Instrument development of Ion Soft-Landing Systems
Nano-DESI imaging of isomeric lipids via online photochemical derivatization of C=C Bonds
Role of viologen substituents and host size in the gas-phase fragmentation of cucurbituril–viologen host–guest complexes
Two-Channel Pneumatically-Assisted Microfluidic Probe for nano-DESI Imaging
Isomer-Selective Mass Spectrometry Imaging Using Nanospray Desorption Electrospray Ionization (Nano-DESI)
Staying Warm in our Parafilm Blankets
Ion Soft-Landing Instrument
May 2026
Congratulations to our undergaduate memers, Erik, Ronnie, and Will for their graduation!
April 2026
Congratulations to on receiving the WISP travel award and Phi Lambda Upsilon (PLU) travel award for attending ASMS!
Congratulations to on receiving the Bilsland Dissertation Fellowship!
Congratulations to our alumnus Hugo on being accepted as an RCSA fellow!
Congratulations to Erik on receiving the Undergraduate Student Award from ASMS!
Congratulations to Sara on receiving the ASMS Graduate Student Award!
March 2026
Alyssa gave an oral presentation at the Gordon Resesearch Conference on Lipidomics in Ventura, CA.
Overview
Our research at the interface of physical and analytical chemistry is focused on the advanced development of preparative and analytical mass spectrometry for applications in materials synthesis, imaging and chemical analysis of biological systems at a subcellular level, and environmental sciences.
Contact Us:
We are located on the 5th floor of the Brown Building
BRWN 5131A (Julia's office)
BRWN 5129/5133 (student/postdoc offices)
BRWN 5125/5135 (Labs)
Shipping/Mailing Address:
Department of Chemistry
Purdue University
560 Oval Drive
West Lafayette, IN 47907-2084
Phone: (765) 494-5464
Email: jlaskin@purdue.edu
Recent Publications
Spatial Lipidomics Reveals Region-Specific Lipid Remodeling in Scn2a-Deficient Mouse Brain
Moore, A., Chen, X., Hernly, E., Zhang, J., Yang, Y., Laskin, J. ACS Chem. Neurosci. (2026).
https://doi.org/10.1021/acschemneuro.6c00199
Imaging of Bioactive Lipid Isomers in Acetaminophen-Induced Liver Injury using Nano-DESI Tandem Mass Spectrometry
Weigand, M. R., Akakpo, J. Y., Hernly, E., Wali, S. N., Zheng, A., Ramachandran, A., Jaeschke, H., Laskin, J. J. Lipid Res. (2026).
https://doi.org/10.1016/j.jlr.2026.100995
Efficient and Cost-Effective Enzyme Deposition onto Tissues for Mass Spectrometry Imaging of N-Glycans Using a Mini-Humidifier
Sveen, E., Moore, A. M., Weigand, M. R., Laskin, J. J. Am. Soc. Mass Spectrom. 37 (3), 746-753 (2026).
https://doi.org/10.1021/jasms.5c00435
Quantitative Mass Spectrometry Imaging of Intact Proteins in Tissues
Iqfath, M., Swansiger, A. K., Yang, M., Miller, L., Moore, A. M., Hernly, E., Bai, Y., Zhang, Z.-Y., Prell, J. S., Laskin, J. Anal. Chem. (2026).
https://doi.org/10.1021/acs.analchem.5c05187
Unraveling Ligand-Driven Isomerism in Redox-Active Mixed-Ligand Polyoxometalates Using Ion Mobility Spectrometry
Wilson, S., Li, X., Gandhi, V. D., Johnson, A., Schreiber, E., Ryan, L., Sertse, L., Larriba-Andaluz, C., Matson, E., Laskin, J. ACS Nano, 44, 38544-38552 (2025).
https://doi.org/10.1021/acsnano.5c12468