via online photochemical derivatization of C=C Bonds
Role of viologen substituents and host size in the gas-phase fragmentation of cucurbituril–viologen host–guest complexes
Two-Channel Pneumatically-Assisted Microfluidic Probe for nano-DESI Imaging
Isomer-Selective Mass Spectrometry Imaging Using Nanospray Desorption Electrospray Ionization (Nano-DESI)
Staying Warm in our Parafilm Blankets
Ion Soft-Landing Instrument
June 2026
Welcome to our new postdoc, Julia Danischewski!
Julia received an award for serving a term as the President of ASMS.
Mushfeqa and Nazifa presented oral presentations at the ASMS Annual Conference in San Diego, CA.
Erik, Sara, Xindi, Paul, Renkai, Rahat, Govindi, Alyssa, Anthony, Bethany, and Tom presented posters at the ASMS Annual Conference in San Diego, CA.
May 2026
Sara received the PGSG Travel Grant to attend the ASMS Annual Conference in San Diego, CA.
Julia presented at the 2026 AFOSR Molecular Dynamics and Theoretical Chemistry Program Review.
Congratulations to our undergraduate members, Erik, Ronnie, and Will for their graduation!
Overview
Our research at the interface of physical and analytical chemistry is focused on the advanced development of preparative and analytical mass spectrometry for applications in materials synthesis, imaging and chemical analysis of biological systems at a subcellular level, and environmental sciences.
Contact Us:
We are located on the 5th floor of the Brown Building
BRWN 5131A (Julia's office)
BRWN 5129/5133 (student/postdoc offices)
BRWN 5125/5135 (Labs)
Shipping/Mailing Address:
Department of Chemistry
Purdue University
560 Oval Drive
West Lafayette, IN 47907-2084
Phone: (765) 494-5464
Email: jlaskin@purdue.edu
Recent Publications
Spatial Lipidomics Reveals Region-Specific Lipid Remodeling in Scn2a-Deficient Mouse Brain
Moore, A., Chen, X., Hernly, E., Zhang, J., Yang, Y., Laskin, J. ACS Chem. Neurosci. (2026).
https://doi.org/10.1021/acschemneuro.6c00199
Imaging of Bioactive Lipid Isomers in Acetaminophen-Induced Liver Injury using Nano-DESI Tandem Mass Spectrometry
Weigand, M. R., Akakpo, J. Y., Hernly, E., Wali, S. N., Zheng, A., Ramachandran, A., Jaeschke, H., Laskin, J. J. Lipid Res. (2026).
https://doi.org/10.1016/j.jlr.2026.100995
Efficient and Cost-Effective Enzyme Deposition onto Tissues for Mass Spectrometry Imaging of N-Glycans Using a Mini-Humidifier
Sveen, E., Moore, A. M., Weigand, M. R., Laskin, J. J. Am. Soc. Mass Spectrom. 37 (3), 746-753 (2026).
https://doi.org/10.1021/jasms.5c00435
Quantitative Mass Spectrometry Imaging of Intact Proteins in Tissues
Iqfath, M., Swansiger, A. K., Yang, M., Miller, L., Moore, A. M., Hernly, E., Bai, Y., Zhang, Z.-Y., Prell, J. S., Laskin, J. Anal. Chem. (2026).
https://doi.org/10.1021/acs.analchem.5c05187
Unraveling Ligand-Driven Isomerism in Redox-Active Mixed-Ligand Polyoxometalates Using Ion Mobility Spectrometry
Wilson, S., Li, X., Gandhi, V. D., Johnson, A., Schreiber, E., Ryan, L., Sertse, L., Larriba-Andaluz, C., Matson, E., Laskin, J. ACS Nano, 44, 38544-38552 (2025).
https://doi.org/10.1021/acsnano.5c12468