Laboratory of Molecular Synthesis and Catalysis

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Purdue University
Department of Chemistry
560 Oval Dr.
West Lafayette, IN 47907

Lab: Wetherill Rm 450

Research in our group spans the organic and inorganic subdisciplines of chemistry with an emphasis on catalytic approaches to unsolved problems in organic synthesis and renewable energy conversion.

News

December 2023

Our collaboration work with Pfizer on the synthesis of bicyclic [3.1.0]proline as the precursor of Nirmatrelvir, an inhibitor of SARS-CoV-2 to fight against COVID-19 pandemic, is published on OPR&D.

November 2023

Welcome first year students Peter, Perry, Meenakshi, Divya and Deepesh to join our group!

October 2023

Vibha gives her Graduate Research Seminar.

Sourish defends his dissertation! We wish you all the best for your future endeavor in Corteva Agriscience!

September 2023

Chris gives his Graduate Research Seminar.

Mingxin and Nguyen's work on cyclopropanations of electron-deficient alkenes with dichloromethane-derived nucleophilic carbenes is published in Angewandte Chemie.

Vibha's research on Co-catalyzed asymmetric ring-opening reactions of unstrained heterocycles by vinylidenes is published in Angewandte Chemie.

Hayden and Qiang publish their paper on catalytic asymmetric zinc metallocycle synthesis from alkynes and imines in JACS.

August 2023

Prof. Uyeda gives a talk at the 2023 Fall ACS Meeting.

July 2023

Prof. Uyeda gives a lecture at 2023 International Symposium on Carbene and Nitrene Chemistry at University of Amsterdam.

Wen presents a poster at the 13th DOC Graduate Research Symposium.

Sourish, Kristen and Chris win the H.C. Brown Travel Grant.

Sourish, Vibha and Mingxin present posters at the 48th National Organic Chemistry Symposium, and Vibha wins the poster award.

Kristen presents a poster at the 2023 Organic Reactions and Processes GRC.

Prof. Uyeda and Chris present posters at the 2023 Organometallic Chemistry GRC.

May 2023

Kristen defends her dissertation!

April 2023

Kristen, Ray and Johnson's research on cobalt-catalyzed asymmetric cyclopropanation is published in JACS.

Kristen wins 2023 H.C. Brown Graduate Student Research Award, and gives a talk at the 38th H.C. Brown Lectures in Organic Chemistry.

Vibha, Wen, Mingxin and Hayden win the H.C. Brown poster award at the 38th H.C. Brown Lectures in Organic Chemistry.

Chris, John and Chengyi's work on dinickel-catalyzed N=N bond rotation is published in Inorganic Chemistry.

March 2023

The group is in Spring 2023 ACS Meeting! Prof. Uyeda, Sourish, Kristen, Vibha, Chris, Kyle, Wen and Mingxin give oral presentations.

December 2022

Kristen wins the Fall 2022 H. C. Brown Graduate Student Seminar Award.

November 2022

Sourish gives his Graduate Research Seminar.

Welcome first-year graduate student Audrey to join our lab!

September 2022

Annah and Megan's dinickel-catalyzed three component cycloaddition of vinylidenes is published in Chemical Science.

Sayan joins the group!

Kristen gives her Graduate Research Seminar.

April 2022

Kristen and Chris win the H.C. Brown poster award at the 37th H.C. Brown Lectures in Organic Chemistry.

Annah defends her dissertation!

January 2022

Annah wins the Fall 2021 H. C. Brown Graduate Student Seminar Award.

November 2021

Talia and Annah's work on dinickel-catalyzed vinylidene–alkene cyclization reactions is published in ACS Catalysis.

New graduate students Sumeet and Ray join the group. Welcome!

August 2021

Annah gives her Graduate Research Seminar.

July 2021

John defends his dissertation!

February 2021

John and Chris publish their paper on dinickel-catalyzed conjugated azopolymer synthesis in JACS

December 2020

Houng's work on nickel-catalyzed vinylidene O–H bond insertion reactions is published in ACS Catalysis.

November 2020

Arnab and Annah publish their work on dinickel-catalyzed diazoalkene-mediated cyclopropanation reactions in Angewandte Chemie.

Sourish and Sudipta publish their work on nickel-catalyzed vinylidene SiH bond insertion reactions in Chemical Communications.

New graduate students Courtney and Hayden join the group.

October 2020

Ian and John's work on dinickel-catalyzed C-H amination reactions is published in Organometallics.

September 2020

Mike publishes his work on dinickel-catalyzed enantioselective [4+1] cycloadditions in JACS.

May 2020

Prof. Uyeda is named the Richard B. Wetherill Associate Professor of Chemistry.

April 2020

Conner and Mike defend their dissertations!

March 2020

Conner wins the H.C. Brown Graduate Student Research Award.

Our laboratory temporarily closes due to COVID-19. Stay safe!

February 2020

Conner, Kohei, You-Yun, and Vibha report a new Co-catalyzed [5+1] cycloaddition reaction in JACS.

Conner and Mike win the Fall 2019 H. C. Brown Graduate Student Seminar Award.

January 2020

Thanks to Lilly for supporting Chris with a Lilly Grantee Award!

November 2019

Kristen and Jake publish their paper on reductive spirocyclopropanation in Advanced Synthesis and Catalysis.

New graduate students Kyle, Wen, Mingxin and Chris join the group.

October 2019

Conner gives his Graduate Research Seminar.

September 2019

Mike gives his Graduate Research Seminar.

July 2019

Guang joins the group as a visiting researcher!

Conner gives a talk at the DOC Graduate Research Symposium, and gives a poster at the Organic Reactions and Processes Gordon Research Conference.

Jake presents a poster at the 2019 Gordon Organometallic Chemistry Conference.

June 2019

Qiang joins the group!

John presents a poster at the 2019 National Organic Chemistry Symposium.

May 2019

Colby and Seulah publish a new catalytic carbonylation reaction in Tetrahedron.

Conner discusses the use of catalytically-active metal-metal bonds in Trends in Chemistry.

Prof. Uyeda is named a Camille Dreyfus Teacher-Scholar.

April 2019

Jake wins the H.C. Brown Graduate Student Research Award, and presents his work at the 36th Annual H.C. Brown Lectures in Organic Chemistry.

Conner wins a poster award at the Brown Lectures.

John wins the 2019 Ian P. Rothwell Award for Outstanding Inorganic Literature Seminar.

February 2019

You-Yun publishes his work on dinickel-catalyzed [4+1] cycloaddition in Science.

October 2018

Kristen, Houng and Vibha join the group. Welcome!

September 2018

Conner, Nish and You-Yun publish their work on nickel-catalyzed cyclopentanation of enones in JACS.

August 2018

Jake publishes his work on Co-catalyzed dimethylcyclopropanation of 1,3-dienes in Angewandte Chemie.

Arnab's beautiful spiderweb appears on the cover of Organometallics.

July 2018

Colby, Ian and Sudipta successfully defend their dissertations!

Sudipta is selected to give a talk at the 2018 Organometallics GRS.

June 2018

Arnab publishes his investigation of carbene formation and transfer on the dinickel NDI platform in Organometallics.

April 2018

Sudipta wins the H.C. Brown Graduate Student Research Award, and presents her research at the 2018 H.C. Brown Lectures in Organic Chemistry.

Talia, Doug and Heather successfully defend their dissertations. Congratulations!

March 2018

Ian reports a new dinickel-catalyzed azoarene synthesis from aryl azides in JACS.

Colby gives her graduate research seminar.

February 2018

Heather publishes her investigation of a dinickel-catalyzed strained-ring–opening reaction in Organometallics.

Heather gives her graduate research seminar.

Sudipta gives her graduate research seminar.

January 2018

Talia wins the H. C. Brown Graduate Student Seminar Award.

Jake's paper on the Co-catalyzed regioselective cyclopropanation of polyenes appears in Chemical Science.

October 2017

New graduate students Annah, Seulah and Sourish join the lab!

Mike wins a poster award at the 2017 PINDU inorganic symposium.

September 2017

Doug reports a catalytic dinuclear C-C bond activation of norbornadiene in JACS.

August 2017

Talia gives her graduate research seminar.

Dr. Uyeda presents our work on catalysis at metal-metal bonds at the 254th ACS National Meeting.

Sudipta and You-Yun publish their vinylidene transfer methodology in JACS.

We are grateful to the NIH MIRA program for funding our research.

June 2017

Check out the entry for our flagship dinickel complex in e-EROS!

May 2017

Colby and Jake publish their paper on dehydrogenative imine transformations in JOC.

Ian's paper on C-H activation by a bridging dinickel nitrene is published in Chem Eur J.

April 2017

Talia is awarded a Bisland Dissertation Fellowship, as well as the Charles Cameron Professional Development Award.

Ian wins a poster award at the 34th Annual H. C. Brown Lectures in Organic Chemistry.

Colby receives the Teaching Academy Teaching Award, as well as a poster award at the Brown Lectures.

Conner wins the prestigious Arthur Kelley Teaching Award. Congratulations!

March 2017

Ian gives a poster presentation at the Inorganic Reaction Mechanisms GRC.

Dr. Uyeda gives a lecture at the Organometallics GRC.

February 2017

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December 2016

Mike's paper on dinuclear oxidative addition is published in Dalton Transactions.

Ian's perspective article on metal-metal bonds in catalysis is published in ACS Catalysis.

November 2016

Ian presents his work on dinickel bridging imidos at PINDU, a regional inorganic chemistry symposium.

October 2016

New graduate students John and Shawn join the group. Welcome!

July 2016

Dr. Uyeda is selected to give a presentation at the organometallics GRC. Talia gives a poster presentation at the organometallics GRC.

May 2016

Talia, Sudipta, Ian, Doug and Dr. Uyeda speak at the 47th Regional ACS Meeting.

April 2016

Doug's paper on the mechanism of the Pauson-Khand reaction is published in Angewandte Chemie.

You-yun wins a poster award at the 2016 Herbert C. Brown Lectures.

March 2016

As a part of the Purdue GSSPC, Heather assists in the organization of a symposium for the 251st ACS National Meeting in San Diego.

February 2016

Dr. Uyeda is awarded a Sloan Fellowship.

You-yun publishes a new catalytic reductive cyclopropanation in Angewandte Chemie.

January 2016

Our work on dinuclear Ni catalysis is reviewed in a Synpacts account.

We are grateful to the NSF CAREER program for supporting our research.

December 2015

Talia presents a seminar on her hydrosilylation work at PINDU, a regional inorganic chemistry conference.

The lab moves into our new space in Wetherill 450!

November 2015

Conner joins our group!

July 2015

Sudipta wins a poster award at the 2015 Negishi-Brown Lectures.

June 2015

Sudipta's paper, "Evaluating the Effect of Catalyst Nuclearity in Ni-Catalyzed Alkyne Cyclotrimerizations," appears in JACS.

April 2015

Talia's paper, "Reversible Substrate Activation and Catalysis at an Intact Metal-Metal Bond Using a Redox-Active Supporting Ligand," appears in JACS.

April 2015

Talia wins a poster award at the H. C. Brown Lectures Symposium

March 2015

Congratulations to Ian on being awarded an NSF graduate research fellowship!

November 2014

Mike and Jake join our group!

October 2014

We are grateful to the ACS Petroleum Research Fund for supporting our research on light-driven dehydrogenation reactions.

Our group's first paper, "Dinuclear Nickel Complexes in Five States of Oxidation Using a Redox-Active Ligand," is published in Inorganic Chemistry.