The late Philip S. Low Lab

under the direction of Madduri Srinivasarao

Next Generation Targeted Therapeutics

Radioligand therapies for cancer

Data derived from two of our recently designed radioligand therapies is shown below.  The first, a single dose of our FAP9-targeted 177Lu radiotherapy is shown to control PANC-1 tumors in mice, while the second, a single dose of three different versions of our bone metastasis-targeted 177Lu radiotherapy is shown to control prostate cancer metastases (implants) to the bone, as measured by serum PSA levels.  Several other radioligand therapies are also under development.

 

A single dose of our FAP9-targeted 177Lu radiotherapy is shown to control PANC-1 tumors in mice   A single dose of three different versions of our bone metastasis-targeted 177Lu radiotherapy are shown to control prostate cancer metastases to the bone.