Laboratory of Molecular Synthesis and Catalysis
Purdue University
Department of Chemistry
560 Oval Dr.
West Lafayette, IN 47907
Lab: Wetherill Rm 450
Research in our group spans the organic and inorganic subdisciplines of chemistry with an emphasis on catalytic approaches to unsolved problems in organic synthesis and renewable energy conversion.
News
June 2024
Our minireview on redox carbene transfers in cyclopropanation reactions is published in Angewandte Chemie.
April 2024
Ray wins the H.C. Brown poster award at the 39th H.C. Brown Lectures in Organic Chemistry.
Mingxin wins 2024 H.C. Brown Graduate Student Research Award, and gives a talk at the 39th H.C. Brown Lectures in Organic Chemistry.
March 2024
Jaysan successfully gives his Graduate Research Seminar.
Prof. Uyeda received the prestigious College of Science Faculty Research Award.
February 2024
Vibha successfully defends her dissertation! Congratulations, Dr. Kanale and we wish you all the best in Eastman!
December 2023
Our collaboration work with Pfizer on the synthesis of bicyclic [3.1.0]proline as the precursor of Nirmatrelvir, an inhibitor of SARS-CoV-2 to fight against COVID-19 pandemic, is published on OPR&D.
November 2023
Welcome first year students Peter, Perry, Meenakshi, Divya and Deepesh to join our group!
October 2023
Vibha gives her Graduate Research Seminar.
Sourish defends his dissertation! We wish you all the best for your future endeavor in Corteva Agriscience!
September 2023
Chris gives his Graduate Research Seminar.
Mingxin and Nguyen's work on cyclopropanations of electron-deficient alkenes with dichloromethane-derived nucleophilic carbenes is published in Angewandte Chemie.
Vibha's research on Co-catalyzed asymmetric ring-opening reactions of unstrained heterocycles by vinylidenes is published in Angewandte Chemie.
Hayden and Qiang publish their paper on catalytic asymmetric zinc metallocycle synthesis from alkynes and imines in JACS.
August 2023
Prof. Uyeda gives a talk at the 2023 Fall ACS Meeting.
July 2023
Prof. Uyeda gives a lecture at 2023 International Symposium on Carbene and Nitrene Chemistry at University of Amsterdam.
Wen presents a poster at the 13th DOC Graduate Research Symposium.
Sourish, Kristen and Chris win the H.C. Brown Travel Grant.
Sourish, Vibha and Mingxin present posters at the 48th National Organic Chemistry Symposium, and Vibha wins the poster award.
Kristen presents a poster at the 2023 Organic Reactions and Processes GRC.
Prof. Uyeda and Chris present posters at the 2023 Organometallic Chemistry GRC.
May 2023
Kristen defends her dissertation!
April 2023
Kristen, Ray and Johnson's research on cobalt-catalyzed asymmetric cyclopropanation is published in JACS.
Kristen wins 2023 H.C. Brown Graduate Student Research Award, and gives a talk at the 38th H.C. Brown Lectures in Organic Chemistry.
Vibha, Wen, Mingxin and Hayden win the H.C. Brown poster award at the 38th H.C. Brown Lectures in Organic Chemistry.
Chris, John and Chengyi's work on dinickel-catalyzed N=N bond rotation is published in Inorganic Chemistry.
March 2023
The group is in Spring 2023 ACS Meeting! Prof. Uyeda, Sourish, Kristen, Vibha, Chris, Kyle, Wen and Mingxin give oral presentations.
December 2022
Kristen wins the Fall 2022 H. C. Brown Graduate Student Seminar Award.
November 2022
Sourish gives his Graduate Research Seminar.
Welcome first-year graduate student Audrey to join our lab!
September 2022
Annah and Megan's dinickel-catalyzed three component cycloaddition of vinylidenes is published in Chemical Science.
Sayan joins the group!
Kristen gives her Graduate Research Seminar.
April 2022
Kristen and Chris win the H.C. Brown poster award at the 37th H.C. Brown Lectures in Organic Chemistry.
Annah defends her dissertation!
January 2022
Annah wins the Fall 2021 H. C. Brown Graduate Student Seminar Award.
November 2021
Talia and Annah's work on dinickel-catalyzed vinylidene–alkene cyclization reactions is published in ACS Catalysis.
New graduate students Sumeet and Ray join the group. Welcome!
August 2021
Annah gives her Graduate Research Seminar.
July 2021
John defends his dissertation!
February 2021
John and Chris publish their paper on dinickel-catalyzed conjugated azopolymer synthesis in JACS.
December 2020
Houng's work on nickel-catalyzed vinylidene O–H bond insertion reactions is published in ACS Catalysis.
November 2020
Arnab and Annah publish their work on dinickel-catalyzed diazoalkene-mediated cyclopropanation reactions in Angewandte Chemie.
Sourish and Sudipta publish their work on nickel-catalyzed vinylidene Si–H bond insertion reactions in Chemical Communications.
New graduate students Courtney and Hayden join the group.
October 2020
Ian and John's work on dinickel-catalyzed C-H amination reactions is published in Organometallics.
September 2020
Mike publishes his work on dinickel-catalyzed enantioselective [4+1] cycloadditions in JACS.
May 2020
Prof. Uyeda is named the Richard B. Wetherill Associate Professor of Chemistry.
April 2020
Conner and Mike defend their dissertations!
March 2020
Conner wins the H.C. Brown Graduate Student Research Award.
Our laboratory temporarily closes due to COVID-19. Stay safe!
February 2020
Conner, Kohei, You-Yun, and Vibha report a new Co-catalyzed [5+1] cycloaddition reaction in JACS.
Conner and Mike win the Fall 2019 H. C. Brown Graduate Student Seminar Award.
January 2020
Thanks to Lilly for supporting Chris with a Lilly Grantee Award!
November 2019
Kristen and Jake publish their paper on reductive spirocyclopropanation in Advanced Synthesis and Catalysis.
New graduate students Kyle, Wen, Mingxin and Chris join the group.
October 2019
Conner gives his Graduate Research Seminar.
September 2019
Mike gives his Graduate Research Seminar.
July 2019
Guang joins the group as a visiting researcher!
Conner gives a talk at the DOC Graduate Research Symposium, and gives a poster at the Organic Reactions and Processes Gordon Research Conference.
Jake presents a poster at the 2019 Gordon Organometallic Chemistry Conference.
June 2019
Qiang joins the group!
John presents a poster at the 2019 National Organic Chemistry Symposium.
May 2019
Colby and Seulah publish a new catalytic carbonylation reaction in Tetrahedron.
Conner discusses the use of catalytically-active metal-metal bonds in Trends in Chemistry.
Prof. Uyeda is named a Camille Dreyfus Teacher-Scholar.
April 2019
Jake wins the H.C. Brown Graduate Student Research Award, and presents his work at the 36th Annual H.C. Brown Lectures in Organic Chemistry.
Conner wins a poster award at the Brown Lectures.
John wins the 2019 Ian P. Rothwell Award for Outstanding Inorganic Literature Seminar.
February 2019
You-Yun publishes his work on dinickel-catalyzed [4+1] cycloaddition in Science.
October 2018
Kristen, Houng and Vibha join the group. Welcome!
September 2018
Conner, Nish and You-Yun publish their work on nickel-catalyzed cyclopentanation of enones in JACS.
August 2018
Jake publishes his work on Co-catalyzed dimethylcyclopropanation of 1,3-dienes in Angewandte Chemie.
Arnab's beautiful spiderweb appears on the cover of Organometallics.
July 2018
Colby, Ian and Sudipta successfully defend their dissertations!
Sudipta is selected to give a talk at the 2018 Organometallics GRS.
June 2018
Arnab publishes his investigation of carbene formation and transfer on the dinickel NDI platform in Organometallics.
April 2018
Sudipta wins the H.C. Brown Graduate Student Research Award, and presents her research at the 2018 H.C. Brown Lectures in Organic Chemistry.
Talia, Doug and Heather successfully defend their dissertations. Congratulations!
March 2018
Ian reports a new dinickel-catalyzed azoarene synthesis from aryl azides in JACS.
Colby gives her graduate research seminar.
February 2018
Heather publishes her investigation of a dinickel-catalyzed strained-ring–opening reaction in Organometallics.
Heather gives her graduate research seminar.
Sudipta gives her graduate research seminar.
January 2018
Talia wins the H. C. Brown Graduate Student Seminar Award.
Jake's paper on the Co-catalyzed regioselective cyclopropanation of polyenes appears in Chemical Science.
October 2017
New graduate students Annah, Seulah and Sourish join the lab!
Mike wins a poster award at the 2017 PINDU inorganic symposium.
September 2017
Doug reports a catalytic dinuclear C-C bond activation of norbornadiene in JACS.
August 2017
Talia gives her graduate research seminar.
Dr. Uyeda presents our work on catalysis at metal-metal bonds at the 254th ACS National Meeting.
Sudipta and You-Yun publish their vinylidene transfer methodology in JACS.
We are grateful to the NIH MIRA program for funding our research.
June 2017
Check out the entry for our flagship dinickel complex in e-EROS!
May 2017
Colby and Jake publish their paper on dehydrogenative imine transformations in JOC.
Ian's paper on C-H activation by a bridging dinickel nitrene is published in Chem Eur J.
April 2017
Talia is awarded a Bisland Dissertation Fellowship, as well as the Charles Cameron Professional Development Award.
Ian wins a poster award at the 34th Annual H. C. Brown Lectures in Organic Chemistry.
Colby receives the Teaching Academy Teaching Award, as well as a poster award at the Brown Lectures.
Conner wins the prestigious Arthur Kelley Teaching Award. Congratulations!
March 2017
Ian gives a poster presentation at the Inorganic Reaction Mechanisms GRC.
Dr. Uyeda gives a lecture at the Organometallics GRC.
February 2017
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December 2016
Mike's paper on dinuclear oxidative addition is published in Dalton Transactions.
Ian's perspective article on metal-metal bonds in catalysis is published in ACS Catalysis.
November 2016
Ian presents his work on dinickel bridging imidos at PINDU, a regional inorganic chemistry symposium.
October 2016
New graduate students John and Shawn join the group. Welcome!
July 2016
Dr. Uyeda is selected to give a presentation at the organometallics GRC. Talia gives a poster presentation at the organometallics GRC.
May 2016
Talia, Sudipta, Ian, Doug and Dr. Uyeda speak at the 47th Regional ACS Meeting.
April 2016
Doug's paper on the mechanism of the Pauson-Khand reaction is published in Angewandte Chemie.
You-yun wins a poster award at the 2016 Herbert C. Brown Lectures.
March 2016
As a part of the Purdue GSSPC, Heather assists in the organization of a symposium for the 251st ACS National Meeting in San Diego.
February 2016
Dr. Uyeda is awarded a Sloan Fellowship.
You-yun publishes a new catalytic reductive cyclopropanation in Angewandte Chemie.
January 2016
Our work on dinuclear Ni catalysis is reviewed in a Synpacts account.
We are grateful to the NSF CAREER program for supporting our research.
December 2015
Talia presents a seminar on her hydrosilylation work at PINDU, a regional inorganic chemistry conference.
The lab moves into our new space in Wetherill 450!
November 2015
Conner joins our group!
July 2015
Sudipta wins a poster award at the 2015 Negishi-Brown Lectures.
June 2015
Sudipta's paper, "Evaluating the Effect of Catalyst Nuclearity in Ni-Catalyzed Alkyne Cyclotrimerizations," appears in JACS.
April 2015
Talia's paper, "Reversible Substrate Activation and Catalysis at an Intact Metal-Metal Bond Using a Redox-Active Supporting Ligand," appears in JACS.
April 2015
Talia wins a poster award at the H. C. Brown Lectures Symposium
March 2015
Congratulations to Ian on being awarded an NSF graduate research fellowship!
November 2014
Mike and Jake join our group!
October 2014
We are grateful to the ACS Petroleum Research Fund for supporting our research on light-driven dehydrogenation reactions.
Our group's first paper, "Dinuclear Nickel Complexes in Five States of Oxidation Using a Redox-Active Ligand," is published in Inorganic Chemistry.