Dr. Chi Zhang Research Group

We play with photons!

Research

Optical spectroscopy and imaging

We develop novel optical spectroscopy and microscopy technologies to map chemical contrast and processes in biological and material samples. Our spectroscopy and imaging modalities are based on nonlinear optical processes, including coherent Raman scattering, harmonic generation, multiphoton excitation fluorescence, and transient absorption. We are interested in improving the chemical selectivity, throughout, and sensitivity of chemical imaging technologies.

Related publications:

Real-time Precision Opto-control

We develop new precision opto-control platforms and use lasers to control chemical processes in living cells. Our method can selectively control chemical processes in living samples without affecting other parts of the sample. RPOC has high chemical specificity, submicron precision, and nanosecond response time.  

Related publications:

 Understanding and controlling cell metabolism

We apply imaging and spectroscopy technologies developed in our lab to understand the metabolism of cancer and bacteria cells, especially in stress conditions. We are especially interested in how lipid metabolism and protein dynamics change in live cells in stress conditions. We also use precision opto-control technologies to manipulate and control cell metabolism.  

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 Research Keywords: Optical imaging, opto-control, Raman spectroscopy, analytical chemistry, cancer biology, cell metabolism.