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Current Research

Much of our current research is centered around amine-boranes.

  • New methods of amine-borane synthesis.
  • Transformation of amine-borane into other reagents
  • Development of synthetic methodolgies using amine-boranes

We use amine-boranes produced by our methodologies for a range of materials chemistry applications, including:

  • Hypergolic propellants
  • Hydrogen storage materials
  • Formation of metal nanoparticles
  • Production of boron-nitrogen polymers

Recent Articles

  1. Interconnected Sn@SnO2 Nanoparticles as an Anode Material for Lithium-Ion Batteries
  2. Balancing Lewis Acidity and Carbocation Stability for the Selective Deoxyhalogenation of Aryl Carbonyls and Carbinols
  3. Alkylthialactonization: A novel protocol for access to either diastereoisomer of α-(thiomethyl)-γ-butyrolactones
  4. Titanium-Mediated Reduction of Carboxamides to Amines with Borane–Ammonia
  5. Dehydroborylation of Terminal Alkynes Using Lithium Aminoborohydrides
  6. Scalable, Green Synthesis of Heteroaromatic Amine-boranes
  7. Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane
  8. A safer reduction of carboxylic acids with titanium catalysis
  9. Monotrifluoroacetoxyborane-amines: chemoselective reagents for challenging reductive aminations
  10. TiCl4-catalyzed hydroboration of ketones with ammonia-borane
  11. Aminoboranes via Tandem Iodination/Dehydroiodination for One-Pot Borylation
  12. Activation of Sodium Borohydride via Carbonyl Reduction for the Synthesis of Amine- and Phosphine-Boranes
  13. Ammonia-borane as a Catalyst for the Direct Amidation of Carboxylic Acids
  14. Experimental Study of Factors Affecting Hypergolic Ignition of Ammonia Borane
  15. Trimethyl Borate-Catalyzed, Solvent-Free Reductive Amination
  16. Amine-boranes as Dual-Purpose Reagents for Direct Amidation of Carboxylic Acids

Recent News

  • Jun. 2023. "Interconnected Sn@SnO2 Nanoparticles as an Anode Material for Lithium-Ion Batteries" published in ACS Applied Nano Materials.
  • Jun. 2023. "Balancing Lewis Acidity and Carbocation Stability for the Selective Deoxyhalogenation of Aryl Carbonyls and Carbinols" published in Organic Letters.
  • Jun. 2023. "Alkylthialactonization: A novel protocol for access to either diastereoisomer of α-(thiomethyl)-γ-butyrolactones" published in Tetrahedron Letters.
  • May 2023. "Titanium-Mediated Reduction of Carboxamides to Amines with Borane–Ammonia" published in Molecules.
  • May 2023. Congratulations! Randy wins an undergraduate teaching award for the Spring Seminar!
  • May 2023. Congratulations! Shivani wins the HC Brown Seminar Award for Outstanding Spring Seminar!
  • Mar. 2023. "Dehydroborylation of Terminal Alkynes Using Lithium Aminoborohydrides" published in Molecules.
  • Mar. 2023. "Scalable, Green Synthesis of Heteroaromatic Amine-boranes" published in Organic Process Research & Development.
  • Mar. 2023. Congratulations Dr. Choudhary! Shivani successfully defended her thesis.
  • Feb. 2023. Shivani presented her seminar on the "Development of Amine-boranes and Derivatives for Reductive Amination."
  • Jan. 2023. "Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane" published in Molecules.
  • Jan. 2023. "Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane" published in Molecules.
  • Nov. 2022. "A Safer Reduction of Carboxylic Acids with Titanium Catalysis" published in Organic Letters.
  • Sept. 2022.Monotrifluoroacetoxyborane-amines as new chemoselective reagents for reductive aminations published in Chemical Communications.
  • Sept. 2022.New, titanium catalyzed ketone hydroboration using ammonia-borane published in The Journal of Organic Chemistry.
Contact Us Our Research

About Us

Welcome to the Ramachandran Research Group. We develop new reagents and reactions in organoboron and fluoroorganic chemistry. These methodologies are applied to the synthesis of natural and unnatural molecules for use in alternative energy, energetic materials, and medicinal chemistry applications.