Research
Our lab has three major research focuses:
(1) Optical spectroscopy and imaging
We develop novel optical spectroscopy and microscopy technologies to map chemical contrast and processes in biological and material samples. Our spectroscopy and imaging modalities are based on nonlinear optical processes, including coherent Raman scattering, harmonic generation, multiphoton excitation fluorescence, and transient absorption. We are interested in improving the chemical selectivity, throughout, and sensitivity of chemical imaging technologies.
(2) Real-time precision opto-control (RPOC)
We develop new precision opto-control platforms and use lasers to control chemical processes in living cells. Our method can selectively control chemical processes in living samples without affecting other parts of the sample. RPOC has high chemical specificity, submicron precision, and nanosecond response time.
(3) Understanding and controlling cell metabolism
We apply imaging and spectroscopy technologies developed in our lab to understand the metabolism of cancer and bacteria cells, especially in stress conditions. We also use precision opto-control technologies to manipulate and control cell metabolism.
Research Keywords: Optical imaging, opto-control, Raman spectroscopy, analytical chemistry, cancer biology, cell metabolism.