Nano-DESI Imaging

Our research is focused on the advanced development of nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI MSI). Nano-DESI is an ambient ionization technique based on localized liquid extraction of molecules from surfaces that enables sensitive quantitative detection of molecules in complex chemical and biological samples.

Publications

P. J. Roach, J. Laskin, A. Laskin "Nanospray Desorption Electrospray Ionization Mass Spectrometry", Analyst, 135, 2233–2236 (2010). DOI: 10.1039/C0AN00312C

I. Lanekoff , M. Thomas, J. P. Carson, J. N. Smith, C. Timchalk, J. Laskin "Imaging of Nicotine in Rat Brain Tissue Using Nanospray Desorption Electrospray Ionization Mass Spectrometry", Anal. Chem., 85, 882−889 (2013). DOI: 10.1021/ac302308p

I. Lanekoff, O. Geydebrekht, G. E. Pinchuk, J. Laskin "Spatially-Resolved Analysis of Glycolipids and Metabolites in Living Synechococcus sp. PCC 7002 Using Nanospray Desorption Electrospray Ionization", Analyst, 138, 1971–1978 (2013). DOI: 10.1039/C3AN36716A

I. Lanekoff, M. Thomas, J. Laskin "Shotgun approach for quantitative imaging of phospholipids using nanospray desorption electrospray ionization mass spectrometry", Anal. Chem., 86, 1872−1880 (2014). DOI: 10.1021/ac403931r