Journal Articles 1984-2015
(204) Factors influencing the cytotoxicity of a-methylene-g -hydroxy esters against pancreatic cancer
Matthew A Helppi; Arlie Lehmkuhler; Jennifer M Marchi; C. Max Schmidt; Michele T Yip-Schneider Bioorg. Med. Chem. Lett. 2015, 25, 4270–4273.
DOI:10.1016/j.bmcl.2015.07.087
(203) Editorial: In celebration of the 80th birthday of Professor Ei-ichi Negishi.
Ramachandran, P. V. Org. Chem. Front. 2015, 2, 872-873.
(202) Asymmetric Synthesis of γ–Arylsubstituted GABA Derivatives via a Highly Diastereoselective Rh- Catalyzed Boronic Acid Addition at Room Temperature
Ramachandran PV, Mitsuhashi, W.; Biswas, B. Org. Chem. Front. 2015, 2, 885-889.
DOI: 10.1039/C5QO00133A
(201) Facile Synthesis of 1-Trifluoromethylalkenes via the Decarboxylation of a-Trifluoromethyl-ß-lactones
Ramachandran, P. V.; Otoo, B. Chem. Commun. 2015, 51, 12388-12390.
DOI: 10.1039/C5CC03230J
(200) Solid Amine-boranes as High Performance and Hypergolic Hybrid Rocket Fuels
Pfeil, M.; Kulkarni, A. S.; Ramachandran, P. V.; Son, S.; Heister, S.; J. Propul. and Power, 2015, 31.
DOI: 10.2514/1.B35591
(199) An Open-flask Synthesis of Amine-boranes via Tandem Amine-Ammonium Salt Equilibration-Metathesis.
Ramachandran, P. V.; Kulkarni, A. S. Inorg. Chem., 2015, 54, 5618–5620.
DOI: 10.1021/acs.inorgchem.5b00572
(198) (+)-B-Chlorodiisopinocampheylborane
Gagare, P. D.; Ramachandran, P. V. Encyclopedia of Reagents for Organic Synthesis, 2015.
DOI: 10.1002/047084289X.rc092.pub2
(197) Bis(bicyclo[2.2.1]-2-heptyl)chloroborane.
Gagare, P. D.; Ramachandran, P. V. Encyclopedia of Reagents for Organic Synthesis. 2015.
DOI: 10.1002/047084289X.rn01789
(196) Diastereoselective synthesis of anti-3-hydroxy-2-trifluoromethyl carboxylic acids
Ramachandran, P. V.; Otoo, B. Chanda, P. B.; Tetrahedron Lett. 2015, 56, 3019–3022.
DOI: 10.1016/j.tetlet.2014.12.045
(195) (Z)- or (E)-selective Hydrogenation of Potassium (3,3,3-trifluoroprop-1-yn-1-yl)trifluoroborate: Route to Either Isomer of β-Trifluoromethylstyrenes
Ramachandran, P. V.; Mitsuhashi, W. Org. Lett. 2015, 17, 1252-1255.
DOI: 10.1021/acs.orglett.5b00235
(194) UV Photofragmentation and IR Spectroscopy of Cold, G-type β-O-4 and β-β Dilignol-Alkali Metal Complexes: Structure and Linkage-Dependent Photofragmentation.
Dean, J. C.; Burke, N. L.; Hopkines, J. R.; Redwine, J. G.; Ramachandran, P. V.; McLuckey, S. A.; Zwier, T.;J. Phys. Chem. A. 2015, 119, 1917–1932.
DOI: 10.1021/jp512603n
(193) Characterization of Ethylenediamine bisborane as an additive for hybrid rocket propulsion.
Pfeil, M. A.; Dennis, J. D.; Son, S. F.; Heister, S. D. Pourpoint., T. L.; Ramachandran, P. V. J. Propul. Power, 2015, 31, 365-372.
DOI: 10.2514/1.B35386
(192) Amine-boranes: Green Hypergolic Fuels with Consistently Low Ignition Delays
Ramachandran, P. V.; Kulkarni, A. S.; Pfeil, M.; Dennis, J. D.; Willits, J. D.; Heister, S.; Son, S.; Pourpoint, T. Chem. Eur. J. 2014, 20, 16869-16872.
DOI: 10.1002/chem.201405224
(191) Diastereoselective Synthesis of α-(Aminomethyl)-γ-Butyrolactones via a Catalyst-free Aminolactonization
Ramachandran, P. V.; Nicponski, D. R. Chem. Commun. 2014, 0000.
DOI: 10.1039/c4cc05765a
(190) Ammonia-mediated, large-scale synthesis of ammonia borane
Ramachandran, P. V.; Mistry, H.; Gagare, P. D.; Kulkarni, A. S. Dalton Trans. 2014, 43, 16580-16583.
DOI: 10.1039/C4DT02467B
(189) Combustion Characterization of Amine-Borane Hypergolic Propellants.
Willits, J. D.; Dennis, J. D.; Kulkarni, A. S.; Ramachandran, P. V.; Pourpoint, T. L. 50th AIAA/ASME/SAE/ASEE Joint Propulsion Conference, July 28-30, 2014, Cleveland, OH,
DOI: 10.2514/6.2014-3884
(188) Syntheses of b- and g-Fluorophenyl cis- and trans-a-Methylene-g-Butyrolactones
Ramachandran, P. V.; Nair, H. N. G.; Gagare, P. D. Tetrahedron Lett. 2014, 55, 5722-5726.
DOI: 10.1016/j.tetlet.2014.07.106
(187) Preparation of and diastereo- and enantioselective trifluorocrotylboration with (Z)-(B)-diisopinocampheyl(4,4,4-trifluorobut-2-en-1-yl)borane
Li, G.; Gagare, P. D.; Ramachandran, P. V. Tetrahedron Lett. 2014, 55, 5736-5738.
(186) Nucleophilic displacement of ammonia from ammonia borane for the preparation of alkylamine-, pyridine- and phosphine-boranes
Ramachandran, P. V.; Kulkarni, A. S. RSC Advances 2014, 4, 26207-26210.
(185) Single-conformation UV and IR spectroscopy of model G-type lignin dilignols: the b-O-4 and b-b linkages.
Dean, J. C.; Walsh, P. S.; Biswas, B.; Ramachandran, P. V. Zwier, T. S. Chem. Sci. 2014, 5, 1940-1955.
DOI: 10.1039/C3SC53260G.
(184) Anti-Selective enolboration–aldolization of propanoic acid.
Ramachandran, P. V.; Chanda, P. B.; Otoo, B. Tetrahedron Lett. 2014, 55, 1289-1291.
(183) Allyl Borons. Ramachandran, P. V.; Gagare, P. D.; Nicponski, D. R.
In Molander, G. A.; Knochel P. (Eds) Comp. Org. Syntheses, 2nd edition, Vol. 2, Oxford: Elsevier, 2014, pp. 1-71.
(182) Allyl Silanes, Stannanes, and Germanes. Ramachandran, P. V.; Gagare, P. D.; Nicponski, D. R. In Molander, G. A.;
Knochel P. (Eds) Comp. Org. Syntheses, 2nd edition, Vol. 2, Oxford: Elsevier, 2014, pp. 72-147.
(181) B-Chlorodiisopinocampheylborane
Ramachandran, P. V.; Gagare, P. D., Encycl. Reagents Org. Synth., 2014. 0000.
(180) Synthetic α-(aminomethyl)-γ-butyrolactones and their anti-pancreatic cancer activities.
Ramachandran, P. V.; Nicponski, D. R. Nair, H. N. G.; Gagare, P. D.; Helppi, M.; Schmidt, C. M.; Yip-Schneider, M. T Bioorg. Med. Chem. Lett. 2013, 23, 6911-6914.
(179) Synthesis of 2-substituted pyrrolidines from nitriles.
Ramachandran, P. V.; Mitsuhashi, W.; Nicponski, D. R. Tetrahedron Lett. 2013, 54, 5001-5003.
(178) Enantio- and Diastereoselective Synthesis of β-Substituted δ-Aminoboronic Esters from Nitriles
Ramachandran, P. V.; Mitsuhashi, W.; Biswas, D.; Nicponski, D. R. Tetrahedron Lett. 2013, 54, 4830-4833.
(177) Overriding effect of temperature over reagent and substrate size for boron-mediated aldol reaction of methyl phenylacetate
Ramachandran, P. V.; Chanda, P. B. Tetrahedron Lett. 2013, 54, 5886-5888.
(176) Focusing on Boron in Medicinal Chemistry.
Ramachandran, P. V. Future Med. Chem. 2013, 5, 611-612.
(175) Total Regio- and Diastereocontrol in the Aldol Reactions of Dienolborinates
Ramachandran, P. V.; Nicponski, D. R.; Kim, B. Org. Lett. 2013, 14, 1398-1401.
(174) Enantioselective synthesis of anti- and syn-β-hydroxy-α-phenyl carboxylates via boron-mediated asymmetric aldol reaction.
Ramachandran, P. V.; Chanda, P. B. Chem. Commun.2013, 49, 3152-3154.
This paper was selected by the Editorial Board of Synfacts for its important insights and important aspects and highlighted in issue 6, 2013 (P006013SF). http://www.thieme-connect.com/ejournals/toc/synfacts
(173) The first synthesis of a borylated α-methylene-γ-butyrolactone
Ramachandran, P. V.; Nicponski, D. R.; Drolet, M. P.; Schmidt, C. M.; Yip-Schneider, M. T. Future Med. Chem. 2013, 5, 633-639.
(172) Prevention of Posttraumatic Axon Sprouting by Blocking Collapsin Response Mediator Protein 2-Mediated Neurite Outgrowth and Tubulin Polymerization
Wilson, S. M.; Xiong, W.; Wang, Y.; Ping, X.; Head, J. D.; Brittain, J. M.; Gagare, P. D.; Ramachandran, P. V. ; Jin, X. ; Khanna, R. Neuroscience, 2012, 210, 451-466.
(171) Solvent- or Temperature-Controlled Diastereoselective Aldol Reaction of Methyl Phenylacetate.
Ramachandran, P. V.; Chanda, P. B. Org. Lett. 2012, 13, 4346-4349.
This paper was selected by the Editorial Board of Synfacts for its important insights and important aspects of this paper was highlighted in issue 12, 2012 (H014112SF). http://www.thieme-connect.com/ejournals/toc/synfacts
(170 One-Pot Synthesis of Ammonia-Borane and Trialkylamine-Boranes from Trimethyl Borate
Ramachandran, P. V.;Raju, B. C.;Gagare, P. D. Org. Lett. 2012, 13, 4044-4047.
(169) One-Pot Asymmetric Synthesis of 2- and 2,3-Disubstituted Tetrahydrofuran Derivatives
Ramachandran, P. V.; Nair, H. N. G.; Gagare, P. D. J. Org. Chem. 2012, 77, 9329-9333.
(168) B-Allyldiisiopinocampheylborane.
Ramachandran, P. V.; Gagare, P. D., Encycl. Reagents Org. Synth., 2012. 0000.
(167) B-(3,3-Difluoroallyl)diisopinocampheylborane for the Enantioselective Fluoroallylboration of Aldehydes
Ramachandran, P. V.; Tafelska-Kaczmarek, A.; Chatterjee, A. J. Org. Chem. 2012, 77, 5394-5398.
This paper was selected by the Editorial Board of Synfacts for its important insights and important aspects of this paper was highlighted in issue 1, 2013 (P016012SF).http://www.thieme-connect.com/ejournals/toc/synfacts
(166) B-Chlorodialkylboranes for the enolboration of 3,3,3-trifluoropropionates
Ramachandran, P. V.; Gagare, P. D.; Parthasarathy, G. Tetrahedron Lett. 2011, 52, 6055-6057.
(165) Asymmetric Fluoroallylboration of Aldehydes
Ramachandran, P. V.; Tafelska-Kaczmarek, A.; Sakavuyi, K. Org. Lett. 2011, 13, 4044-4047.
(164) The role of solvent selection at exploratory and production stages in the pharmaceutical industry.
Nicponski, D. R.; Ramachandran, P. V. Future Med. Chem. 2011, 3, 1469-73.
(163) Conformation-Specific Spectroscopy and Populations of Diastereomers of a Model Monolignol Derivative: Chiral Effects in a Triol Chain.
Dean, J.; Buchanan, E.; James, W.; Gutberlet, A.; Biswas, B.; Ramachandran, P. V.; Zwier, T. J. Phys. Chem. 2011, 115, 8464-8478.
(162) One-Pot Allyl- and Crotylboration-Prins Cyclization of Aldehydes.
Ramachandran, P. V.; Gagare, P. D Tetrahedron Lett. 2011, 52, 4378-4381.
(161) Custom Synthesis of Substituted Butenolides, Dihydropyranones, and alpha-E-Alkylidenelactones via Alkenylalumination.
Ramachandran, P. V.; Pratihar, D.; Garner, G.; Raju, B. C. Tetrahedron Lett. 2011, 52, 4985-4988.
(160) Preparation and application of 2-(arylmethoxy)isopinocampheols for the asymmetric aldol reaction of 3,3,3-trifluoropropionates.
Ramachandran, P. V.; Parthasarathy, G.; Gagare, P. D. Tetrahedron Lett. 2011, 52, 5359-5362.
(159) Fluoroallylboration-Olefination for the Synthesis of (Z)-4,4-difluoropent-e-enoates and 5,5-difluoro-5,6-dihydropyrans-2-ones.
Ramachandran, P. V.; Tafelska-Kaczmarek, A.; Sakavuyi, K.; Chatterjee, A.. Org. Lett. 2011, 13, 1302-1305.
(158) Synthesis of Preparation of β-Amino Esters and β-Lactams from Nitriles via Aldimine-Borane Complexes.
Ramachandran, P. V.; Biswas D.; Chen G. M. Heterocylces. 2011, 82, 1423-1433.
(157) Welcome to GABAergic Drugs.
Ramachandran, P. V.; Shekhar, A. Future Med. Chem. 2011, 3, 139-40.
(156) Synthesis of Ring-substituted N-benzyl g-phenyl GABA derivatives via reductive amination.
Ramachandran, P. V.; Sakavuyi, K.; Mistry, H. Future Med. Chem. 2011, 3, 155-162.
(154) Bis-exo-2-norbornylboron triflate for stereospecific enolization of 3,3,3-trifluoropropionates.
Ramachandran, P. V.; Parthasarathy, G.; Gagare, P. Org. Lett. 2010, 12, 4474-77.
(153) Tailored a-methylene-g-butyrolactones and their effects on growth supression in pancreatic carcinoma cells.
Ramachandran, P. V.; Pratihar, D.; Nair, H. N. G.; Walters, M.; Smith, S.; Yip-Schneider, M. T.; Wu, H.; Schmidt, C. M.
Bioorg. Med. Chem. Lett. 2010, 20, 6620-23.
(152) Reductive amination using ammonia borane.
Ramachandran, P. V.; Gagare, P. D.; Sakavuyi, K.; Clark, P. Tetrahedron Lett. 2010, 51, 3167-69.
(151) Efficient synthesis of chiral C2-symmetric diamines via allylboration of bis-N,N'-metallodiimines.
Ramachandran, P. V.; Biswas, D.; Krzeminski, M. P.; Chen, G. M. Tetrahedron Lett. 2010, 51, 332-336.
(150) Synthesis of α-alkylidene-δ-valerolactones via the conjugate addition of ketone enolates to functionalized allyl acetates.
Ramachandran, P. V.; Bhattacharyya, A. Heterocylces. 2010, 80, 863-872.
(149) 1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-(2-propen-1-yl).
Ramachandran, P. V.; Gagare, P. D. Encycl. Reagents Org. Synth. 2010, 0000.
(148) Welcome to Fluorine in Medicinal Chemistry.
Ramachandran, P. V. Future Med. Chem. 2009, 1, 771-772.
(147) Natural and Synthetic a,b-Unsaturated Carbonyls for NF-kB Inhibition: A Mini-review.
Ramachandran, P. V.; Yip-Schneider, M. T.; Schmidt, C. M. Fut. Med. Chem. 2009, 1, 179.
(146) Asymmetric Aldol Reaction with Diisopinocampheyl Enolborinates of Propionates.
Ramachandran, P. V.; Pratihar, D. Org. Lett. 2009, 11, 1467-70.
(145) g-Fluorophenyl-GABA Derivatives from Fluorobenzonitriles in High Diastereomeric and Enantiomeric Excess.
Ramachandran, P. V.; Ghojala, V. R.; Biswas, D. J. Fluorine Chem. 2009, 130, 204-215.
(144) Facile Allylboration of ketones with β-Benzyloxy-γ,γ-Difluoroallylboronate: Preparation of Gem-Difluorinated Homoallylic tert-Alcohols.
Ramachandran, P. V.; Chatterjee, A. J. Fluorine Chem. 2009, 130, 144-150.
(143) Chemical Kinetics of Ru-catalyzed Ammonia Borane Hydrolysis.
Basu, S.; Brockmana, A.; Gagare, P. D.; Zheng Z.;.Ramachandran, P. V.; Delgass, W. N.; Gore, J. P. J. Power Sources, 2009, 188, 238-243.
(142) Gem-Difluorinated Homoallyl Alcohols, b-Hydroxy Ketones, and syn- and anti-1,3-Diols via b,b-difluoroallylboronates.
Ramachandran, P. V.; Chatterjee, A. Org. Lett. 2008, 10, 1195-1198.
(141) Preparative-scale Synthesis of Hexafluoro-1,3-Butadiene.
Ramachandran, P. V.; Reddy, G. V. J. Fluorine Chem. 2008, 129, 443-446.
(140) Gem-Difluorinated Homoallyl Alcohols, b-Hydroxy Ketones, and syn- and anti-1,3-Diols via b,b-difluoroallylboronates
Ramachandran, P. V.; Chatterjee, A. Org. Lett. 2008, 10, 1195.
(139) Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats
Peng, X. Q.; Li, X.; Li, J.; Ramachandran, P. V.; Gagare, P. D.; Pratihar, D.; Ashby, C. R.; Gardner, E. L.; Xi, Z. X.
Drug and Alcohol Dependence, 2008, 97, 207-15.
(138) Synthesis of (E)- and (Z)-r-Alkylidene-g-aryl-g-butyrolactones via Alkenylalumination of Oxiranes
Ramachandran, P. V.; Garner, G.; Pratihar, D. Org. Lett. 2007, 9, 4753-56.
(137) Preparative-scale Synthesis of 3,3,3-Trifluoropropene Oxide.
Ramachandran, P. V.; Padiya, K. J. J. Fluorine Chem. 2007, 128, 1255–59.
(136) Preparation of Ammonia Borane in High Yield and Purity, Methanolysis and Regeneration.
Ramachandran, P. V.; Gagare, P. D. Inorg. Chem. 2007, 46, 7810-17.
(135) Convenient Synthesis of Stable Aldimine-Borane Complexes, Chiral -Amino Alcohols, and g-Substituted GABA Analogs from Nitriles.
Ramachandran, P. V.; Biswas, D. Org. Lett. 2007, 9, 3025-27.
(134) Acidity-Directed Synthesis of Substituted gamma-Butyrolactones from Aliphatic Aldehydes.
Ramachandran, P. V.; Pratihar, D. Org. Lett. 2007, 9, 2087-90.
(133) The Influence of Fluorine on the Asymmetric Reduction of Fluoromethyl Ketones. Ramachandran, P. V.; Gong, B. Q.; Teodorovic, A. V. J.
Fluorine Chem. 2007, 128, 844-50.
(132) Asymmetric Hydroboration and Matteson Homologation of for the Preparation of Fluorinated a-Phenethanols.
Ramachandran, P. V.; Jennings, M. P. J. Fluorine Chem. 2007, 128, 827-31.
(131) Total Synthesis of Potential Antitumor Agent, (-)-Dictyostatin, Ramachandran, P. V.; Srivastava, A.; Hazra, D. Org. Lett. 2007, 9, 157-160.
(130) Synthesis of Fluorinated Glutamic Acid Derivatives via Vinylalumination,
Ramachandran, P. V.; Madhi, S.; O’Donnell, M. J. J. Fluorine Chem. 2007, 128, 78-83.
(129) Acute and Repeated Administration of Fluoxetine, Citalopram and Paroxetine Significantly Alter the Activity of
Midbrain Dopamine Neurons in Rats: An In Vivo Electrophysiological Study,
Sekine, Y.; Suzuki, K.; Ramachandran, P. V. Blackburn, T.; Ashby, C. R.* Synapse, 2007, 61, 72-77.
(128) Heat of reaction measurements of sodium borohydride alcoholysis and hydrolysis.
Zhang J.; Fisher, T. S*.; Gore, J. P.; Hazra, D.; Ramachandran, P. V.* Int. J. Hydrogen Energy 2006, 31, 2292-98.
(127) Control of Stereochemistry: A General Synthesis of cis- or trans-b,g-Disubstituted-g-butyrolactones following Z-crotylboration,
Ramachandran, P. V.; Pratihar, D.; Biswas, D. Org. Lett. 2006, 8, 3877-80.
(126) Regioselective Hydroboration-oxidation and -amination of Fluoro-substituted Styrenes.
Ramachandran, P. V.; Madhi, S.; O’Donnell, M. J. J. Fluorine Chem. 2006, 127, 1252-55.
(125) Preparation, Alcoholysis, and Regeneration of Ammonia-Borane, Ramachandran, P. V.
Prepr. Pap.-Am. Chem. Soc., Div. Fuel Chem. 2006, 51, 515-16.
(124) Asymmetric Allylboration of N-Metaloimines.
Ramachandran, P. V.; Burghardt, T. Pure Appl. Chem. 2006, 78, 1397-1406.
(123) A Review of Heat Transfer Issues in Hydrogen Storage Technologies by J. Zhang, T.S. Fisher, P.V. Ramachandram, J.P. Gore, I. Mudawar,
Int. J. Heat Transfer, 2005, 127, 1391.
(122) Catalytic Enantioselective Synthesis of Glutamic Acid Derivatives via Tandem Conjugate Addition-Elimination of
Activated Allylic Acetates under Chiral PTC Conditions.
Ramachandran, P. V.; Madhi, S.; Bland-Berry, L.; Reddy, M. V. R.; O’Donnell, M. J. J. Am. Chem. Soc. 2005, 127, 13450-51.
(121) Chiral Synthesis of Functionalized Tetrahydropyridines: -Aminobutyric Acid Uptake Inhibitor Analogues.
Ramachandran, P. V.; Burghardt, T. E.; Bland-Berry, L.; J. Org. Chem., 2005; 70, 7911-7918.
(120) Studies Towards the Synthesis of Epothilone A via Organoboranes.
Ramachandran, P. V.; Chandra, J. S; Prabhudas, B.; Pratihar, D.; Reddy, M. V. R.. Org. Biomol. Chem., 2005, 3, 3812 - 3824
(119) Asymmetric Allylboration of a,b-Enals as a Surrogate for the Enantioselective Synthesis of Allylic Amines and α-Amino Acids.
Ramachandran, P. V.; Burghardt, T. V.; Reddy, M. V. R. J. Org. Chem. 2005, 70, 2329-2931.
(118) Synthesis of 4-Substituted Homoallylic Alcohols via a One-pot Tandem Lewis-Acid Catalyzed Crotylboration-[3,3]-Sigmatropic Rearrangement.
Ramachandran, P. V.; Pratihar, D.; Biswas, D. Chem. Commun. 2005, 1988-1989.
(117) Highly Diastereoselective and Enantioselective Preparation of Homoallylic Amines.
Application for the Synthesis of β-Amino Acids and g-Lactams.
Ramachandran, P. V.; Burghardt, T. V.. Chem. Eur. J. 2005, 4387-4395.
(116) Preparation of N-protected allylic amines and α-methylene-β-amino acids from vinylalumination/Baylis-Hillman products via
tandem SN2' substitution-Overman rearrangement. Ramachandran, P. V.; Burghardt, T. V.; Reddy, M. V. R.
Tetrahedron Lett. 2005, 46, 2121-2124.
(115) Stereoselective Synthesis of Hex-2-(E)-en-4-yn-1,6-dioates and E,Z-Muconic Acid Diesters via Organo-catalyzed Self-coupling of Propiolates.
Ramachandran, P. V.; Rudd, M. T..; Reddy, M. V. R. Tetrahedron Lett. 2005, 2547-2549.
(114) Diastereoselective dihydroxylation and regioselective deoxygenation of dihydropyranones: A novel protocol for the stereoselective synthesis
of C1-C8 and C15-C21 subunits of (+)-Discodermolide. Ramachandran, P. V.*; Prabhudas, B.; Chandra, J. S; Reddy, M. V. R.
J. Org. Chem. 2004, 69, 6294-6304.
(113) Asymmetric synthesis of 6-(2 ',3 ',4 ',5 ',6 '-pentafluorophenyl)-δ-lactones via "allyl"boranes: application for the synthesis of
fluorinated analog of key pharmacophore of statin drugs. Ramachandran, P. V.; Padiya, K. J.; Rauniyar, V.; Reddy, M. V. R.; Brown, H. C.
J. Fluor. Chem. 2004, 125, 615-20.
(112) An efficient enantioselective total synthesis of a trifluoromethyl analog of Blastmycinolactol.
Ramachandran, P. V.; Padiya, K. J.; Reddy, M. V. R.; Brown, H. C. J. Fluor. Chem. 2004, 125, 579-83.
(111) Relationship between the structure and enantioselectivity in the asymmetric reduction of 2',6'-disubstituted acetophenones with
DIP-Chloride™. An ab initio study.
Ramachandran, P. V.; Gong, B. Q.; Brown, H. C.; Francisco, J. S. Tetrahedron Lett. 2004, 45, 2603-05.
(110) Novel functionalized trisubstituted allylboronates via Hosomi-Miyaura borylation of functionalized allyl acetates.
Ramachandran, P. V.; Pratihar, D.; Biswas, D.; Srivastava, A.; Reddy, M. V. R. Org. Lett. 2004, 6, 481-84.
(109) Asymmetric Synthesis of g-Perfluorinated Butyrolactones via Organoboranes.
Ramachandran, P. V.; Padiya, K. J.; Rauniyar, V.; Reddy, M. V. R.; Brown, H. C. Tetrahedron Lett. 2004, 45, 1015-17.
(108) Preparative-Scale Synthesis of Both Antipodes of B-γ,γ-Dimethylallyldiisopinocampheylborane:
Application for the Synthesis of C1-C6 Subunit of Epothilone.
Ramachandran, P. V.; Prabhudas, B.; Chandra, J. S.; Reddy, M. V. R.; Brown, H. C. Tetrahedron Lett. 2004, 45, 1011-13.
(107) Vinylalumination for the Synthesis of Functionalized Allyl Alcohols, Vinylepoxides, and α-Alkylidene-β-hydroxy-γ-lactones.
Ramachandran, P. V.; Rudd, M. T.; Burghardt, T. E.; Reddy, M. V. R. J. Org. Chem. 2003, 68, 9310-16.
(106) Synthesis of Chiral Tertiary Homoallylic Alcohols via Chelation Controlled Diastereoselective Nucleophilic Addition on α-Alkoxyketones:
Application for the Synthesis of C1-C11 Subunit of 8-epi-Fostriecin.
Ramachandran, P. V.; Liu, H.; Reddy, M. V. R.; Brown, H. C. Org. Lett. 2003, 5, 3755-57.
(105) Stereoselective synthesis of the C7-C21 segment of epothilone A via asymmetric alkoxyallyl- and crotylboration.
Ramachandran, P. V.; Prabhudas, B.; Pratihar, D.; Chandra, J. S.; Reddy, M. V. R. Tetrahedron Lett. 2003, 44, 3745-48.
(104) “Pinacolborane”, Ramachandran, P. V. and Chandra, J. S. in Electronic Encyclopedia of Reagents for Organic Synthesis.
Paquette, L.; Fuchs, P. L.; Crich, D.; Molander, G. Eds. John Wiley and Sons. West Sussex, UK.
(103) “Catecholborane”, Ramachandran, P. V. and Chandra, J. S. in Electronic Encyclopedia of Reagents for Organic Synthesis.
Paquette, L.; Fuchs, P. L.; Crich, D.; Molander, G. Eds. John Wiley and Sons. West Sussex, UK.
(102) “Dichloroborane-Methyl Sulfide”, Ramachandran, P. V. and Chandra, J. S. in Electronic Encyclopedia of Reagents for Organic Synthesis.
Paquette, L.; Fuchs, P. L.; Crich, D.; Molander, G. Eds. John Wiley and Sons. West Sussex, UK.
(101) Tandem allylboration-ring-closing metathesis reactions for the preparation of biologically active molecules.
Ramachandran, P. V.; Reddy, M. V. R.; Brown, H. C. Pure Appl. Chem. 2003, 75, 1263.
(100) Sequential Allylboration-ring-closing Metathesis Reactions for the Preparation of Biologically Active Molecules
Ramachandran, P. V.; Reddy, M. V. R.; Brown, H. C. in Boron Chemistry at the Beginning of the 21st Century,
Bubnov, Y. N. Ed. Nauka Publishing, Moscow, Russia, 2003, 66-78.
(99) Applications of B-“Allyl” Diisopinocampheylboranes for Organic Syntheses.
Ramachandran, P. V.; Reddy, M. V. R.; Brown, H. C. Proc. Ind. Natl. Sci. Acad. A 2002, 68, 465.
(98) Selective Reductions. 60. Chemoselective reduction of organyl azides with dichloroborane-dimethyl sulfide.
Salunkhe, A. M.; Ramachandran, P. V.; Brown, H. C. Tetrahedron 2002, 58, 10059-64.
(97) Efficient synthesis of B-iododialkyl- and B-alkyldiiodoboranes as their acetonitrile complexes:
Application for the enolboration-aldolization of ethyl ketones.
Ramachandran, P. V.; Zou, M. F.; Brown, H. C. Helv. Chim. Acta 2002, 85, 3027-32.
(96) Stereoselective Synthesis of (+)-Goniodiol, (-)-Epigoniodiol, and (+)-Deoxygoniopypyrone via Alkoxyallylboration and Ring-Closing Metathesis
Ramachandran, P. V.; Chandra, J. S.; Reddy, M. V. R. J. Org. Chem. 2002, 67, 7547-50.
(95) Study of Fluorocarbonyls in Baylis-Hillman Reaction
Reddy, M. V. R.; Rudd, M. T.; Ramachandran, P. V. J. Org. Chem. 2002, 67, 5382-85.
(94) Selective Reductions. 59. Effective Intramolecular Asymmetric Reductions of a, b, and g-Keto Acids with Diisopinocampheylborane and
Intermolecular Asymmetric Reductions of theCorresponding Esters with B-Chlorodiisopinocampheylborane
Ramachandran, P. V.; Brown, H. C.; Pitre, S. J. Org. Chem. 2002, 67, 5315-19.
(93) Investigation of the Factors Controlling the Regioselectivity of the Hydroboration of Fluoroolefins
Ramachandran, P. V.; Jennings, M. P. Chem. Commun. 2002, 386-87.
(92) Pinane Based Versatile Allylboranes
Ramachandran, P. V. Aldrichim. Acta. 2002, 35, 19.
(91) Boron NMR as a Tool for Organic Chemistry
Ramachandran, P. V. in Organic Syntheses via Boranes, Vol. 2. Chapter 9. Aldrich Chemical Company, Milwaukee, WI, 2001. pp. 325-358.
(90) An Exceptional Hydroboration of Substituted Fluoroolefins Providing Tertiary Alcohols
Ramachandran, P. V.; Jennings, M. P. Org. Lett. 2001, 3, 3789.
(89) Carbonyl and Olefin Reactivities for the Baylis-Hillman Reaction of Fluorocarbonyls
Ramachandran, P. V.; Reddy, M. V. R.; Rudd, M. T. Chem. Commun. 2001, 757-58.
(88) Asymmetric Synthesis of Umuravumbolide
Reddy, M. V. R.; Rearick, J. P.; Hoch, N.; Ramachandran, P. V. Org. Lett. 2001, 3, 19-20.
(87) An Efficient Asymmetric Synthesis of Tarchonanthuslactone
Reddy, M. V. R.; Yucel, A. J.; Ramachandran, P. V. J. Org. Chem. 2001, 66, 2512-14.
(86) Efficient Intramolecular Asymmetric Reductions of a-, b-, and g-Keto Acids with Diisopinocampheylborane
Ramachandran, P. V.; Brown, H. C.; Pitre, S. Org. Lett. 2001, 3, 17-18.
(85) Asymmetric Allylboration for the Synthesis of b-Hydroxy-d-lactone Unit of Statin Drug Analogs
Reddy, M. V. R.; Brown, H. C.; Ramachandran, P. V. J. Organometal. Chem. 2001, 624, 239-43.
(84) Syntheses of Chiral Lactones via Asymmetric Allylboration
Reddy, M. V. R.; Brown, H. C.; Ramachandran, P. V. in Organoboranes for Syntheses ACS Symposium Series # 783, 2001. pp. 220-234.
Ramachandran, P. V.; Brown, H. C. Eds. American Chemical Society, Washington, DC.
(83) Recent Advances in Borane Chemistry
Ramachandran, P. V.; Brown, H. C. in Organoboranes for Syntheses ACS Symposium Series # 783, 2001. pp. 1-17.
Ramachandran, P. V.; Brown, H. C. Eds. American Chemical Society, Washington, DC.
(82) Organoboranes for Syntheses: Current Advances. ACS Symposium Series # 783,
Ramachandran, P. V.; Brown, H. C. Eds. American Chemical Society, Washington, DC, 2001.
(81) Asymmetric Fluoroorganic Chemistry: Synthesis, Applications, and Future Directions.
ACS Symposium Series # 746, Ramachandran, P. V. Ed. American Chemical Society, Washington, DC 2000.
(80) Asymmetric Synthesis of Fluoro-organic Compounds Via Chiral Organoboranes.
Ramachandran, P. V.; Brown, H. C. in Asymmetric Synthesis of Fluoro-organic Compounds ACS Symposium Series # 746, 2000.
Ramachandran, P. V. Ed. American Chemical Society, Washington, DC.
(79) Studies Towards the Syntheses of Functionalized, Fluorinated Allyl Alcohols.
Ramachandran, P. V.; Rudd, M. T.; Reddy, M. V. in Asymmetric Synthesis of Fluoro-organic Compounds ACS Symposium Series #746, 2000.
Ramachandran, P. V. Ed. American Chemical Society, Washington, DC.
(78) Highly enantioselective synthesis of (+)- and (-)-Perfluoroalkyl(aryl) Homoallyl Alcohols
Kumar, D.; Madhavan, S.; Ramachandran, P. V.; Brown, H. C. Tetrahedron Asym. 2000, 11, 4629-32.
(77) A Facile Synthesis of Perfluoroalkyl Vinyl Iodides and Their Palladium Mediated Cross-Coupling Reactions
Jennings, M. P.; Cork, E. A.; Ramachandran, P. V. J. Org. Chem. 2000, 65, 8763-66.
(76) Asymmetric Synthesis of Goniothalamin, Hexadecanolide, Massoia Lactone, and
Parasorbic Acid via Sequential Allylboration-Esterification-Ring-closing Metathesis Reactions
Ramachandran, P. V.; Reddy, M. V. R.; Brown, H. C. Tetrahedron Lett. 2000, 41, 583-86.
(75) An Efficient Enantioselective Synthesis of Argentilactone
Ramachandran, P. V.; Reddy, M. V. R.; Brown, H. C. J. Ind. Chem. Soc. 1999, 739-42.
(74) Critical Role of Catalysts and Borane in Controlling the Regioselectivity in Rhodium-Catalyzed Hydroboration of Perfluoroalkyl(aryl)ethylenes.
Ramachandran, P. V.; Jennings, M. P.; Brown, H. C. Org. Lett. 1999, 1, 1399-1402.
(73) Efficient Synthesis of Functionalized Vinylepoxides
Ramachandran, P. V.; Krzeminski, M. P. Tetrahedron Lett. 1999, 40, 7879-81.
(72) Efficient Diastereoselective Synthesis of anti-a-Bromo-b-hydroxy-ketones.
Brown, H. C.; Zou, M. F. Ramachandran, P. V. Tetrahedron Lett. 1999, 40, 7875-77.
(71) An Improved Vinylalumination Procedure Replacing HMPA with NMO for the Hydroalumination of a-Acetylenic Esters and Ketones.
Ramachandran, P. V.; Reddy, M. V. R.; Rudd, M. T. Chem. Commun. 1999, 1979-80.
(70) Markovnikov Hydroboration of Perfluoroalkylethylenes
Brown, H. C.; Chen, G. M.; Jennings, M. P.; Ramachandran, P. V. Angew. Chem. Internat. Ed. 1999, 38, 2052-54.
(69) The Critical Importance of Water in the Asymmetric Allylboration of N-Trimethylsilylbenz-aldimines with B-Allyldiisopinocampheylborane.
Chen, G. M.; Ramachandran, P. V.; Brown, H. C. Angew. Chem. Int. Ed. Engl. 1999, 38, 825-26.
(68) B-(2-Azido-2-propenyl)-1,3,2-dioxaborinane: A Novel Reagent for Allylboration
Salunkhe, A. M.; Ramachandran, P. V.; Brown, H. C. Tetrahedron Lett. 1999, 40, 1433-36.
(67) A Facile Synthesis of Chiral w-Allyl and w-Propyllactones Via Asymmetric Allylboration of Formyl Esters with B-Allyldiisopinocampheylborane.
Ramachandran, P. V.; Krzeminski, M. P.; Reddy, M. V.; Brown, H. C. Tetrahedron: Asym. 1999, 10, 11-15.
(66) 1,4-Diazabicyclo[2.2.2]octane-Catalyzed Self- and Cross-Condensation of a-Acetylenic Ketones and Esters.
Ramachandran, P. V.; Rudd, M. T.; Reddy, M. V. Tetrahedron Lett. 1999, 40, 3819-22.
(65) Vinylalumination of Activated Carbonyl Compounds.
Ramachandran, P. V.; Reddy, M. V.; Rudd, M. T. Tetrahedron Lett. 1999, 40, 627-30.
(64) Chiral Synthesis Via Organoboranes. 46. An Efficient Preparation of Chiral Pyridino- and Thopheno-18-Crown-6 Ligands from Enantiomerically
Pure C2-Symmetric Pyridine- and Thiophenediols. Chen, G. M.; Brown, H. C.; Ramachandran, P. V. J. Org. Chem. 1999, 64, 721-25.
(63) Asymmetric Reduction of Fluorine-containing Carbonyl Compounds.
Ramachandran, P. V.; Brown, H. C. in "EPC-synthesis of Fluoro-Organic Compounds: Stereochemical Challenges and Biomedical Targets",
Soloshonok, V. A. Ed., John Wiley: Chichester, West Sussex, UK., 1999, Chapter 6, pp. 179-228.
(62) Vinylalumination of Fluoro-carbonyl Compounds.
Ramachandran, P. V.; Reddy, M. V.; Rudd, M. T.; de Alaniz, J. R. Tetrahedron Lett. 1998, 39, 8791.
(61) Asymmetric Reductions with Modified Borohydrides
Ramachandran, P. V The Alembic 1998, 57, 1.
(60) Book Review: Chirality in Industry. Vol. II. Developments in the Manufacture and Applications of Optically Active Compounds.
Collins, A. N.; Sheldrake, G. N.; Crosby, J. Eds.John wiley, Chichester, UK, 1997. J. Am. Chem. Soc. 1998, 120, 4256.
(59) Asymmetric Reductions with Diisopinocampheylborane
Ramachandran, P. V.; Brown, H. C. in Advances in Boron Chemistry, Siebert, W. Ed. The Royal Society of Chemistry Special Publication,
Cambridge, U. K., 1997, p 201-204.
(58) Recent Developments in Our Sixty Year Program on Diborane and Organoboranes for Synthesis
Brown, H. C.; Ramachandran, P. V. in Advances in Boron Chemistry, Siebert, W. Ed. The Royal Society of Chemistry Special Publication,
Cambridge, U. K., 1997, p 151-162.
(57) Efficient Syntheses of Enantiomerically Pure 1,2-Dicyclohexenyl- and 1,2-Dicyclohexyl-1,2-ethanediol Using
B-Cyclohexen-1-yl-diisopinocampheylborane
Chen, G. M.; Ramachandran, P. V. Tetrahedron: Asym. 1997, 8, 3935.
(56) B,B-Dihaloterpenylboranes for the Diastereoselective Enantioselective Synthesis of Syn-Aldols
Ramachandran, P. V.; Xu, W. C.; Brown, H. C. Tetrahedron Asym. 1997, 8, 1379.
(55) Efficient Syntheses of 2-Isopinocampheyl- and Related 2-Terpenyl-1,3,2-Dioxaboroles from 1,2-Dicarbonyls and 2-Hydroxy Ketones.
Diastereo- and Enantioselective Aldol Reaction of Enediol Boronates.
Ramachandran, P. V.; Lu, Z. H.; Brown, H. C. Tetrahedron Lett. 1997, 38, 2421.
(54) Efficient Synthesis of Enantiomerically Pure C2-Symmetric Diols via the Allylboration of Appropriate Dialdehydes.
Ramachandran, P. V.; Chen, G. M.; Brown, H. C. Tetrahedron Lett. 1997, 38, 2417.
(53) The Origins of Stereoselectivity in Asymmetric Reductions with Boranes Based on (+)-a-Pinene. 2.
The Geometries of Competing Transition-States and the Nature of the Reaction. A Semi-empirical Study.
Rogic, M. M.; Ramachandran, P. V.; Zinnen, H.; Brown, L. D.; Zheng, M. Tetrahedron Asym. 1997, 8, 1287.
(52) Organoboranes for Synthesis. 18. C2-Symmetric a,a'-Disubstituted-2,6-Pyridinedimethanols as Catalytic Chiral Ligands for the
Enantioselective Nucleophilic Addition of Diethylzinc to Aldehydes.
Brown, H. C.; Chen, G. M.; Ramachandran, P. V. Chirality 1997, 9, 506.
(51) Rate Enhancing Effect of Hydrogen Chloride and Methanesulfonic Acid on the Intamolecular Asymmetric Reduction of o-Aminoaceto- and
-benzophenones with Diisopinocampheylborane.
Ramachandran, P. V.; Malhotra, S. V.; Brown, H. C. Tetrahedron Lett. 1997, 38, 957.
(50) B,B-Dihaloalkylboranes as Efficient Reagents for the Stereoselective Synthesis of Syn-Aldols
Ramachandran, P. V.; Xu, W. C.; Brown, H. C. Tetrahedron Lett. 1997, 38, 769.
(49) Efficient Syntheses of 1,2- and 1,3-Diols in High Enantiomeric Excess via the Intramolecular Reduction of the Corresponding
Ketoalkyl Diisopinocampheylborinates
Ramachandran, P. V.; Lu, Z. H.; Brown, H. C. Tetrahedron Lett. 1997, 38, 761.
(48) Organoboranes for Synthesis. 17. Generality of Hydroboration-Amination for the Conversion of Terpenes into
Enantiomerically Pure Terpenylamines. Their Utility for Gas Chromatographic Analysis of Chiral Carboxylic Acids.
Brown, H. C.; Malhotra, S. V.; Ramachandran, P. V. Tetrahedron Asym. 1996, 7, 3527.
(47) A General, Efficient, Convenient Synthesis of Bis(terpenyl)haloborane Reagents, Valuable for Asymmetric Synthesis via Organoboranes.
Dhokte, U. P.; Soundararajan, R.; Ramachandran, P. V.; Brown, H. C. Tetrahedron Lett. 1996, 37, 8345.
(46) Contrasting Steric Effects of the Ketones and Aldehydes in the Reactions of the Diisopinocampheylborinates of Methyl Ketones with Aldehydes.
Ramachandran, P. V.; Xu, W. C.; Brown, H. C. Tetrahedron Lett. 1996, 37, 4911.
(45) An Efficient Preparation of Optically Pure C2-Symmetric Aromatic Diols by the Asymmetric Reduction of Diacylaromatic Compounds with
B-Chlorodiisopinocampheylborane.
Ramachandran, P. V.; Chen, G. M.; Lu, Z. H.; Brown, H. C. Tetrahedron Lett. 1996, 37, 3795.
(44) B-iso-2-(2-diethylaminoethyl)apopinocampheyl-9-borabicyclo[3.3.1]nonyl Hydride –
An Improved Chiral Reducing Agent For Straight Chain Aliphatic Ketones.
Ramachandran, P. V.; Weissman, S. A. Tetrahedron Lett. 1996, 37, 3791.
(43) Efficient General Asymmetric Syntheses of 3-Substituted 1(3H)-Isobenzofuranones in Very High Enantiomeric Excess.
Ramachandran, P. V.; Chen, G. M.; Brown, H. C. Tetrahedron Lett. 1996, 37, 2205.
(42) The Effect of the Acute and Chronic Administration of (±)-Fluoxetine on Extracellular DA level in the Nucleus Accumbens and Caudate-Putamen:
An In Vivo Microanalysis Study. Clark, R. N.; Ashby, Jr. C. R.; Ramachandran, P. V.; Dewey, S. L.; Strecker, R. E. Synapse 1996, 23, 125.
(41) Organoboranes for Synthesis. 16. A Convenient Synthesis of Enantiomerically Pure Isopinocampheylamine,
Chiral Derivatizing Agent for Gas Chromatographic Analysis of Optically Active Carboxylic Acids.
Ramachandran, P. V.; Rangaishenvi, M. V.; Singaram, B.; Goralski, C.; Brown, H. C. J. Org. Chem. 1996, 61, 341.
(40) Chiral Synthesis via Organoboranes. 43. Selective Reductions. 58. Reagent-Controlled Diastereoselctive Reduction of
(+)- and (–)-a-Chiral Ketones with (+)- and (–)-B-Chloro-diisopinocampheylborane.
Ramachandran, P. V.; Chen, G. M.; Brown, H. C. J. Org. Chem. 1996, 61, 95.
(39) Chiral Synthesis via Organoboranes. 42. Selective Reductions. 57. Efficient Kinetic Resolution of Representative a-Tertiary Ketones with
B-Chlorodiisopinocampheylborane. Ramachandran, P. V.; Chen, G. M.; Brown, H. C. J. Org. Chem. 1996, 61, 88.
(38) Recent Advances in Asymmetric Reductions with B-Chlorodiisopinocampheylborane.
Ramachandran, P. V.; Brown, H. C. in Reductions in Organic Synthesis, Abdel-Magid, A. F.
Ed. American Chemical Society Symposium Series #641, Washington, DC. 1996, pp 84-97.
(37) Sixty Years of Hydride Reductions.
Brown, H. C.; Ramachandran, P. V. in Reductions in Organic Synthesis, Abdel-Magid, A. F.
Ed. American Chemical Society Symposium Series #641, Washington, DC. 1996, pp 1-30.
(36) Asymmetric Synthesis Via Chiral Organoboranes Based on a-Pinene.
Brown, H. C.; Ramachandran, P. V. in Advances in Asymmetric Synthesis, Vol. 1. Hassner, A. Ed. JAI Press, Greenwich, CT, 1995, pp 144-210.
(35) Effect of a Chiral 4-Alkyl Substituent in Hallucinogenic Amphetamines.
Oberlender, R. A.; Ramachandran, P. V.; Johnson, M. P.; Huang, X.; Nichols, D. E. J. Med. Chem. 1995, 35, 3593.
(34) Selective Reductions. 56. Exploration of the B-Haloisopinocampheylboranes for Asymmetric Reduction of Ketones.
Brown, H. C.; Ramachandran, P. V.; Chandrasekharan, J. Heteroatom Chemistry 1995, 6, 117.
(33) Chiral Synthesis via Organoboranes. 41. The Utility of B-Chlorodiisopinocampheyl-borane for a
General Synthesis of Enantiomerically Pure Drugs
Ramachandran, P. V.; Gong, B.; Brown, H. C. Chirality 1995, 7, 103.
(32) Chiral Synthesis via Organoboranes. 40. Selective Reductions. 55. A Simple One-pot Synthesis of the Enantiomers of Trifluoromethyloxirane.
A General Synthesis in High Optical Purities of a-Trifluoromethyl sec-Alcohols Via the Ring-cleavage Reactions of the Epoxide.
Ramachandran, P. V.; Gong, B.; Brown, H. C. J. Org. Chem. 1995, 60, 41.
(31) Versatile a-Pinene Based Reagents for Asymmetric Synthesis.
Brown, H. C.; Ramachandran, P. V. J. Organometal. Chem. 1995, 500, 1.
(30) Selective Reductions. 53. Asymmetric Reduction of a-Fluoromethyl Ketones with Diisopinocampheylchloroborane and
B-Isopinocampheyl-9-borabicyclo[3.3.1]nonane. Combined Electronic and Steric Contributions to the Enantiocontrol Process.
Ramachandran, P. V.; Teodorovic, A. V.; Gong, B.; Brown, H. C. Tetrahedron: Asym. 1994, 5, 1075.
(29) Selective Reductions. 52. Efficient Asymmetric Reduction of a-Acetylenic a'-Fluoroalkyl Ketones with Either Diisopinocampheylchloroborane or
B-Isopinocampheyl-9-borabicyclo[3.3.1]nonane. The Influence of Electronic Factors in Reduction.
Ramachandran, P. V.; Gong, B.; Teodorovic, A. V.; Brown, H. C. Tetrahedron: Asym. 1994, 5, 1061.
(28) A Remarkable Inversion in Configuration of the Product Alcohols from the Asymmetric Reduction of
ortho-Hydroxyacetophenones with B-Chlorodiisopinocampheylborane.
Ramachandran, P. V.; Gong, B.; Brown, H. C. Tetrahedron Lett. 1994, 35, 2141.
(27) Recent Advances in the Boron Route to Asymmetric Synthesis.
Brown, H. C.; Ramachandran, P. V. in Current Topics in the Chemistry of Boron, Kabalka, G.
Ed. The Royal Society of Chemistry Special Publication No. 143, Cambridge, U. K., 1994, pp 125-129.
(26) An Approach to a General Reagent For Asymmetric Reduction.
Ramachandran, P. V.; Brown, H. C. in Current Topics in the Chemistry of Boron, Kabalka, G.
Ed. The Royal Society of Chemistry Special Publication No. 143, Cambridge, U. K., 1994, pp 101-112.
(25) Recent Advances in the Boron Route to Asymmetric Synthesis.
Brown, H. C.; Ramachandran, P. V. Pure and Appl. Chem. 1994, 66, 201.
(24) Asymmetric Synthesis of Both Enantiomers of a-(4-Fluorophenyl)-4-(2-pyrimidinyl)-1-piperazinebutanol: Potential Antipsychotic Agents
Ramachandran, P. V.; Gong, B.; Brown, H. C. Tetrahedron: Asym. 1993, 4, 2399.
(23) Chiral Synthesis via Organoboranes. 38. Selective Reductions. 48. Asymmetric Reduction of Trifluoromethyl Ketones by
B-Chlorodiisopinocampheylborane in High Enantiomeric Purity.
Ramachandran, P. V.; Teodorovic, A. V.; Brown, H. C. Tetrahedron 1993, 49, 1725.
(22) Chiral Synthesis via Organoboranes. 34. Selective Reductions. 47. Reduction of Hindered a,b-Acetylenic Ketones to
Propargylic Alcohols of Very High Enantiomeric Purity. Modified Workup procedure to isolate the product alcohols.
Ramachandran, P. V.; Teodorovic¢, A. V.; Rangaishenvi, M. V.; Brown, H. C. J. Org. Chem., 1992, 57, 5379.
(21) Asymmetric Reduction With Chiral Organoboranes Based on a-Pinene.
Brown, H. C.; Ramachandran, P. V. Acc. Chem. Res. 1992, 25, 16.
(20) The Boron Approach To Asymmetric Synthesis.
Brown, H. C.; Ramachandran, P. V. Pure and Appl. Chem. 1991, 62, 307.
(19) B-Chlorodiiso-2-ethylapopinocampheylborane – An Extremely Efficient Chiral Reducing Agent for
Prochiral Ketones of Intermediate Steric Requirements.
Brown, H. C.; Ramachandran, P. V.; Teodorovic¢, A. V.; Swaminathan, S. Tetrahedron Lett. 1991, 32, 6691.
(18) Selective Reductions. 46. Effect of the Steric Bulk at the 2-Position of Apopinene on Chiral Reductions. B-Iso-2-ethyl- and
B-Iso-2-n-propylapopinocampheyl-9-borabicyclo-[3.3.1]nonane as Improved Reagents for the Chiral Reduction of
a,b-Acetylenic Ketones and a-Keto Esters. Brown, H. C.; Ramachandran, P. V.; Weissman, S. A.; Swaminathan, S.
J. Org. Chem. 1990, 55, 6328.
(17) Lithium-B-Iso-2-ethylapopinocampheyl-9-borabicyclo[3.3.1]nonyl Hydride as an Improved Reagent for Asymmetric Reduction of
Unhindered Aliphatic Ketones. Further Evidence for the Improved Enantioselectivity in Reductions by Reagents Containing
Increased Steric Requirements at the 2-Position of the Apopinene Structure.
Ramachandran, P. V.; Brown, H. C.; Swaminathan, S. Tetrahedron: Asymm. 1990, 1, 433.
(16) Hydroboration. 84. Controlled and Sequential Hydroboration of Simple Representative Alkenes with Monoorganylboranes in Tetrahydrofuran.
A Convenient Synthesis of Mixed Borinic Esters, R1R2BOR3 and Mixed Trialkylboranes, R1R2R3B.
An Examination of Positional Selectivity in the First and Second States of Hydroboration.
Srebnik, M.; Cole, T. E.; Ramachandran, P. V.; Brown, H. C. J. Org. Chem. 1989, 54, 6085.
(15) Selective Reductions. 45. Asymmetric Reduction of Prochiral Ketones by iso-2-Methyl-, iso-2-Ethyl- and
iso-2-(2-Benzyloxyethyl)-apopinocampheyl-tert-butylchloroboranes. Evidence for a Major Influence of the Steric Requirements of
the 2-Substituent on the Efficiency of Asymmetric Reduction.
Brown, H. C.; Ramachandran, P. V. J. Org. Chem. 1989, 54, 4504.
(14) Chiral Synthesis via Organoboranes. 22. Selective Reductions. 44. The Effect of the Steric Requirements of the Alkyl Substituent in
Isopinocampheylalkylchloroboranes for the Asymmetric Reduction of Representative Ketones.
Brown, H. C.; Srebnik, M.; Ramachandran, P. V. J. Org. Chem. 1989, 54, 1577.
(13) Chiral Synthesis via Organoboranes. 18. Selective Reductions. 43. Diisopinocampheyl-chloroborane as an
Excellent Chiral Reducing Reagent for the Synthesis of Haloalcohols of High Enantiomeric Purity. A Highly Enantioselective synthesis
of Both Optical Isomers of Tomoxetine, Fluoxetine and Nisoxetine.
Srebnik, M.; Ramachandran, P. V.; Brown, H. C. J. Org. Chem. 1988, 53, 2916.
(12) Chiral Synthesis via Organoboranes. 14. Selective Reductions. 41. Diisopinocampheyl-chloroborane, An Exceptionally
Efficient Chiral Reducing Agent. Brown, H. C.; Chandrasekharan, J.; Ramachandran, P. V. J. Am. Chem. Soc. 1988, 110, 1539.
(11) Selective Reductions. 40. A Critical Examination of the Relative Effectiveness of Various Reducing Agents for the
Asymmetric Reduction of Different Classes of Ketones. Brown, H. C.; Park, W. S.; Cho, B. T.; Ramachandran, P. V.
J. Org. Chem. 1987, 52, 5406.
(10) The Utility of Chiral Organoboranes in the Preparation of Optically Active Compounds.
Srebnik, M.; Ramachandran, P. V. Aldrichim. Acta. 1987, 20, 9.
(9) Tomoxetine And The Stereoselectivity of Drug Action.
Oberlender, R.; Nichols, D. E.; Ramachandran, P. V.; Srebnik, M. J. Pharm. Pharmacol. 1987, 39, 1055.
(8) Organoboranes. 47. An Extremely Facile Elimination of Alkenes from Dialkylhaloboranes.
A Comparative Rate Study with Related Trialkylboranes.
Brown, H. C.; Ramachandran, P. V.; Chandrasekharan, J. Organometallics 1986, 5, 2138.
(7) Highly Efficient Asymmetric Reduction of a-Tertiary Alkyl Ketones with Diisopinocampheylchloroborane.
Brown, H. C.; Chandrasekharan, J.; Ramachandran, P. V. J. Org. Chem. 1986, 51, 3394.
(6) Hydroboration. 73. Relative Rates of Hydroboration of Representative Heterocyclic Olefins with 9-Borabicyclo[3.3.1]nonane.
Brown, H. C.; Ramachandran, P. V.; Vara Prasad, J. V. N. J. Org. Chem. 1985, 50, 5583.
(5) Diisopinocampheylchloroborane, A Remarkably Efficient Chiral Reducing Agent for Aromatic Prochiral Ketones.
Chandrasekharan, J.; Ramachandran, P. V.; Brown, H. C. J. Org. Chem. 1985, 50, 5446.
(4) A Study of the Preparation and Reactions of the Unusually Labile 5-Methyl[1,2,4]oxadiazolo-[2,3- c]quinazolin-2-one.
Ranganathan, D.; Bamezai, S.; Ramachandran, P. V. Heterocycles 1985, 23, 623.
(3) Iodoxybenzene. A Remarkably Close Ozone Equivalent.
Ranganathan, S.; Ranganathan, D.; Ramachandran, P. V. Tetrahedron 1984, 40, 3145.
(2) 2-Nitroethyl Phenyl Sulfoxide. A Novel Reagent for Facile Nitroethylene Transfer.
Ranganathan, D.; Ranganathan, S.; Bamezai, S.; Mehrotra, S.; Ramachandran, P. V. J. Chem. Res. (S). 1983, 78.
(1) A Chemical and Thermochemical Study of Non-Observed Symmetry Allowed Reactions.
Ranganathan, S.; Ranganathan, D.; Ramachandran, P. V.; Mahanty, M. K.; Bamezai, S. Tetrahedron 1981, 37, 4171.
(Also in R. B. Woodward Remembered: Barton, D. H. R. Ed.; Pergamon Press: Oxford, 1982, pp 509-521).