Philip S. Low
Next Generation Targeted Therapeutics
Lab Members
Philip Low
Dr. Philip S. Low is the Presidential Scholar for Drug Discovery and the Ralph C. Corley Distinguished Professor of Chemistry. Dr. Low has spent over 50 years exploring:
- targeted therapeutic and imaging agents for multiple human diseases (including cancer, autoimmune, infectious, inherited, and inflammatory diseases),
- the structure, function, and pathologies of the erythrocyte membrane, and
- signal transduction across plant cell membranes.
He has published over 500 scientific articles and has over 360 US patents/patents pending. Eight drugs stemming from his research are undergoing human clinical trials and seven companies (Endocyte Inc., OnTarget Laboratories Inc., Quince Therapeutics Inc., Umoja Biopharma, Eradivir Inc., Morphimmune Inc., and ErythroCure Inc.) have been founded to commercialize these discoveries. Dr. Low received his B.S. in Chemistry from BYU (1971) and his Ph.D. in Biochemistry from UCSD (1975).
Email: plow@purdue.edu
Staff
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Madduri Srinivasarao Research Assistant Professor |
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Charity Lynn Campbell Laboratory Technician |
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Ramesh Mukkamala Associate Research Scientist Design and development of Fibroblast Activation Protein (FAP) targeted ligands and their applications for delivery of attached imaging and therapeutic agents to cancers and fibrotic diseases.
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Sudarsan Reddy Kasireddy Associate Research Scientist Design, synthesis, and evaluation of ligand-targeted oligonucleotides and therapeutic agents for the treatment of cancer and fibrotic diseases.
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Suilan Zheng Research Scientist Design of novel CAR T cell (Chimeric Antigen Receptor T cell) based immunotherapies for solid tumors that can be sensitively and continuously regulated following their infusion into cancer patients.
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Reuben Dass Associate Research Scientist Developing high affinity small molecule ligands and peptides for highly expressed cancer cell surface markers and immune cell receptors for targeted delivery of therapeutic payloads and imaging agents through computer-aided drug design and organic synthesis. Conducting in vivo, ex vivo and in vitro drug candidate efficacy studies such as biodistribution, serum stability, bioavailability, tumor retention in mouse xenografts as well as cell-based binding affinity studies. Additionally, developing formulations to enhance bioavailability of drug candidates in oral suspensions, intranasal suspensions and capsules. |
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Sakkarapalayam M. Mahalingam Research Scientist Design, synthesis and preclinical evaluation of tumor targeted near infra-red dyes for the fluorescence guided surgeries of cancers. Also working on extending the half-life of therapeutics by developing RBC membrane protein binders and plasma protein binders. |
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Patricia Cauble Operations Administrator |
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Suzy Gustafson Senior Administrative Assistant |
Group Members
Visiting Scholars
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Jeffery Nielsen, Vice President of Research and Development at Eradivir Visiting Scholar Developing small molecule targeted immunotherapies to harness the power of the immune system to clear viral infections and cancers. Currently developing therapeutics for treating influenza, RSV, and Dengue. |
Ananda Kumar Kanduluru, Director of Research & Development at Eradivir Visiting Scholar Design and development of targeted therapeutic agents for multiple diseases including infectious (anti viral’s), cancer and autoimmune diseases |
Mary Niedrauer, Director of Drug Development at Eradivir Visiting Scholar Pre-clinical-early clinical development of small molecule targeted immunotherapies to harness the power of the immune system to clear various infections. Currently developing therapeutics for treating influenza, RSV, and Dengue. |
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Conrrad Nicholls, Scientist I at Eradivir Visiting Scholar Applying the immune activating dual hapten technology developed in the Low lab to virus infections, including RSV and dengue virus.
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Imrul Shahriar, Scientist I at Eradivir Visiting Scholar Development of a bispecific immune cell engager platform with applications in cancer, autoimmune, fibrotic, and infectious diseases |
Post-Doctorates
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Mahesh Kumar Rao Yelineni Post-Doctorate Design, Synthesis, and Application Evaluation of Folate targeted Steroids for Autoimmune and Inflammatory Diseases |
Da Sol Jung Post-Doctorate Development of targeted chemo- and radiotherapeutic agents that accumulate specifically in bone metastases and eradicate the painful lesions without causing damage to healthy tissues. |
Suresh Yarlagadda Post-Doctorate Design, Synthesis, and Biological Evaluation of Novel Spleen Tyrosine Kinase Inhibitors for the Treatment of Autoimmune, Inflammatory and Cancerous Diseases. |
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Ravikumar Reddy Chatrala Post-Doctorate |
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Biswajit Sen Post-Doctorate |
Graduate Students
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Jacob David Newey Ph.D. Graduate Student Design, synthesis, and testing of targeted antigens for the treatment of autoimmune diseases and allergies.
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Charles Key Stone Ph.D. Graduate Student Development, synthesis and testing of small molecule immunotherapies targeting Natural Killer cells and Neutrophils for the treatment of Cancer and Autoimmune diseases.
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Christopher Jensen Ph.D. Graduate Student Development of applications for steroids targeted to activated macrophages in the treatment of autoimmune and inflammatory diseases. |
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Pranav Ballaney Ph.D. Graduate Student Computational design, synthesis, and preclinical evaluation immune cell engagers with applications in cancer and autoimmune disorders.
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Zhixia Chi Ph.D. Graduate Student Design and develop new ligand-conjugated antisense oligonucleotides for preclinical studies of fibrotic diseases, with a focus on renal fibrosis |
Mohammed Yusuf Al Amin Ph.D. Graduate Student Development of cytokine inhibitory drugs targeting (a) tumor associated macrophages (TAMs) and cancer associated fibroblasts (CAFs) in the management of cancer, and (b) activated macrophages and fibroblasts in the treatment of fibrosis.
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Shomoita Sayed Ph.D. Graduate Student Development and Optimization of targeted novel therapeutics for the treatment of retinal diseases. |
Yingqi Chen Ph.D. Graduate Student Design and development of an antigen, targeting ligand, and adjuvant integrated into a single universal dendritic cell (DC) targeting vaccine for use in cancer and infectious disease models. |
Hunter Hutson Ph.D. Graduate Student Design and development of small molecule targeted therapeutics for the treatment of CNS diseases. |
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Kavya Ananthaswamy Ph.D. Graduate Student
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Mohammed Sazzadul Bari Ph.D. Graduate Student |
Qingshi Chen Ph.D. Graduate Student |
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Cameron Smith Ph.D. Graduate Student Development and characterization of small molecule drug conjugates for targeting and repolarizing TAMs in the tumor microenvironment for the treatment of cancer. |
Haowei Xu Ph.D. Graduate Student Development of targeted therapeutics to alleviate obesity and renal transplant rejection
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Roman Slowinski Ph.D. Graduate Student Developing molecular shuttling systems to transport therapeutics across the Blood-Brain Barrier. |
